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14 条记录 (耗时 0.023 秒)

    Matrix for sustained-release preparation
    2.
    发明授权
    Matrix for sustained-release preparation 失效
    用于缓释制剂的基质

    公开(公告)号：US5665394A

    公开(公告)日：1997-09-09

    申请号：US723152

    申请日：1996-09-30

    申请人： Yasutaka Igari ,  Akira Saikawa ,  Kayoko Okamoto ,  Shigeru Kamei ,  Masahisa Oka ,  Atsunori Sano

    发明人： Yasutaka Igari ,  Akira Saikawa ,  Kayoko Okamoto ,  Shigeru Kamei ,  Masahisa Oka ,  Atsunori Sano

    IPC分类号： A61K9/16 ,  C08G63/06 ,  A61K9/50 ,  A61F2/02 ,  A61F9/02 ,  A61K9/48

    CPC分类号： C08G63/06 ,  A61K9/1647

    摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.

    摘要翻译： 本发明涉及用于缓释制剂的基质，其包含在直链聚酯的末端羧基上形成的酯，其基本上由α-羟基单羧酸组成。 基质对光，热，水分，着色等均稳定，毒性低。 通过使用本发明的酯制备的缓释制剂在延长的时间内提供稳定的药物释放，确保持续的稳定的效果。 此外，缓释制剂在施用后不显示过量的药物释放。

    Process for producing maltooligosaccharide derivative
    4.
    发明授权
    Process for producing maltooligosaccharide derivative 失效
    生产麦芽低聚糖衍生物的方法

    公开(公告)号：US5300634A

    公开(公告)日：1994-04-05

    申请号：US878266

    申请日：1992-05-04

    申请人： Atsunori Sano ,  Naoki Teno

    发明人： Atsunori Sano ,  Naoki Teno

    IPC分类号： C07H3/06 ,  C12Q1/40 ,  C07H15/00

    CPC分类号： C12Q1/40 ,  C07H3/06 ,  C12Q2334/10

    摘要： A maltooligosaccharide derivative very useful, for example, as a precursor of a modified oligosaccharide derivative having one or more modifying groups at the 6-position or the 4- and 6-positions of the non-reducing end glucose residue which can be effectively used as a substrate for determining .alpha.-amylase activity or an intermediate thereof, can be produced by reacting a compound of the formula: ##STR1## with a compound of the formula: ##STR2## to convert at least the hydroxyl groups at the 4- and 6-positions of non-reducing end glucose residue of the compound of the formula (1) into a cyclic boric acid ester, acylating the reaction product, and then treating the acylated product.

    摘要翻译： 非常有用的麦芽低聚糖衍生物，例如作为在非还原性末端葡萄糖残基的6位或4位和6位上具有一个或多个修饰基团的修饰的寡糖衍生物的前体，其可以有效地用作 用于确定（α） - 淀粉酶活性的底物或其中间体可以通过使下式化合物：（* CHEMICAL STRUCTURE *）（1）与下式化合物反应来制备：（* CHEMICAL STRUCTURE *）（2 ）将至少将式（1）化合物的非还原性末端葡萄糖残基的4-位和6-位的羟基转化成环状硼酸酯，酰化反应产物，然后处理酰化产物 。

    Palladium catalyst composition
    6.
    发明授权
    Palladium catalyst composition 失效
    钯催化剂组合物

    公开(公告)号：US07741242B2

    公开(公告)日：2010-06-22

    申请号：US10527699

    申请日：2003-09-01

    申请人： Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

    发明人： Shu Kobayashi ,  Atsunori Sano ,  Keiji Oono

    IPC分类号： B01J23/44 ,  B01J37/00

    CPC分类号： B01J31/06 ,  B01J2231/44 ,  B01J2231/645 ,  B01J2231/70 ,  C07B2200/11 ,  C07C17/16 ,  C07C41/16 ,  C07C45/29 ,  C07C45/62 ,  C07C67/343 ,  C07D303/16 ,  C07F15/006 ,  C07F15/0066 ,  C07C22/04 ,  C07C47/232 ,  C07C49/213 ,  C07C69/618 ,  C07C43/215

    摘要： The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol.

    摘要翻译： 本发明公开了1）由交联的有机高分子化合物和钯催化剂组成的催化剂组合物，其中所述催化剂物理地携带在所述交联的有机高分子化合物上，2）上述催化剂组合物1）的制备方法，其特征在于均化 具有可交联官能团的直链有机高分子化合物和溶解所述直链有机高分子化合物的溶剂中的钯催化剂，然后沉积由此形成的组合物，并对所述沉积物中的可交联官能团进行交联反应; 3） 在烯丙基位置进行取代反应的方法，其特征在于在上述催化剂组合物1）的存在下使碳酸烯丙酯和亲核试剂反应，和4）一种氧化醇的方法，其特征在于将上述催化剂组合物1） 与酒精反应。

    Process for producing ascorbic acid derivative
    7.
    发明授权
    Process for producing ascorbic acid derivative 失效
    生产抗坏血酸衍生物的方法

    公开(公告)号：US5516919A

    公开(公告)日：1996-05-14

    申请号：US423988

    申请日：1995-04-18

    申请人： Atsunori Sano ,  Kuniaki Okamoto ,  Jun Ebashi

    发明人： Atsunori Sano ,  Kuniaki Okamoto ,  Jun Ebashi

    IPC分类号： C07F9/655 ,  C07D307/62

    CPC分类号： C07F9/65515

    摘要： Metal salts or substitutted or non-substituted ammonium salts of ascorbic acid derivatives can be produced in high yield by treating an acidic aqueous solution containing ascorbic acid-2-phosphate or ascorbic acid-2-sulfate with a porous adsorbent such as activated carbon, followed by treating the adsorbent with a basic aqueous solution containing e.g. a metal salt of an organic acid or substituted or non-substituted ammonium salt ion to elute the desired salt of ascorbic acid derivative.

    摘要翻译： 通过用多孔吸附剂如活性炭处理含有抗坏血酸-2-磷酸或抗坏血酸-2-硫酸的酸性水溶液，可以高收率地生产抗坏血酸衍生物的金属盐或取代或未取代的铵盐，随后 通过用含有例如的碱性水溶液处理吸附剂 有机酸的金属盐或取代或未取代的铵盐离子洗脱所需的抗坏血酸衍生物盐。

    Method for preparation of a quaternary ammonium salt
    8.
    发明授权
    Method for preparation of a quaternary ammonium salt 有权
    季铵盐的制备方法

    公开(公告)号：US06414159B2

    公开(公告)日：2002-07-02

    申请号：US09779743

    申请日：2001-02-09

    申请人： Kimihiko Sano ,  Yoji Urano ,  Takuhiro Kimura ,  Atsunori Sano

    发明人： Kimihiko Sano ,  Yoji Urano ,  Takuhiro Kimura ,  Atsunori Sano

    IPC分类号： C07D21320

    CPC分类号： C07D213/20 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention provides a method for preparation of a quaternary ammonium salt comprising reacting an alkyl halide with 2 equimolar amount or more per the alkyl halide of a pyridine compound or an N-lower alkyl imidazole at 120° C. to 350° C., and a method for the continuous production of a quatemary ammonium salt comprises introducing continuously an alkyl halide and 2 equimolar amount or more per the alkyl halide of a pyridine compound or an N-lower alkyl imidazole into a pipe reactor from the one end thereof under heating at 120 to 350° C. to pass through the pipe reactor wherein a reaction is allowed to take place, and taking out continuously the resulting quaternary ammonium salt from the other end of the reactor.

    摘要翻译： 本发明提供了一种制备季铵盐的方法，包括使卤代烷与卤代吡啶化合物或N-低级烷基咪唑的烷基卤化物在120℃至350℃下反应2摩尔以上， 和连续生产季铵盐的方法包括在加热下从其一端连续引入吡啶化合物或N-低级烷基咪唑的烷基卤化物的烷基卤和2当量等于或更多的烷基卤化物进入管式反应器 在120至350℃下通过允许发生反应的管式反应器，并从反应器的另一端连续取出所得的季铵盐。

    Process for producing maltooligosaccharide derivatives
    9.
    发明授权
    Process for producing maltooligosaccharide derivatives 失效
    麦芽低聚糖衍生物的制备方法

    公开(公告)号：US5393876A

    公开(公告)日：1995-02-28

    申请号：US44627

    申请日：1993-04-09

    申请人： Atsunori Sano ,  Satoshi Hashizume ,  Hiroyuki Tsurumoto

    发明人： Atsunori Sano ,  Satoshi Hashizume ,  Hiroyuki Tsurumoto

    IPC分类号： C07H13/02 ,  C07H13/04 ,  C07H15/203 ,  C08B37/00 ,  C07H15/00 ,  C07H15/04

    CPC分类号： C07H13/04 ,  C07H15/203

    摘要： A polyacyl maltooligosaccharide derivative which is a precursor of a maltooligosaccharide derivative having modified groups at the 6-position or 4- and 6-positions of non-reducing end glucose unit and being effectively used as a substrate for measuring .alpha.-amylase activity, can be produced under mild conditions by crosslinking OH groups in the non-reducing end glucose unit of oligosaccharide with a benzylidene group having an alkoxy group, followed by acylation and treatment with a dilute acid.

    摘要翻译： 作为在非还原性末端葡萄糖单元的6位或4位和6位具有改性基团并且有效地用作测定α-淀粉酶活性的底物的具有修饰基团的麦芽低聚糖衍生物的前体的多酰基麦芽低聚糖衍生物可以是 通过将低聚糖的非还原性末端葡萄糖单元中的OH基与具有烷氧基的亚苄基交联，然后进行酰化和用稀酸处理，在温和条件下生产。