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    BLOOD FLOW COMPUTATION IN VESSELS WITH IMPLANTED DEVICES
    1.
    发明申请
    BLOOD FLOW COMPUTATION IN VESSELS WITH IMPLANTED DEVICES 有权
    血管流动计算在具有植入装置的血管中

    公开(公告)号：US20130191100A1

    公开(公告)日：2013-07-25

    申请号：US13744857

    申请日：2013-01-18

    申请人： Viorel Mihalef ,  Puneet Sharma ,  Thomas Redel ,  Ali Kamen

    发明人： Viorel Mihalef ,  Puneet Sharma ,  Thomas Redel ,  Ali Kamen

    IPC分类号： G06F19/00

    CPC分类号： G16H50/50 ,  A61B6/032 ,  A61B6/486 ,  A61B6/504 ,  A61B6/5217 ,  G06T19/00 ,  G06T2210/41

    摘要： A method for modeling blood flow through a flow diverter includes receiving a medical image containing blood vessels. Vessel geometry is extracted from the received medical image. Inlets and outlets are tagged within the extracted vessel geometry. A desired flow diverter is selected. A model of the selected flow diverter is generated within the imaged blood vessel, the model representing the flow diverter as a tube having a porous surface characterized by a viscous resistance and an inertial resistance. A course of blood flow though the flow diverter is predicted based on the generated model, the extracted vessel geometry, and the tagged inlets and outlets.

    摘要翻译： 通过流转向器对血液流动进行建模的方法包括接收包含血管的医学图像。 从接收到的医学图像中提取血管几何。 进口和出口在提取的容器几何中被标记。 选择所需的分流器。 所选流量分流器的模型在成像的血管内产生，该模型表示流量分流器为具有以粘性阻力和惯性阻力为特征的多孔表面的管。 基于生成的模型，提取的血管几何形状和标记的入口和出口预测通过流量分流器的血液流动过程。

    Blood flow computation in vessels with implanted devices
    2.
    发明授权
    Blood flow computation in vessels with implanted devices 有权
    带有植入装置的血管中的血流计算

    公开(公告)号：US08965084B2

    公开(公告)日：2015-02-24

    申请号：US13744857

    申请日：2013-01-18

    申请人： Viorel Mihalef ,  Puneet Sharma ,  Thomas Redel ,  Ali Kamen

    发明人： Viorel Mihalef ,  Puneet Sharma ,  Thomas Redel ,  Ali Kamen

    IPC分类号： G06K9/00 ,  G06K9/36 ,  G06F19/00 ,  G06T19/00 ,  A61B6/03 ,  A61B6/00

    CPC分类号： G16H50/50 ,  A61B6/032 ,  A61B6/486 ,  A61B6/504 ,  A61B6/5217 ,  G06T19/00 ,  G06T2210/41

    摘要： A method for modeling blood flow through a flow diverter includes receiving a medical image containing blood vessels. Vessel geometry is extracted from the received medical image. Inlets and outlets are tagged within the extracted vessel geometry. A desired flow diverter is selected. A model of the selected flow diverter is generated within the imaged blood vessel, the model representing the flow diverter as a tube having a porous surface characterized by a viscous resistance and an inertial resistance. A course of blood flow though the flow diverter is predicted based on the generated model, the extracted vessel geometry, and the tagged inlets and outlets.

    摘要翻译： 通过流转向器对血液流动进行建模的方法包括接收包含血管的医学图像。 从接收到的医学图像中提取血管几何。 进口和出口在提取的容器几何中被标记。 选择所需的分流器。 所选流量分流器的模型在成像的血管内产生，该模型表示流量分流器为具有以粘性阻力和惯性阻力为特征的多孔表面的管。 基于生成的模型，提取的血管几何形状和标记的入口和出口预测通过流量分流器的血液流动过程。

    Method and System for Functional Assessment of Renal Artery Stenosis from Medical Images
    5.
    发明申请
    Method and System for Functional Assessment of Renal Artery Stenosis from Medical Images 有权
    医学图像肾动脉狭窄功能评估方法与系统

    公开(公告)号：US20150065864A1

    公开(公告)日：2015-03-05

    申请号：US14477770

    申请日：2014-09-04

    申请人： Puneet Sharma ,  Saikiran Rapaka ,  Viorel Mihalef ,  Ali Kamen

    发明人： Puneet Sharma ,  Saikiran Rapaka ,  Viorel Mihalef ,  Ali Kamen

    IPC分类号： A61B5/026 ,  G01R33/563 ,  A61B5/021

    CPC分类号： A61B5/0263 ,  A61B5/021 ,  A61B5/055 ,  A61B2576/023 ,  G01R33/56316 ,  G01R33/5635

    摘要： A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta.

    摘要翻译： 公开了一种用于非侵入性评估肾动脉狭窄的方法和系统。 肾动脉和主动脉的至少一部分的患者特异性解剖模型由患者的医学图像数据产生。 基于患者特异性解剖模型估计肾动脉和主动脉部分血流计算模型的患者特异性边界条件。 使用基于患者特异性边界条件的计算模型在肾动脉和主动脉的部分中模拟血流和压力。 基于肾动脉和主动脉部分的模拟血流量和压力计算表征肾狭窄区域的功能严重性的至少一个血液动力学量。

    Patient Specific Planning and Simulation of Ablative Procedures
    6.
    发明申请
    Patient Specific Planning and Simulation of Ablative Procedures 有权
    消融程序的患者具体规划和模拟

    公开(公告)号：US20140296842A1

    公开(公告)日：2014-10-02

    申请号：US13854991

    申请日：2013-04-02

    申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

    IPC分类号： A61B19/00 ,  G06F17/50 ,  A61B18/12

    CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

    摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

    摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。

    System and Method for Patient Specific Modeling of Liver Tumor Ablation
    7.
    发明申请
    System and Method for Patient Specific Modeling of Liver Tumor Ablation 有权
    肝脏肿瘤消融患者特异性建模的系统和方法

    公开(公告)号：US20140136174A1

    公开(公告)日：2014-05-15

    申请号：US14071688

    申请日：2013-11-05

    申请人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

    发明人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

    IPC分类号： G06F19/12

    CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/3481 ,  G09B23/30

    摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

    摘要翻译： 公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。 根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。 根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。 基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。 基于模拟热扩散模拟肝脏细胞坏死。 生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。

    Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation
    8.
    发明申请
    Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation 审中-公开
    冠状动脉循环多尺度解剖与功能建模方法与系统

    公开(公告)号：US20130132054A1

    公开(公告)日：2013-05-23

    申请号：US13672781

    申请日：2012-11-09

    申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Bogdan Georgescu ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Bogdan Georgescu ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/12

    CPC分类号： G06F19/12 ,  G06F19/00 ,  G06F19/321 ,  G16H50/30 ,  G16H50/50

    摘要： A method and system for multi-scale anatomical and functional modeling of coronary circulation is disclosed. A patient-specific anatomical model of coronary arteries and the heart is generated from medical image data of a patient. A multi-scale functional model of coronary circulation is generated based on the patient-specific anatomical model. Blood flow is simulated in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. Hemodynamic quantities, such as fractional flow reserve (FFR), are computed to determine a functional assessment of the stenosis, and virtual intervention simulations are performed using the multi-scale function model of coronary circulation for decision support and intervention planning.

    摘要翻译： 公开了一种用于冠状循环多尺度解剖和功能建模的方法和系统。 冠状动脉和心脏的患者特异性解剖模型由患者的医学图像数据产生。 基于患者特异性解剖模型产生冠状动脉循环的多尺度功能模型。 使用冠状动脉循环的多尺度功能模型在至少一个冠状动脉的至少一个狭窄区域中模拟血流量。 计算血流动力学量，例如分数流量储备（FFR），以确定狭窄的功能评估，并使用冠状动脉循环的多尺度函数模型进行虚拟干预模拟，以进行决策支持和干预计划。