公开(公告)号：US09464281B2

公开(公告)日：2016-10-11

申请号：US12844742

申请日：2010-07-27

申请人： Yasuo Suda ,  Masahiro Wakao ,  Takashi Kodama

发明人： Yasuo Suda ,  Masahiro Wakao ,  Takashi Kodama

IPC分类号： C12N7/02 ,  G01N33/566 ,  C12N13/00 ,  B03C1/01 ,  B03C1/28 ,  B82Y25/00 ,  C12N1/20 ,  C12N7/00 ,  C12Q1/24 ,  G01N33/543 ,  H01F1/00

CPC分类号： C12N13/00 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B82Y25/00 ,  C12N1/20 ,  C12N7/00 ,  C12N2760/16151 ,  C12Q1/24 ,  G01N33/54326 ,  H01F1/0054

摘要： A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar chain-immobilized magnetic metal nano-particles; and a specimen. Each sugar chain-immobilized metal nano-particle has a structure where a ligand-conjugate is bound to a metal nano-particle via sulfur atoms. The ligand-conjugate has a structure where a linker compound's amino group is connected to a sugar chain having a reducing terminal. The linker compound includes, in molecules thereof, an amino group, sulfur atoms, and a hydrocarbon chain having carbon-nitrogen bonds. This allows short-time concentration of viruses in a sufficient amount almost equal to that of centrifugation concentration, allowing safely and effectively concentrating target viruses, resulting in prompt, easy, and highly sensitive detection and identification of viruses.

摘要翻译： 用于浓缩病毒的方法包括：将磁力施加到含有固定有糖链的磁性金属纳米粒子的混合物，所述糖链固定的磁性金属纳米粒子具有与第一磁性纳米粒子结合的糖链固定金属纳米粒子的结构; 平均粒径大于固定链固定的金属纳米粒子的第二磁性颗粒; 和一个标本。 每个糖链固定的金属纳米颗粒具有其中配体 - 共轭物通过硫原子与金属纳米颗粒结合的结构。 配体 - 缀合物具有其中连接物化合物的氨基连接到具有还原末端的糖链的结构。 连接体化合物在其分子中包含氨基，硫原子和具有碳 - 氮键的烃链。 这允许短时间浓度的病毒足够的量几乎等于离心浓度，允许安全有效地浓缩目标病毒，导致迅速，容易和高度敏感的病毒检测和鉴定。

公开(公告)号：US20080145838A1

公开(公告)日：2008-06-19

申请号：US11818695

申请日：2007-06-15

申请人： Yasuo Suda ,  Tomoaki Nishimura ,  Yuko Kishimoto ,  Sakiko Yamashita ,  Sachiko Tsuruta ,  Masahiro Wakao ,  Tashiomi Okuno

发明人： Yasuo Suda ,  Tomoaki Nishimura ,  Yuko Kishimoto ,  Sakiko Yamashita ,  Sachiko Tsuruta ,  Masahiro Wakao ,  Tashiomi Okuno

IPC分类号： C12Q1/70 ,  C12Q1/02 ,  G01N33/00 ,  G01N33/48 ,  G01N33/92

CPC分类号： G01N33/569 ,  G01N33/5308 ,  G01N33/5432 ,  G01N33/68 ,  G01N33/92 ,  G01N2400/00

摘要： This invention provides a method of screening or patterning a biomaterial in terms of their specificities to sugar chains by performing real-time and comprehensive measurement of an interaction between sugar chains and the biomaterial concurrently with a very small amount of the biomaterial without labeling. It is a method of measuring an interaction between a biomaterial and a sugar chain(s), the method including: bringing a solution containing the biomaterial in contact with a ligand carrier, the ligand carrier including a support whose surface includes a metal, and a ligand conjugate(s) immobilized independently on the surface, the ligand carrier carrying the ligand conjugate(s) in such a manner that 1 to 500 kinds of the ligand conjugate(s) is immobilized per cm2, and each ligand conjugate having a structure in which a sugar chain is bonded with a linker compound having a sulfur atom, and the biomaterial being at least one selected from the groups of proteins, viruses, cells, microorganisms, liposome, and micelles.

摘要翻译： 本发明提供了一种通过与非标量的生物材料同时进行糖链与生物材料之间的相互作用的实时和全面测量来对其对糖链的特异性筛选或图案化生物材料的方法。 它是测量生物材料和糖链之间的相互作用的方法，该方法包括：使含有生物材料的溶液与配体载体接触，所述配体载体包括其表面包括金属的载体，和 配体缀合物独立地固定在表面上，携带配体缀合物的配体载体以每cm 2固定1至500种配体缀合物的方式， 并且每个配体缀合物具有其中糖链与具有硫原子的接头化合物结合的结构，并且所述生物材料是选自蛋白质，病毒，细胞，微生物，脂质体和胶束中的至少一种。

公开(公告)号：US20070213523A1

公开(公告)日：2007-09-13

申请号：US10588612

申请日：2005-02-04

申请人： Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

发明人： Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

IPC分类号： C07D339/04 ,  C07H3/04 ,  C07H3/06

CPC分类号： C07H15/04 ,  C07D339/04 ,  G01N33/54353

摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

摘要翻译： 本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。 连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃 衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。 配体缀合物包括其中引入糖分子的连接体化合物。

公开(公告)号：US09239329B2

公开(公告)日：2016-01-19

申请号：US11818695

申请日：2007-06-15

申请人： Yasuo Suda ,  Tomoaki Nishimura ,  Yuko Kishimoto ,  Sakiko Yamashita ,  Sachiko Tsuruta ,  Masahiro Wakao ,  Toshiomi Okuno

发明人： Yasuo Suda ,  Tomoaki Nishimura ,  Yuko Kishimoto ,  Sakiko Yamashita ,  Sachiko Tsuruta ,  Masahiro Wakao ,  Toshiomi Okuno

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/569 ,  G01N33/543 ,  G01N33/92

CPC分类号： G01N33/569 ,  G01N33/5308 ,  G01N33/5432 ,  G01N33/68 ,  G01N33/92 ,  G01N2400/00

摘要： This invention provides a method of screening or patterning a biomaterial in terms of their specificities to sugar chains by performing real-time and comprehensive measurement of an interaction between sugar chains and the biomaterial concurrently with a very small amount of the biomaterial without labeling. It is a method of measuring an interaction between a biomaterial and a sugar chain(s), the method including: bringing a solution containing the biomaterial in contact with a ligand carrier, the ligand carrier including a support whose surface includes a metal, and a ligand conjugate(s) immobilized independently on the surface, the ligand carrier carrying the ligand conjugate(s) in such a manner that 1 to 500 kinds of the ligand conjugate(s) is immobilized per cm2, and each ligand conjugate having a structure in which a sugar chain is bonded with a linker compound having a sulfur atom, and the biomaterial being at least one selected from the groups of proteins, viruses, cells, microorganisms, liposome, and micelles.

摘要翻译： 本发明提供了一种通过与非标量的生物材料同时进行糖链与生物材料之间的相互作用的实时和全面测量来对其对糖链的特异性筛选或图案化生物材料的方法。 它是测量生物材料和糖链之间的相互作用的方法，该方法包括：使含有生物材料的溶液与配体载体接触，所述配体载体包括其表面包括金属的载体，和 配体缀合物独立地固定在表面上，配体载体携带配体缀合物，使得每cm 2固定1至500种配体缀合物，并且每个配体缀合物具有结构为 其中糖链与具有硫原子的连接体化合物结合，所述生物材料是选自蛋白质，病毒，细胞，微生物，脂质体和胶束中的至少一种。

公开(公告)号：US07838549B2

公开(公告)日：2010-11-23

申请号：US10588612

申请日：2005-02-04

申请人： Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

发明人： Yasuo Suda ,  Akio Arano ,  Shoichi Kusumoto ,  Michael Sobel ,  Masahiro Wakao

IPC分类号： A61K31/385 ,  C07D409/14

CPC分类号： C07H15/04 ,  C07D339/04 ,  G01N33/54353

摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

摘要翻译： 本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。 连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃 衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。 配体缀合物包括其中引入糖分子的连接体化合物。

公开(公告)号：US07262799B2

公开(公告)日：2007-08-28

申请号：US10028448

申请日：2001-10-25

申请人： Yasuo Suda

发明人： Yasuo Suda

IPC分类号： H04N9/097 ,  H04N9/093 ,  H04N3/14

CPC分类号： H04N9/093 ,  H04N5/2254 ,  H04N5/3415

摘要： This invention has as its object to provide an image sensing apparatus which can satisfactorily correct misregistration among images, and can composite the images. To achieve this object, an image sensing apparatus includes: a plurality of apertures that receives external light from different positions; a plurality of image sensing units that outputs image signals obtained by independently receiving light that comes from an identical position of an object and is received via the plurality of apertures, and independently extracting predetermined color components for each received light; and a signal processing device that forms a signal that outputs an object image by mixing the image signals output from the plurality of image sensing units. When it is determined that a predetermined position deviation occurs between the image signals upon forming the signal that outputs the object image, the signal processing device corrects the predetermined position deviation by a signal process, and forms the signal that outputs the object image.

摘要翻译： 本发明的目的是提供一种可以令人满意地校正图像之间的重合不良的图像感测装置，并且可以对图像进行合成。 为了实现该目的，图像感测装置包括：多个孔，其接收来自不同位置的外部光; 多个图像感测单元，其输出通过独立地接收来自物体的相同位置并经由多个孔接收的光而获得的图像信号，并且独立地为每个接收到的光而提取预定的颜色分量; 以及信号处理装置，其通过混合从多个摄像单元输出的图像信号，形成输出对象图像的信号。 当确定在形成输出目标图像的信号之间的图像信号之间发生预定位置偏差时，信号处理装置通过信号处理校正预定位置偏差，并形成输出目标图像的信号。

公开(公告)号：US07112779B2

公开(公告)日：2006-09-26

申请号：US11141347

申请日：2005-05-31

申请人： Yasuo Suda ,  Koichi Washisu

发明人： Yasuo Suda ,  Koichi Washisu

IPC分类号： H01J5/16

CPC分类号： G02B7/34 ,  G02B27/143 ,  G02B27/16 ,  G03B7/08 ,  G03B17/18 ,  H01L27/14625 ,  H04N5/2254

摘要： An optical apparatus is disclosed, which can take high-quality images by using light transmitted through a beam splitter. The optical apparatus comprises a light-receiving element and a beam splitter. The first surface of the beam splitter reflects part of incident light and transmits the other part of the incident light toward the light-receiving element. The second surface transmits other incident light other than the incident light to the first surface toward the light-receiving element. The transmittance of the second surface is set so that a light amount distribution on the light-receiving element may be substantially even in a case where the light is incident to the first and second surfaces from an object having a substantially even luminance.

摘要翻译： 公开了一种光学装置，其可以通过使用通过分束器传输的光来获得高质量的图像。 光学装置包括光接收元件和分束器。 分束器的第一表面反射入射光的一部分，并将入射光的另一部分透射到光接收元件。 第二表面将除了入射光之外的其它入射光透射到第一表面朝向光接收元件。 第二表面的透射率被设定为使得在光从具有基本均匀亮度的物体入射到第一和第二表面的情况下，光接收元件上的光量分布可以基本上均匀。

公开(公告)号：US06597868B2

公开(公告)日：2003-07-22

申请号：US09834790

申请日：2001-04-13

申请人： Yasuo Suda

发明人： Yasuo Suda

IPC分类号： G03B1300

CPC分类号： G03B13/32 ,  H04N5/23212 ,  H04N5/3696 ,  H04N9/045 ,  H04N2101/00

摘要： In a focus detecting device of the type in which light fluxes passing through two areas obtained by dividing a pupil of an image forming lens are received by a sensor to detect a phase difference, pixels of the sensor are disposed in such a manner that the sensor has the light-receiving sensitivity in different directions with respect to the luminance distribution, and the phase-difference detection and the contrast detection are performed according to the direction of the light-receiving sensitivity so as to perform appropriate focus detection.

摘要翻译： 在通过传感器接收通过分割成像透镜的光瞳而获得的两个区域的光束的检测相位差的类型的焦点检测装置中，传感器的像素被设置成使得传感器 具有相对于亮度分布的不同方向的受光灵敏度，根据受光灵敏度的方向进行相位差检测和对比度检测，以进行适当的聚焦检测。

公开(公告)号：US6047139A

公开(公告)日：2000-04-04

申请号：US970148

申请日：1997-11-13

申请人： Yasuo Suda

发明人： Yasuo Suda

IPC分类号： G03B13/02 ,  G02B7/28 ,  G02B23/10 ,  G02B27/00 ,  G02B27/28 ,  G03B17/20 ,  G03B19/12

CPC分类号： G02B23/10 ,  G02B27/0093 ,  G02B27/283 ,  G03B17/20 ,  G03B19/12

摘要： A camera capable of display in a finder, the camera including a finder optical system that allows a user to view an object to be photographed; a liquid crystal display device positioned within an optical path of the finder optical system; a polarizing member positioned in the optical path of the finder optical system and behind the liquid crystal display device, as viewed along an optical axis of the optical system; and projection device for projecting polarized light beams toward the liquid crystal display device from outside the optical path of the finder optical system.

摘要翻译： 一种能够在取景器中显示的照相机，所述照相机包括允许用户观看要拍摄的物体的取景器光学系统; 位于取景器光学系统的光路内的液晶显示装置; 位于取景器光学系统的光路中并且沿着光学系统的光轴观察的偏振构件，并位于液晶显示装置的后方; 以及用于从取景器光学系统的光路外侧将偏振光束朝向液晶显示装置投射的投影装置。

公开(公告)号：US6014524A

公开(公告)日：2000-01-11

申请号：US235337

申请日：1994-04-29

申请人： Kenji Suzuki ,  Akira Ishizaki ,  Keiji Ohtaka ,  Yasuo Suda ,  Hidehiko Fukahori ,  Akihiko Nagano ,  Kazuki Konishi ,  Tokuichi Tsunekawa

发明人： Kenji Suzuki ,  Akira Ishizaki ,  Keiji Ohtaka ,  Yasuo Suda ,  Hidehiko Fukahori ,  Akihiko Nagano ,  Kazuki Konishi ,  Tokuichi Tsunekawa

IPC分类号： G02B7/28 ,  G02B7/34 ,  G03B13/02 ,  G03B13/18 ,  G03B17/00

CPC分类号： G02B7/287 ,  G02B7/346 ,  G03B13/02 ,  G03B2213/025

摘要： A camera comprising: finder means for inspecting an object, illumination means for illuminating an operator's eye by which the operator looks in at the finder means, a condensing optical system for condensing a reflected light from the operator's eye, photoelectric converter means for receiving the condensed reflected light, calculation means for calculating a direction of a visual axis of the operator's eye on the basis of an output of the photoelectric converter means, and condition setting means operable in response to the result of the calculation of the calculation means, for setting taking conditions of the camera.

摘要翻译： 一种照相机，包括：用于检查物体的取景器装置，用于照亮操作人员的眼睛的照明装置，操作人员通过该眼睛操作者在取景器装置中观察;用于聚集来自操作者眼睛的反射光的聚光光学系统，用于接收冷凝的光电转换装置 反射光，用于根据光电转换装置的输出计算操作者眼睛的视轴的方向的计算装置，以及可根据计算装置的计算结果进行操作的条件设定装置， 照相机的条件