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    Process for preparing compounds of chitosan saccharified with aminosugar
    1.
    发明授权
    Process for preparing compounds of chitosan saccharified with aminosugar 失效
    用氨基糖糖化糖壳化合物的方法

    公开(公告)号：US08202971B2

    公开(公告)日：2012-06-19

    申请号：US12499767

    申请日：2009-07-08

    申请人： Xiguang Chen ,  Jing Li ,  Xiaojie Cheng ,  Tao Jiang

    发明人： Xiguang Chen ,  Jing Li ,  Xiaojie Cheng ,  Tao Jiang

    IPC分类号： C08B37/08

    CPC分类号： C08B37/003

    摘要： A process for preparing compounds of chitosan saccharified with aminosugar, adopts chitosan derivatives, aminosugar derivatives and anhydride derivatives as raw materials to synthesize target products. The process comprises: covalently bonding an anhydride derivative as a bonding arm to an aminosugar derivative, so as to form a monosaccharide derivative having an end group of carboxyl; and then covalently bonding the monosaccharide derivative having an end group of carboxyl to a primary amino group of a chitosan derivative via the carboxyl, so as to form a compound of chitosan saccharified with aminosugar.

    摘要翻译： 用氨基糖糖化糖壳化合物的方法，采用壳聚糖衍生物，氨基糖衍生物和酸酐衍生物为原料合成目标产物。 该方法包括：将作为结合臂的酸酐衍生物与氨基糖衍生物共价键合，形成具有羧基端基的单糖衍生物; 然后通过羧基将具有羧基末端基团的单糖衍生物共价键合到壳聚糖衍生物的伯氨基上，以形成用氨基糖糖化的壳聚糖化合物。

    Process for preparing compounds of chitosan saccharified with aminosugar
    2.
    发明申请
    Process for preparing compounds of chitosan saccharified with aminosugar 失效
    用氨基糖糖化糖壳化合物的方法

    公开(公告)号：US20100152430A1

    公开(公告)日：2010-06-17

    申请号：US12499767

    申请日：2009-07-08

    申请人： Xiguang Chen ,  Jing Li ,  Xiaojie Cheng ,  Tao Jiang

    发明人： Xiguang Chen ,  Jing Li ,  Xiaojie Cheng ,  Tao Jiang

    IPC分类号： C08B37/08 ,  C07H1/00

    CPC分类号： C08B37/003

    摘要： A process for preparing compounds of chitosan saccharified with aminosugar, adopts chitosan derivatives, aminosugar derivatives and anhydride derivatives as raw materials to synthesize target products. The process comprises: covalently bonding an anhydride derivative as a bonding arm to an aminosugar derivative, so as to form a monosaccharide derivative having an end group of carboxyl; and then covalently bonding the monosaccharide derivative having an end group of carboxyl to a primary amino group of a chitosan derivative via the carboxyl, so as to form a compound of chitosan saccharified with aminosugar.

    摘要翻译： 用氨基糖糖化糖壳化合物的方法，采用壳聚糖衍生物，氨基糖衍生物和酸酐衍生物为原料合成目标产物。 该方法包括：将作为结合臂的酸酐衍生物与氨基糖衍生物共价键合，形成具有羧基端基的单糖衍生物; 然后通过羧基将具有羧基末端基团的单糖衍生物共价键合到壳聚糖衍生物的伯氨基上，以形成用氨基糖糖化的壳聚糖化合物。

    PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE
    9.
    发明申请
    PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE 有权
    细胞摄取的细胞是可控的

    公开(公告)号：US20120134931A1

    公开(公告)日：2012-05-31

    申请号：US13384591

    申请日：2010-07-15

    申请人： Roger Tsien ,  Tood Aguilera ,  Emilia Olson ,  Tao Jiang ,  Quyen Nguyen

    发明人： Roger Tsien ,  Tood Aguilera ,  Emilia Olson ,  Tao Jiang ,  Quyen Nguyen

    IPC分类号： A61K49/06 ,  C07K9/00 ,  C07K7/02 ,  A61K49/00

    CPC分类号： A61K47/64 ,  A61K47/595 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0056 ,  C07K7/06

    摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

    摘要翻译： 在某些实施方案中，本文公开了具有增加的体内循环的选择性转运分子。 在一些实施方案中，本文公开的选择性转运分子具有式（A-X-B-C）-M，其中C是货物部分; A是具有包含5至9个连续酸性氨基酸的序列的肽，其中所述氨基酸选自：天冬氨酸和谷氨酸; B是具有包含5至20个连续碱性氨基酸的序列的肽; X是一个连接子; M是大分子载体。