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    Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
    1.
    发明授权
    Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same 失效
    具有改变的受体结合特异性和活性的糖蛋白激素的类似物以及制备和使用它们的方法

    公开(公告)号：US5508261A

    公开(公告)日：1996-04-16

    申请号：US425673

    申请日：1995-04-18

    申请人： William R. Moyle ,  Robert K. Campbell ,  Gordon J. Macdonald ,  Yi Han ,  Yanhong Wang

    发明人： William R. Moyle ,  Robert K. Campbell ,  Gordon J. Macdonald ,  Yi Han ,  Yanhong Wang

    IPC分类号： C07K14/59 ,  A61K38/24 ,  A61K38/22 ,  C07K14/575

    CPC分类号： C07K14/59

    摘要： The present invention pertains to an alpha, beta-heterodimeric polypeptide having binding affinity to vertebrate luteinizing hormone (LH) receptors and vertebrate follicle stimulating hormone (FSH) receptors comprising a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide, wherein the beta-subunit polypeptide is a chain of amino acids comprising the following four joined subsequences:(a) a first subsequence homologous to the amino acid sequence of residues 1-93 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG), vertebrate luteinizing hormone (LH), vertebrate follicle stimulating hormone (FSH), and vertebrate thyroid stimulating hormone (TSH);(b) a second subsequence homo logous to the amino acid sequence of residues 94-97 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG) and vertebrate luteinizing hormone (LH);(c) a third subsequence homologous to the amino acid sequence of residues 98-100 of the beta-subunit selected from the group consisting of human chorionic gonadotrophin (hCG), vertebrate luteinizing hormone (LH), vertebrate follicle stimulating hormone (FSH), and vertebrate thyroid stimulating hormone (TSH); and(d) a fourth subsequence homologous to the amino acid sequence of residues 101-110 of the beta-subunit of vertebrate follicle stimulating hormone.

    摘要翻译： 本发明涉及对脊椎动物黄体生成激素（LH）受体和包含糖蛋白激素α-亚基多肽和非天然存在的β-亚基多肽的脊椎动物刺激素（FSH）受体具有结合亲和力的α，β-异二聚体多肽 ，其中所述β-亚基多肽是包含以下四个连接的亚序列的氨基酸链：（a）与β-亚基的残基1-93的氨基酸序列同源的第一亚序列，所述第一亚序列选自人绒毛膜 促性腺激素（hCG），脊椎动物黄体激素（LH），脊椎动物刺激素（FSH）和脊椎动物促甲状腺激素（TSH）; （b）与选自人绒毛膜促性腺激素（hCG）和脊椎动物黄体生成素（LH）的β-亚基的残基94-97的氨基酸序列同源的第二个亚序列; （c）与选自人绒毛膜促性腺激素（hCG），脊椎动物黄体生成激素（LH），脊椎动物刺激素（FSH）的β-亚单位的残基98-100的氨基酸序列同源的第三子序列， 和脊椎动物刺激激素（TSH）; 和（d）与脊椎动物促卵泡激素的β-亚基的残基101-110的氨基酸序列同源的第四个亚序列。

    Method, apparatus, and system for wireless proximity and presence monitoring
    3.
    发明授权
    Method, apparatus, and system for wireless proximity and presence monitoring 有权

    公开(公告)号：US11035940B2

    公开(公告)日：2021-06-15

    申请号：US16667648

    申请日：2019-10-29

    申请人： Qinyi Xu ,  Yi Han ,  Hung-Quoc Duc Lai ,  Beibei Wang ,  Oscar Chi-Lim Au ,  K. J. Ray Liu

    发明人： Qinyi Xu ,  Yi Han ,  Hung-Quoc Duc Lai ,  Beibei Wang ,  Oscar Chi-Lim Au ,  K. J. Ray Liu

    IPC分类号： G01S13/56 ,  G01S13/00 ,  G01S7/00

    摘要： Methods, apparatus and systems for monitoring a presence or a motion of an object in a proximity of an apparatus are described. In one example, a described apparatus is in a venue for wireless proximity monitoring. The apparatus comprises: a transmitter, a receiver, and a processor. The transmitter is configured for transmitting a wireless signal through a wireless multipath channel, wherein the wireless multipath channel is impacted by a motion of an object within a proximity of the apparatus. The receiver is configured for: receiving the wireless signal through the wireless multipath channel between the transmitter and the receiver, and obtaining a time series of channel information (TSCI) of the wireless multipath channel based on the wireless signal received by the receiver. The processor is configured for monitoring the motion of the object within the proximity of the apparatus based at least partially on the TSCI.

    MEMORY DEVICE WITH CONFIGURABLE DELAY TRACKING
    4.
    发明申请
    MEMORY DEVICE WITH CONFIGURABLE DELAY TRACKING 有权
    具有可配置延迟跟踪的存储器件

    公开(公告)号：US20080101143A1

    公开(公告)日：2008-05-01

    申请号：US11552893

    申请日：2006-10-25

    申请人： Seong-Ook Jung ,  Sei Seung Yoon ,  Yi Han

    发明人： Seong-Ook Jung ,  Sei Seung Yoon ,  Yi Han

    IPC分类号： G11C7/02

    CPC分类号： G11C7/08 ,  G11C7/14 ,  G11C7/22 ,  G11C8/08 ,  G11C11/41 ,  G11C11/419 ,  G11C29/02 ,  G11C29/023 ,  G11C29/028 ,  G11C2207/065

    摘要： A memory device with configurable delay tracking is described. The memory device includes M normal word line drivers, a dummy word line driver a memory array, N sense amplifiers, and a timing control circuit. The memory array includes M rows and N columns of memory cells and a column of dummy cells. The word line drivers drive word lines for the rows of memory cells. The dummy word line driver drives a dummy word line for at least one dummy cell in the column of dummy cells. The timing control circuit generates enable signals having configurable delay, which may be obtained with an acceleration circuit that provides variable drive for a dummy bit line coupled to the column of memory cells. The sense amplifiers detect bit lines for the columns of memory cells based on the enable signals.

    摘要翻译： 描述了具有可配置延迟跟踪的存储器件。 存储器件包括M个正常字线驱动器，一个虚拟字线驱动器，一个存储器阵列，N个读出放大器和一个定时控制电路。 存储器阵列包括M行和N列存储器单元和一列虚拟单元。 字线驱动程序驱动内存单元行的字线。 虚拟字线驱动器驱动虚拟单元列中的至少一个虚拟单元的虚拟字线。 定时控制电路产生具有可配置延迟的使能信号，其可以通过为耦合到存储器单元列的虚拟位线提供可变驱动的加速电路来获得。 读出放大器基于使能信号来检测存储器单元列的位线。

    Memory device with configurable delay tracking
    6.
    发明授权
    Memory device with configurable delay tracking 有权
    具有可配置延迟跟踪的存储器

    公开(公告)号：US07755964B2

    公开(公告)日：2010-07-13

    申请号：US11552893

    申请日：2006-10-25

    申请人： Seong-Ook Jung ,  Sei Seung Yoon ,  Yi Han

    发明人： Seong-Ook Jung ,  Sei Seung Yoon ,  Yi Han

    IPC分类号： G11C7/02

    CPC分类号： G11C7/08 ,  G11C7/14 ,  G11C7/22 ,  G11C8/08 ,  G11C11/41 ,  G11C11/419 ,  G11C29/02 ,  G11C29/023 ,  G11C29/028 ,  G11C2207/065

    摘要： A memory device with configurable delay tracking is described. The memory device includes M normal word line drivers, a dummy word line driver a memory array, N sense amplifiers, and a timing control circuit. The memory array includes M rows and N columns of memory cells and a column of dummy cells. The word line drivers drive word lines for the rows of memory cells. The dummy word line driver drives a dummy word line for at least one dummy cell in the column of dummy cells. The timing control circuit generates enable signals having configurable delay, which may be obtained with an acceleration circuit that provides variable drive for a dummy bit line coupled to the column of memory cells. The sense amplifiers detect bit lines for the columns of memory cells based on the enable signals.

    摘要翻译： 描述了具有可配置延迟跟踪的存储器件。 存储器件包括M个正常字线驱动器，一个虚拟字线驱动器，一个存储器阵列，N个读出放大器和一个定时控制电路。 存储器阵列包括M行和N列存储器单元和一列虚拟单元。 字线驱动程序驱动内存单元行的字线。 虚拟字线驱动器驱动虚拟单元列中的至少一个虚拟单元的虚拟字线。 定时控制电路产生具有可配置延迟的使能信号，其可以通过为耦合到存储器单元列的虚拟位线提供可变驱动的加速电路来获得。 读出放大器基于使能信号来检测存储器单元列的位线。