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1.
公开(公告)号:US4529336A
公开(公告)日:1985-07-16
申请号:US482638
申请日:1983-04-06
申请人: Yoshinobu Shinozaki , Motozo Yasuno , Tadaaki Iwamura , Hironari Marushima , Yoshiteru Tagawa , Ryoji Takabe , Takashi Moriyama , Shuzo Fujii , Keiichi Achiba , Hideo Oishi , Yasuo Yanagihara , Yoshiaki Masuda
发明人: Yoshinobu Shinozaki , Motozo Yasuno , Tadaaki Iwamura , Hironari Marushima , Yoshiteru Tagawa , Ryoji Takabe , Takashi Moriyama , Shuzo Fujii , Keiichi Achiba , Hideo Oishi , Yasuo Yanagihara , Yoshiaki Masuda
摘要: A method of distributing powdered or granular material to a plurality of feeding ends in a system having a pressurizing tank for pressurizing and fluidizing a powdered or granular material, a plurality of transportation pipes having one ends constituting discharge nozzles opening above a fluidized bed in the tank and the other ends connected to different feeding ends so as to introduce the material to the feeding ends, and a plurality of booster gas supply pipes for supplying respective transportation pipes with a booster gas. The internal pressure of the tank is controlled by a controller provided with a set valve in accordance with the mean value of the terminal pressures at the feeding ends, the mean value of predetermined set flow rates of the booster gas in the booster gas supplying pipes, and the mean value of predetermined set rates of transportation of material to the feeding ends.
摘要翻译: 一种在具有用于加压和流化粉末或颗粒材料的加压罐的系统中将粉末状或颗粒状材料分配到多个进料端的方法,多个输送管,其一端构成在罐中的流化床上方开口的排出喷嘴 另一端连接到不同的进料端,以将材料引入进料端;以及多个增压气体供应管,用于向相应的输送管提供助燃气体。 通过根据进料端的端子压力的平均值,增压气体供给管中的增压气体的预定设定流量的平均值,由设置有设定阀的控制器来控制油箱的内部压力, 以及将材料输送到给料端的预定设定速率的平均值。
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公开(公告)号:US20120322807A1
公开(公告)日:2012-12-20
申请号:US13526283
申请日:2012-06-18
申请人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号: A61K31/496 , A61P37/08
CPC分类号: C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要: The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group
摘要翻译: 本发明提供含有由通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂,其中X1表示氮原子或-CH =,R1表示-Z-R6基团, 其中Z表示-CO-基团,-CH(OH) - 基等,R6表示具有1-4个氮原子的5至15元单环,二环或三环饱和或不饱和杂环基,氧原子 或硫原子,R 2表示氢原子或卤素原子,Y表示基团-O-,基团-CO-,基团-CH(OH) - 或低级亚烷基,A表示基团
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公开(公告)号:US08263599B2
公开(公告)日:2012-09-11
申请号:US12311500
申请日:2007-10-02
申请人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号: A61K31/497
CPC分类号: C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译: 本发明的目的是提供一种STAT3 / 5激活抑制剂。 本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂,其中,X1表示氮原子或-CH =,R1表示-Z-R6基, 其中Z表示-CO-基团,-CH(OH) - 基等,R6表示具有1-4个氮原子的5至15元单环,二环或三环饱和或不饱和杂环基,氧原子 或硫原子,R 2表示氢原子或卤素原子,Y表示基团-O-,基团-CO-,基团-CH(OH) - 或低级亚烷基,A表示其中R 3表示 氢原子,低级烷氧基等,p表示1或2,R4表示咪唑基低级烷基等。
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公开(公告)号:US6107465A
公开(公告)日:2000-08-22
申请号:US24386
申请日:1987-03-10
申请人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号: A61K38/00 , C07K14/545 , C12N15/24 , C07K14/54 , A61K38/20
CPC分类号: C07K14/545 , A61K38/00 , Y10S930/141
摘要: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
摘要翻译: 白细胞介素1β(IL-1β),其衍生物具有IL-1β的修饰的氨基酸序列,编码所述衍生物的基因,包含所述衍生物作为药学上有效成分的药物组合物和均匀的IL -1 beta和衍生物。
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公开(公告)号:US08188277B2
公开(公告)日:2012-05-29
申请号:US11659689
申请日:2005-08-03
申请人: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
发明人: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
IPC分类号: C07D241/36 , C07D413/12 , C07D403/12 , C07D221/02 , C07D401/12 , C07D213/62 , A61K31/535 , A61K31/497 , A61K31/445
CPC分类号: C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译: 本发明提供了一种新颖的化合物,其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式(1)表示:[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6,其中Z表示基团-CO-,基团-CH(OH) - 等,R6表示5至15元单环,双环或三环饱和或 具有1-4个氮原子的不饱和杂环基,氧原子或硫原子; R2表示氢原子,卤素原子或低级亚烷基; Y表示基团-O-,基团-CO-,基团-CH(OH) - ,低级亚烷基基团等; A表示基团等,其中R3表示氢原子,低级烷氧基等,p表示1或2,R4表示咪唑基低级烷基等。
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公开(公告)号:US20100210661A1
公开(公告)日:2010-08-19
申请号:US12311500
申请日:2007-10-02
申请人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人: Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号: A61K31/496 , C07D401/14 , C07D405/10 , A61P3/04 , A61P25/28 , A61P3/10
CPC分类号: C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译: 本发明的目的是提供一种STAT3 / 5激活抑制剂。 本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂,其中,X1表示氮原子或-CH =,R1表示-Z-R6基, 其中Z表示-CO-基团,-CH(OH) - 基等,R6表示具有1-4个氮原子的5至15元单环,二环或三环饱和或不饱和杂环基,氧原子 或硫原子,R 2表示氢原子或卤素原子,Y表示基团-O-,基团-CO-,基团-CH(OH) - 或低级亚烷基,A表示其中R 3表示 氢原子,低级烷氧基等,p表示1或2,R4表示咪唑基低级烷基等。
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公开(公告)号:US20070270422A1
公开(公告)日:2007-11-22
申请号:US11659689
申请日:2005-08-03
申请人: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
发明人: Tae Fukushima , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
IPC分类号: C07D401/14 , A61K31/165 , A61K31/167 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4523 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61P11/00 , C07C233/00 , C07C233/92 , C07D211/00 , C07D211/40 , C07D211/56 , C07D241/04 , C07D413/14 , C07D413/02 , C07D241/36
CPC分类号: C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译: 本发明提供了一种新颖的化合物,其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式(1)表示:[其中X 1表示氮原子或基团-CH-; R 1表示基团-ZR 6,其中Z表示-CO-基团,-CH(OH) - 基等基团,R“ 6表示具有1至4个氮原子,氧原子或硫原子的5至15元单环,二环或三环饱和或不饱和杂环基; R 2表示氢原子,卤素原子或低级亚烷基; Y表示基团-O-,基团-CO-,基团-CH(OH) - ,低级亚烷基基团等; A表示基团等,其中R 3表示氢原子,低级烷氧基等,p表示1或2,R 4表示 咪唑基低级烷基等。
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公开(公告)号:US5008374A
公开(公告)日:1991-04-16
申请号:US23373
申请日:1987-03-09
申请人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号: C12N15/09 , A61K35/14 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , F16L5/02
CPC分类号: C07K14/545 , F16L5/02 , A61K38/00 , Y10S514/825 , Y10S514/886 , Y10S530/82
摘要: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..
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公开(公告)号:US20120238750A1
公开(公告)日:2012-09-20
申请号:US13409090
申请日:2012-02-29
申请人: Tae FUKUSHIMA , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
发明人: Tae FUKUSHIMA , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
IPC分类号: C07D401/12 , C07D413/14 , C07D211/46 , C07D295/155 , C07D405/14
CPC分类号: C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译: 本发明的化合物由以下通式(1)表示:[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6,其中Z表示基团-CO-,基团-CH(OH) - 等,R6表示5至15元单环,双环或三环饱和或 具有1-4个氮原子的不饱和杂环基,氧原子或硫原子; R2表示氢原子,卤素原子或低级亚烷基; Y表示基团-O-,基团-CO-,基团-CH(OH) - ,低级亚烷基基团等; A表示基团等,其中R3表示氢原子,低级烷氧基等,p表示1或2,R4表示咪唑基低级烷基等。
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公开(公告)号:US5847098A
公开(公告)日:1998-12-08
申请号:US474168
申请日:1995-06-07
申请人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人: Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号: A61K38/00 , C07K14/545 , C12N15/24 , C12N5/10
CPC分类号: C07K14/545 , A61K38/00 , Y10S514/825 , Y10S514/886
摘要: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
摘要翻译: 白细胞介素1β(IL-1β),其衍生物具有IL-1β的修饰的氨基酸序列,编码所述衍生物的基因,包含所述衍生物作为药学上有效成分的药物组合物和均匀的IL -1 beta和衍生物。
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