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![Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2007/02/13/US07176214B2/abs.jpg.150x150.jpg)
1.发明授权Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并稠唑并[4,5-β]吡啶和咪唑并稠合的噻唑并[4,5-β]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US07176214B2
公开(公告)日：2007-02-13
申请号：US10848412
申请日：2004-05-18
申请人： William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude A. Quesnelle , Steven H. Spergel , Fred Christopher Zusi
发明人： William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude A. Quesnelle , Steven H. Spergel , Fred Christopher Zusi
IPC分类号： A61K31/4353 , C07D498/12
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo [4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2008/11/25/US07456194B2/abs.jpg.150x150.jpg)
2.发明授权Imidazo-fused oxazolo [4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US07456194B2
公开(公告)日：2008-11-25
申请号：US11272401
申请日：2005-11-10
申请人： Alaric Dyckman , William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven H. Spergel , F. Christopher Zusi
发明人： Alaric Dyckman , William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven H. Spergel , F. Christopher Zusi
IPC分类号： A61K31/4365 , A61K31/437 , C07D471/14 , C07D471/16
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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3.发明授权Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same 有权基于吡唑并嘌呤的三环化合物和包含它们的药物组合物公开(公告)号：US07329668B2
公开(公告)日：2008-02-12
申请号：US10785612
申请日：2004-02-24
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo[4,5-beta]pyridine and imidazo-fused thiazolo[4,5-beta]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2005/05/12/US20050101626A1/abs.jpg.150x150.jpg)
4.发明申请Imidazo-fused oxazolo[4,5-beta]pyridine and imidazo-fused thiazolo[4,5-beta]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并稠唑并[4,5-β]吡啶和咪唑并稠合噻唑并[4,5-β]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20050101626A1
公开(公告)日：2005-05-12
申请号：US10848412
申请日：2004-05-18
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4353 , A61K31/4745 , C07D20060101 , C07D213/72 , C07D471/02 , C07D491/14 , C07D498/12 , C07D498/14 , C07D513/12 , C07D513/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/09/28/US20060217412A1/abs.jpg.150x150.jpg)
5.发明申请Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 审中-公开咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20060217412A1
公开(公告)日：2006-09-28
申请号：US11444856
申请日：2006-06-01
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4745 , C07D498/14 , C07D491/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/05/18/US20060106051A1/abs.jpg.150x150.jpg)
6.发明申请Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20060106051A1
公开(公告)日：2006-05-18
申请号：US11272401
申请日：2005-11-10
申请人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
发明人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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公开(公告)号：US08143288B2
公开(公告)日：2012-03-27
申请号：US11446788
申请日：2006-06-05
申请人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
发明人： Michael Serrano-Wu , Makonen Belema , Lawrence B. Snyder , Nicholas A. Meanwell , Denis R. St. Laurent , Ramesh Kakarla , Van N. Nguyen , Yuping Qiu , Xuejie Yang , John E. Leet , Min Gao , Donald R. O'Boyle, II , Julie A. Lemm , Fukang Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译： 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。
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8.发明授权Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same 有权可用作抗炎剂的氨基取代的四环化合物和包含其的药物组合物公开(公告)号：US06960585B2
公开(公告)日：2005-11-01
申请号：US09965977
申请日：2001-09-27
申请人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
发明人： Francis Beaulieu , Carl Quellet , Makonen Belema , Yuping Qiu , Xuejie Yang , Fred C. Zusi
IPC分类号： A61K31/4745 , A61K31/4985 , A61K31/519 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/06 , A61P29/00 , A61P31/18 , A61P31/22 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04 , C07D513/04 , Y02A50/411
摘要： Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R2-4 are as defined in the specification.
摘要翻译： 式（I）化合物或其药学上可接受的盐可用于治疗炎症和免疫疾病和病症，其中X，Y 1，Y 2和R 本说明书中所定义的。
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公开(公告)号：US20100068176A1
公开(公告)日：2010-03-18
申请号：US12536362
申请日：2009-08-05
申请人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
发明人： Makonen Belema , Andrew C. Good , Jason Goodrich , Ramesh Kakarla , Guo Li , Omar D. Lopez , Van N. Nguyen , Jayne Kapur , Yuping Qiu , Jeffrey Lee Romine , Denis R. St. Laurent , Michael Serrano-Wu , Lawrence B. Snyder , Fukang Yang
IPC分类号： A61K38/20 , C07D403/14 , A61K31/4184 , A61K31/497 , A61K38/21 , A61K31/7088 , A61P31/12
CPC分类号： C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20060276511A1
公开(公告)日：2006-12-07
申请号：US11446788
申请日：2006-06-05
申请人： Michael Serrano-Wu , Makonen Belema , Lawrence Snyder , Nicholas Meanwell , Denis St. Laurent , Ramesh Kakarla , Van Nguyen , Yuping Qiu , Xuejie Yang , John Leet , Min Gao , Donald O'Boyle , Julie Lemm , Fukang Yang
发明人： Michael Serrano-Wu , Makonen Belema , Lawrence Snyder , Nicholas Meanwell , Denis St. Laurent , Ramesh Kakarla , Van Nguyen , Yuping Qiu , Xuejie Yang , John Leet , Min Gao , Donald O'Boyle , Julie Lemm , Fukang Yang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/42 , A61K31/416 , A61K31/4025 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D207/16 , C07D207/22 , C07D207/277 , C07D209/42 , C07D211/60 , C07D263/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
摘要翻译： 描述具有式I结构的化合物。 该化合物可以抑制丙型肝炎病毒（HCV）复制，特别是可以抑制HCV NS5A蛋白的功能。
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