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公开(公告)号：US20050196520A1
公开(公告)日：2005-09-08
申请号：US11029619
申请日：2005-01-05
申请人： Yongxing Qiu , Lynn Winterton , John Lally , Yasuo Matsuzawa , Rafael Andino , Allen Gilliard
发明人： Yongxing Qiu , Lynn Winterton , John Lally , Yasuo Matsuzawa , Rafael Andino , Allen Gilliard
CPC分类号： G02B1/10 , A61L27/34 , B05D1/18 , B29D11/00865 , Y10S134/901
摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.
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公开(公告)号：US20070032869A1
公开(公告)日：2007-02-08
申请号：US11543695
申请日：2006-10-05
申请人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
发明人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
IPC分类号： A61F2/16
CPC分类号： B29D11/00317 , B29D11/00903 , G02B1/10
摘要： The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.
摘要翻译： 本发明提供了一种将涂层施加到眼用透镜或用于制造眼科镜片或除眼镜之外的医疗装置的模具的方法。 该方法包括使用选自空气辅助雾化和分配过程，超声波辅助雾化和分配过程，压电辅助雾化和分配过程的喷雾方法将至少一层涂布液体喷涂到眼科镜片上 工艺，机电喷射印刷工艺，压电喷墨印刷工艺，静压喷射印刷工艺的压电和热喷涂印刷工艺。 涂层可以包括性质/功能性图案或彩色图像或两者的组合。
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公开(公告)号：US20050076831A1
公开(公告)日：2005-04-14
申请号：US10937140
申请日：2004-09-09
申请人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
发明人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
CPC分类号： B29D11/00317 , B29D11/00903 , G02B1/10
摘要： The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.
摘要翻译： 本发明提供了一种将涂层施加到眼用透镜或用于制造眼科镜片或除眼镜之外的医疗装置的模具的方法。 该方法包括使用选自空气辅助雾化和分配过程，超声波辅助雾化和分配过程，压电辅助雾化和分配过程的喷雾方法将至少一层涂布液体喷涂到眼科镜片上 工艺，机电喷射印刷工艺，压电喷墨印刷工艺，静压喷射印刷工艺的压电和热喷涂印刷工艺。 涂层可以包括性质/功能性图案或彩色图像或两者的组合。
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4.发明申请公开(公告)号：US20050058844A1
公开(公告)日：2005-03-17
申请号：US10732543
申请日：2003-12-10
申请人： Michael Rubner , Sung Yang , Yongxing Qiu , Lynn Winterton , John Lally
发明人： Michael Rubner , Sung Yang , Yongxing Qiu , Lynn Winterton , John Lally
IPC分类号： A61L27/34 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , G02B1/04 , B32B15/04
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译： 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， -COOAg基团和/或银纳米颗粒通过还原与负电聚合物材料的-COO - 基团相关的Ag +离子而形成。 此外，本发明提供了根据本发明的方法制备的医疗装置。
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公开(公告)号：US20050221092A1
公开(公告)日：2005-10-06
申请号：US11137181
申请日：2005-05-25
申请人： Yongxing Qiu , Lynn Winterton , John Lally
发明人： Yongxing Qiu , Lynn Winterton , John Lally
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
摘要翻译： 本发明提供一种医疗装置，优选为眼科装置，更优选隐形眼镜，其包括非共价连接到所述芯材料的芯材料和生物相容性LbL涂层。 生物相容的LbL涂层包含至少一个电荷/非电荷双层，其中所述电荷/非电荷双层以无特别的顺序由一层带电荷的聚合物材料和一层非带电聚合物材料组成，其中 能够非共价地键合到带电的聚合物材料上。
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公开(公告)号：US20050153056A1
公开(公告)日：2005-07-14
申请号：US11076391
申请日：2005-03-09
申请人： Lynn Winterton , Yongxing Qiu , John Lally , Manal Gabriel
发明人： Lynn Winterton , Yongxing Qiu , John Lally , Manal Gabriel
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。
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公开(公告)号：US20050106207A1
公开(公告)日：2005-05-19
申请号：US10969280
申请日：2004-10-20
申请人： Yongxing Qiu , Fiona Carney , Nichola Kotov , John Lally , Carol Morris , Lynn Winterton
发明人： Yongxing Qiu , Fiona Carney , Nichola Kotov , John Lally , Carol Morris , Lynn Winterton
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/30 , A61L27/34 , A61L31/08 , A61L31/10 , G02B1/04 , A61F2/00 , A61J1/00
CPC分类号： A61L27/34 , A61L27/306 , A61L31/088 , A61L31/10 , G02B1/043
摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.
摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。
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公开(公告)号：US20050008676A1
公开(公告)日：2005-01-13
申请号：US10732648
申请日：2003-12-10
申请人： Yongxing Qiu , Lynn Winterton , John Lally , Nicholas Kotov
发明人： Yongxing Qiu , Lynn Winterton , John Lally , Nicholas Kotov
IPC分类号： A61L27/34 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , G02B1/04 , A61K9/00 , A61K33/38
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
摘要翻译： 本发明提供了一种医疗装置，优选隐形眼镜，其中芯材和含抗微生物金属的LbL涂层不共价连接到医疗装置上，并且可以赋予医疗装置增加的亲水性。 本发明的隐形眼镜上的抗微生物金属包衣对于包括革兰氏阳性和革兰氏阴性细菌在内的微生物具有高抗微生物效力，并且具有低毒性，同时保持所需的体积特性，如透氧性和透镜材料的离子渗透性 。 这种透镜可用作延长佩戴的隐形眼镜。 另外，本发明提供了制造其上具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法。
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公开(公告)号：US20050142287A1
公开(公告)日：2005-06-30
申请号：US11065113
申请日：2005-02-23
申请人： Yasuo Matsuzawa , Lynn Winterton
发明人： Yasuo Matsuzawa , Lynn Winterton
IPC分类号： G02B1/10 , B05B13/02 , B05C9/04 , B05D3/04 , B05D7/00 , B05D7/24 , B29C59/14 , B29D11/00 , C08J7/16 , C23C16/50 , C23C16/54 , B05D5/06 , H05H1/24
CPC分类号： B05D1/62 , B29C59/14 , B29C2059/147 , B29D11/00009 , B29L2011/0041 , C23C16/54 , Y10S414/139
摘要： The invention provides a system and method for plasma coating of an optical lens, particularly lenses made of silicone-containing polymer. A system of the invention comprises an entry chamber, a coating chamber downstream from the entry chamber, and an exit chamber downstream from the coating chamber. The coating chamber includes a pair of spaced apart electrodes disposed therein. A system of the invention is configured in a way so that a lens may enter, pass through and exit the system without requiring the coating chamber to be repeatedly pressurized and depressurized.
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公开(公告)号：US20060251696A1
公开(公告)日：2006-11-09
申请号：US11416260
申请日：2006-05-02
申请人： Lynn Winterton , John Lally
发明人： Lynn Winterton , John Lally
IPC分类号： A61F13/00
CPC分类号： G02B1/043 , A61K9/0051 , B29D11/00038 , B29D11/00865 , C08L29/04
摘要： The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.
摘要翻译： 本发明涉及具有以时间控制释放方式输送客体材料（例如润滑剂或药物）的能力的眼用产品。 本发明还提供了制备本发明的眼用产品的方法。 此外，本发明提供了药物或润滑剂的时间控制递送的方法。
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