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16 条记录 (耗时 0.013 秒)

    Method for making collagen sponge
    2.
    发明授权
    Method for making collagen sponge 失效
    胶原蛋白海绵的制作方法

    公开(公告)号：US4193813A

    公开(公告)日：1980-03-18

    申请号：US720563

    申请日：1976-09-07

    申请人： Milos Chvapil

    发明人： Milos Chvapil

    IPC分类号： A61F6/06 ,  A61K9/00 ,  B29D27/00 ,  C07G7/00 ,  C07G7/06

    CPC分类号： A61K9/0036 ,  Y10S128/08

    摘要： Method for making a collagen sponge including the following steps. Native collagen form of fibrillar protein is comminuted and homogenized in an acid environment; noncollagenous material is removed and residual collagen is mixed with water the pH of the resulting slurry is adjusted to 4.5 to 5.0 by the addition of acetic acid; gluteraldehyde is then added and the slurry poured into molds and frozen at approximately -10.degree. centigrade for approximately 20 hours. The frozen mass is then thawed, washed, and immersed in a wash of pH 8 to 9 for approximately 2 hours at 20.degree. centigrade. Sufficient reducing agent is added to the wash to create excess reducing equivalents. The sponge is then immersed in a buffer solution of pH 4 to 5 for a time sufficient to equilibrate to uniform pH. The sponge formed by the above method is then moistended and self-administered in the upper vault of the vagina proximal to the cervix. The sponge is then retained for a desired period, usually several days to one month.

    摘要翻译： 制造胶原蛋白海绵的方法，包括以下步骤。 原生胶原蛋白形式的纤维蛋白质在酸性环境中粉碎和匀浆; 除去非胶原材料，并将残留的胶原与水混合，通过加入乙酸将所得浆液的pH调节至4.5至5.0; 然后加入戊二醛，将浆料倒入模具中并在约-10℃下冷冻约20小时。 然后将冷冻的质量解冻，洗涤，并在pH8-9的洗涤液中浸入20℃的温度下约2小时。 向洗涤液中加入足够的还原剂以产生过量的还原当量。 然后将海绵浸入pH4至5的缓冲溶液中一段足以平衡至均匀pH的时间。 然后通过上述方法形成的海绵被润湿并在靠近子宫颈的阴道的上部拱顶中自我施用。 然后将海绵保持期望的时间，通常几天至一个月。

    Antimicrobial wound dressing
    3.
    发明授权
    Antimicrobial wound dressing 失效
    抗菌伤口敷料

    公开(公告)号：US5116620A

    公开(公告)日：1992-05-26

    申请号：US742319

    申请日：1991-08-08

    申请人： Milos Chvapil ,  Bruce A. Barber

    发明人： Milos Chvapil ,  Bruce A. Barber

    IPC分类号： A61F13/00 ,  A61F13/02 ,  A61L15/18 ,  A61L15/32

    CPC分类号： A61F13/00012 ,  A61F13/00063 ,  A61F13/0206 ,  A61F13/022 ,  A61F13/0223 ,  A61F13/0276 ,  A61L15/18 ,  A61L15/325 ,  A61F2013/0091

    摘要： An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite, and an adjacent layer secured thereto containing a dry, activating amount of an acidic compound, such as citric acid, whereby moisture from the wound activates the dry chlorine moiety to treat the wound.

    摘要翻译： 一种抗微生物伤口敷料和伤口处理方法，所述伤口敷料具有浸渍有活化二氧化氯的冻干稳定的含氯化合物的胶原敷料材料层，如氯酸钠和亚氯酸钠的混合物，以及相邻的 层包含干燥的活化量的酸性化合物如柠檬酸，由此来自伤口的水分激活干氯部分以治疗伤口。

    Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs
    7.
    发明授权
    Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs 失效
    通过局部施用化合物治疗纤维化病变的方法

    公开(公告)号：US4485088A

    公开(公告)日：1984-11-27

    申请号：US362241

    申请日：1982-03-26

    申请人： Milos Chvapil

    发明人： Milos Chvapil

    IPC分类号： A61K31/275 ,  A61L15/44 ,  A61K9/70

    CPC分类号： A61L15/44 ,  A61K31/275 ,  A61L2300/204

    摘要： The disclosure deals with a method of treating fibrotic lesions related to abnormal collagen polymerization by topical administration of lathyrogenic substances, such as .beta.-aminopropionitrile fumarate, aminoacetonitrile, D-penicillamine, into the site of the injury. The lathyrogenic drugs are administered by local injection or onto the skin and percutaneously transported into the site of the lesion. Lathyrogens, administered locally as a single drug or in combination do not produce any local or systemic toxic effects and are improving the function of the pathological fibrosis based on the accumulation of polymerized collagenous protein.

    摘要翻译： 本公开涉及通过局部施用诸如β-氨基丙腈富马酸盐，氨基乙腈，D-青霉胺等病原体物质来治疗与异常胶原聚合有关的纤维化病变的方法。 视神经药物通过局部注射或皮肤施用，经皮输送到病变部位。 局部作为单一药物或组合施用的Lathyrogens不产生任何局部或全身的毒性作用，并且基于聚合的胶原蛋白的积聚改善病理性纤维化的功能。

    Intravaginal contraceptive and drug release device and method for making and using same
    8.
    发明授权
    Intravaginal contraceptive and drug release device and method for making and using same 失效
    阴道避孕药和药物释放装置及其使用方法

    公开(公告)号：US4274410A

    公开(公告)日：1981-06-23

    申请号：US112157

    申请日：1980-01-16

    申请人： Milos Chvapil

    发明人： Milos Chvapil

    IPC分类号： A61F6/08 ,  A61K9/00 ,  A61F13/20

    CPC分类号： A61K9/0036 ,  A61F6/08 ,  Y10S128/08

    摘要： A contraceptive device and method of contraception as well as a method of making the contraceptive device are described. Native collagen form of fibrillar protein is comminuted and homogenized in an acid environment; noncollagenous material is removed and residual collagen is mixed with water the pH of the resulting slurry is adjusted to 4.5 to 5.0 by the addition of acetic acid; gluteraldehyde is then added and the slurry poured into molds and frozen at approximately -10.degree. centigrade for approximately 20 hours. The frozen mass is then thawed, washed, and immersed in a wash of pH 8 to 9 for approximately 2 hours at 20.degree. centigrade. Sufficient reducing agent is added to the wash to create excess reducing equivalents. The sponge is then immersed in a buffer solution of pH 4 to 5 for a time sufficient to equilibrate to uniform pH. The sponge formed by the above method is then moistened and self-administered in the upper vault of the vagina proximal to the cervix. The sponge is then retained for a desired period, usually several days to one month.

    摘要翻译： 描述避孕装置和避孕方法以及避孕装置的制造方法。 原生胶原蛋白形式的纤维蛋白质在酸性环境中粉碎和匀浆; 除去非胶原材料，并将残留的胶原与水混合，通过加入乙酸将所得浆液的pH调节至4.5至5.0; 然后加入戊二醛，将浆料倒入模具中并在约-10℃下冷冻约20小时。 然后将冷冻的质量解冻，洗涤，并在pH8-9的洗涤液中浸入20℃下约2小时。 向洗涤液中加入足够的还原剂以产生过量的还原当量。 然后将海绵浸入pH4至5的缓冲溶液中一段足以平衡至均匀pH的时间。 然后通过上述方法形成的海绵在靠近子宫颈的阴道的上部拱顶中被润湿并自我施用。 然后将海绵保持期望的时间，通常几天至一个月。

    Composition and method using local application of lipophilic lathyrogens sustained release formulations
    9.
    发明申请
    Composition and method using local application of lipophilic lathyrogens sustained release formulations 审中-公开
    组合物和方法，使用局部应用的亲脂性甲状旁腺缓释制剂

    公开(公告)号：US20050276855A1

    公开(公告)日：2005-12-15

    申请号：US11153582

    申请日：2005-06-15

    申请人： Milos Chvapil

    发明人： Milos Chvapil

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K31/22 ,  A61K47/10

    CPC分类号： A61L31/16 ,  A61K9/0019 ,  A61K31/22 ,  A61K47/10

    摘要： A method is disclosed to treat a patient having a wound in a tissue structure, where the wound is defined by a wound line, by inhibiting the crosslinking of collagen during the healing of that wound. The method provides a lipophilic lathyrogen, and injects that lipophilic lathyrogen into the tissue structure adjacent the wound line. The wound may result from either injury or surgery. The would may comprise a skin wound, a stenoses, a stricture, a burn, a fibrotic adhesion, and the like.

    摘要翻译： 公开了一种治疗患有组织结构中的伤口的患者的方法，其中伤口由伤口线限定，通过在伤口愈合期间抑制胶原蛋白的交联。 该方法提供亲脂性的草药，并将该亲脂性的草药注射到伤口线附近的组织结构中。 伤口可能是受伤或手术造成的。 该病可包括皮肤伤口，狭窄，狭窄，烧伤，纤维粘连等。