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公开(公告)号：US20140370614A1
公开(公告)日：2014-12-18
申请号：US13918481
申请日：2013-06-14
Applicant: Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
Inventor： Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
IPC: B01J20/281
CPC classification number: G01N30/482 , B01D15/305 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J43/00
Abstract: The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.
Abstract translation: 本发明提供了聚集的多峰色谱介质。 本发明的介质包括在阴离子交换，阳离子交换和亲水相互作用层析方式中有活性的基团。 本发明提供了制备这些介质并将其用于分析物分离的方法。 还提供了并入介质的分离装置和并入这些分离装置的系统。
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2.发明申请EPOXY CHEMISTRY DERIVED MATERIALS AS MIXED MODE CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE 有权环氧化学衍生的材料作为混合模式色谱介质，其合成和使用方法公开(公告)号：US20140273264A1
公开(公告)日：2014-09-18
申请号：US13842391
申请日：2013-03-15
Applicant: Xiaodong LIU , Liang CAO , Christopher A. POHL
Inventor： Xiaodong LIU , Liang CAO , Christopher A. POHL
IPC: B01J20/281
CPC classification number: G01N30/482 , B01J20/289 , B01J20/3257 , B01J20/3259 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J2220/54
Abstract: This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.
Abstract translation: 本发明提供了混合模式固定相组合物，包含固定相的装置和系统以及使用环氧化物开环反应制备这些组合物的方法。 还提供了在分离中使用本发明的固定相的方法。
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3.发明申请公开(公告)号：US20190016899A1
公开(公告)日：2019-01-17
申请号：US15929043
申请日：2018-09-17
Applicant: Xiaodong LIU
Inventor： Xiaodong LIU
IPC: C09D1/00 , C09D5/00 , C09D183/04 , C09D183/02 , C09D1/02 , C08K3/36 , C08K3/10 , C09D1/04 , C09D183/00
Abstract: The present invention relates to coating composition. And in particular, to an inorganic coating composition which can be cured at low temperature and a preparation method thereof. In order to solve the problems that the organic coating is harmful for the environment, the inorganic coating has bad flexibility, and the traditional ceramic coatings need heat and is inconvenient for curing in prior art, the present invention provide an inorganic coating composition which can be cured at low temperature and a preparation method thereof. The inorganic coating composition comprises the ingredient as below: 70-80 wt % of inorganic solution; 5-10 wt % of functional additives, which are potassium titanate, alumina, or a compound thereof; 10-20 wt % of inorganic pigment; 0.5-2.0 wt % of other functional additives. The said inorganic solution comprises the following ingredients: 30-40 wt % of organic alkoxy-silane, 15-20 wt % of organic solvent, and 25-30 wt % of silica sol. The inorganic coating composition is able to be cured at low temperature, the film formed by it has excellent flexibility, and the film will not release harmful organic gases, and is beneficial to the environmental.
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4.发明申请INORGANIC COATING COMPOSITION WHICH CAN BE CURED AT LOW TEMPERATURE AND A PREPARATION METHOD THEREOF 审中-公开可以在低温下固化的无机涂料组合物及其制备方法公开(公告)号：US20170009079A1
公开(公告)日：2017-01-12
申请号：US15202238
申请日：2016-07-05
Applicant: Xiaodong LIU
Inventor： Xiaodong LIU
IPC: C09D1/00
CPC classification number: C09D1/00 , C08K3/10 , C08K3/36 , C09D1/02 , C09D1/04 , C09D5/00 , C09D183/00 , C09D183/02 , C09D183/04
Abstract: The present invention relates to coating composition. And in particular, to an inorganic coating composition which can be cured at low temperature and a preparation method thereof. In order to solve the problems that the organic coating is harmful for the environment, the inorganic coating has bad flexibility, and the traditional ceramic coatings need heat and is inconvenient for curing in prior art, the present invention provide an inorganic coating composition which can be cured at low temperature and a preparation method thereof. The inorganic coating composition comprises the ingredient as below: 70-80 wt % of inorganic solution; 5-10 wt % of functional additives, which are potassium titanate, alumina, or a compound thereof; 10-20 wt % of inorganic pigment; 0.5-2.0 wt % of other functional additives. The said inorganic solution comprises the following ingredients: 30-40 wt % of organic alkoxy-silane, 15-20 wt % of organic solvent, and 25-30 wt % of silica sol. The inorganic coating composition is able to be cured at low temperature, the film formed by it has excellent flexibility, and the film will not release harmful organic gases, and is beneficial to the environmental.
Abstract translation: 本发明涉及涂料组合物。 特别涉及可在低温下固化的无机涂料组合物及其制备方法。 为了解决有机涂层对环境有害的问题，无机涂层柔软性差，传统陶瓷涂层需要热量，在现有技术中不易固化，本发明提供了一种无机涂料组合物，其可以是 在低温下固化及其制备方法。 无机涂料组合物包含如下成分：70-80重量％的无机溶液; 5-10重量％的功能添加剂，它们是钛酸钾，氧化铝或其化合物; 10-20重量％的无机颜料; 0.5-2.0重量％的其他功能添加剂。 所述无机溶液包含以下成分：30-40重量％的有机烷氧基硅烷，15-20重量％的有机溶剂和25-30重量％的二氧化硅溶胶。 无机涂料组合物能够在低温下固化，由其形成的膜具有优异的柔韧性，并且该膜不会释放有害的有机气体，并且有益于环境。
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公开(公告)号：US20160340317A1
公开(公告)日：2016-11-24
申请号：US15034280
申请日：2014-11-04
Applicant: Donatella CHIANELLI , Xiaodong LIU , Valentina MOLTENI , John NELSON , Jason Thomas ROLAND , Paul Vicent RUCKER , David Charles TULLY
Inventor： Donatella CHIANELLI , Xiaodong LIU , Valentina MOLTENI , John NELSON , Jason Thomas ROLAND , Paul Vicent RUCKER , David Charles TULLY
IPC: C07D231/54 , A61K31/4162 , A61K31/4439 , A61K31/4745 , A61K31/416 , C07D491/052 , C07D471/06
CPC classification number: C07D231/54 , A61K31/416 , A61K31/4162 , A61K31/4439 , A61K31/4745 , C07D471/04 , C07D471/06 , C07D491/052
Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).
Abstract translation: 立体异构体，对映体，其药学上可接受的盐或氨基酸缀合物; 其中变量如本文所定义; 和它们的药物组合物，其可用作法呢素X受体（FXR）活性的调节剂。
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Patent Agency Ranking
6.发明申请EPOXY CHEMISTRY DERIVED MATERIALS AS REVERSED-PHASE AND HYDROPHOBIC INTERACTION CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE 有权环氧化学衍生的材料作为反相和疏水相互作用色谱介质，其合成和使用方法公开(公告)号：US20140260563A1
公开(公告)日：2014-09-18
申请号：US13841484
申请日：2013-03-15
Applicant: Xiaodong LIU , Liang CAO , Christopher A. POHL
Inventor： Xiaodong LIU , Liang CAO , Christopher A. POHL
IPC: B01J20/22 , B01D15/20 , G01N30/02 , B01J20/287
CPC classification number: B01J20/22 , B01D15/20 , B01J20/286 , B01J20/287 , B01J20/3257 , B01J20/3259 , G01N30/02
Abstract: This invention provides aqueous-compatible, polar-embedded reversed-phase stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.
Abstract translation: 本发明提供含水相容的极性嵌入式反相固相组合物，包含固定相的装置和体系以及使用环氧化物开环反应制备这些组合物的方法。 还提供了在分离中使用本发明的固定相的方法。
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公开(公告)号：US20140228347A1
公开(公告)日：2014-08-14
申请号：US14258963
申请日：2014-04-22
Applicant: Valentina MOLTENI , Hank Michael James PETRASSI , Xiaolin LI , Xiaodong LIU , Jon LOREN , Juliet NABAKKA , Bao NGUYEN , Vince YEH
Inventor： Valentina MOLTENI , Hank Michael James PETRASSI , Xiaolin LI , Xiaodong LIU , Jon LOREN , Juliet NABAKKA , Bao NGUYEN , Vince YEH
IPC: C07D498/04 , C07D491/044 , C07D491/107 , C07D471/04
CPC classification number: C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
Abstract translation: 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。
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公开(公告)号：US20140178912A1
公开(公告)日：2014-06-26
申请号：US13724178
申请日：2012-12-21
Applicant: Xiaodong LIU , Udayanath AICH , Christopher A. POHL
Inventor： Xiaodong LIU , Udayanath AICH , Christopher A. POHL
CPC classification number: C08B37/0063 , B01D15/3847 , B01J20/286 , B01J20/3285 , B01J41/20 , B01J43/00 , B01J2220/54 , C07K1/165 , G01N30/482 , B01D15/363 , B01D15/305 , B01D15/325 , B01D15/362
Abstract: An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.
Abstract translation: 本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。 在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中聚糖分离和聚糖混合物分析的方式相互作用。 将介质并入用于色谱分析的装置和系统中。 还提供了使用本发明的多峰介质来分析聚糖的方法。
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公开(公告)号：US20130059846A1
公开(公告)日：2013-03-07
申请号：US13595575
申请日：2012-08-27
Applicant: Vince YEH , Xiaolin LI , Xiaodong LIU , Jon LOREN , Valentina MOLTENI , Juliet NABAKKA , Bao NGUYEN , Hank Michael James PETRASSI
Inventor： Vince YEH , Xiaolin LI , Xiaodong LIU , Jon LOREN , Valentina MOLTENI , Juliet NABAKKA , Bao NGUYEN , Hank Michael James PETRASSI
IPC: A61K31/437 , A61K31/496 , A61K31/5377 , A61P19/04 , A61P11/00 , A61P1/00 , A61P37/06 , A61P3/00 , A61P21/00 , A61P17/00 , A61P9/12 , A61P11/06 , A61P37/08 , A61P9/00 , A61P3/10 , C07D471/04
CPC classification number: C07D471/04
Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
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公开(公告)号：US20130059832A1
公开(公告)日：2013-03-07
申请号：US13598213
申请日：2012-08-29
Applicant: Valentina MOLTENI , Hank Michael James PETRASSI , Xiaolin LI , Xiaodong LIU , Jon LOREN , Juliet NABAKKA , Bao NGUYEN , Vince YEH
Inventor： Valentina MOLTENI , Hank Michael James PETRASSI , Xiaolin LI , Xiaodong LIU , Jon LOREN , Juliet NABAKKA , Bao NGUYEN , Vince YEH
IPC: A61K31/437 , C07D491/048 , A61K31/4545 , A61K31/5377 , C07D491/107 , A61K31/496 , A61P11/00 , A61P29/00 , A61P1/00 , A61P3/00 , A61P37/00 , A61P17/00 , A61P9/12 , A61P11/06 , A61P11/02 , A61P37/08 , A61P3/10 , A61P7/00 , A61P1/16 , C07D471/04
CPC classification number: C07D491/107 , C07D471/04 , C07D491/044 , C07D491/048 , C07D498/04
Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
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