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    Cyclic anthranililc acid carboxylic acid derivatives and medical therapeutic use thereof
    2.
    发明授权
    Cyclic anthranililc acid carboxylic acid derivatives and medical therapeutic use thereof 失效
    环丙磺酸酸性羧酸衍生物及其医疗治疗用途

    公开(公告)号：US5112836A

    公开(公告)日：1992-05-12

    申请号：US538785

    申请日：1990-06-15

    申请人： Yasushi Kohno ,  Eisuke Kojima

    发明人： Yasushi Kohno ,  Eisuke Kojima

    IPC分类号： A61K31/47 ,  A61P29/00 ,  A61P37/00 ,  C07D215/50 ,  C07D215/52 ,  C07D471/06

    CPC分类号： C07D471/06 ,  C07D215/50 ,  C07D215/52

    摘要： Cyclic anthranilic acid carboxylic acid derivatives of the following formula, ##STR1## wherein R.sup.1 is hydrogen atom, carboxyl group, lower alkoxy carbonyl group having 1 to 3 carbon atoms, or phenyl group which may be substituted, r.sup.2 and R.sup.4 are each independently a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms or benzyl group, R.sup.3 is a hydrogen atom, halogen atom, nitro group, amino group, cyano group, carbamoyl group, carboxyl group, lower alkanoylamino group having 1 to 4 carbon atoms, benzoylamino group, lower alkylsulfonylamino group having 1 to 3 carbon atoms or phenylsulfonylamino group which may be substituted by methyl group; the acid addition or alkali salts thereof, are useful as drugs treat autoimmune diseases, antirheumatic agents and therapeutic or prophylactic agents to treat metabolic bone diseases.

    Cyclic aminophenylacetic acid derivatives, process for preparing the same and immune response modulator having the same as an effective ingredient
    3.
    发明授权
    Cyclic aminophenylacetic acid derivatives, process for preparing the same and immune response modulator having the same as an effective ingredient 失效
    环状氨基苯乙酸衍生物，其制备方法和具有与有效成分相同的免疫应答调节剂

    公开(公告)号：US5359076A

    公开(公告)日：1994-10-25

    申请号：US956012

    申请日：1992-12-09

    申请人： Yasushi Kohno ,  Katsuya Awano ,  Takayoshi Ishizaki ,  Eisuke Kojima ,  Shinji Kudoh ,  Yasuhiko Sakoe ,  Koji Saito

    发明人： Yasushi Kohno ,  Katsuya Awano ,  Takayoshi Ishizaki ,  Eisuke Kojima ,  Shinji Kudoh ,  Yasuhiko Sakoe ,  Koji Saito

    IPC分类号： A61K31/47 ,  A61P29/00 ,  A61P37/00 ,  A61P37/02 ,  C07C311/21 ,  C07C317/48 ,  C07C323/63 ,  C07C331/14 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/22 ,  C07D215/26 ,  C07D215/36 ,  C07D215/40 ,  C07D215/48 ,  C07D498/04 ,  C07D498/06 ,  C07F7/08 ,  C07D215/24 ,  C07D215/06 ,  C07D215/16

    CPC分类号： C07D215/14 ,  C07C311/21 ,  C07C317/48 ,  C07C323/63 ,  C07C331/14 ,  C07D215/12 ,  C07D215/18 ,  C07D215/36 ,  C07D215/40 ,  C07D215/48 ,  C07F7/0812

    摘要： The present invention provides novel cyclic aminophenylacetic acid derivatives having modulating action on immune response, their optical isomers, their salts and their preparative processes, and therapeutic agents for autoimmune diseases containing them as effective ingredients, the cyclic aminophenylacetic acid derivatives being represented by a general formula (1) ##STR1## wherein R and R.sup.1 each independently denotes hydrogen atom or lower alkyl group having 1 to 3 carbon atoms, R.sup.2 denotes a phenyl group (which may be substituted with 1 to 3 groups of halogen atom, methoxy group or their combinations) or trifluoromethyl group, and X denotes a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, cyano group, thiocyano group, trimethylsilylethinyl group, phenyl group (which may be substituted with halogen atom, methoxy group, methyl group or their combinations), carbamoyl group, carboxyl group, lower alkoxycarbonyl group having 1 to 3 carbon atoms, acetyl group, benzoyl group, nitro group, amino group, lower alkanoylamino group having 1 to 3 carbon atoms, benzoylamino group which may be substituted, phenylsulfonylamino group which may be substituted, lower alkylthio group having 1 to 3 carbon atoms, lower alkylsulfinyl group having 1 to 3 carbon atoms, lower alkylsulfonyl group having 1 to 3 carbon atoms or halogen atom.

    摘要翻译： PCT No.PCT / JP92 / 00476 Sec。 371日期：1992年12月9日 102（e）日期1992年12月9日PCT提交1992年4月15日PCT公布。 公开号WO92 / 18482 本发明提供了具有对免疫应答的调节作用的新型环状氨基苯乙酸衍生物，其旋光异构体，其盐及其制备方法，以及含有它们作为有效成分的自身免疫性疾病的治疗剂，环状氨基苯乙酸 衍生物由通式（1）表示，其中R和R 1各自独立地表示氢原子或具有1至3个碳原子的低级烷基，R 2表示苯基（可被1至3个取代基取代） 卤素原子，甲氧基或它们的组合基团）或三氟甲基，X表示氢原子，碳原子数1〜3的低级烷基，碳原子数1〜3的低级烷氧基，氰基，硫氰基，三甲基甲硅烷基乙炔基 ，苯基（其可以被卤素原子，甲氧基，甲基或它们的组合取代），氨基甲酰基，羧基，低级烷氧基 具有1至3个碳原子的酰基，乙酰基，苯甲酰基，硝基，氨基，具有1至3个碳原子的低级烷酰基氨基，可被取代的苯甲酰基氨基，可被取代的苯基磺酰基氨基，具有1个 3个碳原子，具有1至3个碳原子的低级烷基亚磺酰基，具有1至3个碳原子的低级烷基磺酰基或卤素原子。

    Air flow rate measuring apparatus
    5.
    发明授权
    Air flow rate measuring apparatus 有权
    空气流量测量仪

    公开(公告)号：US08695409B2

    公开(公告)日：2014-04-15

    申请号：US13596385

    申请日：2012-08-28

    申请人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

    发明人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

    IPC分类号： G01M15/04

    CPC分类号： G01F1/6842 ,  G01F1/698 ,  G01F1/6983 ,  G01F5/00

    摘要： An air flow rate measuring apparatus includes a heater and a control circuit. The heater heats a part of an intake air sucked into an engine. The control circuit controls an energization of the heater. The heater has a measuring-mode temperature when a flow rate of the intake air is measured. The control circuit has a heat cleaner which temporarily raises a temperature of the heater higher than the measuring-mode temperature when an energization of the air flow rate measuring apparatus is started.

    摘要翻译： 空气流量测量装置包括加热器和控制电路。 加热器加热吸入发动机的进气的一部分。 控制电路控制加热器的通电。 当测量进气的流量时，加热器具有测量模式温度。 控制电路具有在开始空气流量测量装置通电时临时使加热器的温度高于测量模式温度的热清洁器。

    Flow measuring device having resistors arranged in nesting arrangement
    8.
    发明授权
    Flow measuring device having resistors arranged in nesting arrangement 失效
    具有布置成嵌套布置的电阻的流量测量装置

    公开(公告)号：US07703320B2

    公开(公告)日：2010-04-27

    申请号：US12120517

    申请日：2008-05-14

    申请人： Junzo Yamaguchi ,  Yasushi Kohno

    发明人： Junzo Yamaguchi ,  Yasushi Kohno

    IPC分类号： G01F1/68

    CPC分类号： G01F1/692

    摘要： According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

    摘要翻译： 根据流量测量装置，由第一多个电阻器形成的第一范围在流动方向坐标轴上形成单个连续值范围。 因此，第一多个电阻器被限制为在流动方向上彼此热绝缘，从而提高了检测性。 此外，由第二多个电阻器形成的第二范围在纵向坐标轴上形成另一个单个连续值范围。 另一连续值范围包括对应于加热元件在纵向上的半长度的位置。 结果，在最佳检测温度的位置处获得检测差异，从而进一步提高检测性。

    Flow meter having airflow sensor
    10.
    发明授权
    Flow meter having airflow sensor 有权
    流量计有气流传感器

    公开(公告)号：US06694811B2

    公开(公告)日：2004-02-24

    申请号：US10379938

    申请日：2003-03-06

    申请人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

    发明人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

    IPC分类号： G01F168

    CPC分类号： G01F1/6842

    摘要： A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.

    摘要翻译： 流量计形成有用于引入和携带空气进行测量的通道，并且具有设置在通道中的用于测量空气流量的感测部分。 收缩部分形成在通道的内表面上，使得收缩部分面向感测部分。 收缩部分使感应部分附近的空气流动变窄。 收缩部分的平坦表面形成为与感测部分的表面平行并且至少在感测部分的上游。 因此，抑制了颗粒与传感部分的碰撞以及污染物与传感污染物的粘附。 同时，稳定且准确地测量空气的流量。