-
公开(公告)号：US06068982A
公开(公告)日：2000-05-30
申请号：US767942
申请日：1996-12-17
申请人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
发明人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
IPC分类号： G01N33/48 , C07K16/40 , C12N9/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6842 , C12N9/93 , C12Q1/25 , G01N33/68 , A01K2217/05
摘要： The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
摘要翻译： 本发明涉及药物筛选测定法，其提供了用于鉴定能够抑制泛素介导的细胞周期调节蛋白如p53，p27，myc，fos，MATα2等的降解的候选试剂的系统和实用的方法。 或细胞周期蛋白。 本发明还涉及新的泛素结合酶及其相关用途。
-
公开(公告)号：US06509152B1
公开(公告)日：2003-01-21
申请号：US09012399
申请日：1998-01-23
IPC分类号： C12Q168
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译： 本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。
-
公开(公告)号：US5968761A
公开(公告)日：1999-10-19
申请号：US486663
申请日：1995-06-07
申请人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
发明人： Mark Rolfe , Maria Isabel Chiu , Guillaume Cottarel , Vivian Berlin , Veronique Damagnez , Giulio Draetta
IPC分类号： G01N33/48 , C07K16/40 , C12N9/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/68 , C12Q1/48 , C12N9/10
CPC分类号： G01N33/6842 , C12N9/93 , C12Q1/25 , G01N33/68 , A01K2217/05
摘要： The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.
-
公开(公告)号：US20110065898A1
公开(公告)日：2011-03-17
申请号：US12625940
申请日：2009-11-25
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译： 本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。
-
公开(公告)号：US6127521A
公开(公告)日：2000-10-03
申请号：US12515
申请日：1998-01-23
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07K19/00 , C07K11/00 , C07K14/00
CPC分类号： G01N33/5091 , C07K14/40 , C07K14/4702 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , A01K2217/05 , C07K2319/00 , C12Q2600/158 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
-
公开(公告)号：US06464974B1
公开(公告)日：2002-10-15
申请号：US09012504
申请日：1998-01-23
IPC分类号： C07K1600
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes and provides, e.g., isolated polypeptides, nucleic acids encoding such, antibodies, screening methods, and diagnostic and therepeutic methods.
摘要翻译： 本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标，并提供例如分离的多肽，编码此类核酸，抗体，筛选方法以及诊断和方法。
-
公开(公告)号：US6150137A
公开(公告)日：2000-11-21
申请号：US360144
申请日：1994-12-20
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07H21/04
CPC分类号： G01N33/5091 , C07K14/40 , C07K14/4702 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , A01K2217/05 , C07K2319/00 , C12Q2600/158 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
-
公开(公告)号：US20050059803A1
公开(公告)日：2005-03-17
申请号：US10877320
申请日：2004-06-24
IPC分类号： G01N33/53 , C07K14/40 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12P21/02 , C12Q1/25 , C12Q1/68 , G01N33/566 , G01N33/68 , G01N33/94 , C07K14/74
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
摘要： The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.
摘要翻译： 本发明涉及哺乳动物来源的新型蛋白质的发现，其是FKBP /雷帕霉素复合物的即时下游靶标。
-
9.发明授权Assays and reagents for identifying anti-fungal agents, and uses related thereto 失效用于鉴定抗真菌剂的试剂和试剂及其相关用途公开(公告)号：US06727082B1
公开(公告)日：2004-04-27
申请号：US09041990
申请日：1998-03-13
IPC分类号： C12N910
CPC分类号： C12N9/1085 , A61K38/00 , C07K14/40 , C07K16/14 , C07K2319/00 , C12N9/16 , C12Q1/18 , C12Q1/48 , C12Q1/6895 , C12Q1/6897 , C12Y205/01029 , C12Y301/05001 , G01N33/573 , G01N2333/40 , G01N2333/91091 , G01N2333/91165
摘要： The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
摘要翻译： 本发明涉及用于筛选和鉴定特异性抑制真菌GTP酶蛋白质，特别是参与细胞壁完整性，菌丝形成和/或对发病机制至关重要的其它细胞功能的GTP酶的药学有效化合物的快速，可靠和有效的测定。 本发明的另一方面涉及新颖的念珠菌基因和基因产物。
-
10.发明授权Candida geranylgeranyl-protein transferase polypetide, compositions and methods related thereto 失效念珠菌香叶基香叶基蛋白转移酶多肽，其组合物和方法公开(公告)号：US06696280B2
公开(公告)日：2004-02-24
申请号：US09945249
申请日：2001-08-31
IPC分类号： C12N910
CPC分类号： C12N9/1085 , A61K38/00 , C07K14/40 , C07K16/14 , C07K2319/00 , C12N9/16 , C12Q1/18 , C12Q1/48 , C12Q1/6895 , C12Q1/6897 , C12Y205/01029 , C12Y301/05001 , G01N33/573 , G01N2333/40 , G01N2333/91091 , G01N2333/91165
摘要： The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
摘要翻译： 本发明涉及用于筛选和鉴定特异性抑制真菌GTP酶蛋白质，特别是参与细胞壁完整性，菌丝形成和/或对发病机制至关重要的其它细胞功能的GTP酶的药学有效化合物的快速，可靠和有效的测定。 本发明的另一方面涉及新颖的念珠菌基因和基因产物。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.034 秒)
