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    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains
    4.
    发明申请
    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains 失效
    使用N-结合型糖链诊断胰腺癌的方法

    公开(公告)号：US20110065141A1

    公开(公告)日：2011-03-17

    申请号：US12991340

    申请日：2009-05-08

    申请人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    发明人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    IPC分类号： C12Q1/37 ,  C12Q1/34

    CPC分类号： G01N33/57438 ,  Y10T436/24

    摘要： The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone cases and 8 pancreatitis cases) and patients of 54 cases with pancreatic cancer, and mass spectrometry was performed on N-linked sugar chains in plasma. From the 74 mass-spectrometric peaks detected, 65 sugar chains were extracted based on the results of PAM analysis. These extracted sugar chains were then used to predict pancreatic cancer or pancreaticobiliary-duct benign disorder, to correctly diagnose 74% cases. Further, a T-test was performed between the two groups, the group of pancreaticobiliary-duct benign disorder and the group of pancreatic cancer, which identified two sugar chains, the sugar chain of m/z 3031 and the sugar chain of m/z 2362, as sugar chains demonstrating significant difference (p

    摘要翻译： 本发明提供一种用于诊断胰腺癌的新型标记物，用于确定受试者是否使用标记物的胰腺癌的方法等。本发明人从78例患者中收集了总共包括24例胰腺胆管癌患者的血液， 膀胱良性疾病（16例胆囊病例和8例胰腺炎病例）和54例胰腺癌患者，并对血浆中的N链糖链进行质谱分析。 根据PAM分析结果，从检测到的74个质谱峰中提取出65个糖链。 然后将这些提取的糖链用于预测胰腺癌或胰胆管良性疾病，以正确诊断74％的病例。 此外，在两组之间进行T检验，即胰胆管良性病变组和胰腺癌组，鉴定了两条糖链，m / z 3031的糖链和m / z的糖链 2362，由于糖链显示出显着性差异（p <0.05），并且两组之间的表达水平呈现2倍或更大的差异。 使用这些糖链的正确检测率用六个分类器计算，所有这些分类器都得到约70％的正确检测结果。

    HETEROMONOCYCLIC COMPOUND AND USE THEREOF
    6.
    发明申请
    HETEROMONOCYCLIC COMPOUND AND USE THEREOF 审中-公开
    异环化合物及其用途

    公开(公告)号：US20080207654A1

    公开(公告)日：2008-08-28

    申请号：US11943910

    申请日：2007-11-21

    申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

    发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

    IPC分类号： A61K31/506 ,  C07D239/22 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D413/14 ,  C07D413/10 ,  C07D417/14

    摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8′, or a salt thereof. The compound of the present invention is useful as a drug for the prophylaxis or treatment of circulatory diseases, metabolic diseases and/or central nervous system diseases.

    摘要翻译： 由式（I）表示的化合物：其中R1是氧代基，-N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：R 3和R 4各自为H或C 1 -C 6烷基，C 3 -C 6环烷基，C 1 -C 6烷氧基，C 1 -C 6 烷基氨基，二（C 1 -C 6）烷基氨基或C 1 -C 6烷硫基，其各自任选被取代; 和R 5为H或C 1 -C 6烷基，C 2 -C 6烯基，环状基团，各自为任选取代的-CO-R 8或-O-R 8'或其盐。 本发明的化合物可用作预防或治疗循环系统疾病，代谢疾病和/或中枢神经系统疾病的药物。

    Thiazoline derivative and use of the same
    7.
    发明申请
    Thiazoline derivative and use of the same 失效
    噻唑啉衍生物和使用相同

    公开(公告)号：US20070010528A1

    公开(公告)日：2007-01-11

    申请号：US10574048

    申请日：2004-09-29

    申请人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

    发明人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

    IPC分类号： A61K31/496 ,  A61K31/454 ,  A61K31/426 ,  C07D417/02

    CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

    摘要： A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R5)—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or —N(R6)—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

    摘要翻译： 由式（I）表示的噻唑啉衍生物：其中R是可被取代的环状烃基或可被取代的杂环基; X是可以被取代的键或二价链烃基; X'是键或-N（R 5） - ; Y是可以被取代的二价烃基; Y'是键或-C（-O） - ; 环A是可以被取代的含氮杂环; Z 1和Z 3各自独立地为可以被取代的键或二价链烃基; Z 2是键或-N（R 6） - ; 并且B是由下式表示的基团：其可用作血栓形成的治疗药物。

    Benzinidazole Derivative and Use As AII Receptor Antagonist
    8.
    发明申请
    Benzinidazole Derivative and Use As AII Receptor Antagonist 有权
    苯硝唑衍生物和用作AII受体拮抗剂

    公开(公告)号：US20060281795A1

    公开(公告)日：2006-12-14

    申请号：US11466633

    申请日：2006-08-23

    申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Mami Ojima

    发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Mami Ojima

    IPC分类号： A61K31/4245 ,  C07D413/02 ,  C07D413/14

    CPC分类号： C07D413/14

    摘要： The present invention relates to a compound represented by the formula (I) wherein R1 is a group represented by the formula wherein R2, R3, R4, R5, R6, R7 and R8 are each independently a hydrogen atom or a C1-6 alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

    摘要翻译： 本发明涉及由式（I）表示的化合物，其中R 1为由下式表示的基团：其中R 2，R 3， R 4，R 5，R 6，R 7和R 8，R 8， >各自独立地为氢原子或C 1-6烷基，或其盐。 本发明的化合物可用作预防或治疗诸如高血压等循环系统疾病和糖尿病等代谢疾病的药剂。

    Method of laser quenching
    9.
    发明授权
    Method of laser quenching 失效
    激光淬火方法

    公开(公告)号：US5182433A

    公开(公告)日：1993-01-26

    申请号：US780500

    申请日：1991-10-22

    申请人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

    发明人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

    IPC分类号： C21D1/09

    CPC分类号： C21D1/09

    摘要： A method of laser transformation hardening adapted to irradiate a laser beam in a sense of P polarization on a work piece at an angle of incidence to a surface of the work piece of 60.degree. or more which comprises steps of: forming a plurality of triangular ridges on a horizontal plane adjacent to a surface of the work piece, having a first plurality of inclined surfaces inclined at a first angle to the horizontal plane and a second plurality of inclined surfaces inclined at a second angle to the horizontal plane, the first angle being smaller than the second angle; and irradiating the laser on the work piece at the angle of incidence to the surface of the work piece of 65.degree. to 70.degree. from a direction on the side of the second plurality of inclined surface.

    摘要翻译： 一种激光变换硬化的方法，其适用于以与60度以上的工件的表面成角度的方式在工件上照射P极化的激光束，该方法包括以下步骤：形成多个三角形脊 在与所述工件的表面相邻的水平面上具有与所述水平面倾斜成第一角度的第一多个倾斜面和与所述水平面倾斜第二角度的第二多个倾斜面，所述第一角度为 小于第二角度; 以及从第二多个倾斜面的一侧的方向以与工件表面65°〜70°的角度的入射角将激光照射在工件上。

    Built-in-coil substrate
    10.
    发明授权
    Built-in-coil substrate 有权
    内置线圈基板

    公开(公告)号：US08410887B2

    公开(公告)日：2013-04-02

    申请号：US13602600

    申请日：2012-09-04

    申请人： Jyunichi Nanjyo ,  Hiroki Sakamoto

    发明人： Jyunichi Nanjyo ,  Hiroki Sakamoto

    IPC分类号： H01F5/00 ,  H01F27/30

    CPC分类号： H05K1/165 ,  H01F3/14 ,  H01F17/0033 ,  H05K3/4629 ,  H05K2201/0215 ,  H05K2201/09672

    摘要： In a built-in-coil substrate, when viewed in perspective in a stacking direction in which insulating layers of a substrate body are stacked, mutually superposed second coil elements are located further inward than inner peripheries of mutually superposed first coil elements. A cavity is continuous between at least one of the second coil elements and one insulating layer that is in contact with the second coil element(s), and another insulating layer that opposes the second coil element(s) such that the second coil element(s) are exposed, and, when viewed in perspective in the stacking direction, the cavities have annular shapes and extend further inward than the outer peripheries of the mutually superposed first coil elements, there being an interval provided between the cavities and these outer peripheries, and further outward than the inner peripheries of the mutually superposed second coil elements.

    摘要翻译： 在内置线圈基板中，当层叠基板主体的绝缘层的层叠方向的立体图来看，相互重叠的第二线圈元件位于相互叠置的第一线圈元件的内周的内侧的位置的内侧。 在第二线圈元件中的至少一个和与第二线圈元件接触的一个绝缘层之间连续地形成空腔，以及与第二线圈元件相对的另一个绝缘层，使得第二线圈元件 并且当从层叠方向的角度看时，空腔具有环形形状，并且比相互重叠的第一线圈元件的外周更向内延伸，在空腔和这些外周之间设有间隔， 并且比相互叠置的第二线圈元件的内周更向外。