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公开(公告)号：US20110111492A1
公开(公告)日：2011-05-12
申请号：US12863015
申请日：2009-01-21
IPC分类号： C12N5/00
CPC分类号： C12N5/067 , A61K35/12 , C12N5/0607 , C12N5/0671 , C12N2500/02 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2503/02 , C12N2506/03
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stern cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译： 本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎细胞但可分化为外胚层，去皮肤和中胚层胚胎胚层中至少两种的细胞类型 ，例如干细胞。
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公开(公告)号：US20130315882A1
公开(公告)日：2013-11-28
申请号：US13889015
申请日：2013-05-07
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , A61K35/12 , C12N5/0607 , C12N5/0671 , C12N2500/02 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2503/02 , C12N2506/03
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译： 本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎干细胞但可以分化为至少两种外胚层，去皮肤和中胚层胚胎胚层的细胞类型 ，例如干细胞。
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公开(公告)号：US08609406B2
公开(公告)日：2013-12-17
申请号：US13217052
申请日：2011-08-24
CPC分类号： C12N5/0607 , C12N5/0606 , C12N5/0662 , C12N5/0692 , C12N5/0695 , C12N5/0696 , C12N2500/02 , C12N2501/602 , C12N2501/603 , C12N2502/02 , C12N2513/00
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译： 本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎干细胞但可分化为至少两种外胚层，内胚层和中胚层胚胎胚层的细胞类型， 例如，干细胞。
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公开(公告)号：US20120052568A1
公开(公告)日：2012-03-01
申请号：US13217052
申请日：2011-08-24
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： C12N5/0607 , C12N5/0606 , C12N5/0662 , C12N5/0692 , C12N5/0695 , C12N5/0696 , C12N2500/02 , C12N2501/602 , C12N2501/603 , C12N2502/02 , C12N2513/00
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译： 本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎干细胞但可分化为至少两种外胚层，内胚层和中胚层胚胎胚层的细胞类型， 例如，干细胞。
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公开(公告)号：US09974811B2
公开(公告)日：2018-05-22
申请号：US12416700
申请日：2009-04-01
CPC分类号： A61K35/28 , A61K48/00 , A61K2035/124 , A61K2039/5156 , C12N5/0607 , C12N2501/105 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2503/00 , C12N2510/00 , C12Y207/07049
摘要： The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
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6.发明申请Use of Multipotent Adult Stem Cells in Treatment of Myocardial Infarction and Congestive Heart Failure 审中-公开使用多能成人干细胞治疗心肌梗死和充血性心力衰竭公开(公告)号：US20120064047A1
公开(公告)日：2012-03-15
申请号：US13301186
申请日：2011-11-21
CPC分类号： A61K35/34 , A61K2035/124 , C12N5/0607 , C12N2500/36 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2501/33 , C12N2501/39 , C12N2533/52
摘要： The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells in cardiac indications.
摘要翻译： 本发明提供了非胚胎来源的分离的干细胞，其可以保持在未分化状态的培养物中或分化成多种组织类型的细胞。 还提供了分离和培养的方法，以及在心脏适应症中分离的细胞的治疗用途。
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公开(公告)号：US07838289B2
公开(公告)日：2010-11-23
申请号：US10467963
申请日：2002-02-14
IPC分类号： C12N5/00
CPC分类号： A61K39/001 , A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/106 , A61K35/12 , A61K48/00 , C12N5/0607 , C12N5/0619 , C12N5/0622 , C12N5/067 , C12N15/873 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/135 , C12N2501/235 , C12N2501/237 , C12N2502/08 , C12N2502/30 , C12N2503/00 , C12N2506/03 , C12N2517/02
摘要： The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
摘要翻译： 本发明一般涉及哺乳动物多潜能成体干细胞（MASC），更具体地涉及用于获得，维持和分化MASC至多种组织类型的细胞的方法。 还提供了MASC在治疗疾病中的用途。
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8.发明申请DIFFERENTIATION OF NON-EMBRYONIC STEM CELLS TO CELLS HAVING A PANCREATIC PHENOTYPE 有权非胚胎干细胞对具有胰腺癌细胞的细胞的分化公开(公告)号：US20090092586A1
公开(公告)日：2009-04-09
申请号：US12089868
申请日：2006-10-16
CPC分类号： C12N5/0607 , A61K35/12 , C12N5/0676 , C12N2500/38 , C12N2501/11 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/19 , C12N2501/41 , C12N2506/03 , C12N2510/00
摘要： The invention provides methods for differentiating non-embryonic multipotent stem cells along the pancreatic lineage. The present invention further provides non-embryonic multipotent stem cells and progeny derived therefrom to provide pancreatic cells to a subject.
摘要翻译： 本发明提供了沿着胰腺谱系分化非胚胎多潜能干细胞的方法。 本发明进一步提供非胚胎多能干细胞及其衍生的后代以向受试者提供胰腺细胞。
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9.发明申请公开(公告)号：US20140057313A1
公开(公告)日：2014-02-27
申请号：US13996248
申请日：2012-01-30
CPC分类号： C12N5/0696 , C12N5/0603 , C12N5/0605 , C12N5/0607 , C12N2500/02 , C12N2501/11 , C12N2501/135 , C12N2501/235 , G01N33/5008
摘要： The invention is directed to methods for making cells in vitro that have an extra-embryonic endodermal precursor phenotype. The method involves culturing cells from blastocysts under specific defined conditions.
摘要翻译： 本发明涉及用于在体外制备具有胚外胚胎前体表型的细胞的方法。 该方法包括在特定的条件下从囊胚培养细胞。
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10.发明申请Optimized Methods for Differentiation of Cells into Cells With Hepatocyte and Hepatocyte Progenitor Phenotypes, Cells Produced by the Methods, and Methods of Using the Cells 有权用细胞分化成肝细胞和肝细胞祖细胞表型细胞的优化方法，使用细胞的方法和方法产生细胞公开(公告)号：US20110287539A1
公开(公告)日：2011-11-24
申请号：US13126834
申请日：2008-10-31
IPC分类号： C12N5/0735 , C12N5/07
CPC分类号： C12N5/0606 , C12N5/067 , C12N5/0696 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2506/02 , C12N2506/03
摘要： The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.
摘要翻译： 本发明涉及培养细胞的方法，使得细胞被诱导分化成表达肝细胞表型和肝细胞祖细胞表型的细胞。 更具体地说，本发明涉及培养细胞的方法，使得细胞被诱导分化成表达定形内胚层表型，肝定型内胚层表型，成肝细胞表型和肝细胞表型的细胞。 本发明还涉及通过本发明的方法生产的细胞。 除了别的以外，细胞可用于治疗肝脏缺乏症，肝脏代谢研究和肝脏毒性研究。
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