公开(公告)号：US20180085459A1

公开(公告)日：2018-03-29

申请号：US15563398

申请日：2015-04-01

申请人： Yale University ,  Magnus Flow Limited ,  University College London ,  Queen Mary University of London

发明人： Tarek Fahmy ,  Albert Sinusas ,  Jung Seok Lee ,  Dongin Kim ,  Anthony Mathur ,  John Martin

IPC分类号： A61K41/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/08 ,  A61L31/06 ,  A61L31/02 ,  A61L27/58 ,  A61L27/34 ,  A61L27/30 ,  A61L27/18 ,  A61L27/06 ,  A61L27/04 ,  A61L27/02 ,  A61K35/545 ,  A61K35/44

CPC分类号： A61K41/0052 ,  A61F2/82 ,  A61F2210/0076 ,  A61F2210/009 ,  A61K35/44 ,  A61K35/545 ,  A61L27/025 ,  A61L27/042 ,  A61L27/047 ,  A61L27/06 ,  A61L27/18 ,  A61L27/306 ,  A61L27/34 ,  A61L27/58 ,  A61L31/022 ,  A61L31/028 ,  A61L31/06 ,  A61L31/088 ,  A61L31/10 ,  A61L31/148 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  A61L2430/20 ,  A61N2/002 ,  A61N2/06

摘要： It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.

公开(公告)号：US11285211B2

公开(公告)日：2022-03-29

申请号：US15563398

申请日：2015-04-01

申请人： Yale University

发明人： Tarek Fahmy ,  Albert Sinusas ,  Jung Seok Lee ,  Dongin Kim ,  Anthony Mathur ,  John Martin

IPC分类号： A61K41/00 ,  A61N2/00 ,  A61N2/06 ,  A61K35/44 ,  A61K35/545 ,  A61L27/02 ,  A61L27/04 ,  A61L27/06 ,  A61L27/18 ,  A61L27/30 ,  A61L27/34 ,  A61L27/58 ,  A61L31/02 ,  A61L31/06 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61F2/82

摘要： It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.