摘要:
The present invention provides a novel fructose responsive transcription control cis-element and a transcriptional regulatory factor that interacts therewith, a non-human animal having them transferred or inactivated, a diagnostic method for genetic susceptibility to a metabolic disorder using them, and a screening method for a prophylactic or therapeutic drug for a metabolic disorder using them.
摘要:
The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is —(CH2)m—X— (X is —N(R8)—, —C(R9)(R10)—, —CO— or —CO—N(R8)—); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is —(Y)s1-(A2)s-Z (Y is —O—, —S(O)t—, —N(R13)—, —N(R14)—CO—, —N(R14)—SO2—, —SO2—N(R14)— and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.
摘要:
Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.
摘要:
Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.
摘要:
The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is —(CH2)m—X— (X is —N(R8)—, —C(R9)(R10)—, —CO— or —CO—N(R8)—); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is —(Y)s1-(A2)s-Z (Y is —O—, —S(O)t—, —N(R13)—, —N(R14)—CO—, —N(R14)—SO2—, —SO2—N(R14)— and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.
摘要:
The present invention provides an optical pickup device that is resistant to noise in a signal or an RF signal outputted from each light receiving member. Current signals outputted from the light receiving members are converted into voltage signals by I/V converters. The voltage signals are then added up by an adder, and then the added voltage signal is attenuated by an attenuator, so as to obtain an RF signal having the same signal level as the voltage signal outputted from each I/V converter. The RF signal is then transmitted from the optical pickup device to a circuit substrate through a signal line.
摘要:
A device for demodulating position information that is recorded as track wobbling in a record medium by a BPSK scheme includes a carrier-wave-generation circuit which derives a carrier wave from a wobbling signal obtained from the record medium, a phase-adjustment circuit which generates a phase-comparison signal having a 90° phase difference relative to the carrier wave, a multiplier which multiplies the wobbling signal and the phase-comparison signal to supply a product signal, and a detection circuit which detects a phase error of the carrier wave introduced by the carrier-wave-generation circuit by detecting the phase error between the wobbling signal and the phase-comparison signal based on the product signal.
摘要:
A trial writing operation is performed on a phase-change optical disc using write and erase light-emitting powers, which together are varied according to predetermined variation ratios respectively. Signals relevant to said trial writing operation are reproduced from said disc. Optimum ones of the write and erase light-emitting powers are determined using the thus-reproduced signals. The predetermined variation ratios for the write and erase light-emitting powers may be the same as each other. Alternatively, the trial writing operation may be performed on a phase-change optical disc using write and erase light-emitting powers which are individually varied according to predetermined variation ratios respectively.
摘要:
A reference clock frequency divider feasible for a motor drive IC (Integrated Circuit), optical disk drive, hard disk drive or similar apparatus. The frequency divider is capable of setting not only integral frequency division ratios but also decimal frequency division ratios without any circuit modification.
摘要:
A display unit displays information without a power supply. An area identifying unit determines whether the display apparatus is inside a permission area where a read of the information displayed on the display unit is permitted. A data controller deletes the information displayed on the display unit or displays other information on the display unit, when the area identifying unit determines that the display apparatus has moved from inside the permission area to outside the permission area.