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    Method and apparatus for a microscope image selector
    1.
    发明申请
    Method and apparatus for a microscope image selector 有权

    公开(公告)号：US20080088844A1

    公开(公告)日：2008-04-17

    申请号：US11902874

    申请日：2007-09-26

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/25

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    Method and apparatus for dense spectrum unmixing and image reconstruction of a sample
    3.
    发明申请
    Method and apparatus for dense spectrum unmixing and image reconstruction of a sample 审中-公开
    密度谱解混合和样品图像重建的方法和装置

    公开(公告)号：US20070171408A1

    公开(公告)日：2007-07-26

    申请号：US11649292

    申请日：2007-01-04

    申请人： Xinghua Wang ,  Thomas Voigt

    发明人： Xinghua Wang ,  Thomas Voigt

    IPC分类号： G01J3/40

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/024 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0294 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/44 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6417

    摘要： In one embodiment, the disclosure relates to a method including: collecting photons from the sample having a plurality of regions to form a sample optical data set; selectively transmitting a first portion of the optical data set through a first of a plurality of apertures of an electro-optical shutter, each of the plurality of apertures optically communicating a portion of the optical data set; geometrically conforming the first portion of the optical data set for communication with a spectrometer opening; processing the conformed first portion of the optical data set at the spectrometer to obtain a spectrum for a first of the plurality of sample regions.

    摘要翻译： 在一个实施例中，本公开涉及一种方法，包括：从具有多个区域的样本收集光子以形成样本光学数据集; 通过电光快门的多个孔中的第一个选择性地传输光学数据组的第一部分，多个孔中的每一个光学地传送光学数据组的一部分; 在几何上符合用于与光谱仪开口通信的光学数据组的第一部分; 处理在光谱仪上的光学数据集合的合适的第一部分以获得多个样本区域中的第一个的光谱。

    Method and apparatus for a microscope image selector
    4.
    发明申请
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US20060170922A1

    公开(公告)日：2006-08-03

    申请号：US11045080

    申请日：2005-01-31

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/64 ,  G01N21/65

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Method and apparatus for a microscope image selector
    5.
    发明授权
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US07414725B2

    公开(公告)日：2008-08-19

    申请号：US11902874

    申请日：2007-09-26

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/25 ,  G02B21/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Single detector based dual excitation wavelength spectra display
    6.
    发明授权
    Single detector based dual excitation wavelength spectra display 有权
    基于单探测器的双激发波长光谱显示

    公开(公告)号：US07609370B2

    公开(公告)日：2009-10-27

    申请号：US12017409

    申请日：2008-01-22

    申请人： Thomas Voigt ,  David Tuschel

    发明人： Thomas Voigt ,  David Tuschel

    IPC分类号： G01J3/44 ,  G01J3/443 ,  G01N21/64 ,  G01N21/65

    CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/1838 ,  G01J3/2823 ,  G01N21/65

    摘要： A single detector based spectroscopy system using FAST (fiber array spectral translator) fibers and two excitation sources in conjunction with a holographic spectrum analyzer (HSA) to obtain simultaneous and selective display of spectroscopic regions of interest. A sample can be illuminated with different laser excitation wavelengths and resulting multiple spectra can be comparatively observed on a single display screen for more fruitful analysis of sample spectral responses (and, hence, sample chemical or physical properties) under different excitations. The HSA may be configured to focus on user-selected spectral regions of interest from different such spectra and a single CCD detector may be configured to collect spectral data from all selected spectral regions of interest in corresponding portions of the CCD pixel array, thereby allowing subsequent simultaneous display of such selected spectral regions of interest. The HSA may also allow simultaneous collection and display of portions of a single spectrum from a single excitation wavelength. A user can perform better comparative analysis when spectral regions of interest are juxtaposed with each other on a single electronic display.

    摘要翻译： 基于单个检测器的光谱系统，使用FAST（光纤阵列光谱转换器）光纤和两个激光源与全息光谱分析仪（HSA）结合，以获得感兴趣的光谱区域的同时和选择性显示。 可以用不同的激光激发波长照射样品，并且可以在单个显示屏上比较观察到所得到的多个光谱，以便在不同激发下对样品光谱响应（以及因此的样品化学或物理性质）进行更有效的分析。 HSA可以被配置为聚焦于来自不同这样的光谱的用户选择的感兴趣的光谱区域，并且单个CCD检测器可以被配置为从CCD像素阵列的对应部分中的所有所选择的光谱区域收集光谱数据，从而允许随后的 同时显示所选择的所选择的光谱区域。 HSA还可以允许从单个激发波长同时收集和显示单个光谱的部分。 当感兴趣的光谱区域在单个电子显示器上彼此并置时，用户可以执行更好的比较分析。

    Dynamic imaging of biological cells and other subjects
    7.
    发明申请
    Dynamic imaging of biological cells and other subjects 有权
    生物细胞和其他科目的动态成像

    公开(公告)号：US20070182959A1

    公开(公告)日：2007-08-09

    申请号：US10556038

    申请日：2005-06-30

    申请人： John Maier ,  Patrick Treado ,  David Tuschel ,  Thomas Voigt

    发明人： John Maier ,  Patrick Treado ,  David Tuschel ,  Thomas Voigt

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    摘要翻译： 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    Method for operating an optical filter in multiple modes
    8.
    发明申请
    Method for operating an optical filter in multiple modes 有权
    用于在多种模式下操作滤光器的方法

    公开(公告)号：US20120062888A1

    公开(公告)日：2012-03-15

    申请号：US13199859

    申请日：2011-09-12

    申请人： Thomas Voigt ,  Michael Fuhrman ,  Lei Shi

    发明人： Thomas Voigt ,  Michael Fuhrman ,  Lei Shi

    IPC分类号： G01J3/28

    CPC分类号： G01J3/1256 ,  G01J3/12 ,  G01J3/26

    摘要： A method for operating an optical filter in multiple modes. In one embodiment, an optical filter may be operated in a sensitivity mode to thereby generate a white light image representative of a region of interest. The optical filter may then be operated in a specificity mode to thereby generate a hyperspectral image representative of said region of interest. The white light image and the hyperspectral image may be fused to generate a hybrid image that provides morphological and hyperspectral data. The white light image and the hyperspectral image may be generated using a single detector, eliminating the need for image realignment.

    摘要翻译： 一种用于以多种模式操作滤光器的方法。 在一个实施例中，可以以灵敏度模式操作滤光器，从而产生表示感兴趣区域的白光图像。 然后可以以特异性模式操作滤光器，从而产生代表所述感兴趣区域的高光谱图像。 可以融合白光图像和高光谱图像以产生提供形态和高光谱数据的混合图像。 可以使用单个检测器生成白光图像和高光谱图像，从而不需要图像重新对准。