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1.发明申请COMPOSITIONS COMPRISING HPV POLYPEPTIDES AND IMMUNOENHANCEMENT PEPTIDES FOR THE TREATMENT AND PREVENTION OF CERVICAL CANCER 有权包含HPV多肽的组合物和用于治疗和预防癌症的免疫抑制肽公开(公告)号：US20090305979A1
公开(公告)日：2009-12-10
申请号：US12297407
申请日：2006-04-19
申请人： Young Chul Sung , Hyun Tak Jin , Sang Hwan Seo , Sang Hoon Park , Je-In Youn
发明人： Young Chul Sung , Hyun Tak Jin , Sang Hwan Seo , Sang Hoon Park , Je-In Youn
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/53 , A61K2039/585 , C07K14/475 , C07K14/70575 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to a fusion protein comprising a fusion polypeptide of E6 and E7 of a human papilloma virus, a signal peptide for secreting the polypeptide out of the cell, and an immune enhancing peptide for a subject; a polynucleotide encoding the fusion protein; and a vector containing the polynucleotide. The present invention further relates to a pharmaceutical composition comprising the fusion protein or the vector; and a method for treating a disease caused by a human papilloma virus using the pharmaceutical composition.
摘要翻译： 本发明涉及包含人乳头瘤病毒的E6和E7的融合多肽的融合蛋白，用于从细胞中分泌多肽的信号肽和受试者的免疫增强肽; 编码融合蛋白的多核苷酸; 和含有多核苷酸的载体。 本发明还涉及包含融合蛋白或载体的药物组合物; 以及使用该药物组合物治疗由人乳头状瘤病毒引起的疾病的方法。
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2.发明授权Compositions comprising HPV polypeptides and immunoenhancement peptides for the treatment and prevention of cervical cancer 有权包含HPV多肽和用于治疗和预防子宫颈癌的免疫增强肽的组合物公开(公告)号：US08137674B2
公开(公告)日：2012-03-20
申请号：US12297407
申请日：2006-04-19
申请人： Young Chul Sung , Hyun Tak Jin , Sang Hwan Seo , Sang Hoon Park , Je-In Youn
发明人： Young Chul Sung , Hyun Tak Jin , Sang Hwan Seo , Sang Hoon Park , Je-In Youn
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/53 , A61K2039/585 , C07K14/475 , C07K14/70575 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to a fusion protein comprising a fusion polypeptide of E6 and E7 of a human papilloma virus, a signal peptide for secreting the polypeptide out of the cell, and an immune enhancing peptide for a subject; a polynucleotide encoding the fusion protein; and a vector containing the polynucleotide. The present invention further relates to a pharmaceutical composition comprising the fusion protein or the vector; and a method for treating a disease caused by a human papilloma virus using the pharmaceutical composition.
摘要翻译： 本发明涉及包含人乳头瘤病毒的E6和E7的融合多肽的融合蛋白，用于从细胞中分泌多肽的信号肽和受试者的免疫增强肽; 编码融合蛋白的多核苷酸; 和含有多核苷酸的载体。 本发明还涉及包含融合蛋白或载体的药物组合物; 以及使用该药物组合物治疗由人乳头状瘤病毒引起的疾病的方法。
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3.发明授权Composition for preventing or treating cervical cancer having human papillomavirus plasmodium and immunity enhancer 有权用于预防或治疗具有人乳头状瘤病毒疟原虫和免疫增强剂的宫颈癌的组合物公开(公告)号：US09000139B2
公开(公告)日：2015-04-07
申请号：US13816716
申请日：2010-08-13
申请人： Young Chul Sung , Sang Hwan Seo , You Suk Suh
发明人： Young Chul Sung , Sang Hwan Seo , You Suk Suh
IPC分类号： C07K14/01 , C12N15/62 , C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , C07K14/01 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
摘要： A composition for preventing or treating cervical cancer comprising a human papillomavirus plasmodium and an immunity enhancer is provided. A fusion protein including a fusion polypeptide recombined to transform a 3D structure of E6 and E7, which are antigens against types 16 and 18 human papillomavirus (HPV), a signal peptide for secreting the fusion polypeptide outside the cells and an immunity enhancer peptide present in an individual is also provided. The fusion protein may be useful in treating HPV-triggered tumors by inducing an immune response specific to the antigens against the HPV types 16 and 18.
摘要翻译： 提供了一种用于预防或治疗宫颈癌的组合物，其包含人乳头瘤病毒疟原虫和免疫增强剂。 包含融合多肽的融合蛋白重组以转化E6和E7的3D结构，E6和E7是针对16型和18型人乳头状瘤病毒（HPV）的抗原，用于分泌细胞外的融合多肽的信号肽和存在于细胞内的免疫增强子肽 还提供个人。 通过诱导针对HPV 16型和18型的抗原特异性的免疫应答，融合蛋白可用于治疗HPV触发的肿瘤。
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公开(公告)号：US20130195905A1
公开(公告)日：2013-08-01
申请号：US13816716
申请日：2010-08-13
申请人： Young Chul Sung , Sang Hwan Seo , You Suk Suh
发明人： Young Chul Sung , Sang Hwan Seo , You Suk Suh
IPC分类号： C07K14/01
CPC分类号： C07K14/005 , A61K39/12 , C07K14/01 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
摘要： A composition for preventing or treating cervical cancer comprising a human papillomavirus plasmodium and an immunity enhancer is provided. A fusion protein including a fusion polypeptide recombined to transform a 3D structure of E6 and E7, which are antigens against types 16 and 18 human papillomavirus (HPV), a signal peptide for secreting the fusion polypeptide outside the cells and an immunity enhancer peptide present in an individual is also provided. The fusion protein may be useful in treating HPV-triggered tumors by inducing an immune response specific to the antigens against the HPV types 16 and 18.
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5.发明授权Intracellular viral vector delivery method employing iron ion/viral vector composite 有权使用铁离子/病毒载体复合物的细胞内病毒载体递送方法公开(公告)号：US09228202B2
公开(公告)日：2016-01-05
申请号：US13499101
申请日：2010-09-28
申请人： Young Chul Sung , Sang Hoon Park , Ki Seok Park
发明人： Young Chul Sung , Sang Hoon Park , Ki Seok Park
IPC分类号： C12N15/86 , C12N15/63 , C12N15/864 , C12N15/861 , C12N15/867 , C12N15/00 , C12N15/863
CPC分类号： C12N15/86 , C12N15/00 , C12N15/63 , C12N15/861 , C12N15/863 , C12N15/8636 , C12N15/864 , C12N15/867 , C12N2710/10343 , C12N2710/10345 , C12N2810/10
摘要： The present invention relates to an intracellular viral vector delivery method employing an iron ion/viral vector composite. The iron ion/viral vector composite according to the present invention is not dependent on the expression of CAR and so improves the efficiency of delivery of viral vectors and gene expression in cells of diverse types, and has an outstanding virus-neutralizing antibody escape performance, exhibits little cytotoxicity and is outstandingly stable even when subjected to iron ion processing at low concentration, and hence can be used to advantage in recombinant viral vaccine compositions.
摘要翻译： 本发明涉及使用铁离子/病毒载体复合物的细胞内病毒载体递送方法。 根据本发明的铁离子/病毒载体复合物不依赖于CAR的表达，因此提高病毒载体的传递效率和在不同类型的细胞中的基因表达，并且具有优异的病毒中和抗体逃逸性能， 表现出很小的细胞毒性，即使在低浓度下进行铁离子处理也显着稳定，因此可用于重组病毒疫苗组合物中。
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6.发明申请INTRACELLULAR VIRAL VECTOR DELIVERY METHOD EMPLOYING IRON ION/VIRAL VECTOR COMPOSITE 有权使用铁离子/病毒载体复合材料的细胞内载体递送方法公开(公告)号：US20120183573A1
公开(公告)日：2012-07-19
申请号：US13499101
申请日：2010-09-28
申请人： Young Chul Sung , Sang Hoon Park , Ki Seok Park
发明人： Young Chul Sung , Sang Hoon Park , Ki Seok Park
IPC分类号： A61K39/385 , C12N15/86 , C12N15/867 , C12N15/864 , C12N15/863 , A61P31/12 , C12N15/861
CPC分类号： C12N15/86 , C12N15/00 , C12N15/63 , C12N15/861 , C12N15/863 , C12N15/8636 , C12N15/864 , C12N15/867 , C12N2710/10343 , C12N2710/10345 , C12N2810/10
摘要： The present invention relates to an intracellular viral vector delivery method employing an iron ion/viral vector composite. The iron ion/viral vector composite according to the present invention is not dependent on the expression of CAR and so improves the efficiency of delivery of viral vectors and gene expression in cells of diverse types, and has an outstanding virus-neutralizing antibody escape performance, exhibits little cytotoxicity and is outstandingly stable even when subjected to iron ion processing at low concentration, and hence can be used to advantage in recombinant viral vaccine compositions.
摘要翻译： 本发明涉及使用铁离子/病毒载体复合物的细胞内病毒载体递送方法。 根据本发明的铁离子/病毒载体复合物不依赖于CAR的表达，因此提高病毒载体的传递效率和在不同类型的细胞中的基因表达，并且具有优异的病毒中和抗体逃逸性能， 表现出很小的细胞毒性，即使在低浓度下进行铁离子处理也显着稳定，因此可用于重组病毒疫苗组合物中。
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7.发明申请公开(公告)号：US20110124343A1
公开(公告)日：2011-05-26
申请号：US12907467
申请日：2010-10-19
申请人： Young Jun HONG , Tae Soo Kwon , Chang Yong Shin , Kyung Hun Jang , Hee Jung Yu , Hak Soo Kim , Yong Hoon Lee , Young Chul Sung
发明人： Young Jun HONG , Tae Soo Kwon , Chang Yong Shin , Kyung Hun Jang , Hee Jung Yu , Hak Soo Kim , Yong Hoon Lee , Young Chul Sung
IPC分类号： H04W16/00
CPC分类号： H04W16/06 , H04W16/08 , H04W16/10 , H04W16/32 , H04W52/244 , H04W72/082
摘要： Provided is a method, and an apparatus and communication system to perform the method, of detecting a victim terminal and performing an interference coordination in a multi-cell environment. The multi-cell environment may include a heterogeneous cell environment including a small cell and a macro cell. The method includes determining whether a macro terminal is located within a cell coverage of a small base station, and adjusting the cell coverage according to the determination.
摘要翻译： 提供了一种执行该方法的方法和装置和通信系统，用于检测受害终端并在多小区环境中执行干扰协调。 多小区环境可以包括包括小小区和宏小区的异构小区环境。 该方法包括：确定宏终端是否位于小型基站的小区覆盖范围内，以及根据确定调整小区覆盖。
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8.发明授权Method and apparatus of controlling inter cell interference based on cooperation of intra cell terminals 有权基于内部小区终端协同控制小区间干扰的方法和装置公开(公告)号：US08412104B2
公开(公告)日：2013-04-02
申请号：US13157181
申请日：2011-06-09
申请人： Won Jae Shin , Cheul Soon Kim , Chang Yong Shin , Won Jong Noh , Hyun Ho Choi , Young Chul Sung , Yong Hoon Lee
发明人： Won Jae Shin , Cheul Soon Kim , Chang Yong Shin , Won Jong Noh , Hyun Ho Choi , Young Chul Sung , Yong Hoon Lee
CPC分类号： H04W28/04 , H04W8/24 , H04W28/06 , H04W72/046 , H04W92/18
摘要： Provided is a method and apparatus for controlling inter cell interference based on cooperation between intra cell terminals. The intra cell terminals may exchange interference channel information, and may determine a receive beamforming vector based on the exchanged interference channel information. At least one intra cell terminal may feed back, to a neighboring cell base station, information associated with an effective interference channel using the receive beamforming vector. A base station may determine a transmit beamforming vector based on information associated with an effective interference channel using receive beamforming vectors of neighboring cell terminals that are received from at least one neighboring cell terminal.
摘要翻译： 提供了一种基于小区内终端之间的协作来控制小区间干扰的方法和装置。 内部小区终端可以交换干扰信道信息，并且可以基于所交换的干扰信道信息来确定接收波束形成向量。 至少一个小区内终端可以使用接收波束形成向量向相邻小区基站反馈与有效干扰信道相关联的信息。 基站可以使用从至少一个相邻小区终端接收的相邻小区终端的接收波束成形向量，基于与有效干扰信道相关联的信息来确定发射波束形成向量。
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公开(公告)号：US20060223144A1
公开(公告)日：2006-10-05
申请号：US10595200
申请日：2004-09-24
申请人： Se Hwan Yang , Young Chul Sung , Kyu-Heum Na , Sung Hee Lee , Won Bae Kim
发明人： Se Hwan Yang , Young Chul Sung , Kyu-Heum Na , Sung Hee Lee , Won Bae Kim
CPC分类号： A61K38/44 , A61K38/00 , A61K48/00 , C07K14/59 , C12N15/85 , C12N2840/203 , C12Y105/01003
摘要： The present invention relates to a method for mass-production of human follicle stimulating hormone, more precisely, to an expression vector containing human follicle stimulating hormone gene, a transformant transfected with the expression vector and a method for mass-production of human follicle stimulating hormone by using the same. Human follicle stimulating hormone can be produced largely by using an expression vector and a transformant of the present invention. Therefore the expression vector and the transformant of the present invention can be effectively used for the treatment of infertility.
摘要翻译： 本发明涉及一种批量生产人卵泡刺激素的方法，更确切地说，涉及含有人促卵泡激素基因的表达载体，用表达载体转染的转化体和大量生产人卵泡刺激素的方法 通过使用相同。 可以通过使用本发明的表达载体和转化体大量产生人类促卵泡激素。 因此，本发明的表达载体和转化体可以有效地用于治疗不育症。
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10.发明授权Communication system of detecting victim terminal and performing interference coordination in multi-cell environments 有权检测受害终端的通信系统，并在多小区环境中执行干扰协调公开(公告)号：US08737921B2
公开(公告)日：2014-05-27
申请号：US12907467
申请日：2010-10-19
申请人： Young Jun Hong , Tae Soo Kwon , Chang Yong Shin , Kyung Hun Jang , Hee Jung Yu , Hak Soo Kim , Yong Hoon Lee , Young Chul Sung
发明人： Young Jun Hong , Tae Soo Kwon , Chang Yong Shin , Kyung Hun Jang , Hee Jung Yu , Hak Soo Kim , Yong Hoon Lee , Young Chul Sung
CPC分类号： H04W16/06 , H04W16/08 , H04W16/10 , H04W16/32 , H04W52/244 , H04W72/082
摘要： Provided is a method, and an apparatus and communication system to perform the method, of detecting a victim terminal and performing an interference coordination in a multi-cell environment. The multi-cell environment may include a heterogeneous cell environment including a small cell and a macro cell. The method includes determining whether a macro terminal is located within a cell coverage of a small base station, and adjusting the cell coverage according to the determination.
摘要翻译： 提供了一种执行该方法的方法和装置和通信系统，用于检测受害终端并在多小区环境中执行干扰协调。 多小区环境可以包括包括小小区和宏小区的异构小区环境。 该方法包括：确定宏终端是否位于小型基站的小区覆盖范围内，以及根据确定调整小区覆盖。
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