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公开(公告)号：US10183999B2
公开(公告)日：2019-01-22
申请号：US15149047
申请日：2016-05-06
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07H21/04 , C12P21/06 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/395 , C07K16/22 , C07K16/42 , C40B30/02 , G06F19/16 , G06F19/22 , C12P21/00 , G06F19/12 , A61K39/00
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US20160347837A1
公开(公告)日：2016-12-01
申请号：US15167822
申请日：2016-05-27
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , G16B5/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16C20/60
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US20180141997A1
公开(公告)日：2018-05-24
申请号：US15633651
申请日：2017-06-26
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US10184000B2
公开(公告)日：2019-01-22
申请号：US15167832
申请日：2016-05-27
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07H21/04 , C12N15/00 , C12N5/02 , C12P21/06 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/395 , C07K16/22 , C07K16/42 , C40B30/02 , G06F19/16 , G06F19/22 , C12P21/00 , G06F19/12 , A61K39/00
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US09714282B2
公开(公告)日：2017-07-25
申请号：US14286825
申请日：2014-05-23
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07K16/00 , C12P21/08 , C07H21/02 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/00 , C12N1/20 , C07K16/28 , C07K16/32 , C07K1/00
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US20160347825A1
公开(公告)日：2016-12-01
申请号：US15167832
申请日：2016-05-27
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US08809503B2
公开(公告)日：2014-08-19
申请号：US13898386
申请日：2013-05-20
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US20160318993A1
公开(公告)日：2016-11-03
申请号：US15149047
申请日：2016-05-06
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US09353187B2
公开(公告)日：2016-05-31
申请号：US13773485
申请日：2013-02-21
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , C07K16/00 , C07K16/32 , C07K16/28 , C07K16/22 , C07K16/42 , A61K39/00
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US08858937B2
公开(公告)日：2014-10-14
申请号：US13773473
申请日：2013-02-21
申请人： Xencor, Inc.
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , A61K39/40 , C07K16/28 , C07K16/22 , C07K16/32 , C07K16/42 , C07K16/00 , A61K39/00
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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