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公开(公告)号：US07179562B2
公开(公告)日：2007-02-20
申请号：US10630541
申请日：2003-07-29
申请人： Vladimir Zolotnik , Alex Z. Pàl , Jose A. Ulloa , Vladimir Gusev , Joseph Wong
发明人： Vladimir Zolotnik , Alex Z. Pàl , Jose A. Ulloa , Vladimir Gusev , Joseph Wong
CPC分类号： H01M2/266 , H01M10/04 , Y10T29/49108 , Y10T29/49114
摘要： An electrode assembly and construction method therefor for use in small high performance batteries suitable for implantable medical device applications. The electrode assembly comprises a stack of precisely aligned planar elements including alternately arranged positive and negative planar electrodes having a planar separator interposed between adjacent electrodes. Each electrode is preferably formed of a thin metal substrate carrying active material on front and rear faces. The peripheral edge of each electrode defines an active area and a tab extending therefrom. The front and rear faces of the active area each carries a layer of active material. The faces of the tab area are preferably bare. The positive electrode tabs are located at a first position along the peripheral edge whereas the negative tabs are located at a second position spaced from said first position. Each tab carries a clip to form a reinforcing strip adjacent each tab face. Alignment holes are formed in the clips and tabs.
摘要翻译： 一种用于适用于可植入医疗器械应用的小型高性能电池的电极组件及其构造方法。 电极组件包括精确排列的平面元件的堆叠，包括交替布置的正平面电极和负平面电极，其间具有介于相邻电极之间的平面分离器。 每个电极优选由在前表面和后表面上承载活性材料的薄金属基底形成。 每个电极的外围边缘限定有效区域和从其延伸的突片。 活动区域的前后表面各有一层活性材料。 标签区域的面最好是裸露的。 正极片位于沿着周边边缘的第一位置，而负极片位于与所述第一位置间隔开的第二位置。 每个翼片都带有一个夹子，以形成一个邻近每个翼片面的加强条。 对准孔形成在夹子和突片中。
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公开(公告)号：US20050273773A1
公开(公告)日：2005-12-08
申请号：US10908654
申请日：2005-05-20
申请人： Steven Gold , David Baker , Vladimir Gusev , Hongping Liang
发明人： Steven Gold , David Baker , Vladimir Gusev , Hongping Liang
CPC分类号： G06F8/34 , Y10S707/99944
摘要： A software system is provided including an Object Process Graph for defining applications and a Dynamic Graph Interpreter that interprets Object Process Graphs. An Object Process Graph defines all of an application's manipulations and processing steps and all of the application's data. An Object Process Graph is dynamic, making it possible to change any aspect of an application's data entry, processing or information display at any time. When an Object Process Graph is interpreted, it functions to accept data, process the data and produce information output. Modifications made to an Object Process Graph while it is being interpreted take affect immediately and can be saved. Object Process Graphs and Dynamic Graph Interpreters can be deployed on single user workstation computers or on distributed processing environments where central servers store Object Process Graphs and run Dynamic Graph Interpreters, and workstation computers access the servers via the intranet or local intranets.
摘要翻译： 提供了一个软件系统，包括用于定义应用程序的对象过程图和解释对象过程图的动态图解释器。 对象过程图定义了应用程序的所有操作和处理步骤以及所有应用程序的数据。 对象过程图是动态的，可以随时更改应用程序的数据输入，处理或信息显示的任何方面。 当对象过程图被解释时，它用于接受数据，处理数据并产生信息输出。 对象进程图在进行解释时进行的修改立即生效，可以保存。 对象过程图和动态图解释器可以部署在单用户工作站计算机或分布式处理环境中，其中中央服务器存储对象过程图并运行动态图解释器，工作站计算机通过Intranet或本地Intranet访问服务器。
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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060015857A1
公开(公告)日：2006-01-19
申请号：US10908653
申请日：2005-05-20
申请人： Steven Gold , David Baker , Vladimir Gusev , Hongping Liang
发明人： Steven Gold , David Baker , Vladimir Gusev , Hongping Liang
IPC分类号： G06F9/45
CPC分类号： G06F9/451
摘要： A computer software system is provided, namely, An Object Process Graph Application Controller-Viewer (OPGACV) system. The OPGACV controls a running Object Process Graph (OPG) application by inducing a Dynamic Graph Interpreter (DGI) to transition applications from one state to another, and using application designer/user defined properties, it renders application state, structure, and data on display mediums and validates data inputs to applications. The OPGACV also controls the import and export of OPG applications.
摘要翻译： 提供了一种计算机软件系统，即对象过程图应用控制器 - 查看器（OPGACV）系统。 OPGACV通过引入动态图解释器（DGI）来将应用程序从一个状态转换到另一个状态，并使用应用程序设计器/用户定义的属性来控制正在运行的对象进程图（OPG）应用程序，它将显示应用程序状态，结构和数据 介质并验证应用程序的数据输入。 OPGACV还控制OPG应用的进出口。
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公开(公告)号：US07316001B2
公开(公告)日：2008-01-01
申请号：US10908654
申请日：2005-05-20
CPC分类号： G06F8/34 , Y10S707/99944
摘要： A software system is provided including an Object Process Graph for defining applications and a Dynamic Graph Interpreter that interprets Object Process Graphs. An Object Process Graph defines all of an application's manipulations and processing steps and all of the application's data. An Object Process Graph is dynamic, making it possible to change any aspect of an application's data entry, processing or information display at any time. When an Object Process Graph is interpreted, it functions to accept data, process the data and produce information output. Modifications made to an Object Process Graph while it is being interpreted take affect immediately and can be saved. Object Process Graphs and Dynamic Graph Interpreters can be deployed on single user workstation computers or on distributed processing environments where central servers store Object Process Graphs and run Dynamic Graph Interpreters, and workstation computers access the servers via the intranet or local intranets.
摘要翻译： 提供了一个软件系统，包括用于定义应用程序的对象过程图和解释对象过程图的动态图解释器。 对象过程图定义了应用程序的所有操作和处理步骤以及所有应用程序的数据。 对象过程图是动态的，可以随时更改应用程序的数据输入，处理或信息显示的任何方面。 当对象过程图被解释时，它用于接受数据，处理数据并产生信息输出。 对象进程图在进行解释时进行的修改立即生效，可以保存。 对象过程图和动态图解释器可以部署在单用户工作站计算机或分布式处理环境中，其中中央服务器存储对象过程图并运行动态图解释器，工作站计算机通过Intranet或本地Intranet访问服务器。
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公开(公告)号：US07360209B2
公开(公告)日：2008-04-15
申请号：US10908653
申请日：2005-05-20
CPC分类号： G06F9/451
摘要： A computer software system is provided, namely, An Object Process Graph Application Controller-Viewer (OPGACV) system. The OPGACV controls a running Object Process Graph (OPG) application by inducing a Dynamic Graph Interpreter (DGI) to transition applications from one state to another, and using application designer/user defined properties, it renders application state, structure, and data on display mediums and validates data inputs to applications. The OPGACV also controls the import and export of OPG applications.
摘要翻译： 提供了一种计算机软件系统，即对象过程图应用控制器 - 查看器（OPGACV）系统。 OPGACV通过引入动态图解释器（DGI）来将应用程序从一个状态转换到另一个状态，并使用应用程序设计器/用户定义的属性来控制正在运行的对象进程图（OPG）应用程序，它将显示应用程序状态，结构和数据 介质并验证应用程序的数据输入。 OPGACV还控制OPG应用的进出口。
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公开(公告)号：US20060111561A1
公开(公告)日：2006-05-25
申请号：US11217997
申请日：2005-08-31
申请人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
发明人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/475 , C07K16/22
摘要： Disclosed are novel proteins and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the proteins and polynucleotides, as well as methods for using same.
摘要翻译： 公开了编码相同的新蛋白质和核酸。 还公开了用于产生蛋白质和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。
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公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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9.发明申请公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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