Process for preparing compounds of chitosan saccharified with aminosugar
    1.
    发明授权
    Process for preparing compounds of chitosan saccharified with aminosugar 失效
    用氨基糖糖化糖壳化合物的方法

    公开(公告)号:US08202971B2

    公开(公告)日:2012-06-19

    申请号:US12499767

    申请日:2009-07-08

    IPC分类号: C08B37/08

    CPC分类号: C08B37/003

    摘要: A process for preparing compounds of chitosan saccharified with aminosugar, adopts chitosan derivatives, aminosugar derivatives and anhydride derivatives as raw materials to synthesize target products. The process comprises: covalently bonding an anhydride derivative as a bonding arm to an aminosugar derivative, so as to form a monosaccharide derivative having an end group of carboxyl; and then covalently bonding the monosaccharide derivative having an end group of carboxyl to a primary amino group of a chitosan derivative via the carboxyl, so as to form a compound of chitosan saccharified with aminosugar.

    摘要翻译: 用氨基糖糖化糖壳化合物的方法,采用壳聚糖衍生物,氨基糖衍生物和酸酐衍生物为原料合成目标产物。 该方法包括:将作为结合臂的酸酐衍生物与氨基糖衍生物共价键合,形成具有羧基端基的单糖衍生物; 然后通过羧基将具有羧基末端基团的单糖衍生物共价键合到壳聚糖衍生物的伯氨基上,以形成用氨基糖糖化的壳聚糖化合物。

    Process for preparing compounds of chitosan saccharified with aminosugar
    2.
    发明申请
    Process for preparing compounds of chitosan saccharified with aminosugar 失效
    用氨基糖糖化糖壳化合物的方法

    公开(公告)号:US20100152430A1

    公开(公告)日:2010-06-17

    申请号:US12499767

    申请日:2009-07-08

    IPC分类号: C08B37/08 C07H1/00

    CPC分类号: C08B37/003

    摘要: A process for preparing compounds of chitosan saccharified with aminosugar, adopts chitosan derivatives, aminosugar derivatives and anhydride derivatives as raw materials to synthesize target products. The process comprises: covalently bonding an anhydride derivative as a bonding arm to an aminosugar derivative, so as to form a monosaccharide derivative having an end group of carboxyl; and then covalently bonding the monosaccharide derivative having an end group of carboxyl to a primary amino group of a chitosan derivative via the carboxyl, so as to form a compound of chitosan saccharified with aminosugar.

    摘要翻译: 用氨基糖糖化糖壳化合物的方法,采用壳聚糖衍生物,氨基糖衍生物和酸酐衍生物为原料合成目标产物。 该方法包括:将作为结合臂的酸酐衍生物与氨基糖衍生物共价键合,形成具有羧基端基的单糖衍生物; 然后通过羧基将具有羧基末端基团的单糖衍生物共价键合到壳聚糖衍生物的伯氨基上,以形成用氨基糖糖化的壳聚糖化合物。

    Feeding device
    3.
    发明授权
    Feeding device 有权
    送料装置

    公开(公告)号:US09180993B2

    公开(公告)日:2015-11-10

    申请号:US13482365

    申请日:2012-05-29

    IPC分类号: B65B39/00

    摘要: A feeding device includes a material pipe, a first container, a second container and a constant-length linkage mechanism. The material pipe is configured for feeding a first material. The first container is configured for receiving the first material and supplying a timed amount of the first material to a first material feed port. The second container is configured for storing a second material and supplying the second material to a second material feed port. The constant-length linkage mechanism is connected to the first container and the second container. When the first container is actually supplying the first material to the first material feed port, the constant-length linkage mechanism allows the second container to supply the second material to the second material feed port simultaneously.

    摘要翻译: 进料装置包括材料管,第一容器,第二容器和恒定长度连杆机构。 材料管被配置为供给第一材料。 第一容器构造成用于接收第一材料并将定时量的第一材料供应到第一材料供给口。 第二容器构造成用于存储第二材料并将第二材料供应到第二材料进料口。 恒定连杆机构连接到第一容器和第二容器。 当第一容器实际上将第一材料供应到第一材料供给口时,恒定连杆机构允许第二容器同时将第二材料供应到第二材料进料口。

    Pair of Projector Glasses
    4.
    发明申请
    Pair of Projector Glasses 审中-公开
    一对投影机眼镜

    公开(公告)号:US20140253867A1

    公开(公告)日:2014-09-11

    申请号:US14198583

    申请日:2014-03-05

    IPC分类号: G02C11/00

    CPC分类号: G02C11/10

    摘要: A pair of projector glasses is an eyewear apparatus that provides a user with a convenient means of acquiring, viewing, and listening to digital content. The eyewear apparatus mainly includes a glasses frame, a pair of temples, a projector, a wireless module, a pair of headphone speakers, and a pair of portable power sources. The glasses frame and the pair of temples are used to support the eyewear apparatus on the user's head. The wireless module retrieves digital content from an external source such as a smart-phone, a computer, or the Internet. The wireless module then distributes the audio portion of the digital content to the pair of speakers and the visual portion of the digital content to the projector. The portable power sources are separately positioned on the eyewear apparatus so that each source can power the electrical components that are in close proximity to the source itself.

    摘要翻译: 一副投影机眼镜是一种眼镜装置,为用户提供了获取,观看和收听数字内容的便利手段。 眼镜装置主要包括眼镜架,一对镜腿,投影仪,无线模块,一对耳机扬声器和一对便携式电源。 眼镜架和一对镜腿用于支撑使用者头部的眼镜装置。 无线模块从诸如智能电话,计算机或因特网的外部来源检索数字内容。 无线模块然后将数字内容的音频部分分配给一对扬声器和数字内容的可视部分到投影仪。 便携式电源分开地定位在眼镜装置上,使得每个源可以对靠近源本身的电气部件供电。

    Peptides whose uptake by cells is controllable
    5.
    发明授权
    Peptides whose uptake by cells is controllable 有权
    细胞摄取的肽是可控的

    公开(公告)号:US08642561B2

    公开(公告)日:2014-02-04

    申请号:US13314134

    申请日:2011-12-07

    摘要: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.

    摘要翻译: 本发明的肽的一般结构包括A-X-B-C,其中C是货物部分,B部分包括碱性氨基酸,X是可切割的接头序列,A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而,在X的细胞外裂解时,B-C部分被吸收,将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂,化学治疗药物或用于治疗的放射线敏化剂。 X的裂解允许A与B分离,揭示B中碱性氨基酸的正常能力,将货物C拖入裂解事件附近的细胞。 X在细胞外裂解,优选在生理条件下。 对于A和B部分,D-氨基酸是优选的,以使由背景肽酶或蛋白酶的免疫原性和非特异性切割最小化。

    Process for preparing hydrocodone using a super acid
    7.
    发明授权
    Process for preparing hydrocodone using a super acid 失效
    使用超酸制备氢可酮的方法

    公开(公告)号:US08367827B2

    公开(公告)日:2013-02-05

    申请号:US12627355

    申请日:2009-11-30

    IPC分类号: C07D489/02 C07D221/22

    CPC分类号: C07D489/02 C07D221/28

    摘要: The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomenine starting compound to a super acid-assisted furan ring closure reaction.

    摘要翻译: 本公开内容一般涉及将稠合的三环化合物转化为在其中包含呋喃环的稠合四环化合物的方法。 更具体地,本公开涉及制备氢可酮化合物或其结构相关的化合物的方法,特别是(+) - 氢可酮,通过使结构相应的青藤碱起始化合物经受超酸辅助的呋喃环闭合反应 。

    N-Demethylation of 6-Keto Morphinans
    10.
    发明申请
    N-Demethylation of 6-Keto Morphinans 有权
    6-酮基吗啡的N-去甲基化

    公开(公告)号:US20120035366A1

    公开(公告)日:2012-02-09

    申请号:US13196929

    申请日:2011-08-03

    IPC分类号: C07D489/02

    CPC分类号: C07D489/08 C07D489/02

    摘要: The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.

    摘要翻译: 本发明提供了包含酮官能团的N-甲基吗啡喃的去甲基化方法。 特别地,本发明提供了保护酮官能团的方法,使得在N-甲基吗啡喃脱甲基期间不产生杂质。