利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

53 条记录 (耗时 0.2 秒)

    Azole compound and medicinal use thereof
    2.
    发明授权
    Azole compound and medicinal use thereof 失效
    唑类化合物及其药用

    公开(公告)号：US07163952B2

    公开(公告)日：2007-01-16

    申请号：US10497492

    申请日：2002-12-03

    申请人： Takashi Inaba ,  Tomoyuki Ikemoto ,  Shohei Sakata ,  Hiroshi Maegawa ,  Atsunori Kashiwagi

    发明人： Takashi Inaba ,  Tomoyuki Ikemoto ,  Shohei Sakata ,  Hiroshi Maegawa ,  Atsunori Kashiwagi

    IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/535 ,  C07D401/00 ,  C07D415/00

    CPC分类号： C07D417/04 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D277/30 ,  C07D277/42 ,  C07D417/12 ,  A61K2300/00

    摘要： The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetrazolyl; R1, R2, R3 and R4 are H and the like; A is —(CH2)m—X— (X is —N(R8)—, —C(R9)(R10)—, —CO— or —CO—N(R8)—); B is aryl or aromatic heterocyclic group; R5 is H and the like; R6 is —(Y)s1-(A2)s-Z (Y is —O—, —S(O)t—, —N(R13)—, —N(R14)—CO—, —N(R14)—SO2—, —SO2—N(R14)— and the like, A2 is alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.

    摘要翻译： 本发明涉及由式[I]表示的唑类化合物，其中W为S或O; R是-COOR 7，-X 1 - ， - - - - - COOR 7（R 7） H是烷基）或四唑基; R 1，R 2，R 3和R 4是H等; A是 - （CH 2 CH 2）m -X-（X是-N（R 8） - ， - C（R' （R 10） - ， - CO - 或-CO-N（R 8） - ）; B是芳基或芳族杂环基; R 5是H等; R 6是 - （Y）S 1 - （A 2 - ） - S（Y是-O- ，-S（O）n - ， - N（R 13） - ， - N（R 14）-CO - ， - N （R 14）-SO 2 - ， - SO 2 -N（R 14） - 等等 A 2是亚烷基，Z是环烷基，芳基，芳族杂环基，茚满基，哌嗪基，其前药或其药学上可接受的盐。本发明的化合物[I] 酪氨酸磷酸酶1B抑制活性，可用作糖尿病治疗剂，糖尿病并发症治疗药物或高脂血症治疗药物。

    Aluminum alloy sheet, method for producing the same, and aluminum alloy container
    6.
    发明授权
    Aluminum alloy sheet, method for producing the same, and aluminum alloy container 有权
    铝合金板，其制造方法和铝合金容器

    公开(公告)号：US07704451B2

    公开(公告)日：2010-04-27

    申请号：US11109637

    申请日：2005-04-20

    申请人： Kenji Kuroda ,  Etsuko Kuroda, legal representative ,  Takashi Inaba

    发明人： Kenji Kuroda ,  Takashi Inaba

    IPC分类号： C22C21/08 ,  C22C21/06 ,  C22F1/04

    CPC分类号： C22C21/08

    摘要： An aluminum alloy sheet contains 0.1% to 0.4% by mass of Cu, 0.5% to 1.5% by mass of Mg, 0.5% to 1.5% by mass of Mn, 0.2% to 0.7% by mass of Fe, and 0.1% to 0.3% by mass of Si. The number density of Al—Mn—Fe—Si-based intermetallic compound having a maximum length of 8 to 15 μm per unit area is 179 grains/mm2 or less. An oxide film having an average thickness of 30 nm or less is formed on the surface of the aluminum alloy sheet. The arithmetic average roughness Ra of the surface of the aluminum alloy sheet is 0.30 to 0.45 μm.

    摘要翻译： 铝合金板含有0.1质量％〜0.4质量％的Cu，0.5〜1.5质量％的Mg，0.5〜1.5质量％的Mn，0.2〜0.7质量％的Fe，0.1〜0.3 质量％的Si。 每单位面积的最大长度为8〜15μm的Al-Mn-Fe-Si系金属间化合物的数密度为179个/ mm 2以下。 在铝合金板的表面上形成平均厚度为30nm以下的氧化膜。 铝合金板的表面的算术平均粗糙度Ra为0.30〜0.45μm。

    Copper alloy sliding material
    7.
    发明授权
    Copper alloy sliding material 有权

    公开(公告)号：US06334914B1

    公开(公告)日：2002-01-01

    申请号：US09749442

    申请日：2000-12-28

    申请人： Kenji Sakai ,  Naohisa Kawakami ,  Satoru Kurimoto ,  Takashi Inaba ,  Koichi Yamamoto ,  Takayuki Shibayama

    发明人： Kenji Sakai ,  Naohisa Kawakami ,  Satoru Kurimoto ,  Takashi Inaba ,  Koichi Yamamoto ,  Takayuki Shibayama

    IPC分类号： C22C902

    摘要： Disclosed is a copper alloy sliding material comprising 0.5 to 15 mass % Sn and 0.1 to 10 vol % of hard particles consisting of one or more selected from WC, W2C and Mo2C. The hard particles have preferably an average particle size of 0.1 to 10 &mgr;m, whereby they are dispersed in the copper alloy matrix so as to make the sliding-contact surface uneven, from which the hard particles protrude partially. The sliding material comprises an amount or a total amount of not more than 40 mass % of one or more selected from Ni, Ag, Fe, Al, Zn, Mn, Co, Si and P, an amount or a total amount of not more than 10 mass % of Bi and/or Pb, and/or an amount or a total amount of not more than 10 vol % of a solid lubricant comprising BN, graphite, MoS2 and/or WS2.

    Production of amide derivatives and intermediate compounds therefor
    8.
    发明授权
    Production of amide derivatives and intermediate compounds therefor 失效
    酰胺衍生物及其中间体化合物的制备

    公开(公告)号：US06194589B1

    公开(公告)日：2001-02-27

    申请号：US09458004

    申请日：1999-12-10

    申请人： Takashi Inaba ,  Yasuki Yamada

    发明人： Takashi Inaba ,  Yasuki Yamada

    IPC分类号： C07D32106

    CPC分类号： C07D321/06 ,  C07C319/20 ,  C07D317/28 ,  C07D319/20 ,  C07C323/25

    摘要： A method for producing an amide derivative of the formula [XV] wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.

    摘要翻译： 一种制备式[XV]的酰胺衍生物的方法，其中每个符号如说明书中所定义，及其对映异构体，可用于制备所述化合物的新型中间体及其制备方法。本发明的制备方法是 与常规方法相比非常容易和简单，并且能够以高产率有效生产化合物[XV]，其包括具有HIV蛋白酶抑制作用的化合物[XVI]。 此外，本发明的新型中间体作为用于生产上述化合物[XVI]的中间体以及用作X射线造影剂的化合物是非常有用的。

    Process for producing amide derivatives and intermediate compounds
    9.
    发明授权
    Process for producing amide derivatives and intermediate compounds 失效
    酰胺衍生物和中间体化合物的制备方法

    公开(公告)号：US06121468A

    公开(公告)日：2000-09-19

    申请号：US43667

    申请日：1998-05-19

    申请人： Takashi Inaba ,  Yasuki Yamada ,  James Shanley ,  Michael Deason

    发明人： Takashi Inaba ,  Yasuki Yamada ,  James Shanley ,  Michael Deason

    IPC分类号： C07C319/20 ,  C07C323/25 ,  C07D317/28 ,  C07D319/20 ,  C07D321/06 ,  C07D301/02 ,  C07D303/04

    CPC分类号： C07D317/28 ,  C07C319/20 ,  C07D319/20 ,  C07D321/06

    摘要： A process for producing amide derivatives represented by general formula (XV) ##STR1## or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds (XV), i.e., those involving the compounds (XVI) having an HIV protease inhibitory effect in high yields. The novel intermediates are highly advantageous as intermediates for producing not only the above compounds (XVI) but also those which are useful as an X-ray contrast medium, etc.

    摘要翻译： PCT No.PCT / JP96 / 02757 Sec。 371日期1998年5月19日 102（e）日期1998年5月19日PCT PCT 1996年9月24日PCT公布。 公开号WO97 / 11938 日期1997年4月3日制造通式（XV）表示的酰胺衍生物或其对映异构体的方法，可用于制备这些化合物的新型中间体化合物等及其制备方法，其中每个符号如 规范。 与常规方法相比，上述方法可以非常容易地实现，并且能够以高产率有效地生成化合物（XV），即涉及具有HIV蛋白酶抑制作用的化合物（ⅩⅥ）的那些。 新颖的中间体作为不仅产生上述化合物（XVI）的中间体而且作为用作X射线造影剂等的那些是非常有利的。