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    RNA REVERSE TRANSCRIPTION AMPLIFICATION METHOD
    6.
    发明申请
    RNA REVERSE TRANSCRIPTION AMPLIFICATION METHOD 审中-公开

    公开(公告)号：US20190316176A1

    公开(公告)日：2019-10-17

    申请号：US16314356

    申请日：2017-06-29

    申请人： Xiamen University

    发明人： Shiyin ZHANG ,  Shengxiang GE ,  Jin WANG ,  Jun ZHANG ,  Ningshao XIA

    IPC分类号： C12Q1/686 ,  C12N15/10

    摘要： A ribonucleic acid (RNA) reverse transcription amplification method, comprising the steps of reverse transcription of RNA into cDNA and immediate amplification of cDNA, characterized in that the process of reverse transcription of RNA into cDNA is completed during the process that a cDNA amplification reaction system is heated to reach the reaction condition for cDNA amplification. The RNA reverse transcription amplification method can combine the reaction condition for reverse transcription of RNA into cDNA with the reaction condition for cDNA amplification, thereby significantly shorten the time required for RNA reverse transcription amplification. And in the whole process of RNA reverse transcription amplification, there is no need to change the instrument temperature, and thus, it is possible to achieve detection at any time.

    ANTI-HEPATITIS B VIRUS ANTIBODIES AND USE THEREOF
    8.
    发明申请
    ANTI-HEPATITIS B VIRUS ANTIBODIES AND USE THEREOF 有权

    公开(公告)号：US20220251173A1

    公开(公告)日：2022-08-11

    申请号：US17613392

    申请日：2020-05-22

    申请人： XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

    发明人： Wenxin LUO ,  Yichao JIANG ,  Chao YU ,  Xiaoqing CHEN ,  Jixian TANG ,  Quan YUAN ,  Tianying ZHANG ,  Ningshao XIA

    IPC分类号： C07K16/08 ,  A61P31/20

    摘要： Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.

    COXSACKIE VIRUS B FOR TREATING TUMORS
    9.
    发明申请
    COXSACKIE VIRUS B FOR TREATING TUMORS 有权

    公开(公告)号：US20210154249A1

    公开(公告)日：2021-05-27

    申请号：US17047783

    申请日：2019-04-15

    申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

    发明人： Tong CHENG ,  Wei WANG ,  Xiangzhong YE ,  Wenkun FU ,  Dequan PAN ,  Jun ZHANG ,  Ningshao XIA

    IPC分类号： A61K35/76 ,  C12N7/00 ,  A61P35/04

    摘要： Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.

    Mutant of L1 Protein of Human Papillomavirus Type 58
    10.
    发明申请
    Mutant of L1 Protein of Human Papillomavirus Type 58 审中-公开

    公开(公告)号：US20200268869A1

    公开(公告)日：2020-08-27

    申请号：US15781035

    申请日：2016-12-02

    申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

    发明人： Shaowei LI ,  Zhihai LI ,  Shuo SONG ,  Maozhou HE ,  Ying GU ,  Ningshao XIA

    IPC分类号： A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61P31/20 ,  C12N15/70

    摘要： Provided are a mutated HPV58 L1 protein or a variant thereof, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein or a variant thereof and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types, and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.