摘要:
Cyclooctadiene derivative of the following formula (1): ##STR1## wherein A.sup.1, A.sup.2, A.sup.3 and A.sup.4 each independently represent COOR.sup.5 (where R.sup.5 represents a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group, a phenyl group, a C.sub.7 -C.sub.12 aralkyl group or CONR.sup.6 R.sup.7 (where R.sup.6 and R.sup.7 each independently represent a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group or a phenyl group), or A.sup.1 and A.sup.2, and/or A.sup.3 and A.sup.4 may be combined together to represent group(s) of: ##STR2## in which X represents an oxygen atom or NR.sup.8 {where R.sup.8 represents a hydrogen atom, a C.sub.1 -C.sub.10 alkyl group or a phenyl group), R.sup.0, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group and an C.sub.1 -C.sub.10 alkyl group, the symbol ------ represents a single or double bond, and when it is a double bond, then R.sup.1 and R.sup.3 each independently may represent an oxygen atom; provided that the case where all of R.sup.0, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent hydrogen atoms at the same time is excluded, and agrohorticultural fungicides, antimold agents and antithrombocytic agents containing said derivatives. The compounds have superior fungicidal activity, antimold activity and activity for preventing platelet aggregation, and are useful as an agrohorticultural fungicide, an antimold agent and an antithrombocytic agent.
摘要:
The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要:
A nail detecting lever 36 formed with a detecting end 35 capable of advancing to inside of a nail containing portion 26 of a magazine 18 is rotatably arranged between a downwardmost pusher 27a and a pusher 27 thereabove on one side of the magazine 18 interposing the nail containing portion 26. There is provided an idle striking preventing arm 33 an upper end of which is arranged at a vicinity of starting means 22, a lower end of which is arranged to be opposed to an end portion on a side opposed to a detecting end 35 of the detecting lever 36 and which is operated to start a nailing machine 10 in cooperation with the starting means 22. Further, other side of the magazine 18 interposing the nail containing portion 26 is formed with a detecting end containing portion (39) for containing the detecting end 35 of the nail detecting lever 36.
摘要:
A magazine includes a nail guide surface and a movable guide wall. The nail guide surface is linear and continuous to a nail introducing opening and has a shoulder for supporting the nail heads of a connected nail assembly. The movable guide wall is confronted with the nail guide surface. In the magazine, a plurality of connected nail assemblies are loaded and placed in side-by-side relation, while being in contact with each other, between the nail guide surface and the movable guide wall. The plurality of connected nail assemblies are pressed against the guide surface of the magazine by pressing members provided on the movable guide wall. The movable guide wall is turned, for opening and closing, between a position being confronted with the nail guide surface of the magazine and a position at which the nail guide surface is opened.
摘要:
The operation mode of a nailing machine can be automatically and reliably switched, for its selection, from the successive nailing mode and the one-shot nailing mode and vice versa by changing the order of operating a trigger lever and a contact arm. In the selected mode, the nailing work can be performed. By releasing both the trigger lever and the contact arm, the machine is returned to its initial mode. When the contact arm is moved to the top dead center after the trigger lever is operated, a portion of a slide die comes in contact with the underside of the trigger lever. When the trigger lever is operated after the contact arm is moved to the top dead center, the portion of the slide die comes in contact with the upper side of the trigger lever, thereby preventing a further movement of the contact arm to the bottom dead center.
摘要:
A pneumatic tool includes a tool body, a nose part for ejecting a nail, which is provided in a lower part of the tool body, an air chamber for storing compressed air, which is provided in the tool body, an air supply pipe for supplying the compressed air from an air supply source to the air chamber, an air duster, an air duster pipeline connected to an air outlet of the air duster, and an air duster valve for controlling supply of the compressed air to the air duster pipeline.
摘要:
A sensor part detects an actual driving signal in the driving time by a pneumatic tool. A control part, based on the detected actual driving signal, makes an addition to the actual driving number which has already stored in a memory part to updates the actual driving number, and compares the updated accumulative actual driving number with the previously set basic maintenance number. As a result of the comparison, in case the accumulative actual driving number exceeds the basic maintenance number, it is determined that maintenance is necessary for the pneumatic tool. A light emitting part emits the light and blinks by an instruction from the control part, thereby to warn a user that the pneumatic tool is into the maintenance time. Hereby, the user can grasp the maintenance time of the tool surely and exactly.
摘要:
The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要:
A combustion gas type nailing machine includes a lock-out bar 31 of which one end is coupled to a movable sleeve 12; a cam member 32 which is provided opposed to the other end of the lock-out bar 31 and cooperates with a trigger unit 27 rotatably; a cam surface 34 which is formed on the cam member 32, and comes into contact with the lower end of the lock-out bar 31 thereby to retain the movable sleeve 12 in a state where a combustion chamber 6 is closed; and a step portion 44 which is formed on the cam surface 34 and can engage with the lock-out bar 31. When the cam surface 34 retains the movable sleeve 12, the step portion 44 engages with the lock-out bar 31 to interrupt the rotational movement of the cam member 32, whereby it is prevented that the trigger unit 27 is operated to a position where the trigger 27 mechanism ignites the inflammable gas.
摘要:
Gas oils comprises one or more gas oil bases obtained by subjecting specific fractions from distilled petroleum fractions to hydrogenating treatment under specific conditions and optionally a small amount of a straight kerosene or gas oil. The gas oils have a sulfur concentration of 350 ppm or below.