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68 条记录 (耗时 0.041 秒)

    Topical administration of NF-kappaB decoy to treat atopic dermatitis
    4.
    发明授权
    Topical administration of NF-kappaB decoy to treat atopic dermatitis 有权
    NF-κB诱饵的局部给药治疗特应性皮炎

    公开(公告)号：US09012417B2

    公开(公告)日：2015-04-21

    申请号：US10468717

    申请日：2002-02-06

    申请人： Ryuichi Morishita ,  Motokuni Aoki ,  Toshio Ogihara ,  Yasufumi Kaneda ,  Hiroshige Nakamura

    发明人： Ryuichi Morishita ,  Motokuni Aoki ,  Toshio Ogihara ,  Yasufumi Kaneda ,  Hiroshige Nakamura

    IPC分类号： A61K48/00 ,  A61K31/711 ,  A61K38/17 ,  C12N15/113

    CPC分类号： A61K31/711 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/13

    摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, or Crohn's disease.

    摘要翻译： 一种用于对皮肤病进行治疗的药物组合物，所述药物组合物包含至少一种诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NF-和kgr B诱饵，STAT-1诱饵，GATA-3诱饵，STAT-6诱饵，AP-1诱饵和Ets诱饵。 所述至少一个诱饵可以是包含至少两个彼此键合的诱饵的寡核苷酸，所述至少两个诱饵选自由NF-和κB诱饵，STAT-1诱饵，GATA-3诱饵 ，STAT-6诱饵，AP-1诱饵和Ets诱饵。 皮肤病可能是特应性皮炎，寻常型牛皮癣，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎或克罗恩病。

    Therapeutic/prophylactic agent for prostate cancer
    5.
    发明授权
    Therapeutic/prophylactic agent for prostate cancer 有权
    前列腺癌的治疗/预防剂

    公开(公告)号：US08691212B2

    公开(公告)日：2014-04-08

    申请号：US13119148

    申请日：2009-09-16

    申请人： Yasufumi Kaneda ,  Yoshifumi Kawaguchi ,  Toshimitsu Itai

    发明人： Yasufumi Kaneda ,  Yoshifumi Kawaguchi ,  Toshimitsu Itai

    IPC分类号： A61K48/00 ,  C12N15/63

    CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/76 ,  A61K35/768 ,  A61K45/06 ,  C12N2760/18833 ,  A61K2300/00

    摘要： Provided are a novel therapeutic agent and therapeutic method for prostatic cancers. More specifically, a prostatic cancer therapeutic/prophylactic agent having a viral envelope vector, particularly a Sendai viral envelope vector, as an active ingredient, the therapeutic/prophylactic agent which is an apoptosis induction promoter, the therapeutic/prophylactic agent used for prostatic cancers whose androgen susceptibility has been partially or completely reduced, and a melanoma therapeutic/prophylactic agent containing a Sendai viral envelope vector as the only active ingredient, and the like are provided.

    摘要翻译： 提供前列腺癌的新型治疗剂和治疗方法。 更具体地，具有病毒包膜载体，特别是仙台病毒包膜载体作为活性成分的前列腺癌治疗/预防剂，作为凋亡诱导启动子的治疗/预防剂，用于前列腺癌的治疗/预防剂，其用于前列腺癌 已经部分地或完全地降低了雄激素敏感性，并且提供了含有仙台病毒包膜载体作为唯一活性成分的黑素瘤治疗/预防剂等。

    Agent for Recruitment of Bone-Marrow-Derived Pluripotent Stem Cell Into Peripheral Circulation
    6.
    发明申请
    Agent for Recruitment of Bone-Marrow-Derived Pluripotent Stem Cell Into Peripheral Circulation 有权
    骨髓衍生多能干细胞募集周围循环的代理

    公开(公告)号：US20110091928A1

    公开(公告)日：2011-04-21

    申请号：US12990047

    申请日：2009-04-30

    申请人： Katsuto Tamai ,  Takehiko Yamazaki ,  Takenao Chino ,  Yasufumi Kaneda

    发明人： Katsuto Tamai ,  Takehiko Yamazaki ,  Takenao Chino ,  Yasufumi Kaneda

    IPC分类号： C12Q1/02 ,  C07K2/00 ,  C12N5/071 ,  C12N15/63 ,  C12N5/077

    CPC分类号： A61K35/36 ,  A61K38/1709 ,  G01N33/5029

    摘要： The present invention for the first time demonstrated that:(1) bone marrow-derived pluripotent tissue stem cells can be induced in peripheral blood by intravenously administering tissue extract prepared from isolated skin pieces; (2) the substance in the isolated skin pieces, which is responsible for mobilizing bone marrow-derived pluripotent tissue stem cells to peripheral blood, is HMGB1; and (3) HMGB1 with the activity of mobilizing bone marrow-derived pluripotent stem cells to peripheral blood can be easily purified from cultured cells.

    摘要翻译： 本发明首次证明：（1）通过静脉内施用从分离的皮肤片制备的组织提取物可以在外周血中诱导骨髓衍生的多能组织干细胞; （2）负责将骨髓衍生的多能组织干细胞移植至外周血的分离皮肤块中的物质为HMGB1; 和（3）可以从培养的细胞中容易地纯化具有将骨髓衍生的多能干细胞移动到外周血的活性的HMGB1。

    Composition having antitumor effect
    7.
    发明授权
    Composition having antitumor effect 有权
    具有抗肿瘤作用的组合物

    公开(公告)号：US07871765B2

    公开(公告)日：2011-01-18

    申请号：US10594443

    申请日：2005-03-31

    申请人： Hitoshi Kotani ,  Yasufumi Kaneda ,  Hirokazu Kawano ,  Masayuki Fukumura ,  Masayuki Kurooka

    发明人： Hitoshi Kotani ,  Yasufumi Kaneda ,  Hirokazu Kawano ,  Masayuki Fukumura ,  Masayuki Kurooka

    IPC分类号： C12Q1/70

    CPC分类号： A61K39/0011 ,  A61K9/5184 ,  A61K31/24 ,  A61K31/282 ,  A61K31/704 ,  A61K31/7064 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/585 ,  A61K2039/6006 ,  C12N2760/18842

    摘要： The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.

    摘要翻译： 本发明旨在提供一种药物组合物，其用于使用病毒包膜载体将化疗药物，优选抗癌药物递送至细胞或生物体内，并提供药物组合物，所述药物组合物包含化学治疗剂包封或与 ，具有佐剂性作为活性成分的病毒包膜载体。 因此，通过共同施用另一种抗癌药物，可以将包封在病毒包膜载体中的抗癌药物直接引入肿瘤中，以便通过HVJ-E的辅助作用诱导肿瘤细胞特异性抗肿瘤免疫，因此可以 回归肿瘤。 本发明还提供了包含病毒包膜载体和作为活性成分的化学治疗剂的药物组合物。

    Mutant paramyxovirus and method for production thereof
    8.
    发明授权
    Mutant paramyxovirus and method for production thereof 有权

    公开(公告)号：US07811805B2

    公开(公告)日：2010-10-12

    申请号：US12085355

    申请日：2006-11-24

    申请人： Yasufumi Kaneda ,  Katsuto Tamai ,  Kotaro Saga ,  Masako Kawachi

    发明人： Yasufumi Kaneda ,  Katsuto Tamai ,  Kotaro Saga ,  Masako Kawachi

    IPC分类号： C12N7/01 ,  C12N7/02 ,  C12N5/10 ,  C12N15/86 ,  C12N15/62 ,  C12N15/45 ,  C07K14/115 ,  C07K19/00

    摘要： The present invention provides a modified paramyxovirus containing a reduced amount of receptor-binding protein compared with the wild type; a method of preparing a modified paramyxovirus, comprising the following steps: (1) a step for introducing a nucleic acid that suppresses the expression of a receptor-binding protein of a paramyxovirus into an animal cell, (2) a step for infecting the paramyxovirus to the cell, and (3) a step for isolating paramyxovirus particles replicated in the cell; and a modified paramyxovirus prepared by the method of preparation mentioned above.The present invention also provides a chimera protein wherein a fusion protein of a virus has been joined or bound to a peptide that binds specifically to a cell surface marker; a nucleic acid that encodes the chimera protein; an animal cell capable of expressing the chimera protein on the cell surface thereof; a modified paramyxovirus expressing the chimera protein on the virus particle surface thereof; and a method of preparing a tissue targeting paramyxovirus, comprising: (1) a step for supplying a nucleic acid that encodes a chimera protein wherein a fusion protein of a virus has been joined or bound to a peptide that binds specifically to a cell surface marker of the target cells, (2) a step for introducing the nucleic acid supplied in (1) into an animal cell in an expressible state, and expressing the same, (3) a step for infecting a paramyxovirus to the cell, and (4) a step for isolating paramyxovirus particles replicated in the cell.

    BALANCE FILTER
    9.
    发明申请
    BALANCE FILTER 失效
    平衡过滤器

    公开(公告)号：US20090261921A1

    公开(公告)日：2009-10-22

    申请号：US12392622

    申请日：2009-02-25

    申请人： Akira MORIYA ,  Yasufumi Kaneda ,  Osamu Kawachi

    发明人： Akira MORIYA ,  Yasufumi Kaneda ,  Osamu Kawachi

    IPC分类号： H03H9/54 ,  H03H9/64 ,  H03H7/42

    CPC分类号： H03H9/0076 ,  H03H9/02913 ,  H03H9/1092

    摘要： A balance filter includes two acoustic wave filters connected between a single unbalanced terminal and two balanced terminals, and a ground terminal connected to the two acoustic wave filters via a first interconnection portion and a second interconnection portion. The first interconnection portion is connected to the two acoustic wave filters, and the second interconnection portion is connected to the first interconnection portion in a region that is located between the two acoustic wave filters and extends in a direction orthogonal to a direction in which the two acoustic wave filters are aligned.

    摘要翻译： 平衡滤波器包括连接在单个不平衡端子和两个平衡端子之间的两个声波滤波器，以及经由第一互连部分和第二互连部分连接到两个声波滤波器的接地端子。 第一互连部分连接到两个声波滤波器，并且第二互连部分在位于两个声波滤波器之间的区域中连接到第一互连部分，并且在与两个声波滤波器的方向正交的方向上延伸 声波滤波器对齐。

    Pharmaceutical composition containing decoy and method of using the same
    10.
    发明申请
    Pharmaceutical composition containing decoy and method of using the same 审中-公开
    含有诱饵的药物组合物及其使用方法

    公开(公告)号：US20090105183A1

    公开(公告)日：2009-04-23

    申请号：US12314009

    申请日：2008-12-02

    申请人： Ryuichi Morishita ,  Motokuni Aoki ,  Toshio Ogihara ,  Yasufumi Kaneda ,  Hiroshige Nakamura

    发明人： Ryuichi Morishita ,  Motokuni Aoki ,  Toshio Ogihara ,  Yasufumi Kaneda ,  Hiroshige Nakamura

    IPC分类号： A61K31/7088 ,  A61P17/00

    CPC分类号： A61K31/711 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/13

    摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, or Crohn's disease.

    摘要翻译： 一种用于对皮肤病进行治疗的药物组合物，所述药物组合物包含至少一种诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NF-κB诱饵，STAT-1诱饵，GATA-3诱饵，STAT-6诱饵，AP-1诱饵和Ets诱饵。 所述至少一个诱饵可以是包含至少两个彼此键合的诱饵的寡核苷酸，所述至少两个诱饵选自NF-κB诱饵，STAT-1诱饵，GATA-3诱饵， STAT-6诱饵，AP-1诱饵和Ets诱饵。 皮肤病可能是特应性皮炎，寻常型牛皮癣，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎或克罗恩病。