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公开(公告)号：US4625041A
公开(公告)日：1986-11-25
申请号：US770472
申请日：1985-08-29
IPC分类号： A23K20/195 , C07H19/01 , C12P19/44 , C12P19/60 , C07D309/10
CPC分类号： C07H19/01 , A23K20/195 , C12P19/445 , C12P19/60 , C12R1/465
摘要： A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
摘要翻译： 一种新的酸性多环醚抗生素CP-63,517，具有下式：其中通过唾液链霉菌（Streptomyces endus subsp。）的浸没有氧繁殖产生的阳离子盐。 金黄色葡萄球菌ATCC-39574是从日本土壤样品中分离的新菌株，该抗生素的生产方法及其用于改善饲料利用，促进牛和猪生长以及控制球虫病的方法。
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2.发明授权
公开(公告)号：US4543334A
公开(公告)日：1985-09-24
申请号：US562784
申请日：1983-12-16
CPC分类号： C07H17/08 , C12P19/62 , C12R1/465 , Y10S435/886
摘要： An antibiotic complex, consisting of one major and two minor components, has been isolated from fermentation of a new Streptomyces culture. The components from the complex are three new macrolides which are active as antibacterial agents against certain gram-negative and gram-positive microorganisms.
摘要翻译： 由一种主要和两个次要组分组成的抗生素复合物已经从新的链霉菌培养物的发酵中分离出来。 来自该复合物的组分是三种新的大环内酯类，其作为针对某些革兰氏阴性和革兰氏阳性微生物的抗菌剂是有活性的。
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公开(公告)号：US4652523A
公开(公告)日：1987-03-24
申请号：US660619
申请日：1984-10-15
IPC分类号： C07D493/10 , C12P17/18 , C12R1/465
CPC分类号： C07D493/10 , C12P17/181 , Y10S435/886
摘要： A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has been named Streptomyces routienii Huange sp. nov., (ATCC 30446). The new antibiotic exhibits antibacterial activity against a variety of gram-positive bacteria; it can be used to control swine dysentery; and it promotes increased efficiency of feed utilization (i.e. promotes increased growth) in swine and ruminants.
摘要翻译： 已经从链霉菌属的新微生物的发酵中分离出新的聚醚抗生素。 这种新的微生物被命名为N478-13，它被命名为Streptomyces routienii Huange sp。 （ATCC 30446）。 新型抗生素对各种革兰氏阳性菌具有抗菌活性; 可用于控制猪痢疾; 并且促进猪和反刍动物饲料利用效率提高（即促进生长增长）。
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公开(公告)号：US4707493A
公开(公告)日：1987-11-17
申请号：US931587
申请日：1986-11-17
IPC分类号： C07H19/01 , C12P19/44 , C12P19/60 , C07D309/10
CPC分类号： C07H19/01 , C12P19/445 , C12P19/60 , C12R1/55
摘要： Antibiotic 19-epi-dianemycin, process for its preparation by fermenting a new strain of Streptomyces hygroscopicus, and isolation from the fermentation broth; and its use as an anticoccidial agent and antibacterial agent against gram-positive bacteria.
摘要翻译： 抗生素19-epi-dianemycin，其制备方法是通过发酵新的吸水链霉菌菌株和从发酵液中分离; 并作为抗球虫剂和抗革兰氏阳性菌的抗菌剂使用。
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公开(公告)号：US4547523A
公开(公告)日：1985-10-15
申请号：US549378
申请日：1983-11-07
IPC分类号： C07D493/10 , C12P17/18 , C07D263/56
CPC分类号： C07D493/10 , C12P17/181 , Y10S435/886
摘要： A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has ben named Streptomyces routienii Huang sp. nov., (ATCC 39446). The new antibiotic exhibits antibacterial activity against a variety of gram-positive bacteria; it can be used to control swine dysentery; and it promotes increased efficiency of feed utilization (i.e. promotes increased growth) in swine and ruminants.
摘要翻译： 已经从链霉菌属的新微生物的发酵中分离出新的聚醚抗生素。 这种新的微生物被指定为N478-13，它具有本命名为Streptomyces routienii Huang sp。 nov。，（ATCC 39446）。 新型抗生素对各种革兰氏阳性菌具有抗菌活性; 可用于控制猪痢疾; 并且促进猪和反刍动物饲料利用效率提高（即促进生长增长）。
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6.发明授权Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus 失效通过培养新型链霉菌属亚种金黄色葡萄球菌生产酸性多环醚抗生素的方法
公开(公告)号：US4552843A
公开(公告)日：1985-11-12
申请号：US581384
申请日：1984-02-17
IPC分类号： C07D519/00 , A23K1/16 , A23K1/17 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P3/00 , C07H17/04 , C07H19/01 , C12N1/20 , C12P1/00 , C12P17/18 , C12P19/00 , C12P19/44 , C12P19/60 , C12R1/465 , C12P19/62
CPC分类号： C07H19/01 , A23K20/195 , C12P19/445 , C12P19/60 , C12R1/465 , Y10S435/886
摘要： A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
摘要翻译： 一种新的酸性多环醚抗生素CP-63,517，具有下式：其中通过唾液链霉菌（Streptomyces endus subsp。）的淹没有氧繁殖产生的阳离子盐。 金黄色葡萄球菌ATCC-39574是从日本土壤样品中分离的新菌株，该抗生素的生产方法及其用于改善饲料利用，促进牛和猪生长以及控制球虫病的方法。
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7.发明授权Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant 失效酸性多环醚可用作抗球虫剂和作为生长促进剂
公开(公告)号：US5891727A
公开(公告)日：1999-04-06
申请号：US849553
申请日：1992-03-11
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K20/195 , C07H17/04 , C12P17/16 , C12P19/60 , C12N1/00
CPC分类号： C12P17/162 , A23K20/195 , C07H17/04 , C12P19/60 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53676.这种新型抗生素在小鸡和牛和猪的生长促进剂中作为抗球虫病有用。
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公开(公告)号：US5418152A
公开(公告)日：1995-05-23
申请号：US30086
申请日：1993-03-12
申请人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , A61K31/35 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P33/02 , C07D493/10 , C07H17/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12P19/60 , C12R1/03 , C12P17/16
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/181 , C12P19/445 , C12R1/01
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
摘要翻译： PCT No.PCT / US91 / 06084 Sec。 371日期1993年3月12日 102（e）1993年3月12日PCT 1991年8月30日PCT申请。具有通过X射线晶体学建立的结构的酸性多环醚类抗生素通过新型微生物Actinomadura sp。 ATCC 55080.这种新型抗生素可用作家禽中的抗球虫病，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。
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公开(公告)号：US5403738A
公开(公告)日：1995-04-04
申请号：US169566
申请日：1993-12-17
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/18 , C12P19/44 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53764.这种新型抗生素可用作鸡的抗球虫病，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。
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公开(公告)号：US4992423A
公开(公告)日：1991-02-12
申请号：US153187
申请日：1988-02-08
申请人： Walter P. Cullen , Hiroshi Maeda , John C. Ruddock , Junsuke Tone
发明人： Walter P. Cullen , Hiroshi Maeda , John C. Ruddock , Junsuke Tone
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , A61P33/02 , C07H17/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12P19/60 , C12R1/03
CPC分类号： C07H19/01 , C12P19/44 , C12P19/60 , C12R1/03 , Y10S435/825
摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
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