-
1.发明授权Process for surface modifying substrates and modified substrates resulting therefrom 有权用于表面改性基材和由其得到的改性基材的方法公开(公告)号：US06893685B2
公开(公告)日：2005-05-17
申请号：US09939145
申请日：2001-08-24
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Paul Pasic , Hans Griesser , Peter Kambouris , Peter Chabrecek
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Paul Pasic , Hans Griesser , Peter Kambouris , Peter Chabrecek
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double b3nd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译： 本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯属不饱和双b 3 nd的双官能化合物共价结合到连接层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。 通过本发明的方法可获得的涂覆制品具有关于与基材的粘合性，耐久性，亲水性，润湿性，生物相容性和渗透性有关的所需特性，因此可用于制造生物医学制品如眼科装置。
-
公开(公告)号：US06589665B2
公开(公告)日：2003-07-08
申请号：US09867827
申请日：2001-05-30
申请人： Peter Chabrecek , Dieter Lohmann , Jörg Leukel , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally
发明人： Peter Chabrecek , Dieter Lohmann , Jörg Leukel , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally
IPC分类号： G02B104
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/21 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要： The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having attached to its surface at least one polyionic material that comprises covalently bound initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic monomers or macromonomers to the bulk material surface provided with the initiator radicals and polymerizing said monomers or macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译： 本发明涉及新颖的复合材料，其包括（a）无机或有机本体材料，其在其表面附着至少一种聚离子材料，其包含共价结合的用于自由基聚合的引发剂部分; 和（b）可通过将一种或多种不同的烯属不饱和亲水单体或大分子单体施用于提供有引发剂基团的本体材料表面并聚合所述单体或大分子单体而获得的亲水性表面涂层。本发明的复合材料具有关于粘附 底物，耐久性，亲水性，润湿性，生物相容性和渗透性，因此可用于制造生物医学制品如眼科装置。
-
3.发明授权公开(公告)号：US08309117B2
公开(公告)日：2012-11-13
申请号：US10732543
申请日：2003-12-10
IPC分类号： A61K9/00
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译： 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， 通过还原与带负电荷的聚离子材料的-COO-基团相关联的Ag +离子形成的-COOAg基团和/或银纳米颗粒。 此外，本发明提供了根据本发明的方法制备的医疗装置。
-
4.发明授权公开(公告)号：US06940580B2
公开(公告)日：2005-09-06
申请号：US10338631
申请日：2003-01-08
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。
-
公开(公告)号：US06858248B2
公开(公告)日：2005-02-22
申请号：US10153007
申请日：2002-05-22
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
CPC分类号： G02B1/10 , A61L27/34 , B05D1/18 , B29D11/00865 , Y10S134/901
摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.
摘要翻译： 本发明提供了一种有效地将涂层施加到从由眼科镜片，用于制造眼镜片的模具和其他医疗装置组成的组中的多个物体中的每一个上的方法，所述方法包括将多个物体浸入含有 具有涂料的涂布溶液; 并且以手段产生对流电流，从而迫使在多个眼科镜片中的每一个上流动的涂覆溶液。 在优选实施例中，多个物体被保持在篮子中，篮子被预处理成具有第一层聚电解质和第二层水溶液，或者在篮子的表面上具有聚电解质和水溶液的混合层。
-
公开(公告)号：US06815074B2
公开(公告)日：2004-11-09
申请号：US10153040
申请日：2002-05-22
申请人： Celeste Aguado , Paul Clement Nicolson , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Jacalyn Mary Schremmer
发明人： Celeste Aguado , Paul Clement Nicolson , Lynn Cook Winterton , Yongxing Qiu , John Martin Lally , Jacalyn Mary Schremmer
IPC分类号： B32B904
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/34 , A61L2430/16 , Y10T428/31663 , C08L51/085
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。
-
公开(公告)号：US06926965B2
公开(公告)日：2005-08-09
申请号：US10654566
申请日：2003-09-03
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/34 , A61L31/10 , G02B1/04 , B32B25/20 , B32B27/08 , B32B27/30
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
-
公开(公告)号：US06896926B2
公开(公告)日：2005-05-24
申请号：US10654340
申请日：2003-09-03
IPC分类号： G02C7/04 , A61L27/00 , A61L27/34 , A61L29/00 , A61L31/00 , B05D1/18 , G02B1/04 , G02C13/00 , B05D1/36 , B05D1/38
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
摘要翻译： 本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。 根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性 作为透镜材料的透氧性和离子透过性。
-
9.发明授权Process for surface modifying substrates and modified substrates resulting therefrom 有权用于表面改性基材和由其得到的改性基材的方法公开(公告)号：US06852353B2
公开(公告)日：2005-02-08
申请号：US09911218
申请日：2001-07-23
摘要： The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.
摘要翻译： 本发明总体上涉及一种通过用具有反应性位点的聚合物连接层至少部分地涂覆这些基底的表面来改性基底例如隐形眼镜和其它生物医学制品的表面的方法。 然后可以通过经典的化学附着机制将其它部分与反应性位点反应，将各种其它部分化学连接到制品表面。
-
公开(公告)号：US07211149B2
公开(公告)日：2007-05-01
申请号：US11029619
申请日：2005-01-05
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa , Rafael Victor Andino , Allen Gilliard
IPC分类号： B05C19/02
CPC分类号： G02B1/10 , A61L27/34 , B05D1/18 , B29D11/00865 , Y10S134/901
摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.
摘要翻译： 本发明提供了一种有效地将涂层施加到从由眼科镜片，用于制造眼镜片的模具和其他医疗装置组成的组中的多个物体中的每一个上的方法，所述方法包括将多个物体浸入含有 具有涂料的涂布溶液; 并且以手段产生对流电流，从而迫使在多个眼科镜片中的每一个上流动的涂覆溶液。 在优选实施例中，多个物体被保持在篮子中，篮子被预处理成具有第一层聚电解质和第二层水溶液，或者在篮子的表面上具有聚电解质和水溶液的混合层。
-
-
-
-
-
-
-
-
-
搜索结果
73 条记录 (耗时 0.033 秒)
