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公开(公告)号：US4828705A
公开(公告)日：1989-05-09
申请号：US925347
申请日：1986-10-31
IPC分类号： A61K9/28 , B01D61/14 , B01D61/18 , B01D61/22 , B01D63/00 , B01D65/02 , B01D65/08 , B01D69/02 , B01D69/12
CPC分类号： B01D61/142 , A61K9/284 , B01D69/02 , B01D69/12
摘要： Pressure-dependent anisotropic behavior is provided by a size selective separation membrane system having two successive porous layers. The first layer is a soft, elastic, effectively porous material, and the second layer is a substantially rigid porous material. When positive pressure presses the first layer against the second layer, the second layer serves as a rigid support, and the first layer is compressed to reduce its effective pore size. The first layer material is characterized by sufficient compressibility, that, when a pressure differential of 100 psi is applied across the thickness of the system, the effective flow rate is reduced by a factor of at least 20 compared to the flow rate when 100 psi is exerted in the opposite direction. A substance can be separated from a liquid mixture using the membrane system by: positioning the second layer of the membrane system in contact with the mixture; exerting pressure on the mixture to force liquid with the substance first through the pores of the rigid layer and the soft layer of the system; and reversing the flow through the membrane system by exerting pressure on the resulting filtrate, in a manner to compress the soft material sufficiently to reduce the pore size to prevent passage of the substance. The membrane system is manufactured by coagulating the layers from polymers in solution.
摘要翻译： 压力依赖的各向异性行为由具有两个连续多孔层的尺寸选择性分离膜系统提供。 第一层是柔软的，弹性的，有效的多孔材料，第二层是基本刚性的多孔材料。 当正压力将第一层压在第二层上时，第二层用作刚性支撑体，并且第一层被压缩以减小其有效孔径。 第一层材料的特征在于具有足够的压缩性，当在整个系统的厚度上施加100psi的压力差时，当100psi为100psi时，与流速相比，有效流速降低至少20倍 施加在相反的方向。 可以使用膜系统将物质与液体混合物分离，方法是将膜系统的第二层与混合物接触; 对混合物施加压力以迫使液体与物质首先通过刚体层和系统的软层的孔; 并通过对所得滤液施加压力来反转通过膜系统的流动，以充分压缩软材料以减小孔径以防止物质通过。 膜系统通过从溶液中的聚合物凝结层来制造。
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2.发明授权Implantable ophthalmic lens, a method of manufacturing same and a mold for carrying out said method 失效可植入眼科镜片，其制造方法和用于实施所述方法的模具
公开(公告)号：US5674283A
公开(公告)日：1997-10-07
申请号：US565255
申请日：1995-11-30
申请人： Vladimir A. Stoy
发明人： Vladimir A. Stoy
CPC分类号： A61F2/1616 , Y10S425/808 , Y10S623/901
摘要： An implantable ophthalmic lens manufactured at least partly out of soft, elastic and pliable material substantially in the shape of a saucer is described. It includes an outer optical face forming one side of the lens, and an inner optical face forming the other side of the lens. A center portion of the inner optical face of the lens as well as the lens rim each have the shape of meniscus derived from the corresponding meniscus of a liquid precursor prior to solidification, the center portion meniscus and the rim meniscus being connected by an annular ring, all surfaces of the lens except the center portion of the inner optical face and the lens rim being replicas of a solid mold from which it is formed. The inner optical face center portion and the lens rim have the shape of a liquid precursor solidified in contact with an inert fluid. The method of manufacturing an ophthalmic lens involves solidification of a liquid precursor in an at least bipartite mold with a dished base and a tubular top member which is extendable under the surface of a liquid precursor. The annular ring is preferably a conically ground face.
摘要翻译： 描述了至少部分地由基本上为碟形形状的柔软，弹性和柔韧材料制成的可植入眼科镜片。 它包括形成透镜一侧的外光学面和形成透镜另一侧的内光学面。 透镜的内部光学面的中心部分以及透镜边缘各自具有在凝固之前衍生自液体前体的相应弯液面的弯液面的形状，中心部弯月面和边缘弯液面通过环形环连接 除了内光学面的中心部分和透镜边缘之外的透镜的所有表面都是与其形成的实心模的复制品。 内部光学面中心部分和透镜边缘具有与惰性流体接触固化的液体前体的形状。 制造眼用镜片的方法包括在具有可在液体前体的表面下延伸的碟状底座和管状顶部构件的至少二分之一模具中固化液体前体。 环形环最好是圆锥形地面。
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公开(公告)号：US4921323A
公开(公告)日：1990-05-01
申请号：US288629
申请日：1988-12-22
CPC分类号： B29C61/003 , B29C61/06 , G02B6/3803 , B29C35/049
摘要： The present invention involves an optical fiber splicer made of a unistructural mass of inherent shaped memory polymer material. The splicer has a longitudinal dimension with opposite ends having first bore at one end and a second bore at the other end wherein the bores go into the mass and to each other. Preferably, the first bore and the second bore are merely a single continuous oriface. The unistructural mass has a first shape and a second shape. The first shape is a recoverable, predetermined inherent shape wherein the first bore and second bore each have a preset diameter to accomodate and tightly hold end segments of denuded optical fibers of predetermined diameter in spliced, butted alignment with one another. The second shape is such that the first bore and second bore each have swollen predetermined diameters which are greater than the diameters of the end segments of optical fibers so as to loosely and freely receive the end segments. The unistructural mass of inherent shape memory polymer material is initially formed in the first, inherent shape, and is then swollen and partially shrunk to its second, deformed shape and is capable of being returned to its first shape by application of a non-mechanical stimulus thereto, such as heat. The invention is also directed to preparing the optical splicer as well as to using the optical splicer to obtain a butt-to-butt splicing of optical fibers.
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公开(公告)号：US4563182A
公开(公告)日：1986-01-07
申请号：US667265
申请日：1984-11-01
申请人： Vladimir A. Stoy , George P. Stoy
发明人： Vladimir A. Stoy , George P. Stoy
CPC分类号： A61K9/02 , A61F5/0093 , A61F7/12 , A61F2007/0028 , A61F2007/0214 , Y10S424/15
摘要： A method of treating hemorrhoids which comprises inserting into the rectum of a subject afflicted therewith a substantially cylindrical shaped insert, comprising a water swellable polymer having a water content of at least 35% by weight, said insert having previously been frozen by being subjected to a temperature below 0.degree. C. for a sufficient amount of time to freeze the free water therein and maintaining said insert with at least a portion thereof outside the sphincter muscle, and apparatus therefore.
摘要翻译： PCT No.PCT / US83 / 00300 Sec。 371日期1984年11月1日 102（e）1984年11月1日日期PCT提交1983年3月4日PCT公布。 公开号WO84 / 03434 日本1984年9月13日。一种治疗痔疮的方法，其包括将患有基本上圆柱形的插入物的受试者的直肠插入，所述插入物包含水含量为至少35重量％的水溶胀性聚合物，所述插入物先前 通过在0℃以下的温度下冷冻足够的时间以使其中的游离水冷冻并将所述插入物至少保持在括约肌外部，并因此装置。
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公开(公告)号：US06264695B1
公开(公告)日：2001-07-24
申请号：US09410268
申请日：1999-09-30
申请人： Vladimir A. Stoy
发明人： Vladimir A. Stoy
IPC分类号： A61F244
CPC分类号： A61L27/20 , A61F2/441 , A61F2/442 , A61F2002/30075 , A61F2002/4435 , A61F2002/444 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/44 , A61L27/50 , A61L27/52 , A61L2430/38 , C08L33/00 , C08L31/00 , C08L29/00 , C08L27/00 , C08L23/00 , C08L85/02 , C08L83/04 , C08L67/00 , C08L75/00
摘要： The present invention is a spinal nucleus implant for replacement of at least a portion of nucleus pulposus tissue removed from a spinal disc of a living vertebrate to restore function of the spinal disc and related vertebral joint. The implant is an anisotropically swellable, biomimetic xerogel plastic, having a two phase structure with a hydrophobic phase having high crystallinity and low water content and with hydrophilic phase having low crystallinity and high water content and having a negatively charged lubricious surface. The xerogel plastic is capable of rehydration and of osmotic movement of liquid therethrough in response to osmotic pressure change to thereby increase and decrease liquid content in its hydrated state. The present invention also relates to surgical implant procedures utilizing this spinal nucleus implant.
摘要翻译： 本发明是用于替代从活脊椎动物的脊椎盘移除的至少一部分髓核组织的脊髓核植入物，以恢复脊椎盘和相关椎体关节的功能。 植入物是各向异性可溶胀的仿生干凝胶塑料，具有两相结构，疏水相具有高结晶度和低水含量，亲水相具有低结晶度和高含水量并具有带负电荷的光滑表面。 干凝胶塑料响应于渗透压变化能够使液体进行再水化和渗透运动，从而增加和减少其水合状态下的液体含量。 本发明还涉及利用这种脊髓核植入物的手术植入手术。
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公开(公告)号：US06232406B1
公开(公告)日：2001-05-15
申请号：US09409995
申请日：1999-09-30
申请人： Vladimir A. Stoy
发明人： Vladimir A. Stoy
IPC分类号： C08F812
摘要： The present invention is a method of making acrylonitrile copolymers having multi block structure comprising acrylic acid, acryl amids and acrylamidine hydrophilic groups in hydrophilic blocks and residual nitrile groups in hydrophobic blocks, by partial hydrolysis of polyacrylonitrile to a predetermined hydrolysis conversion at which the hydrolysis is self terminating by a process that improves quality and reduces product heterogeneity. It includes forming a first reaction mixture which includes polyacrylonitrile dissolved in an aqueous reactive solvent containing sodium thiocyanate; forming a second reaction mixture comprising a reaction catalyst of the general formula MY dissolved in an aqueous reactive solvent containing sodium thiocyanate; mixing the reaction mixtures of steps (a) and (b) above to form a master reaction mix; dividing the reaction mix into a plurality of physical reaction compartments so as to increase outer surface area relative to volume as compared to outer surface area of a single reaction compartment to enhance cooling efficiency and to reduce undesirable center core thermal effects; and, heating the divided master reaction mix to a predetermined reaction temperature range and maintaining the temperature range for a predetermined time sufficient for completion of a predetermined level of hydrolysis at which the resulting copolymer solution is substantially stable at ambient temperature. The invention also includes hydrogel products resulting from the method.
摘要翻译： 本发明是一种制备具有多嵌段结构的丙烯腈共聚物的方法，其通过将聚丙烯腈部分水解成水解所需的水解转化率，在亲水嵌段和疏水嵌段中的残余腈基中包含丙烯酸，丙烯酰胺和丙烯酰胺亲水基团 通过提高质量并降低产品异质性的过程自我终止。 其包括形成第一反应混合物，其包括溶解在含有硫氰酸钠的水性反应性溶剂中的聚丙烯腈; 形成第二反应混合物，其包含溶解在含有硫氰酸钠的水性反应性溶剂中的通式MY的反应催化剂; 混合上述步骤（a）和（b）的反应混合物以形成主反应混合物; 将反应混合物分成多个物理反应室，以增加与单个反应室的外表面积相比相对于体积的外表面积，以提高冷却效率并减少不期望的中心核热效应; 并将分割的主反应混合物加热到预定的反应温度范围，并将温度范围保持足够的预定时间以完成预定水解的水解，其中所得共聚物溶液在环境温度下基本上是稳定的。 本发明还包括由该方法得到的水凝胶产品。
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公开(公告)号：US6040493A
公开(公告)日：2000-03-21
申请号：US66146
申请日：1998-04-24
CPC分类号： A61L15/40 , A61F13/023 , A61L15/20 , A61L15/32 , A61L15/60 , A61F2013/00157 , A61F2013/00748 , A61F2013/00846 , A61F2013/15024 , Y10T428/249939 , Y10T428/249994
摘要： The present invention is a bioreactor wound dressing which includes a first layer, being a transport layer, in direct contact with a wound. It includes at least one layer of a permeable polymeric media containing, in equilibrium with body fluids, at least 40% by weight of liquid, and is impermeable for infectious agents of any kind and being permeable to water soluble substances having molecular weight up to at least 1000 Daltons. There is a second layer, being a fluid reservoir layer that is adjacent to the transport layer and is capable of containing between 40% and 100% of its volume of an aqueous liquid, wherein the transport layer and reservoir layer are permeably interconnected for aqueous solutions and are in a substantial osmotic equilibrium. The invention also includes a method of wound treatment utilizing the bioreactor wound dressing.
摘要翻译： 本发明是一种生物反应器伤口敷料，其包括与伤口直接接触的作为输送层的第一层。 其包括至少一层可渗透的聚合物介质，其与体液平衡，至少40重量％的液体，并且对于任何类型的感染剂都是不可渗透的，并且对具有分子量直至最高分子量的水溶性物质是可渗透的 至少1000道尔顿。 存在第二层，其是与输送层相邻并且能够含有其体积的水性液体的40％至100％的流体储存层，其中输送层和储存层可渗透地互连用于水溶液 并且处于实质的渗透平衡。 本发明还包括利用生物反应器伤口敷料进行伤口治疗的方法。
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公开(公告)号：US5736127A
公开(公告)日：1998-04-07
申请号：US711345
申请日：1996-09-05
IPC分类号： A61K31/167 , A61K31/4178 , A61K31/513 , A61K31/65 , A61K47/48 , A61K31/74
CPC分类号： A61K47/48176 , A61K31/167 , A61K31/4178 , A61K31/513 , A61K31/65
摘要： The present invention is directed to a composition comprising a nitrogen-containig drug-polymer salt and a method for making said composition. The drug-polymer salt is comprised of one or more drugs having basic groups as part of their chemical structure which are capable of forming salts with acids and one or more hydrophilic polymers containing carboxylate groups and amidine groups as pendant groups. Such polymeric salts of drugs have been found to have excellent bio-availability and advantageous release profiles in various forms (gels, ointments, pills, etc.). Particularly advantageous polymers contain pendant nitrile groups in addition to carboxyls and amidines which provide the polymer with hydrogel characteristics.
摘要翻译： 本发明涉及包含含氮的药物 - 聚合物盐的组合物和制备所述组合物的方法。 药物 - 聚合物盐由一种或多种具有碱性基团的药物组成，其化学结构的一部分能够与酸形成盐，和一种或多种含有羧酸酯基和脒基的亲水性聚合物作为侧基。 已经发现这些药物的聚合盐具有优异的生物利用度和各种形式的有利的释放特征（凝胶，软膏，丸剂等）。 特别优选的聚合物除了提供具有水凝胶特性的聚合物的羧基和脒之外，还含有侧基腈基。
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公开(公告)号：US4631188A
公开(公告)日：1986-12-23
申请号：US646243
申请日：1984-08-31
申请人： Vladimir A. Stoy , Milos Chvapil
发明人： Vladimir A. Stoy , Milos Chvapil
CPC分类号： A61K9/0024 , A61K31/74 , A61L24/0031 , A61L24/06 , A61L27/16 , A61L27/52 , A61L2400/06
摘要： There is disclosed a non-toxic physiologically-acceptable polymeric composition comprised of water insoluble, non-crosslinked polymeric compounds having a solubility parameter of between 9.2 and 15.5 (cal/cc).sup.1/2 dissolved in a polar, non-toxic water miscible solvent, which polymeric composition solidifies when placed in contact with living tissue by absorbtion of water and by gradual release of solvent into the surrounding tissue.
摘要翻译： 公开了一种无毒的生理上可接受的聚合物组合物，其包含水溶性，非交联的聚合物，其溶解度参数为9.2至15.5（cal / cc）1/2，溶于极性无毒的水混溶性溶剂 当聚合物组合物通过吸收水和通过逐渐释放溶剂进入周围组织而与活组织接触时固化。
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10.发明授权Hydrogel-based prosthetic device for replacing at least a part of the nucleus of a spinal disc 失效基于水凝胶的假体装置用于替换脊髓盘的至少一部分核公开(公告)号：US07204897B2
公开(公告)日：2007-04-17
申请号：US10830578
申请日：2004-04-23
IPC分类号： B32B37/00
CPC分类号： A61L27/20 , A61F2/441 , A61F2/442 , A61F2002/30075 , A61F2002/4435 , A61F2002/444 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/44 , A61L27/50 , A61L27/52 , A61L2430/38 , C08L33/00 , C08L31/00 , C08L29/00 , C08L27/00 , C08L23/00 , C08L85/02 , C08L83/04 , C08L67/00 , C08L75/00
摘要： The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers. The invention also includes a method of prosthesis production, which involves prefabricating soft and rigid layers; stacking at least two prefabricated soft and at least one prefabricated rigid layer in a parallel fashion into their final form, and, permitting the layers to firmly connect to one another by mutual interaction. In this method, at least one type of the layers is prefabricated in the dehydrated state, which is done by dehydrating stretched foil in an apparatus preventing its contraction and thereby decreasing its area. There is at least partial dehydration of the prosthesis under pressure applied in a direction tangent to the planes of the layers. In preferred embodiments, while in the state of almost full dehydration, is sterilized using ionizing radiation or a gaseous chemical agent, after which it is partially rehydrated within the sterile wrapper using water vapor.
摘要翻译： 本发明是用于替代椎间盘的核的至少一部分的假体。 假体装置由至少两个基本上平行的可弹性变形的水凝胶和至少一个刚性层的软层组成，刚性层具有比软层更小的压缩性，与软层平行的软层相邻并且牢固地附着 给他们。 在一些实施例中，软层具有相同的厚度和组成。 通常，假体具有多于一个刚性层，并且这些刚性层具有相同的厚度和组成。 软层的数量通常比刚性层的数量多一个，例如至少三个软层。 本发明还包括一种假体生产方法，其涉及预制柔性和刚性层; 将至少两个预制的软和至少一个预制刚性层以平行的方式堆叠成其最终形式，并且允许层通过相互作用彼此牢固地连接。 在这种方法中，至少一种类型的层是在脱水状态下预制的，其通过在防止其收缩的装置中脱水拉伸的箔并由此减小其面积来进行。 在与层的平面相切的方向施加压力的假体至少部分脱水。 在优选的实施方案中，在几乎完全脱水的状态下，使用电离辐射或气体化学试剂灭菌，然后使用水蒸汽在无菌包装内部分地再水化。
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