利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.022 秒)

    Temperature-insensitive vertical-cavity surface-emitting lasers and method for fabrication thereof
    1.
    发明授权
    Temperature-insensitive vertical-cavity surface-emitting lasers and method for fabrication thereof 失效
    不敏感的垂直腔表面发射激光器及其制造方法

    公开(公告)号：US5712865A

    公开(公告)日：1998-01-27

    申请号：US535597

    申请日：1995-09-28

    申请人： Weng W. Chow ,  Kent D. Choquette ,  Paul L. Gourley

    发明人： Weng W. Chow ,  Kent D. Choquette ,  Paul L. Gourley

    IPC分类号： H01S5/068 ,  H01S5/183 ,  H01S5/34 ,  H01S5/343 ,  H01S3/19

    CPC分类号： B82Y20/00 ,  H01S5/18308 ,  H01S2301/04 ,  H01S5/02469 ,  H01S5/1221 ,  H01S5/2213 ,  H01S5/3418 ,  H01S5/3432

    摘要： A temperature-insensitive vertical-cavity surface-emitting laser (VCSEL) and method for fabrication thereof. The temperature-insensitive VCSEL comprises a quantum-well active region within a resonant cavity, the active region having a gain spectrum with a high-order subband (n.gtoreq.2) contribution thereto for broadening and flattening the gain spectrum, thereby substantially reducing any variation in operating characteristics of the VCSEL over a temperature range of interest. The method for forming the temperature-insensitive VCSEL comprises the steps of providing a substrate and forming a plurality of layers thereon for providing first and second distributed Bragg reflector (DBR) mirror stacks with an active region sandwiched therebetween, the active region including at least one quantum-well layer providing a gain spectrum having a high-order subband (n.gtoreq.2) gain contribution, and the DBR mirror stacks having predetermined layer compositions and thicknesses for providing a cavity resonance within a predetermined wavelength range substantially overlapping the gain spectrum.

    摘要翻译： 不敏感的垂直腔表面发射激光器（VCSEL）及其制造方法。 温度不敏感的VCSEL包括在谐振腔内的量子阱有源区域，有源区域具有增益谱，具有对其增益和平坦化增益谱的高阶子带（n> / = 2）贡献，从而大大减少 VCSEL在感兴趣的温度范围内的工作特性的任何变化。 用于形成温度不敏感VCSEL的方法包括以下步骤：提供衬底并在其上形成多个层以提供第一和第二分布布拉格反射镜（DBR）反射镜叠层，其中夹在其间的有源区域，该有源区域包括至少一个 提供具有高阶子带（n> / = 2）增益贡献的增益谱的量子阱层，以及具有预定层组成和厚度的DBR反射镜叠层，用于在与增益光谱基本重叠的预定波长范围内提供空腔谐振 。

    Micro-optical cavity with fluidic transport chip for bioparticle analysis
    2.
    发明授权
    Micro-optical cavity with fluidic transport chip for bioparticle analysis 有权
    具有流体输送芯片的微光腔用于生物粒子分析

    公开(公告)号：US09063117B2

    公开(公告)日：2015-06-23

    申请号：US13337051

    申请日：2011-12-24

    申请人： Paul L. Gourley

    发明人： Paul L. Gourley

    IPC分类号： G01N33/48 ,  G01N33/483 ,  G01N15/14

    CPC分类号： G01N33/4833 ,  G01N15/1404 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/47 ,  G01N21/6428 ,  G01N21/7746 ,  G01N33/574 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1493 ,  G01N2015/1495

    摘要： This invention provides new methods and apparatus for rapidly analyzing single bioparticles to assess their material condition and health status. The methods are enabled by a resonant cavity to measure optical properties related to the bioparticle size and refractive index. Refractive index measurements are useful for determining material properties and biomolecular composition of the bioparticle. These properties and composition are dependent on the health state of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The methods are illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for multiple measurements in a single device, analyzing and manipulating bioparticles that are much smaller than the wavelength of light, and provides a microfluidic transport chip to enable rapid single bioparticle analysis of large populations of bioparticles.

    摘要翻译： 本发明提供用于快速分析单个生物颗粒以评估其物质状况和健康状况的新方法和装置。 该方法通过谐振腔来实现，以测量与生物颗粒尺寸和折射率相关的光学性质。 折射率测量可用于确定生物颗粒的材料性质和生物分子组成。 这些性质和组成取决于生物颗粒的健康状态。 因此，可以使用测量的光学性质来区分来自细胞或组织的生物颗粒的正常（健康）和异常（患病）状态。 用具有增益介质的谐振器获得的数据说明了这些方法。 本发明还提供了在单个装置中进行多次测量的新方法，分析和操作比光的波长小得多的生物颗粒，并且提供了一种微流控输送芯片，以实现大量生物颗粒的快速单一生物颗粒分析。

    Resonant-cavity apparatus for cytometry or particle analysis
    4.
    发明授权
    Resonant-cavity apparatus for cytometry or particle analysis 失效
    用于细胞计数或粒子分析的共振腔装置

    公开(公告)号：US5793485A

    公开(公告)日：1998-08-11

    申请号：US782039

    申请日：1997-01-13

    申请人： Paul L. Gourley

    发明人： Paul L. Gourley

    IPC分类号： G01N15/10 ,  G01N15/14 ,  G01N21/39 ,  G02B21/32 ,  G21K1/00 ,  G01J3/30

    CPC分类号： G01N15/1429 ,  G01N15/1484 ,  G01N2015/1477 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2015/1493 ,  G01N2021/391 ,  G02B21/32

    摘要： A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

    摘要翻译： 用于细胞计数或粒子分析的共振腔装置。 该装置包括谐振光学腔，其具有在腔内的分析区域，用于容纳待分析的一个或多个生物体或介电粒子。 在存在细胞或颗粒的情况下，在共振光学腔内产生自发发射或激光形式的光束，并且用关于细胞或颗粒的信息进行编码。 在装置内提供了包括光谱仪和/或脉冲高度分析器的分析装置，用于从光束恢复信息以确定关于被分析的细胞或颗粒的尺寸，形状，识别或其它特性。 恢复的信息可以被分组在多维坐标空间中，用于识别特定类型的细胞或颗粒。 在装置的一些实施例中，谐振光学腔可以至少部分地由垂直腔表面发射激光器形成。 该装置和方法特别适用于包括血细胞在内的生物细胞的分析，并且还可以包括用于在分析细胞后操作，分选或根除细胞的处理装置。

    Method for determining properties of red blood cells
    5.
    发明授权
    Method for determining properties of red blood cells 有权
    确定红细胞性质的方法

    公开(公告)号：US06187592B1

    公开(公告)日：2001-02-13

    申请号：US09221331

    申请日：1998-12-23

    申请人： Paul L. Gourley

    发明人： Paul L. Gourley

    IPC分类号： G01N3372

    CPC分类号： G01N21/05 ,  G01N21/39 ,  G01N2021/0346

    摘要： A method for quantifying the concentration of hemoglobin in a cell, and indicia of anemia, comprises determining the wavelength of the longitudinal mode of a liquid in a laser microcavity; determining the wavelength of the fundamental transverse mode of a red blood cell in the liquid in the laser microcavity; and determining if the cell is anemic from the difference between the wavelength of the longitudinal mode and the fundamental transverse mode. In addition to measuring hemoglobin, the invention includes a method using intracavity laser spectroscopy to measure the change in spectra as a function of time for measuring the influx of water into a red blood cell and the cell's subsequent rupture.

    摘要翻译： 用于量化细胞中血红蛋白浓度和贫血标记的方法包括确定激光微腔中的液体的纵向模式的波长; 确定激光微腔中的液体中的红细胞的基本横向模式的波长; 以及根据所述纵向模式的波长与所述基本横向模式之间的差异来确定所述单元是否是贫血。 除了测量血红蛋白之外，本发明还包括使用腔内激光光谱测量作为时间的函数的光谱变化的方法，用于测量水进入红细胞的流入以及细胞随后的破裂。

    Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells
    6.
    发明授权
    Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells 失效
    用于微生物细胞的微观和光谱分析和处理的激光装置和方法

    公开(公告)号：US5608519A

    公开(公告)日：1997-03-04

    申请号：US407345

    申请日：1995-03-20

    申请人： Paul L. Gourley ,  Mark F. Gourley

    发明人： Paul L. Gourley ,  Mark F. Gourley

    IPC分类号： G01N15/10 ,  G01N15/14 ,  G01N21/39 ,  G02B21/32 ,  G21K1/00 ,  G01J3/30

    CPC分类号： G01N15/1429 ,  G01N15/10 ,  G01N2015/1062 ,  G01N2015/1087 ,  G01N2015/149 ,  G01N2021/391 ,  G02B21/32

    摘要： An apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

    摘要翻译： 一种生物细胞微观和光谱分析与处理的装置和方法。 该装置包括具有在激光腔内的用于容纳待分析的一个或多个生物细胞的分析区域的激光器。 与激光增益介质的激活部分叠加在分析区域内的单元的存在用于在激光束上编码关于单元的信息，小区信息可由分析装置恢复，分析装置优选地包括阵列光电检测器 作为CCD相机和光谱仪。 该装置和方法可以用于分析包括血细胞等的生物医学细胞，并且可以包括用于在分析细胞后操作，分选或根除细胞的处理装置。

    Micro-Optical Cavity with Fluidic Transport Chip for Bioparticle Analysis
    7.
    发明申请
    Micro-Optical Cavity with Fluidic Transport Chip for Bioparticle Analysis 审中-公开
    具有用于生物颗粒分析的流体传输芯片的微光腔

    公开(公告)号：US20150049333A1

    公开(公告)日：2015-02-19

    申请号：US13337051

    申请日：2011-12-24

    申请人： Paul L. Gourley

    发明人： Paul L. Gourley

    IPC分类号： G01N33/483 ,  G01N15/14

    CPC分类号： G01N33/4833 ,  G01N15/1404 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/47 ,  G01N21/6428 ,  G01N21/7746 ,  G01N33/574 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1493 ,  G01N2015/1495

    摘要： This invention provides new methods and apparatus for rapidly analyzing single bioparticles to assess their material condition and health status. The methods are enabled by a resonant cavity to measure optical properties related to the bioparticle size and refractive index. Refractive index measurements are useful for determining material properties and biomolecular composition of the bioparticle. These properties and composition are dependent on the health state of the bioparticle. Thus, measured optical properties can be used to differentiate normal (healthy) and abnormal (diseased) states of bioparticles derived from cells or tissues. The methods are illustrated with data obtained from a resonator with a gain medium. The invention also provides new methods for multiple measurements in a single device, analyzing and manipulating bioparticles that are much smaller than the wavelength of light, and provides a microfluidic transport chip to enable rapid single bioparticle analysis of large populations of bioparticles.

    摘要翻译： 本发明提供用于快速分析单个生物颗粒以评估其物质状况和健康状况的新方法和装置。 该方法通过谐振腔来实现，以测量与生物颗粒尺寸和折射率相关的光学性质。 折射率测量可用于确定生物颗粒的材料性质和生物分子组成。 这些性质和组成取决于生物颗粒的健康状态。 因此，可以使用测量的光学性质来区分来自细胞或组织的生物颗粒的正常（健康）和异常（患病）状态。 用具有增益介质的谐振器获得的数据说明了这些方法。 本发明还提供了在单个装置中进行多次测量的新方法，分析和操作比光的波长小得多的生物颗粒，并且提供了一种微流控输送芯片，以实现大量生物颗粒的快速单一生物颗粒分析。

    Analysis of Bioparticles in an Optical Microcavity
    10.
    发明申请
    Analysis of Bioparticles in an Optical Microcavity 审中-公开
    光学微腔中生物颗粒的分析

    公开(公告)号：US20150316464A1

    公开(公告)日：2015-11-05

    申请号：US14708064

    申请日：2015-05-08

    申请人： Paul L. Gourley

    发明人： Paul L. Gourley

    IPC分类号： G01N15/14

    CPC分类号： G01N33/4833 ,  G01N15/1404 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/47 ,  G01N21/6428 ,  G01N21/7746 ,  G01N33/574 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1493 ,  G01N2015/1495

    摘要： This invention provides new methods and apparatus for rapidly analyzing a single bioparticle or a plurality of bioparticles to assess their condition. The invention is enabled by an optical microcavity comprising reflective structures to confine light and bioparticles in the same space. Under resonance conditions, an electromagnetic standing wave is established in the microcavity to interact with the bioparticle. Means are provided to bring a bioparticle into the microcavity and to detect changes in the resonance condition with and without the bioparticle in the microcavity. Information about the bioparticle is obtained using the benefits of light interactions as fast, non-contacting, and non-destructive.

    摘要翻译： 本发明提供用于快速分析单个生物颗粒或多个生物颗粒以评估其状况的新方法和装置。 本发明通过包括反射结构的光学微腔实现，以将光和生物颗粒限制在相同的空间中。 在共振条件下，在微腔中建立电磁驻波与生物粒子相互作用。 提供了使生物颗粒进入微腔的装置，并且在微腔内检测和不使用生物颗粒的共振条件的变化。 关于生物颗粒的信息是使用光相互作用作为快速，非接触和非破坏性的益处获得的。