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11 条记录 (耗时 0.028 秒)

    High performance chiral selector
    4.
    发明授权
    High performance chiral selector 失效
    高性能手性选择器

    公开(公告)号：US5422004A

    公开(公告)日：1995-06-06

    申请号：US127931

    申请日：1993-09-27

    申请人： Qing Yang ,  William H. Pirkle ,  Christopher J. Welch ,  William E. Bowen

    发明人： Qing Yang ,  William H. Pirkle ,  Christopher J. Welch ,  William E. Bowen

    IPC分类号： B01J20/32 ,  C07B57/00 ,  C07C233/83 ,  C07C237/22 ,  B01D15/08

    CPC分类号： C07C233/83 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  C07B57/00 ,  C07C237/22

    摘要： A high performance chiral selector having the formula: ##STR1## wherein Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, NO.sub.2, N(R.sub.5).sub.3.sup.+, CN, COOR.sub.6 SO.sub.3 H and COR.sub.7 groups wherein R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 to C.sub.6 alkyl or phenyl;R.sub.3 and R.sub.4 are each independently C.sub.1 to C.sub.12 alkyl or C.sub.2 to C.sub.12 alkenyl; andm and n are each independently zero or 1, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

    摘要翻译： 具有下式的高性能手性选择剂：其中Ar是具有至多10个环碳原子的单环或邻 - 稠合多环芳族部分，其中任一个可以是未取代的或被一个或多个C 1 -C 6烷基取代，C 1 至C 6烷氧基，NO 2，N（R 5）3+，CN，COOR 6 SO 3 H和COR 7基团，其中R 5，R 6和R 7各自独立地为氢或C 1至C 6烷基; R 1和R 2各自独立地为氢，C 1至C 6烷基或苯基; R 3和R 4各自独立地为C 1至C 12烷基或C 2至C 12烯基; 并且m和n各自独立地为0或1，所述化合物是R或S对映体或R和S对映异构体的混合物。

    High performance chiral selector
    5.
    发明授权
    High performance chiral selector 失效
    高性能手性选择器

    公开(公告)号：US5290440A

    公开(公告)日：1994-03-01

    申请号：US902616

    申请日：1992-06-23

    申请人： William H. Pirkle ,  Christopher J. Welch ,  William E. Bowen ,  Qing Yang

    发明人： William H. Pirkle ,  Christopher J. Welch ,  William E. Bowen ,  Qing Yang

    IPC分类号： B01J20/32 ,  C07B57/00 ,  C07C233/83 ,  C07C237/22 ,  B01D15/08

    CPC分类号： C07C233/83 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  C07B57/00 ,  C07C237/22

    摘要： A high performance chiral selector having the formula: ##STR1## wherein Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, NO.sub.2, N(R.sub.5).sub.3.sup.+, CN, COOR.sub.6, SO.sub.3 H and COR.sub.7 groups wherein R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.1 and R.sub.2 ar each independently hydrogen, C.sub.1 to C.sub.6 alkyl or phenyl;R.sub.3 and R.sub.4 are each independently C.sub.1 to C.sub.12 alkyl or C.sub.2 to C.sub.12 alkenyl; andm and n are each independently zero or 1, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

    摘要翻译： 具有下式的高性能手性选择剂：其中Ar是具有至多10个环碳原子的单环或邻 - 稠合多环芳族部分，其中任一个可以是未取代的或被一个或多个C 1 -C 6烷基取代，C 1 至C 6烷氧基，NO 2，N（R 5）3+，CN，COOR 6，SO 3 H和COR 7基团，其中R 5，R 6和R 7各自独立地为氢或C 1至C 6烷基; R 1和R 2各自独立地为氢，C 1至C 6烷基或苯基; R 3和R 4各自独立地为C 1至C 12烷基或C 2至C 12烯基; 并且m和n各自独立地为0或1，所述化合物是R或S对映体或R和S对映异构体的混合物。

    Face-to-face/face-to-edge interactive chiral selectors and related apparatuses
    7.
    发明授权
    Face-to-face/face-to-edge interactive chiral selectors and related apparatuses 失效
    面对面/面对面交互式手写选择器及相关设备

    公开(公告)号：US5674387A

    公开(公告)日：1997-10-07

    申请号：US470848

    申请日：1995-06-06

    申请人： William H. Pirkle ,  Christopher J. Welch ,  Bo Robert Lamm

    发明人： William H. Pirkle ,  Christopher J. Welch ,  Bo Robert Lamm

    IPC分类号： C07C51/487 ,  C07C275/30 ,  B01D15/08

    CPC分类号： C07C51/487 ,  C07C275/30

    摘要： The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsteroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

    摘要翻译： 本发明涉及可用于分离非甾体抗炎剂，特别是萘普生和其它芳基乙酸化合物的未衍生化对映异构体的手性选择剂，涉及使用手性选择剂实现这种分离的方法，其也可用于实现对映体分离 的胺，醇衍生物，环氧化物和亚砜。 本发明还涉及一种包括手性选择器的装置。

    Chiral selector useful for separation of enantiomers of .beta.-amino alcohol compounds
    9.
    发明授权
    Chiral selector useful for separation of enantiomers of .beta.-amino alcohol compounds 失效
    可用于分离β-氨基醇化合物对映异构体的手性选择剂

    公开(公告)号：US5254258A

    公开(公告)日：1993-10-19

    申请号：US761212

    申请日：1991-09-17

    申请人： William H. Pirkle ,  John A. Burke, III

    发明人： William H. Pirkle ,  John A. Burke, III

    IPC分类号： C07D205/085 ,  C07F7/18 ,  C07F9/40 ,  B01D61/38

    CPC分类号： C07F7/1836 ,  C07D205/085 ,  C07F9/4015

    摘要： Underivatized enantiomers of a beta -amino alcohol compound are directly separated by means of a chiral selector compound having the formula I wherein R2 and R3 are each independently lower alkyl, preferably methyl; R4 and R5 are each independently NO2, N(R6)3+, CN, COOR2, SO3H or COR8, preferably NO2; R6, R7 and R8 are each independently hydrogen or lower alkyl, preferably hydrogen or methyl, W is H or CH=CH2, X and Y are each independently OR9 or NR10R11, preferably X and Y are the same and most preferably X and Y are each OR9, or X and Y together with the P to which they are attached form a 5- or 6-membered ring having the formula R9, R10, R11 and R12 are each independently hydrogen or lower alkyl, R9 is preferably methyl, R10, R11 and R12 are preferably hydrogen or methyl, Z is O or NH, n is 1 to 20, preferably 1 to 8 when W is H, and 1 to 3 when W is CH=CH2, and m is 1 or 2, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

    摘要翻译： β-氨基醇化合物的未衍生的对映异构体通过具有下式的手性选择化合物直接分离：其中R 2和R 3各自独立地为低级烷基，优选甲基; R 4和R 5各自独立地为NO 2，N（R 6）3+，CN，COOR 2，SO 3 H或COR 8，优选为NO 2; R 6，R 7和R 8各自独立地为氢或低级烷基，优选氢或甲基，W为H或CH = CH 2，X和Y各自独立地为OR 9或NR 10 R 11，优选X和Y为相同且最优选X和Y为 每个OR 9或X和Y与它们所连接的P一起形成具有下式的5-或6-元环：R 9，R 10，R 11和R 12各自独立地为氢或低级烷基，R 9优选为甲基 R 10，R 11和R 12优选为氢或甲基，Z为O或NH，当W为H时，n为1至20，优选1至8，W为CH = CH 2时为1至3，m为1或2 所述化合物是R或S对映体或R和S对映异构体的混合物。