利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.027 秒)

    METHOD AND SYSTEM FOR MONITORING CORNEAL TISSUE HEALTH
    1.
    发明申请
    METHOD AND SYSTEM FOR MONITORING CORNEAL TISSUE HEALTH 有权

    公开(公告)号：US20230101480A1

    公开(公告)日：2023-03-30

    申请号：US17947661

    申请日：2022-09-19

    申请人： W. L. Gore & Associates, Inc. ,  Johns Hopkins University School of Medicine

    发明人： Esen K. Akpek ,  Gopalan V. Balaji ,  Jose J. de la Cruz ,  Theodore C. Fleck ,  Genevieve M. Gurczenski ,  Thomas B. Schmiedel

    IPC分类号： A61B3/10 ,  G16H50/20

    摘要： Methods, apparatuses, and systems for monitoring health of corneal tissue are disclosed. The system includes a corneal measurement device configured to measure a first state of health indicator that is tissue thickness or volume of a region of the corneal tissue during a first period of time and a second state of health indicator that is tissue thickness or volume of the region during a second period of time after the first period of time. The system further includes a processing unit configured to receive the first and second state of health indicators from the corneal measurement device and generate a health map of the region based on the first and second state of health indicators, the health map indicative of a change between the first and second state of health indicators as measured from the first period of time to the second period of time in the region of the cornea.

    METHOD AND SYSTEM FOR MONITORING CORNEAL TISSUE HEALTH
    3.
    发明申请
    METHOD AND SYSTEM FOR MONITORING CORNEAL TISSUE HEALTH 有权

    公开(公告)号：US20230086902A1

    公开(公告)日：2023-03-23

    申请号：US17947646

    申请日：2022-09-19

    申请人： W. L. Gore & Associates, Inc.

    发明人： Gopalan V. Balaji ,  Jose J. de la Cruz ,  Theodore C. Fleck ,  Genevieve M. Gurczenski ,  Thomas B. Schmiedel

    IPC分类号： A61B3/10 ,  A61B3/107

    摘要： Methods, apparatuses, and systems for monitoring health of corneal tissue are disclosed. The system includes a corneal measurement device configured to measure a first state of health indicator that is tissue opacity or density of a region of the corneal tissue during a first period of time and a second state of health indicator that is tissue opacity or density of the region during a second period of time after the first period of time. The system further includes a processing unit configured to receive the first and second state of health indicators from the corneal measurement device and generate a health map of the region based on the first and second state of health indicators, the health map indicative of a change between the first and second state of health indicators as measured from the first period of time to the second period of time in the region of the cornea.

    EPITHELIAZING MICROPOROUS BIOMATERIAL FOR USE IN AVASCULAR ENVIRONMENTS AND IN CORNEAL IMPLANTS
    4.
    发明申请
    EPITHELIAZING MICROPOROUS BIOMATERIAL FOR USE IN AVASCULAR ENVIRONMENTS AND IN CORNEAL IMPLANTS 有权

    公开(公告)号：US20210252194A1

    公开(公告)日：2021-08-19

    申请号：US17252036

    申请日：2019-06-14

    申请人： W. L. Gore & Associates, Inc.

    发明人： Gopalan V. Balaji ,  Paul J. Fischer ,  Thomas B. Schmiedel ,  Anuraag Singh

    IPC分类号： A61L27/56 ,  A61L27/16 ,  A61L27/34 ,  A61L27/44

    摘要： A microporous biocomposite that is suitable for surgical implantation in an avascular environment is provided. The microporous biocomposite includes (1) a polymer scaffold having a thickness less than about 100 μm and nodal structures that extend to at least one surface of the polymer scaffold and (2) a hydrophilic coating on the polymer scaffold. In some embodiments, the porous scaffold is a microporous biomaterial with nodal structures that extend from a first surface to a second surface of the microporous biomaterial. The hydrophilic coating may be a node and fibril coating. The microporous biocomposite allows for the integration and sustained viability of epithelial cells on the surface thereof as well as tissue integration and the internal colonization of the biomaterial with other cell types, such as keratocytes and fibroblasts. In at least one embodiment, the microporous biocomposite may be incorporated into an artificial corneal implant or in other avascular mesoplants.

    ARTIFICIAL CORNEA
    5.
    发明申请
    ARTIFICIAL CORNEA 有权

    公开(公告)号：US20210244528A1

    公开(公告)日：2021-08-12

    申请号：US17252017

    申请日：2019-06-14

    申请人： W. L. Gore & Associates, Inc. ,  The Johns Hopkins University

    发明人： Gopalan V. Balaji ,  Thomas B. Schmiedel ,  Anuraag Singh ,  Esen K. Akpek

    IPC分类号： A61F2/14 ,  A61F2/00 ,  A61L27/16 ,  A61B3/16 ,  C08F214/26 ,  C08F216/14

    摘要： Artificial corneas suitable for surgical implantation are provided. Embodiments of artificial corneas include an optical an optical element that includes a body having an anterior side and a posterior side, an annular flange extending about the body, the anterior side including an anterior optical surface and the posterior side of the body including a posterior optical surface, and a tissue integration skirt coupled to the optical element, the tissue integration skirt being configured to promote tissue ingrowth, the tissue integration skirt being coupled to the optical element such that at least a portion of a periphery of the annular flange defined between the anterior and posterior sides of the optical element is covered by the tissue integration skirt. Also described are methods for implanting an artificial cornea of the present disclosure, the methods including providing the artificial cornea, removing a section of corneal tissue from the patient's cornea to form a tissue bed of existing tissue to which the artificial cornea can be affixed, implanting the art the artificial cornea such that the posterior side of the artificial cornea is suspended above the interior of the eye, and mechanically affixing the implanted artificial cornea to the existing corneal tissue of the tissue bed.