公开(公告)号：US20230101326A1

公开(公告)日：2023-03-30

申请号：US17896938

申请日：2022-08-26

Applicant: Waters Technologies Corporation

Inventor： MingCheng Xu ,  Darryl W. Brousmiche ,  Daniel P. Walsh ,  Nicole L. Lawrence ,  Kevin D. Wyndham

IPC: B01J13/14 ,  C08L83/04 ,  C08L39/06

Abstract: In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such core-shell particles and (b) flowing a mobile phase through the column.

公开(公告)号：US20230073279A1

公开(公告)日：2023-03-09

申请号：US17896324

申请日：2022-08-26

Applicant: Waters Technologies Corporation

Inventor： MingCheng Xu ,  Darryl W. Brousmiche ,  Kevin Wyndham ,  Daniel P. Walsh ,  Nicole L. Lawrence

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/285

Abstract: In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 Å to 3000 Å. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such organic polymer core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such organic polymer core-shell particles and (b) flowing a mobile phase through the column.

公开(公告)号：US20250033028A1

公开(公告)日：2025-01-30

申请号：US18785487

申请日：2024-07-26

Applicant: Waters Technologies Corporation

Inventor： MingCheng Xu ,  Matthew Lauber ,  Balasubrahmanyam Addepalli ,  Kristine Joy Camacho ,  Oksana Tchoul ,  Lavelay Kizekai

IPC: B01J20/289 ,  B01J20/22 ,  B01J20/28 ,  G01N30/16 ,  G01N30/74

Abstract: The present disclosure is directed to hybrid-bonded siliceous materials. The materials of the present disclosure exhibit enhanced base stability and reduced baseline noise. As such, the materials disclosed herein are suitable for use across a range of chromatography applications, including size-exclusion chromatography and reversed-phase chromatography.

公开(公告)号：US20240359161A1

公开(公告)日：2024-10-31

申请号：US18647811

申请日：2024-04-26

Applicant: Waters Technologies Corporation

Inventor： Kevin Wyndham ,  Beatrice Muriithi ,  Oksana Tchoul ,  Yeliz Tunc Sarisozen ,  MingCheng Xu ,  Matthew Lauber

IPC: B01J20/289 ,  B01D15/22 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

CPC classification number: B01J20/289 ,  B01D15/22 ,  B01D15/3809 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3274

Abstract: The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with streptavidin. The streptavidin functionalized particles of the present disclosure can be bound to biotinylated antibodies, biotinylated antigen-binding fragments thereof, or biotinylated oligonucleotides to create customizable affinity chromatography columns. That is, the functionalized nonporous polymer particles can be packed in a stainless steel, titanium, or other metal or metal alloy column for affinity high pressure liquid chromatography (HPLC).

公开(公告)号：US20230182114A1

公开(公告)日：2023-06-15

申请号：US18056434

申请日：2022-11-17

Applicant: Waters Technologies Corporation

Inventor： Yeliz Tunc Sarisozen ,  Nicole L. Lawrence ,  Darryl W. Brousmiche ,  MingCheng Xu ,  Kevin Wyndham

IPC: B01J20/289 ,  B01J20/287 ,  B01J20/28 ,  B01J20/10 ,  B01D15/34

CPC classification number: B01J20/289 ,  B01D15/34 ,  B01J20/103 ,  B01J20/287 ,  B01J20/2808 ,  B01J20/28052 ,  B01J20/28083 ,  B01J20/28085 ,  B01J2220/54 ,  B01J2220/64 ,  B01J2220/66

Abstract: The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.