公开(公告)号：US09611157B2

公开(公告)日：2017-04-04

申请号：US13979819

申请日：2012-01-06

申请人： Yasuhito Inagaki ,  Kohei Shimizu ,  Masato Hasegawa

发明人： Yasuhito Inagaki ,  Kohei Shimizu ,  Masato Hasegawa

IPC分类号： B01J20/24 ,  C02F1/54 ,  C02F1/56 ,  B03D1/01 ,  C02F1/52

CPC分类号： C02F1/54 ,  B01J20/24 ,  C02F1/5263 ,  Y02W10/37

摘要： Disclosed are a plant-derived flocculant and a flocculant mixture having a higher flocculation capacity. The plant-derived flocculant comprises at least one of a dried matter of Corchorus olitorius, a dried matter of Begonia fimbristipula, a dried matter of bananas, and a dried matter of Corchorus capsularis; the plant-derived flocculant has a colloid equivalent of −1.5 mEq/g to −0.20 mEq/g, and the 2 weight % aqueous solution of the plant-derived flocculant has a viscosity of at least 6.0×10−3 Pa·s (6.0 cP). The flocculant mixture of the invention comprises the plant-derived flocculant described above and a synthetic polymer flocculant having a colloid equivalent of −4.5 mEq/g to −1.2 mEq/g, whose 0.2 weight % aqueous solution has a viscosity of 1.3×10−1Pa·s to 4×10−1 Pa·s (130 cP to 400 cP).

公开(公告)号：US20130299433A1

公开(公告)日：2013-11-14

申请号：US13979819

申请日：2012-01-06

申请人： Yasuhito Inagaki ,  Kohei Shimizu ,  Masato Hasegawa

发明人： Yasuhito Inagaki ,  Kohei Shimizu ,  Masato Hasegawa

IPC分类号： C02F1/54

CPC分类号： C02F1/54 ,  B01J20/24 ,  C02F1/5263 ,  Y02W10/37

摘要： Disclosed are a plant-derived flocculant and a flocculant mixture having a higher flocculation capacity. The plant-derived flocculant comprises at least one of a dried matter of Corchorus olitorius, a dried matter of Begonia fimbristipula, a dried matter of bananas, and a dried matter of Corchorus capsularis; the plant-derived flocculant has a colloid equivalent of −1.5 mEq/g to −0.20 mEq/g, and the 2 weight % aqueous solution of the plant-derived flocculant has a viscosity of at least 6.0×10−3 Pa·s (6.0 cP). The flocculant mixture of the invention comprises the plant-derived flocculant described above and a synthetic polymer flocculant having a colloid equivalent of −4.5 mEq/g to −1.2 mEq/g, whose 0.2 weight % aqueous solution has a viscosity of 1.3×10−1Pa·s to 4×10−1 Pa·s (130 cP to 400 cP).

摘要翻译： 公开了具有较高絮凝能力的植物来源的絮凝剂和絮凝剂混合物。 植物来源的絮凝剂包括枸杞干物质，秋海棠干物质，香蕉干物质和caps a干物质中的至少一种; 植物来源的絮凝剂的胶体当量为-1.5mEq / g至-0.20mEq / g，植物来源的絮凝剂的2重量％水溶液的粘度至少为6.0×10-3Pa·s（ 6.0 cP）。 本发明的絮凝剂混合物包含上述植物来源的絮凝剂和胶体当量为-4.5mEq / g至-1.2mEq / g的合成聚合物絮凝剂，其0.2重量％的水溶液的粘度为1.3×10- 1Pa·s〜4×10-1Pa·s（130cP〜400cP）。

公开(公告)号：US20140248657A1

公开(公告)日：2014-09-04

申请号：US14348024

申请日：2012-05-18

申请人： Takashi Nonaka ,  Masami Masuda ,  Makiko Yamashita ,  Haruhiko Akiyama ,  Masato Hasegawa

发明人： Takashi Nonaka ,  Masami Masuda ,  Makiko Yamashita ,  Haruhiko Akiyama ,  Masato Hasegawa

IPC分类号： C07K14/47 ,  G01N33/50

CPC分类号： C07K14/47 ,  C07K14/4711 ,  C12P21/02 ,  G01N33/5058 ,  G01N33/6896

摘要： The purpose of the present invention is to develop a method for producing a large amount of an insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate of a neurodegenerative-disease-related protein according to the present invention comprises the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cultured cell in which the neurodegenerative-disease-related protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) extracting separating an insoluble fraction from the cultured cell. Optionally, the method may additionally comprise a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.

摘要翻译： 本发明的目的是开发用于生产大量不溶性聚集体的方法，其相当于形成在患者脑中的不溶性聚集体。 根据本发明的生产神经变性疾病相关蛋白质的不溶性聚集体的方法包括以下步骤：（1）将来自神经变性疾病患者的脑的不溶性级分引入培养的细胞中，其中神经变性 - 疾病相关蛋白可以以组成型表达; （2）培养其中引入不溶性级分的培养细胞; 和（3）从培养的细胞中提取不溶性级分。 任选地，所述方法还可以包括扩增培养细胞中神经变性疾病相关蛋白质的不溶性聚集体的步骤。

公开(公告)号：US20100254006A1

公开(公告)日：2010-10-07

申请号：US12740094

申请日：2008-10-31

申请人： Tomoyuki Ueno ,  Masato Hasegawa

发明人： Tomoyuki Ueno ,  Masato Hasegawa

IPC分类号： G02B5/18 ,  B29D11/00

CPC分类号： G02B5/1814 ,  B28B11/003 ,  B28B11/005 ,  C04B35/14 ,  C04B35/443 ,  C04B35/486 ,  C04B35/547 ,  C04B35/553 ,  C04B35/645 ,  C04B2235/446 ,  C04B2235/5436 ,  C04B2235/6581 ,  C04B2235/661 ,  C04B2235/94 ,  C04B2235/945 ,  C04B2235/963 ,  C04B2235/9653 ,  G02B5/1847

摘要： A diffractive optical element (1) composed of a ceramic, in which the optical characteristics are enhanced by enhancing the machining precision, is composed of an infrared-transmissive ceramic, and prominent portions (11) and groove portions (12) are repeatedly formed on a surface of the diffractive optical element (1). The average value of the surface roughness Ra within an optical effective area (10) of the surface of the diffractive optical element is 0.05 μm or less, and the difference in the surface roughness Ra within the optical effective area (10) of the surface is 0.02 μm or less.

摘要翻译： 通过提高加工精度提高光学特性的由陶瓷构成的衍射光学元件（1）由红外线透射性陶瓷构成，突出部（11）和槽部（12）重复形成在 衍射光学元件（1）的表面。 衍射光学元件的表面的光学有效面积（10）内的表面粗糙度Ra的平均值为0.05μm以下，表面光学有效面积（10）内的表面粗糙度Ra的差为 0.02μm以下。

公开(公告)号：US09624279B2

公开(公告)日：2017-04-18

申请号：US14348024

申请日：2012-05-18

申请人： Takashi Nonaka ,  Masami Masuda ,  Makiko Yamashita ,  Haruhiko Akiyama ,  Masato Hasegawa

发明人： Takashi Nonaka ,  Masami Masuda ,  Makiko Yamashita ,  Haruhiko Akiyama ,  Masato Hasegawa

IPC分类号： C07K14/47 ,  C12P21/02 ,  G01N33/68 ,  G01N33/50

CPC分类号： C07K14/47 ,  C07K14/4711 ,  C12P21/02 ,  G01N33/5058 ,  G01N33/6896

摘要： The purpose of the present invention is to develop a method for amplifying in vitro to a large amount of a homogenous insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate including TDP-43 protein and fragments thereof according to the present invention includes the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cell culture in which the intact TDP-43 protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) separating an insoluble fraction from the cultured cell. Optionally, the method may additionally include a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.

公开(公告)号：US20100047826A1

公开(公告)日：2010-02-25

申请号：US12086124

申请日：2006-12-06

申请人： Takashi Nonaka ,  Sayuri Watanabe ,  Masami Masuda ,  Masato Hasegawa

发明人： Takashi Nonaka ,  Sayuri Watanabe ,  Masami Masuda ,  Masato Hasegawa

IPC分类号： G01N33/53 ,  C12N5/071

CPC分类号： C07K14/47 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2503/02 ,  C12N2510/00 ,  G01N33/5058 ,  G01N33/6896 ,  G01N2500/10

摘要： The present invention has the object of providing a cell into which a protein, which can serve as a polymerization nucleus of a protein polymer, or polymer thereof is introduced, and a method for producing the cell. The invention relates to a cell into which a protein, which can serve as a polymerization nucleus of a protein polymer, or a polymer thereof is introduced, a method for producing the cell, and a method of screening for a compound inhibiting an intracellular accumulation of a protein containing fibril structures, wherein the method comprises bringing a candidate substance into contact with the cell.

摘要翻译： 本发明的目的是提供一种细胞，其中可以引入蛋白质聚合物的聚合核的蛋白质或其聚合物，以及该细胞的制造方法。 本发明涉及引入可用作蛋白质聚合物的聚合核的蛋白质或其聚合物的细胞，细胞的制备方法和筛选抑制细胞内积累的化合物的方法 含有原纤维结构的蛋白质，其中所述方法包括使候选物质与细胞接触。

公开(公告)号：US20080199641A1

公开(公告)日：2008-08-21

申请号：US11905617

申请日：2007-10-02

申请人： Masato Hasegawa ,  Hiroki Okamura

发明人： Masato Hasegawa ,  Hiroki Okamura

IPC分类号： B32B1/00 ,  B32B37/10

CPC分类号： F16D13/64 ,  F16D69/02 ,  F16D2069/005 ,  F16D2069/0483 ,  F16D2069/0491 ,  F16D2250/00 ,  Y10T428/13 ,  Y10T428/21 ,  Y10T428/213 ,  Y10T428/218

摘要： In a wet-type friction material, a ring-shaped friction material substrate is compressed and fixed on a surface of a core metal by heat-pressing by a manufacturing metal mold. At the same time, a taper of an angle α corresponding to a taper at an outer peripheral side of an upper mold is provided on an outer peripheral side of the ring-shaped friction material substrate. Thus, the taper is formed such that a thickness in a radial direction of the ring-shaped friction material substrate becomes smaller from a middle point toward an outer peripheral edge.

摘要翻译： 在湿式摩擦材料中，通过制造金属模具的热压将环形摩擦材料基板压缩固定在芯金属的表面上。 同时，在环状摩擦材料基板的外周侧设置有与上模的外周侧的锥形相对应的角度α的锥度。 因此，锥形形成为使得环状摩擦材料基板的径向厚度从中点朝向外周边缘变小。

公开(公告)号：US06980700B2

公开(公告)日：2005-12-27

申请号：US09739352

申请日：2000-12-18

申请人： Yoshiyuki Endo ,  Shinichi Matsumoto ,  Kiyoshi Iwabuchi ,  Mamoru Ozawa ,  Hideki Narushima ,  Masato Hasegawa ,  Tatsuya Hisatomi

发明人： Yoshiyuki Endo ,  Shinichi Matsumoto ,  Kiyoshi Iwabuchi ,  Mamoru Ozawa ,  Hideki Narushima ,  Masato Hasegawa ,  Tatsuya Hisatomi

IPC分类号： H04N5/232 ,  G06T3/00 ,  G06T11/80 ,  H04N1/00 ,  H04N1/387 ,  H04N5/265 ,  H04N5/91 ,  G06K9/36

CPC分类号： H04N1/00352 ,  H04N1/00392 ,  H04N1/00411 ,  H04N1/00416 ,  H04N1/00421 ,  H04N1/00427 ,  H04N1/0044 ,  H04N1/00453 ,  H04N1/00474 ,  H04N1/3871 ,  H04N2101/00 ,  H04N2201/3266

摘要： There is provided an image processing apparatus and an image processing method which are capable of inserting in real time a desired image into a desired portion of a desired created frame image or a desired previously captured image to enable an operator to synthesize the images with a simple operation without using a personal computer, and a storage medium storing a program for executing the image processing method. An image of an object obtained by photographing the object is input in real time as digital object image data. Frame image data comprising characters and graphics is created. At least one area of the created frame image where the input object image data is to be inserted is designated. The created frame image data is displayed, and the input object image data is inserted into the designated area of the displayed frame image and the designated area with the input object image data inserted therein is displayed. The inserted and displayed object image data is established.

摘要翻译： 提供了一种图像处理装置和图像处理方法，其能够将期望的图像实时地插入期望的所产生的帧图像或期望的先前捕获的图像的期望部分，以使操作者能够以简单的方式合成图像 操作而不使用个人计算机，以及存储介质，用于存储用于执行图像处理方法的程序。 通过拍摄对象获得的对象的图像被实时输入为数字对象图像数据。 创建包括字符和图形的帧图像数据。 指定要插入输入对象图像数据的所创建的帧图像的至少一个区域。 显示所创建的帧图像数据，并且将输入对象图像数据插入到所显示的帧图像的指定区域中，并且显示其中插入有输入对象图像数据的指定区域。 建立插入和显示的对象图像数据。

公开(公告)号：US06245575B1

公开(公告)日：2001-06-12

申请号：US09194127

申请日：1999-07-16

申请人： Michel Goedert ,  Ross Jakes ,  Maria Grazia Spillantini ,  Masato Hasegawa ,  Michael John Smith ,  Richard Anthony Crowther

发明人： Michel Goedert ,  Ross Jakes ,  Maria Grazia Spillantini ,  Masato Hasegawa ,  Michael John Smith ,  Richard Anthony Crowther

IPC分类号： G01N3300

CPC分类号： G01N33/6896 ,  Y10T436/144444

摘要： A method of screening an agent for potential use in the treatment of Alzheimer's disease, comprises reacting, in the presence of the agent, tau protein with a suitable sulphated carbohydrate under appropriate conditions to form filaments, and monitoring for the presence of filaments. Tau protein and sulphated carbohydrate, e.g. sulphated glycosaminoglycan, will react under appropriate conditions to form filaments, either paired helical filaments or straight filaments. If filament formation is affected when the reaction is carried out in the presence of an agent being screened, this is possibly due to an interfering, inhibiting or blocking effect of the agent. An agent which inhibits assembly of PHFs in vitro may also have an inhibiting effect in vivo and thus have potential therapeutic value in delaying the dementing effects of Alzheimer's disease. The invention can thus provide a screen to identify agents worthy of further investigation for use in the treatment of Alzheimer's disease.

摘要翻译： 筛选用于治疗阿尔茨海默病的潜在用途的试剂的方法包括在适当条件下，在试剂存在下，将tau蛋白与合适的硫酸化碳水化合物反应以形成细丝并监测长丝的存在。 Tau蛋白和硫酸化碳水化合物，例如 硫酸化糖胺聚糖，将在合适的条件下反应形成细丝，成对的螺旋丝或直丝。 如果在被筛选的试剂存在下进行反应时影响细丝形成，这可能是由于试剂的干扰，抑制或阻断作用。 体外抑制PHF装配的药剂也可能在体内具有抑制作用，因此具有延缓阿尔茨海默氏病的痴呆作用的潜在治疗价值。 因此，本发明可以提供一种筛选器，用于鉴定用于治疗阿尔茨海默病的值得进一步研究的药剂。

公开(公告)号：USD404026S

公开(公告)日：1999-01-12

申请号：US80708

申请日：1997-12-15

申请人： Masato Hasegawa

设计人： Masato Hasegawa