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1.发明申请公开(公告)号：US20150038577A1
公开(公告)日：2015-02-05
申请号：US14142683
申请日：2013-12-27
申请人： Xueju Xie , Rhett Sean Daniels , Patricia Gahan
发明人： Xueju Xie , Rhett Sean Daniels , Patricia Gahan
CPC分类号： A61K31/315 , A23L33/165 , A23L33/175 , A23L33/18 , A23V2002/00 , A61K31/555 , C07F1/08 , C07F3/02 , C07F3/06 , C07F15/025 , A23V2200/30 , A23V2200/322 , A23V2200/324 , A23V2250/156 , A23V2250/1586 , A23V2250/1588 , A23V2250/1592 , A23V2250/1608 , A23V2250/161 , A23V2250/1612 , A23V2250/1626 , A23V2250/1642 , A23V2250/55
摘要： A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.
摘要翻译： 一种人的营养补充剂，该补充物具有由与金属键合形成螯合环的N-乙酰基-L-半胱氨酸配体组成的螯合物。 一种制备由N-乙酰基-L-半胱氨酸配体和金属组成的螯合物的方法，其步骤为：将一定量的N-乙酰基-L-半胱氨酸溶解在水溶液中，向该水溶液中加入金属，窒息和 加热水溶液，并在减压下除去溶剂。 一种治疗人类患有氧化应激，心血管疾病，脑血管疾病，神经变性疾病，阿尔茨海默病，ADHD，双相，精神分裂症，孤独症，痴呆和HIV中的一种或多种的方法，包括给予有效量的具有 与金属螯合形成的N-乙酰基-L-半胱氨酸。 具有金属被N-乙酰基-L-半胱氨酸配体螯合的螯合剂的化合物。
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公开(公告)号：US09186385B2
公开(公告)日：2015-11-17
申请号：US12716167
申请日：2010-03-02
申请人： Xueju Xie , Jason Jiang-Chung Ko
发明人： Xueju Xie , Jason Jiang-Chung Ko
IPC分类号： A61K36/00 , A61K36/355 , A61K36/315 , A61K36/076 , A61K36/185
CPC分类号： A61K36/076 , A61K36/185 , A61K36/315 , A61K36/355 , A61K2300/00
摘要： A composition for affecting one or more of influenza, inflammation, and immune system function, said composition comprising an extract prepared from Radix isatidis and an extract prepared from Flos Lonicerae. In alternative embodiments, the composition further comprises one or more of an extract prepared from Poria cocos(Schw.) Wolf and an extract prepared from Herba houttuyniae. Method for treating one or more of influenza, inflammation by administering a patient a therapeutically effective amount of the above composition.
摘要翻译： 一种用于影响流感，炎症和免疫系统功能中的一种或多种的组合物，所述组合物包含由甘草制成的提取物和由金银花提取物制备的提取物。 在替代实施方案中，组合物还包含一种或多种由茯苓（Schw。）Wolf制备的提取物和由Herba hoewuyniae制备的提取物。 通过给予患者治疗有效量的上述组合物来治疗一种或多种流感，炎症的方法。
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公开(公告)号：US20090098275A1
公开(公告)日：2009-04-16
申请号：US12344085
申请日：2008-12-24
IPC分类号： B05D3/02 , C09D101/08
CPC分类号： A61K9/4891 , A61K9/286 , A61K9/2866 , C08K5/0016 , C08L1/28 , C08L5/04 , C09D101/28 , C09D105/04 , C08L2666/26
摘要： A dry suspendible enteric coating composition for suspension in water and then encasing orally ingestible articles. The dry suspendible enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three-step method for providing a stable outer enteric coating on an ingestible item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition.
摘要翻译： 一种用于悬浮在水中然后包裹口服可摄取物品的干燥悬浮肠溶包衣组合物。 干悬浮肠溶包衣组合物包含选自含有藻酸盐和海藻酸的pH依赖性聚合物，选自乙基纤维素和含乙基纤维素的组合物的基于pH的不溶于水的聚合物，以及选自三乙基 柠檬酸盐，甘油，丙二醇，甘油三乙酸酯，乙酰化单酸甘油酯，癸二酸二丁酯，聚乙二醇，山梨醇，中链甘油三酯及其组合。 一种用于在可摄入物品上提供稳定的外肠衣的三步法，其包括用包含至少糖和微晶纤维素的混合物的悬浮液包裹物品的第一步骤，然后将所述物品与 包含成膜聚合物和增塑剂的混合物的悬浮液，以及最终用肠溶剂组合物包装该物品的第三步骤。
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公开(公告)号：US20100092548A1
公开(公告)日：2010-04-15
申请号：US12537092
申请日：2009-08-06
申请人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
发明人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
CPC分类号： A61K9/4816 , A23L27/72 , A23P10/30 , A61K9/0056
摘要： A chewable softgel capsule configured for encasing orally ingestible articles. The chewable soft capsule is provided with an outer shell composition which comprises at least one gelatin in a range of 20% to 60% of the total weight of the shell composition, at least one plasticizer in an amount selected to render flexible the outer shell composition, an anti-tacking agent in an amount selected to render the outer shell composition non-sticky, and water. In one embodiment the chewable soft capsule further comprises at least one starch in a range of 0.1% to 35% of the total weight of the shell composition. The chewable softgel capsule is suitable for encasing therein medicines, pharmaceutical compositions, nutraceuticals, vitamins, nutritional supplements, and the like.
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公开(公告)号：US20090074855A1
公开(公告)日：2009-03-19
申请号：US12037740
申请日：2008-02-26
申请人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
发明人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
CPC分类号： A61K9/4891 , A61K9/286 , A61K9/2866 , C08K5/0016 , C08L1/28 , C08L5/04 , C09D101/28 , C09D105/04 , C08L2666/26
摘要： A suspendible enteric coating composition for encasing orally ingestible articles wherein the enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three step method for providing a stable outer enteric coating on an ingestable item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition.
摘要翻译： 一种用于包封口服可摄取物品的可悬挂肠溶包衣组合物，其中所述肠溶包衣组合物包含选自含有藻酸盐和海藻酸的pH的pH依赖性聚合物，选自包含乙基纤维素和含乙基纤维素的组合物的pH的不依赖于水的不溶性聚合物， 和选自柠檬酸三乙酯，甘油，丙二醇，三醋精，乙酰化单甘油酯，癸二酸二丁酯，聚乙二醇，山梨醇，中链甘油三酯及其组合的增塑剂。 一种用于在可摄取物品上提供稳定的外部肠溶衣的三步法，其包括用包含至少糖和微晶纤维素的混合物的悬浮液包裹物品的第一步骤，然后将悬挂物品包装的第二步骤 包括成膜聚合物和增塑剂的混合物，以及最后用肠溶剂组合物包装该物品的第三步骤。
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公开(公告)号：US20120107395A1
公开(公告)日：2012-05-03
申请号：US12962556
申请日：2010-12-07
申请人： Xueju Xie , Jason Jiang-Chung Ko
发明人： Xueju Xie , Jason Jiang-Chung Ko
CPC分类号： A61K35/744 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K35/741 , A61K35/742 , A61K35/745 , A61K35/747 , A61K36/064 , Y02A50/473
摘要： Soft gel capsules are formed from an outer gelatin-containing shell and a filling. The filling includes a probiotic and a dessicant.
摘要翻译： 软凝胶胶囊由外部含有明胶的外壳和填充物形成。 灌装包括益生菌和干燥剂。
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公开(公告)号：US07662406B1
公开(公告)日：2010-02-16
申请号：US12543435
申请日：2009-08-18
申请人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
发明人： Xueju Xie , Yu-Lung Ko , Chien-Kuang Ko , Jason Jiang-Chung Ko
CPC分类号： A61K9/4816 , A23L27/72 , A23P10/30 , A61K9/0056
摘要： A chewable softgel capsule configured for encasing orally ingestible articles. The chewable soft capsule is provided with an outer shell composition which comprises at least one gelatin in a range of 20% to 60% of the total weight of the shell composition, at least one plasticizer in an amount selected to render flexible the outer shell composition, an anti-tacking agent in an amount selected to render the outer shell composition non-sticky, and water. In one embodiment the chewable soft capsule further comprises at least one starch in a range of 0.1% to 35% of the total weight of the shell composition. The chewable softgel capsule is suitable for encasing therein medicines, pharmaceutical compositions, nutraceuticals, vitamins, nutritional supplements, and the like.
摘要翻译： 一种可咀嚼的软胶囊，其构造成用于包装口服可摄取物品。 可咀嚼软胶囊设置有外壳组合物，该外壳组合物包含至少一种在壳组合物总重量的20％至60％范围内的明胶，至少一种增塑剂的量选择为使外壳组合物变得柔软 ，选择用于使外壳组合物不粘的量的抗粘合剂和水。 在一个实施方案中，咀嚼软胶囊还包含至少一种占壳组合物总重量的0.1％至35％的淀粉。 咀嚼软胶囊适用于包装药物，药物组合物，营养保健品，维生素，营养补充剂等。
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8.发明授权公开(公告)号：US07341708B1
公开(公告)日：2008-03-11
申请号：US11613963
申请日：2006-12-20
CPC分类号： A61K31/28 , A23L33/175 , A61K31/195 , A61K31/295 , A61K31/30 , A61K31/315
摘要： A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a metal hydroxyl amino acetate. The second stage comprises contacting the metal hydroxyl amino acetate from the first stage, with at least one amino-containing compound provided in excess thereby producing a reaction solution containing an amino acid chelate reaction product comprising a metal ion bound to a plurality of amino acid ligands wherein the plurality of amino acid ligands is equal to the coordination number of the metal ion, and then separating the amino acid chelate from the reaction solution. The second stage may include a plurality of steps for sequentially reacting the reaction product with a plurality of amino-containing compounds. The amino acid chelates thus produced can be incorporated into compositions comprising beverages, foodstuffs, nutraceuticals and pharmaceutical adjuvants.
摘要翻译： 制备基本上纯的氨基酸螯合物的两阶段方法，其中第一步包括使金属氧化物或氢氧化物的金属离子与氨基酸接触，从而产生金属羟基氨基乙酸酯。 第二阶段包括使来自第一阶段的金属羟基氨基乙酸酯与至少一种过量提供的含氨基化合物接触，从而产生含有氨基酸螯合反应产物的反应溶液，所述氨基酸螯合反应产物包含与多个氨基酸配体结合的金属离子 其中多个氨基酸配体等于金属离子的配位数，然后将氨基酸螯合物与反应溶液分离。 第二阶段可以包括使反应产物与多种含氨基化合物顺序反应的多个步骤。 由此生产的氨基酸螯合物可以掺入包含饮料，食品，保健品和药物佐剂的组合物中。
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