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1.发明申请N-'4-(2-imino-pyrrolidin-1-yl)phenyl!-acetamide and corresponding piperidine derivatives as factor xa inhibitors for the treatment of thrombo-embolic diseases 审中-公开N-4-（2-亚氨基 - 吡咯烷-1-基）苯基 - 乙酰胺和相应的哌啶衍生物作为因子xa抑制剂用于治疗血栓栓塞性疾病公开(公告)号：US20050176760A1
公开(公告)日：2005-08-11
申请号：US10510046
申请日：2003-03-07
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Christopher Barnes , Johannes Gleitz
IPC分类号： C07D211/76 , A61K31/402 , A61K31/4178 , A61K31/423 , A61K31/439 , A61K31/451 , A61K31/4725 , A61P7/02 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , C07D207/22 , C07D207/24 , C07D211/72 , C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06 , A61K31/4709 , A61K31/40 , A61K31/445
CPC分类号： C07D401/12 , C07D207/22 , C07D207/24 , C07D211/72 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, M, W, X, Y, T and R1 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，M，W，X，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防 和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050171102A1
公开(公告)日：2005-08-04
申请号：US10513451
申请日：2003-04-07
申请人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
发明人： Werner Mederski , Dieter Dorsch , Christos Tsaklakidis , Christopher Barnes , Bertram Cezanne , Johannes Gleitz
IPC分类号： C07D295/12 , A61K31/402 , A61K31/421 , A61K31/439 , A61K31/4418 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D221/22 , C07D223/10 , C07D237/14 , C07D241/08 , C07D241/18 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06 , C07D413/02 , A61K31/4245 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/5377
CPC分类号： C07D207/26 , C07D211/76 , C07D213/64 , C07D223/10 , C07D237/14 , C07D241/08 , C07D263/22 , C07D265/32 , C07D295/135 , C07D453/06
摘要： Novel compounds of the formula I in which R, R1, R1, X are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，R 1，R 1，X 1如权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050137230A1
公开(公告)日：2005-06-23
申请号：US11059655
申请日：2005-02-17
申请人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Bertram Cezanne , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D295/12 , A61K31/17 , A61K31/27 , A61K31/381 , A61K31/402 , A61K31/405 , A61K31/4172 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/4535 , A61K31/4545 , A61K31/495 , A61K31/497 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07C271/28 , C07C273/18 , C07C275/28 , C07C275/30 , C07C303/40 , C07C311/39 , C07C311/46 , C07C315/04 , C07C317/32 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/18 , C07D209/20 , C07D211/20 , C07D211/26 , C07D211/58 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/74 , C07D213/75 , C07D223/10 , C07D233/54 , C07D233/64 , C07D241/08 , C07D265/32 , C07D295/135 , C07D295/20 , C07D295/205 , C07D333/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/44
CPC分类号： C07D207/27 , C07C271/28 , C07C275/28 , C07C275/30 , C07C311/46 , C07C317/32 , C07C323/60 , C07C2601/02 , C07D209/20 , C07D211/20 , C07D211/58 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/75 , C07D223/10 , C07D233/64 , C07D241/08 , C07D265/32 , C07D295/135 , C07D295/205 , C07D333/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/14
摘要： Novel compounds of the formula I in which R1, D, E, W, X and n are as defined in claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中R 1，D，E，W，X和n如权利要求1所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/或 治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US06943179B2
公开(公告)日：2005-09-13
申请号：US10472084
申请日：2002-02-27
申请人： Werner Mederski , Bertram Cezanne , Dieter Dorsch , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Werner Mederski , Bertram Cezanne , Dieter Dorsch , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D223/10 , A61K31/45 , A61K31/4545 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/10 , A61P29/00 , A61P35/00 , A61P35/04 , C07C281/06 , C07C309/66 , C07D211/76 , C07D213/64 , C07D241/08 , C07D265/32 , C07D401/04 , A61K31/4412 , A61K31/495 , C07D281/06
CPC分类号： C07C281/06
摘要： Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors
摘要翻译： 其中X，Y，Z，R，R 1，R 2和R 3的式I的新化合物如专利中所定义 权利要求1是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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5.发明申请Heterocyclic amides and their use treating thromboembolic diseases and tumors 审中-公开杂环酰胺及其用途治疗血栓栓塞性疾病和肿瘤公开(公告)号：US20060135515A1
公开(公告)日：2006-06-22
申请号：US10530876
申请日：2003-09-18
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D409/12 , C07D333/36 , C07D409/14 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T and R1 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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6.发明申请2-(Phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses 审中-公开2-（苯基）-2h-吡唑-3-羧酸 - 正-4-（硫代 - 杂环基） - 苯基 - 酰胺衍生物和相应的亚氨基 - 杂环基衍生物，并涉及用作凝血因子xa和/或 用于治疗血栓的病毒公开(公告)号：US20050203127A1
公开(公告)日：2005-09-15
申请号：US10519356
申请日：2003-06-05
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , A61P7/02 , A61P9/08 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D403/12 , C07D413/14 , C07D417/12 , C07D413/02 , A61K31/423 , A61K31/4245 , A61K31/4709
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , C07D403/14 , C07D413/14 , C07D417/12 , Y02P20/55
摘要： The invention relates to the novel compounds of formula (I), wherein D, M, W, X, Y, T, R1 and R1′ are defined as in patent claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
摘要翻译： 本发明涉及新的式（I）化合物，其中D，M，W，X，Y，T，R 1和R 1定义如 本发明化合物是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US07183277B2
公开(公告)日：2007-02-27
申请号：US10512478
申请日：2003-03-31
申请人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
IPC分类号： A61K31/5375 , A61K31/451 , A61K31/40 , A61K31/4168 , A61K31/433 , C07D211/72 , C07D207/22
CPC分类号： C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，W，X，Y，T和R 1如专利权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/ 或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050171154A1
公开(公告)日：2005-08-04
申请号：US10512478
申请日：2003-03-31
申请人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
发明人： Dieter Dorsch , Werner Mederski , Johannes Gleitz , Bertram Cezanne , Christos Tsaklakidis , Christopher Barnes
IPC分类号： C07D211/56 , A61K31/40 , A61K31/4025 , A61K31/4172 , A61K31/4178 , A61K31/4545 , A61P7/02 , A61P9/00 , A61P25/06 , A61P29/00 , A61P35/00 , C07D207/14 , C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
CPC分类号： C07D207/22 , C07D211/72 , C07D213/73 , C07D233/46 , C07D233/48 , C07D265/30 , C07D401/12 , C07D403/12 , C07D409/12 , C07D453/06
摘要： Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中D，W，X，Y，T和R 1如权利要求1中所定义的式I的新型化合物是凝血因子Xa的抑制剂，可用于预防和/ 或治疗血栓栓塞性疾病和治疗肿瘤。
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公开(公告)号：US20050119316A1
公开(公告)日：2005-06-02
申请号：US10506801
申请日：2003-02-06
申请人： Werner Mederski , Bertram Cezanne , Christos Tsaklakidis , Dieter Dorsch , Christopher Barnes , Johannes Gleitz
发明人： Werner Mederski , Bertram Cezanne , Christos Tsaklakidis , Dieter Dorsch , Christopher Barnes , Johannes Gleitz
IPC分类号： C07C317/42 , A61K20060101 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/4245 , A61P20060101 , A61P7/02 , A61P9/08 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C20060101 , C07C281/06 , C07C311/47 , C07C317/40 , C07D20060101 , C07D271/06
CPC分类号： C07C317/32 , C07C311/47
摘要： Novel compounds of the formula I, in which R, R1, R2 and R3 are as defined in patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式I的新型化合物，其中R，R 1，R 2和R 3如专利权利要求1中所定义，均为抑制剂 的凝血因子Xa，并且可以用于预防和/或治疗血栓栓塞性疾病和用于治疗肿瘤。
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公开(公告)号：US07902223B2
公开(公告)日：2011-03-08
申请号：US10486238
申请日：2002-07-12
申请人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Christos Tsaklakidis , Werner Mederski , Johannes Gleitz , Christopher Barnes
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D401/12 , C07D211/76 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1如专利权利要求1中所定义，是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病 并用于治疗肿瘤。
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