公开(公告)号：US09314749B2

公开(公告)日：2016-04-19

申请号：US13639814

申请日：2011-03-28

申请人： Takanobu Yagi ,  Young Kwang Park ,  Mitsuo Umezu

发明人： Takanobu Yagi ,  Young Kwang Park ,  Mitsuo Umezu

IPC分类号： A61M37/00 ,  B01F5/00 ,  A61J1/20 ,  A61M5/145 ,  A61M5/168 ,  B01F3/08 ,  A61M5/00 ,  A61M39/22

CPC分类号： B01F5/0068 ,  A61J1/20 ,  A61K49/005 ,  A61K49/0071 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/16827 ,  A61M5/19 ,  A61M39/223 ,  A61M2206/16 ,  B01F3/0865 ,  B01F5/0057 ,  B01F2215/0032

摘要： To provide a mixing device, a mixing tube, a drug solution injecting system, and a drug solution mixing method capable of evenly and efficiently mixing a plurality of kinds of drug solutions. The mixing device according to the present invention includes: a swirling flow generating chamber; a first inflow opening for introducing a first drug solution into the swirling flow generating chamber in a direction parallel to a central axis of the swirling flow; a second inflow opening for introducing a second drug solution into the swirling flow generating chamber so as to generate a swirling flow of the second drug solution having a specific gravity lower than that of the first drug solution; an outflow opening for discharging a mixed drug solution; and a narrowing chamber which is interposed between the swirling flow generating chamber and the outflow opening and has a space continuously narrowed toward the outflow opening.

摘要翻译： 提供能够均匀有效地混合多种药物溶液的混合装置，混合管，药液注射系统和药物溶液混合方法。 根据本发明的混合装置包括：旋流产生室; 第一流入开口，用于将第一药液沿平行于旋流的中心轴的方向引入旋流产生室; 第二流入口，用于将第二药液引入旋流产生室，以产生比第一药物溶液的比重低的第二药液的旋流; 用于排出混合药液的流出口; 以及狭窄室，其设置在旋流产生室和流出口之间，并且具有朝向流出开口连续变窄的空间。

公开(公告)号：US20130028841A1

公开(公告)日：2013-01-31

申请号：US13639814

申请日：2011-03-28

申请人： Takanobu Yagi ,  Young Kwang Park ,  Mitsuo Umezu

发明人： Takanobu Yagi ,  Young Kwang Park ,  Mitsuo Umezu

IPC分类号： B01F5/04 ,  A61B6/00 ,  A61K49/00

CPC分类号： B01F5/0068 ,  A61J1/20 ,  A61K49/005 ,  A61K49/0071 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/16827 ,  A61M5/19 ,  A61M39/223 ,  A61M2206/16 ,  B01F3/0865 ,  B01F5/0057 ,  B01F2215/0032

摘要： To provide a mixing device, a mixing tube, a drug solution injecting system, and a drug solution mixing method capable of evenly and efficiently mixing a plurality of kinds of drug solutions. The mixing device according to the present invention includes: a swirling flow generating chamber; a first inflow opening for introducing a first drug solution into the swirling flow generating chamber in a direction parallel to a central axis of the swirling flow; a second inflow opening for introducing a second drug solution into the swirling flow generating chamber so as to generate a swirling flow of the second drug solution having a specific gravity lower than that of the first drug solution; an outflow opening for discharging a mixed drug solution; and a narrowing chamber which is interposed between the swirling flow generating chamber and the outflow opening and has a space continuously narrowed toward the outflow opening.

摘要翻译： 提供能够均匀有效地混合多种药物溶液的混合装置，混合管，药液注射系统和药物溶液混合方法。 根据本发明的混合装置包括：旋流产生室; 第一流入开口，用于将第一药液沿平行于旋流的中心轴的方向引入旋流产生室; 第二流入口，用于将第二药液引入旋流产生室，以产生比第一药物溶液的比重低的第二药液的旋流; 用于排出混合药液的流出口; 以及狭窄室，其设置在旋流产生室和流出口之间，并且具有朝向流出开口连续变窄的空间。

公开(公告)号：US20120040323A1

公开(公告)日：2012-02-16

申请号：US13257610

申请日：2009-03-20

申请人： Young Kwang Park ,  Mitsuo Umezu

发明人： Young Kwang Park ,  Mitsuo Umezu

IPC分类号： G09B23/28 ,  B23P11/00

CPC分类号： G09B23/30 ,  G09B23/303 ,  Y10T29/49826

摘要： A blood vessel model for medical training not deforming with time and approximated to a real blood vessel without using any other tool when the blood vessel wall of the simulated blood vessel is incised or cut off. The blood vessel model 10 includes a simulated blood vessel 11 simulating a blood vessel and artificially fabricated and a base 12 supporting the simulated blood vessel 11. The simulated blood vessel 11 has a circumferentially exposed part and the other part buried in the base 12. The base 12 has a jointed part 24 disposed in a position below the simulated blood vessel 11 and formed by joining forming edges 26A, 26A of a cutout 26 extending along the simulated blood vessel 11 to impart a tensile stress in the diameter-increasing direction to the simulated blood vessel 11.

摘要翻译： 用于医疗训练的血管模型，当模拟血管的血管壁切开或切断时，不随时间变形并且近似于真实血管而不使用任何其它工具。 血管模型10包括模拟血管并人工制造的模拟血管11和支撑模拟血管11的基部12.模拟血管11具有周向暴露部分，另一部分埋在基部12中。 底座12具有设置在模拟血管11下方的位置处的接合部分24，并且通过连接沿着模拟血管11延伸的切口26的成形边缘26A，26A形成，以在直径增加方向上施加拉伸应力 模拟血管11。

公开(公告)号：US08469717B2

公开(公告)日：2013-06-25

申请号：US13257610

申请日：2009-03-20

申请人： Young Kwang Park ,  Mitsuo Umezu

发明人： Young Kwang Park ,  Mitsuo Umezu

IPC分类号： G09B23/28

CPC分类号： G09B23/30 ,  G09B23/303 ,  Y10T29/49826

摘要： A blood vessel model for medical training not deforming with time and approximated to a real blood vessel without using any other tool when the blood vessel wall of the simulated blood vessel is incised or cut off. The blood vessel model 10 includes a simulated blood vessel 11 simulating a blood vessel and artificially fabricated and a base 12 supporting the simulated blood vessel 11. The simulated blood vessel 11 has a circumferentially exposed part and the other part buried in the base 12. The base 12 has a jointed part 24 disposed in a position below the simulated blood vessel 11 and formed by joining forming edges 26A, 26A of a cutout 26 extending along the simulated blood vessel 11 to impart a tensile stress in the diameter-increasing direction to the simulated blood vessel 11.

摘要翻译： 用于医疗训练的血管模型，当模拟血管的血管壁切开或切断时，不随时间变形并且近似于真实血管而不使用任何其它工具。 血管模型10包括模拟血管并人工制造的模拟血管11和支撑模拟血管11的基部12.模拟血管11具有周向暴露部分，另一部分埋在基部12中。 底座12具有设置在模拟血管11下方的位置处的接合部分24，并且通过连接沿着模拟血管11延伸的切口26的成形边缘26A，26A形成，以在直径增加方向上施加拉伸应力 模拟血管11。

公开(公告)号：US20110217684A1

公开(公告)日：2011-09-08

申请号：US12921462

申请日：2007-03-02

申请人： Young Kwang Park ,  Yasuyuki Shiraishi ,  Mitsuo Umezu

发明人： Young Kwang Park ,  Yasuyuki Shiraishi ,  Mitsuo Umezu

IPC分类号： G09B23/30

CPC分类号： G09B23/285 ,  A61B2017/00716

摘要： A system for evaluating training 1 comprises a pulsating flow generating unit 11 for imparting a pulsating flow to a designated fluid, a coronary artery flow generating unit 12 that branches off from that pulsating flow generating unit 11 and by which a flow condition of that pulsating flow can be converted to generate a coronary artery flow, and a surgery training unit 13 provided between the pulsating flow generating unit 11 and the coronary artery flow generating unit 12 and that operates to enable coronary artery bypass surgery training under pulsation. This system for evaluating training 1 has a circuit configured to enable the coronary artery flow fluid generated by the coronary artery flow generating unit 12 to pass through a simulated blood vessel that has been subjected to a designated treatment in training using the surgery training unit 13.

摘要翻译： 用于评估训练1的系统包括用于向指定流体施加脉动流的脉动流产生单元11，从该脉动流产生单元11分支的冠状动脉流产生单元12，并且通过该脉动流 可以转换为产生冠状动脉血流，以及设置在脉动流产生单元11和冠状动脉血流产生单元12之间的手术训练单元13，其操作以在脉动下进行冠状动脉旁路手术训练。 用于评估训练1的系统具有电路，该电路构造成能够使冠状动脉血流产生单元12产生的冠状动脉流动流体通过使用手术训练单元13的训练中经受指定治疗的模拟血管。

公开(公告)号：US08636520B2

公开(公告)日：2014-01-28

申请号：US13003922

申请日：2009-01-28

申请人： Kiyotaka Iwasaki ,  Mitsuo Umezu ,  Takashi Tanaka

发明人： Kiyotaka Iwasaki ,  Mitsuo Umezu ,  Takashi Tanaka

IPC分类号： G09B23/28

CPC分类号： G09B23/288 ,  G09B23/30

摘要： Disclosed is a method whereby a narrowed part similar to an actual lesioned blood vessel can be easily obtained. A mold (10) comprises first and second molded members (16, 17) having inner spaces (29, 40, 57) passing through in the axial direction and an axial member (18) detachably inserted through the individual inner spaces (29, 40, 57) of the individual molded members (16, 17). The molded members (16, 17) have tapered front parts (27, 27) respectively. In the state of facing the front ends (20) of the tapered front parts (27) to each other and thus forming a concave (12), the axial member (18) is attached. A first material (75) made of a mixed material comprising calcium carbonate or the like and silicone or the like is applied to the concave (12). A second material (76) such as silicone is applied to the entire outer periphery of the mold (10). After hardening the materials (75, 76), the mold (10) is withdrawn by detaching the axial member (18) and dividing the concave (12). Thus, a simulated blood vessel (78) having a simulated narrowed part of the blood vessel caused by calcification can be obtained.

摘要翻译： 公开了可以容易地获得与实际损伤的血管类似的变窄部分的方法。 模具（10）包括具有沿轴向通过的内部空间（29,40,57）的第一和第二模制构件（16,17），以及可拆卸地插入穿过各个内部空间（29,40）的轴向构件 ，57）各个模制构件（16,17）。 模制构件（16,17）分别具有锥形前部（27,27）。 在将锥形前部（27）的前端（20）彼此面对并因此形成凹部（12）的状态下，安装轴向构件（18）。 由包含碳酸钙等的混合材料和硅树脂等制成的第一材料（75）施加到凹部（12）上。 将诸如硅树脂的第二材料（76）施加到模具（10）的整个外周。 在硬化材料（75,76）之后，通过拆卸轴向构件（18）并分开凹部（12）来撤回模具（10）。 因此，可以获得由钙化引起的具有模拟的血管狭窄部分的模拟血管（78）。

公开(公告)号：US5458468A

公开(公告)日：1995-10-17

申请号：US218153

申请日：1994-03-25

申请人： Chun-Xia Ye ,  Mitsuo Umezu ,  Allen H. Nugent

发明人： Chun-Xia Ye ,  Mitsuo Umezu ,  Allen H. Nugent

IPC分类号： F04B43/02 ,  A61F2/24 ,  A61M1/10 ,  F04B43/06 ,  F04B53/10

CPC分类号： F04B43/06 ,  A61F2/2406 ,  A61M1/1037 ,  A61M1/1096 ,  F04B53/104 ,  A61M1/106

摘要： A pump (10) has a housing (11), a base (12) and a flexible diaphragm (13) between the housing and the base. The diaphragm (13) and the base (12) define a driving chamber and the diaphragm (13) and the housing (11) define a pump chamber. The driving chamber is coupled to a pump driver adapted to direct fluid to and from the driving chamber to drive the diaphragm. The pump chamber is of generally conical form with its outlet (21) being located at the apex of the conical pump chamber and the inlet (22) being disposed at an angle inclined to the plane of the base of the conical pump chamber and being generally tangential to the outer portion of the base of pump chamber such that flow through the pump chamber is in the form of a continuous spiral vortex.

摘要翻译： 泵（10）在壳体和基座之间具有壳体（11），基座（12）和柔性隔膜（13）。 隔膜（13）和底座（12）限定驱动室，隔膜（13）和壳体（11）限定泵室。 驱动室耦合到泵驱动器，该泵驱动器适于将流体引导到驱动室和从驱动室驱动隔膜。 泵室是大致锥形的，其出口（21）位于锥形泵室的顶点处，并且入口（22）以与锥形泵室的底部平面倾斜的角度设置，并且通常 与泵室的底部的外部部分相切，使得通过泵室的流动是连续螺旋涡流的形式。

公开(公告)号：US08043854B2

公开(公告)日：2011-10-25

申请号：US10556400

申请日：2004-05-12

申请人： Mitsuo Umezu ,  Kiyotaka Iwasaki ,  Shigeyuki Ozaki ,  Yuji Morimoto ,  Osamu Endo

发明人： Mitsuo Umezu ,  Kiyotaka Iwasaki ,  Shigeyuki Ozaki ,  Yuji Morimoto ,  Osamu Endo

IPC分类号： A01N1/00

CPC分类号： A61K35/34 ,  A61F2/2415 ,  Y10S623/901

摘要： In the transplant of a living organism tissue, such as a heart valve, taken from an animal, etc. into a human body, a cell removing solution for removing original cells from the living organism tissue is provided with flow approximately equal to the bloodstream of transplant recipient living body, and the living organism tissue is placed in the flow so as to effect immersion of the living organism tissue in the cell removing solution. In the immersion, it is preferred that the living organism tissue placed in the cell removing solution, while being rotated, be irradiated with microwave. As a result, original cells can be removed from the living organism tissue uniformly and reliably, so that the biocompatibility of living organism tissue after transplant can be enhanced.

摘要翻译： 在将从动物等取出的生物体组织如心脏瓣膜等移植到人体内时，从生物体组织中除去原始细胞的细胞去除溶液具有大约等于 移植受体活体，并将活体组织置于流中，以使活体组织浸入细胞去除溶液中。 在浸渍中，优选将放置在细胞去除溶液中的活体组织在旋转的同时用微波照射。 结果，原始细胞可以均匀可靠地从生物体组织中去除，从而可以提高移植后活体组织的生物相容性。

公开(公告)号：US20130173018A1

公开(公告)日：2013-07-04

申请号：US13823007

申请日：2011-09-14

申请人： Katsuhisa Sakaguchi ,  Tatsuya Shimizu ,  Hidekazu Sekine ,  Mitsuo Umezu ,  Teruo Okano

发明人： Katsuhisa Sakaguchi ,  Tatsuya Shimizu ,  Hidekazu Sekine ,  Mitsuo Umezu ,  Teruo Okano

IPC分类号： C12N5/071 ,  A61F2/02

CPC分类号： C12N5/0691 ,  A61F2/02 ,  C12M21/08 ,  C12M25/02 ,  C12N5/0657 ,  C12N2502/28 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/56

摘要： A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.

摘要翻译： 一种制造多层细胞片的方法，其特征在于制造血管床，其构建从用于灌注介质的通道延伸到所述表面的血管网络，所述通道嵌入凝胶中; 并将细胞片层压到血管床上以在细胞片中构建血管网络。 该制造方法使得可以在细胞片中构建血管网络并且通过分层细胞片以简单的方式制造厚的多层细胞片。 这种厚的多层细胞片可用作涉及各种组织的再生医学中的体内组织替代物。

公开(公告)号：US20100261262A1

公开(公告)日：2010-10-14

申请号：US12681049

申请日：2008-10-10

申请人： Kiyotaka Iwasaki ,  Mitsuo Umezu ,  Koji Kojima ,  Charles Alfred Vacanti

发明人： Kiyotaka Iwasaki ,  Mitsuo Umezu ,  Koji Kojima ,  Charles Alfred Vacanti

IPC分类号： A01N1/02

CPC分类号： A61F2/062 ,  C12M29/12 ,  C12M29/18 ,  C12M35/04 ,  C12M41/26

摘要： A system (10) for forming and maintaining a biological tissue by which a biological tissue can be artificially formed by culturing cells, which comprises a pulse pump (12), a circulation pathway (13) having such a circuit structure as allowing a liquid cell culture medium discharged from the pulse pump (12) to return into the pulse pump (12), and a cell culture section (14A) and a gas exchange section (14B) provided along the circulation pathway (13). The cell culture section (14A) holds a cell holder (H) in such a manner to form a first channel wherein the liquid cell culture medium flowing in the circulation pathway (13) passes through the cell holder (H) and returns into the circulation pathway (13) and a second channel wherein the liquid cell culture medium flowing in the circulation pathway (13) passes outside the cell holder (H) and returns into the circulation pathway (13), thereby bringing about a difference in pressure between the liquid cell culture medium passing through the respective channels. The gas exchange section (14B) supplies a mixed gas containing oxygen and carbon oxide to the liquid cell culture medium circulating within the circulation pathway (13) and thus controls the pH value of the liquid cell culture medium at a definite level.

摘要翻译： 一种用于形成和维持生物组织的系统（10），通过该生物组织可以通过培养细胞人造地形成生物组织，所述系统包括脉冲泵（12），具有允许液体细胞的电路结构的循环通路（13） 从脉冲泵（12）排出的返回到脉冲泵（12）的培养基，沿着循环通路（13）设置的细胞培养部（14A）和气体交换部（14B）。 细胞培养部（14A）以形成第一通道的方式保持细胞保持器（H），其中在循环路径（13）中流动的液体细胞培养基通过细胞保持器（H）并返回循环 通路（13）和第二通道，其中在所述循环通路（13）中流动的液体细胞培养基通过所述细胞保持器（H）的外部并返回到所述循环通路（13）中，从而导致所述液体 通过相应通道的细胞培养基。 气体交换部（14B）将含有氧和碳氧化物的混合气体供给到在循环路径（13）内循环的液体细胞培养基，从而将液体细胞培养基的pH值控制在一定水平。