公开(公告)号：US6075878A

公开(公告)日：2000-06-13

申请号：US979623

申请日：1997-11-28

申请人： Hiroyuki Yoshida ,  Wei Zhang ,  Robert M. Nishikawa ,  Kunio Doi

发明人： Hiroyuki Yoshida ,  Wei Zhang ,  Robert M. Nishikawa ,  Kunio Doi

IPC分类号： G06F17/14 ,  G06T7/00 ,  G06K9/00

CPC分类号： G06F17/148 ,  G06T7/0012

摘要： A computer-aided diagnosis (CAD) method for detection of clustered microcalcifications in digital mammograms based on an image reconstruction using a substantially optimally weighted wavelet transform. Weights at individual scales of the wavelet transform are optimized based on a supervised learning method. In the learning method, an error function represents a difference between a desired output and a reconstructed image obtained from weighted wavelet coefficients of the wavelet transform for a given mammogram. The error function is then minimized by modifying the weights by means of a conjugate gradient algorithm. Performance of the optimally weighted wavelets was evaluated by means of receiver-operating characteristic (ROC) analysis which indicated that the present invention outperformed both a difference-image technique and partial reconstruction method currently used in CAD methods.

摘要翻译： 一种用于基于使用基本上最佳加权的小波变换的图像重建来检测数字乳腺X线照片中的聚类微钙化的计算机辅助诊断（CAD）方法。 基于监督学习方法优化小波变换的个体尺度权重。 在学习方法中，误差函数表示对于给定的乳腺X线照片，从小波变换的加权小波系数获得的期望输出和重建图像之间的差。 然后通过使用共轭梯度算法修改权重来最小化误差函数。 通过接收机操作特性（ROC）分析评估了最佳加权小波的性能，表明本发明优于当前在CAD方法中使用的差分图像技术和部分重建方法。

公开(公告)号：US5732697A

公开(公告)日：1998-03-31

申请号：US562188

申请日：1995-11-22

申请人： Wei Zhang ,  Kunio Doi

发明人： Wei Zhang ,  Kunio Doi

IPC分类号： A61B6/00 ,  G06F15/18 ,  G06N3/00 ,  G06N3/08 ,  G06Q50/00 ,  G06T1/40 ,  G06T7/00 ,  A61B5/00 ,  A61B5/05

CPC分类号： G06T7/0012

摘要： A computerized method and system using a shift-invariant artificial neural network (SIANN) for the quantitative analysis of image data. A series of digitized medical images are used to train an artificial neural network to differentiate between diseased and normal tissue. The sum of the weights in groups between layers is constrained to be substantially zero so as to avoid saturation of layers which would otherwise be saturated by low frequency background noise. The method and system also include utilizing training-free zones to exclude from training the center portions of microcalcifications in the digitized images. The method and system further include rule-based selection criteria for providing a more accurate diagnosis.

摘要翻译： 一种使用移位不变人工神经网络（SIANN）进行图像数据定量分析的计算机化方法和系统。 使用一系列数字化医学图像来训练人造神经网络来区分患病和正常组织。 层之间的组中的权重之和被约束为基本为零，以避免否则将被低频背景噪声饱和的层的饱和。 该方法和系统还包括利用无训练区域来排除在数字化图像中训练微钙化的中心部分。 该方法和系统还包括用于提供更准确的诊断的基于规则的选择标准。

公开(公告)号：US5491627A

公开(公告)日：1996-02-13

申请号：US060531

申请日：1993-05-13

申请人： Wei Zhang ,  Kunio Doi

发明人： Wei Zhang ,  Kunio Doi

IPC分类号： A61B6/00 ,  G06F19/00 ,  G06T7/00

CPC分类号： G06T7/0012 ,  G06F19/345 ,  G06F19/321 ,  G06T2207/10116 ,  G06T2207/20084 ,  G06T2207/30068 ,  Y10S128/924 ,  Y10S128/925

摘要： A method and system for the detection of microcalcifications in digital mammograms. Digital mammograms are obtained and regions-of-interest (ROIs) are selected therefrom which contain suspected microcalcifications, either individual or clustered microcalcifications. The suspect ROIs are background-trend corrected, followed by Fourier transformation and power spectrum calculation to perform detection in the frequency domain. Detection can also be carried out in the spatial domain by omitting the Fourier transformation and power spectrum calculation. The ROI is then scaled for input into a neural network trained to detect microcalcifications. The neural network outputs ROIs with detected microcalcifications. The method and system can also include normalizing the background-trend corrected ROIs and imputing the normalized ROI to a shift-invariant neural network trained to detect microcalcifications. The output ROI of the shift-invariant neural network is thresholded to remove additional false positive detections, and then the thresholded ROI undergoes a cluster detection to detect clustered microcalcifications. Feature extraction techniques can be applied to the remaining ROI to remove additional false positive detections.

摘要翻译： 用于检测数字乳腺X线照片中微钙化的方法和系统。 获得数字乳腺X线照片，并从中选择感兴趣区域（ROI），其中包含怀疑的微钙化，单个或聚集的微钙化。 可疑ROI是背景趋势校正，随后进行傅里叶变换和功率谱计算，以在频域中进行检测。 也可以通过省略傅里叶变换和功率谱计算在空间域中进行检测。 然后，将ROI投影到经过训练以检测微钙化的神经网络中。 神经网络通过检测到的微钙化输出ROI。 该方法和系统还可以包括对背景趋势校正的ROI进行归一化，并将归一化的ROI估算为经过训练以检测微钙化的移位不变神经网络。 移位不变神经网络的输出ROI被阈值化以去除额外的假阳性检测，然后阈值ROI进行聚类检测以检测聚类微钙化。 特征提取技术可以应用于剩余的ROI以消除额外的假阳性检测。

公开(公告)号：US20220110303A1

公开(公告)日：2022-04-14

申请号：US17067711

申请日：2020-10-11

申请人： Wei Zhang

发明人： Wei Zhang

IPC分类号： A01K87/02

摘要： Methods and apparatus for expanding a rod from a collapsed position to a formed position are disclosed. One such apparatus includes a plurality of segments for forming the body of the collapsible rod including with each segment coupled to each immediately adjacent segment of the plurality of segments. The apparatus may include a coupler for coupling each segment of the plurality of segments to each immediately adjacent segment of the plurality of segments. The coupler may stretch from a base segment to the tip of the apparatus and may be biased to apply a force to hold the plurality of segments in a formed position and to urge the plurality of segments into a formed position from a collapsed position. In the formed position, the plurality of segments may be aligned end-to-end to form a rod and in the collapsed position, the plurality of segments may be folded against each other such that cylindrical walls of each of the plurality of segments are positioned adjacent each other.

公开(公告)号：US20180295974A1

公开(公告)日：2018-10-18

申请号：US15731045

申请日：2017-04-12

申请人： Wei Zhang

发明人： Wei Zhang

IPC分类号： A45F4/02 ,  F41H1/02 ,  A45C15/00 ,  F41H5/08

CPC分类号： A45F4/02 ,  A45C3/001 ,  A45C7/0068 ,  A45C13/103 ,  A45C15/00 ,  A45F3/04 ,  A45F3/06 ,  F41H1/00 ,  F41H1/02 ,  F41H5/00 ,  F41H5/08

摘要： A convertible bullet-proof backpack and vest includes a body section divided into a front portion, a middle portion, and back portion. The middle portion has a head slot opening, and the front and back portions have respective sections of bullet-proof fabric integrated therein. A zipper runs around an outer perimeter of the front and back portions. In a backpack configuration, the front portion and the back portion fold toward each other and the zipper secures the outer perimeters of the front portion and the back portion together thereby forming a hollow backpack interior between them. In a bullet-proof vest configuration, the zipper is unzipped thereby allowing a user to insert their head through the head slot opening such that the front portion hangs in front of a torso of the user and the back portion hangs behind the torso of the user.

公开(公告)号：US20180177625A1

公开(公告)日：2018-06-28

申请号：US15820401

申请日：2017-11-21

申请人： Wei Zhang

发明人： Wei Zhang

IPC分类号： A61F5/41

CPC分类号： A61F5/41 ,  A61F2005/411

摘要： The present invention strategically utilizes the sturdiness of thin wires enwrapped inside a thick layer of soft material such as silicone rubber which is smoother and softer than human tissue. Therefore, the device doesn't cause any damage or side effect and feels comfortable to user. The exposure of skin is 90% or higher, therefore solves the lack of sensation issue faced by prior art devices. The device is hard and yet flexible, the side walls or double bars are positioned toward ventral side of the device so that it is pleasing to the eye during use in addition to feeling good by the user.

公开(公告)号：US09574001B2

公开(公告)日：2017-02-21

申请号：US13958145

申请日：2013-08-02

申请人： Thomas M. Wisniewski ,  Wei Zhang ,  Suying Dang

发明人： Thomas M. Wisniewski ,  Wei Zhang ,  Suying Dang

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2848 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73

摘要： The present invention relates to methods inhibiting tumor metastasis and treating cancer in a subject that involve administering to the subject an antibody which recognizes GPIIIa49-66, under conditions effective to inhibit tumor metastasis and/or treat cancer in the subject.

摘要翻译： 本发明涉及在受试者中抑制肿瘤转移和治疗癌症的方法，所述方法包括在有效抑制肿瘤转移和/或治疗受试者的癌症的条件下向受试者施用识别GPIIIa49-66的抗体。

公开(公告)号：US09478746B2

公开(公告)日：2016-10-25

申请号：US13911351

申请日：2013-06-06

申请人： Xiong Gong ,  Stephen Z. D. Cheng ,  Wei Zhang

发明人： Xiong Gong ,  Stephen Z. D. Cheng ,  Wei Zhang

IPC分类号： H01L51/00 ,  H01L51/42

CPC分类号： H01L51/0047 ,  H01L51/0037 ,  H01L51/0043 ,  H01L51/0077 ,  H01L51/4253 ,  H01L2251/308 ,  Y02E10/549

摘要： A photovoltaic cell has an active area formed electron donor-fullerene conjugated molecules. The electron donor is formed of a polymer, which is conjugated with an electron acceptor, such as fullerene. By conjugating the fullerene, such as C60, with electron donor moieties, such as that of the polymer, double channels are formed therebetween, whereby one channel provides hole transport and the other channel provides electron transport. As a result, the electronic coupling between the fullerene and the electron donor moiety leads to increased short-circuit current density (Jsc) and increased open-circuit voltage (Voc), resulting in high power conversion efficacy (PCE) in the solar cell.

摘要翻译： 光伏电池具有形成的电子供体 - 富勒烯共轭分子的有源区。 电子给体由与电子受体（例如富勒烯）共轭的聚合物形成。 通过将诸如C60的富勒烯与诸如聚合物的电子供体部分共轭，在其间形成双通道，由此一个通道提供空穴传输，另一个通道提供电子传输。 结果，富勒烯和电子给体部分之间的电子耦合导致短路电流密度（Jsc）增加和开路电压（Voc）增加，导致太阳能电池中的高功率转换效率（PCE）。

公开(公告)号：US09453062B2

公开(公告)日：2016-09-27

申请号：US14125061

申请日：2012-06-08

申请人： Tao Ma ,  Shusen Xu ,  Zhijun Liu ,  Bo Zhang ,  Ning Shen ,  Hai Yang ,  Wei Zhang ,  Yuhua Li ,  Sunghwan Moon ,  Maengsup Kim

发明人： Tao Ma ,  Shusen Xu ,  Zhijun Liu ,  Bo Zhang ,  Ning Shen ,  Hai Yang ,  Wei Zhang ,  Yuhua Li ,  Sunghwan Moon ,  Maengsup Kim

IPC分类号： A61K38/22 ,  A61K38/00 ,  A61K38/28 ,  A61K38/26 ,  A61K38/16 ,  A61P3/04 ,  A61P3/10 ,  A61P7/12 ,  A61P19/10 ,  C07K14/605 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K38/16 ,  A61K38/22 ,  C07K14/00 ,  C07K14/605

摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.

摘要翻译： 本发明提供衍生自GIP（1-29，SEQ ID NO：1）的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性，并且包含由下式I表示的氨基酸序列： Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。

公开(公告)号：US20160190293A1

公开(公告)日：2016-06-30

申请号：US13704613

申请日：2012-12-14

申请人： Dongping Wu ,  Chaochao Fu ,  Wei Zhang ,  Shili Zhang

发明人： Dongping Wu ,  Chaochao Fu ,  Wei Zhang ,  Shili Zhang

IPC分类号： H01L29/737 ,  H01L29/08 ,  H01L29/165 ,  H01L21/285 ,  H01L29/45 ,  H01L29/417 ,  H01L29/66 ,  H01L21/02 ,  H01L29/10 ,  H01L29/167

CPC分类号： H01L29/7378 ,  H01L21/02532 ,  H01L21/0257 ,  H01L21/02598 ,  H01L21/0262 ,  H01L21/28518 ,  H01L21/2855 ,  H01L29/0817 ,  H01L29/0821 ,  H01L29/1004 ,  H01L29/165 ,  H01L29/167 ,  H01L29/41708 ,  H01L29/456 ,  H01L29/66242 ,  H01L29/7371

摘要： A SiGe HBT has an inverted heterojunction structure, where the emitter layer is formed prior to the base layer and the collector layer. The frequency performance of the SiGe HBT is significantly improved through a better thermal process budget for the base profile, essential for higher cut-off frequency (fT) and a minimal collector-base area for a reduced parasitic capacitance, essential for higher maximum oscillation frequency (fmax). This inverted heterojunction structure can be fabricated by using ALE processes to form an emitter on a preformed epitaxial silicide, a base over the emitter and a collector over the base.

摘要翻译： SiGe HBT具有反相异质结结构，其中发射极层在基极层和集电极层之前形成。 SiGe HBT的频率性能通过基底轮廓的更好的热处理预算得到显着改善，对于较高的截止频率（fT）和减少的寄生电容的最小集电极基极面积是必不可少的，因为较高的最大振荡频率 （fmax）。 该反转异质结结构可以通过使用ALE工艺在预制的外延硅化物上形成发射极，在发射极上的基极和在基极上的集电极来制造。