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公开(公告)号：US09255864B2
公开(公告)日：2016-02-09
申请号：US14001895
申请日：2012-03-05
CPC分类号： G01N1/30 , B01L3/502 , B01L3/5023 , B01L3/50255 , B01L2200/026 , B01L2200/028 , B01L2200/10 , B01L2300/0681 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2300/0887 , B01L2400/049 , C12N15/1017 , G01N1/34
摘要： A first apparatus (100) for processing a liquid sample is disclosed. The apparatus (100) includes a sample-receiving (120), a filtrate-receiving component (150), and an analyte-capture element (170). The apparatus (100) forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element (170) to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first (100) apparatus and the analyte-capture element (170) is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus (200) for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.
摘要翻译： 公开了一种用于处理液体样品的第一装置（100）。 装置（100）包括样品接收（120），滤液接收组分（150）和分析物捕获元件（170）。 装置（100）形成液体流动通道，样品通过该流路，从而使得分析物捕获元件（170）捕获分析物（如果存在）。 公开了一种方法，其中液体样品通过第一（100）装置，并且分析物捕获元件（170）容易与装置分离，用于进一步处理和检测分析物。 还公开了一种用于处理多个液体样品的结构相关的第二装置（200）和相应的使用方法。
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公开(公告)号：US20130344478A1
公开(公告)日：2013-12-26
申请号：US14001895
申请日：2012-03-05
IPC分类号： G01N1/34
CPC分类号： G01N1/30 , B01L3/502 , B01L3/5023 , B01L3/50255 , B01L2200/026 , B01L2200/028 , B01L2200/10 , B01L2300/0681 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2300/0887 , B01L2400/049 , C12N15/1017 , G01N1/34
摘要： A first apparatus (100) for processing a liquid sample is disclosed. The apparatus (100) includes a sample-receiving (120), a filtrate-receiving component (150), and an analyte-capture element (170). The apparatus (100) forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element (170) to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first (100) apparatus and the analyte-capture element (170) is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus (200) for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.
摘要翻译： 公开了一种用于处理液体样品的第一装置（100）。 装置（100）包括样品接收（120），滤液接收组分（150）和分析物捕获元件（170）。 装置（100）形成液体流路，样品通过该流路，从而使分析物捕获元件（170）捕获分析物（如果存在）。 公开了一种方法，其中液体样品通过第一（100）装置，并且分析物捕获元件（170）容易与装置分离，以进一步处理和检测分析物。 还公开了一种用于处理多个液体样品的结构相关的第二装置（200）和相应的使用方法。
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公开(公告)号：US20130260370A1
公开(公告)日：2013-10-03
申请号：US13876022
申请日：2011-11-30
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising (1) a porous fibrous nonwoven matrix and (2) a plurality of particles of at least one concentration agent that comprises a metal silicate, the particles being enmeshed in the porous fibrous nonwoven matrix; (b) providing a sample comprising at least one target cellular analyte; (c) contacting the concentration device with the sample such that at least a portion of the at least one target cellular analyte is bound to or captured by the concentration device; and (d) detecting the presence of at least one bound target cellular analyte.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供浓缩装置，其包括（1）多孔纤维非织造基质和（2）至少一种包含金属硅酸盐的浓缩剂的颗粒，所述颗粒 位于多孔纤维非织造基体中; （b）提供包含至少一种靶细胞分析物的样品; （c）使浓缩装置与样品接触，使得至少一部分目标细胞分析物与浓缩装置结合或捕获; 和（d）检测至少一种结合的靶细胞分析物的存在。
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公开(公告)号：US20130244225A1
公开(公告)日：2013-09-19
申请号：US13825676
申请日：2011-11-23
IPC分类号： G01N1/40 , G01N33/569
CPC分类号： G01N1/405 , B01D2239/0442 , B01D2239/0618 , C12M47/02 , C12Q1/06 , G01N33/56911 , G01N2001/4088 , Y02A50/52
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising (1) a porous fibrous nonwoven matrix and (2) a plurality of particles of at least one concentration agent that comprises diatomaceous earth, the particles being enmeshed in the porous fibrous nonwoven matrix; (b) providing a sample comprising at least one target cellular analyte; (c) contacting the concentration device with the sample such that at least a portion of the at least one target cellular analyte is bound to or captured by the concentration device; and (d) detecting the presence of at least one bound target cellular analyte.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供浓缩装置，其包括（1）多孔纤维非织造基质和（2）至少一种包含硅藻土的浓缩剂的颗粒，所述颗粒为 嵌入多孔纤维非织造基质中; （b）提供包含至少一种靶细胞分析物的样品; （c）使浓缩装置与样品接触，使得至少一部分目标细胞分析物与浓缩装置结合或捕获; 和（d）检测至少一种结合的靶细胞分析物的存在。
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公开(公告)号：US20120009569A1
公开(公告)日：2012-01-12
申请号：US13257406
申请日：2010-03-22
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising ferric oxide, titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供包含烧结多孔聚合物基质的浓缩装置，所述多孔聚合物基质包含至少一种含有硅藻土的浓缩剂，所述浓缩剂在其表面的至少一部分上具有包括 包含氧化铁，二氧化钛，细纳米金或铂的表面改性剂或其组合; （b）提供包含至少一种微生物菌株的样品; 和（c）使浓缩装置与样品接触，使得至少一部分微生物菌株与浓缩装置结合或捕获。
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6.发明授权公开(公告)号：US07488422B2
公开(公告)日：2009-02-10
申请号：US11241482
申请日：2005-09-30
申请人： Andrew W. Rabins , Kelly J. Gibbens , Masayuki Nakamura , Kannan Seshadri , Robert T. Fitzsimons, Jr. , Larry J. Carson , Stephen M. Larsen
发明人： Andrew W. Rabins , Kelly J. Gibbens , Masayuki Nakamura , Kannan Seshadri , Robert T. Fitzsimons, Jr. , Larry J. Carson , Stephen M. Larsen
IPC分类号： B01D15/08
CPC分类号： B01J20/28033 , B01D15/1828
摘要： A simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. Each filter cartridge module also includes recirculation piping in fluid connection with a filter cartridge outlet and a filter cartridge inlet.
摘要翻译： 描述了一种模拟移动床装置和方法，用于使用模拟移动床系统从目标分子与液体混合物连续分离。 模拟移动床系统包括串联流体连通的多个滤芯模块。 每个过滤器滤芯模块包括邻近多孔基底层的体积的固定相颗粒。 每个过滤筒模块还包括与过滤器滤芯出口和过滤器滤芯入口流体连接的再循环管道。
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7.发明申请SINGLE PASS METHOD AND APPARATUS FOR SEPARATING A TARGET MOLECULE FROM A LIQUID MIXTURE 有权从液体混合物分离目标分子的单通道方法和装置公开(公告)号：US20080264849A1
公开(公告)日：2008-10-30
申请号：US12171743
申请日：2008-07-11
申请人： Kelly J. GIBBENS , Masayuki Nakamura , Kannan Seshadri , Andrew W. Rabins , Larry J. Carson , Robert T. Fitzsimons
发明人： Kelly J. GIBBENS , Masayuki Nakamura , Kannan Seshadri , Andrew W. Rabins , Larry J. Carson , Robert T. Fitzsimons
IPC分类号： B01D15/08
CPC分类号： B01D15/1828 , B01D15/1842
摘要： A single pass simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. The volume of stationary phase particulates has a bed height of less than 1 centimeter.
摘要翻译： 描述了使用模拟移动床系统连续分离目标分子与液体混合物的单程模拟移动床装置和方法。 模拟移动床系统包括串联流体连通的多个滤芯模块。 每个过滤器滤芯模块包括邻近多孔基底层的体积的固定相颗粒。 固定相颗粒的体积具有小于1厘米的床高度。
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公开(公告)号：US20130090397A1
公开(公告)日：2013-04-11
申请号：US13703267
申请日：2011-06-17
申请人： Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, JR. , Andrew W. Rabins , Taib K. Ansera
发明人： Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, JR. , Andrew W. Rabins , Taib K. Ansera
CPC分类号： B01J41/14 , B01J39/20 , B01J39/26 , B01J41/20 , C08J3/246 , C08J2333/26 , C08J2400/00 , C08L23/06 , C08L33/26 , C08L77/00 , C08L101/00 , C08L2205/04 , C08L2205/16 , C08L2205/22 , C08L2312/00
摘要： Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.
摘要翻译： 描述了半互穿聚合物网络。 更具体地说，半互穿聚合物网络包括至少两种紧密相关的聚合物。 第一聚合物是不交联的离子聚合物。 第二聚合物是可以是另一离子聚合物或非离子聚合物的交联聚合物。 还描述了制备半互穿聚合物网络的方法，含有半互穿聚合物网络的制品以及使用半互穿聚合物网络的方法。 半互穿聚合物网络可用作离子交换树脂。
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公开(公告)号：US20130068693A1
公开(公告)日：2013-03-21
申请号：US13700930
申请日：2011-06-06
CPC分类号： B01J20/261 , B01D15/00 , B01J20/26 , B01J20/28011 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J20/28033 , B01J20/3042 , B01J20/3208 , B01J20/3248 , B01J20/3251 , B01J2220/46 , C02F1/285 , C02F1/288 , C02F2101/20
摘要： Described herein is a low back-pressure, solid phase extraction media for removing dissolved metals in a liquid. The solid phase extraction media comprises particles entrapped in a porous polymeric fiber matrix. The particles comprise at least one of a thiol-containing moiety or a thiourea-containing moiety, and the porous polymeric fiber matrix comprises a plurality of fibers and a polymeric binder.
摘要翻译： 本文描述了用于去除液体中溶解的金属的低背压固相萃取介质。 固相萃取介质包含被包埋在多孔聚合物纤维基质中的颗粒。 颗粒包含含硫醇部分或含硫脲部分中的至少一种，多孔聚合物纤维基质包含多根纤维和聚合物粘合剂。
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公开(公告)号：US20120034621A1
公开(公告)日：2012-02-09
申请号：US13257382
申请日：2010-03-22
IPC分类号： C12Q1/04 , C12N7/02 , C12N1/14 , C08J9/00 , C12N1/20 , C12N1/10 , C08K3/34 , G01N33/569 , C12N1/16
CPC分类号： C08J9/0066 , B01D61/147 , B01D63/00 , C08J9/0061 , C08J2323/06 , C08J2423/06 , C12Q1/24
摘要： A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.
摘要翻译： 用于捕获或浓缩用于检测或测定的微生物的方法包括（a）提供包含烧结的多孔聚合物基质的浓缩装置，所述多孔聚合物基质包含至少一种浓缩剂，所述浓缩剂包含无定形金属硅酸盐，并且具有具有金属原子与硅原子的表面组成 比例小于或等于0.5，如通过X射线光电子能谱（XPS）测定的; （b）提供包含至少一种微生物菌株的样品; 和（c）使浓缩装置与样品接触，使得至少一部分微生物菌株与浓缩装置结合或捕获。
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