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    System, method and apparatus for capturing and processing call processing failures occurring at a telephone switch control processor
    1.
    发明授权
    System, method and apparatus for capturing and processing call processing failures occurring at a telephone switch control processor 失效

    公开(公告)号：US06975705B2

    公开(公告)日：2005-12-13

    申请号：US09746505

    申请日：2000-12-22

    申请人： Yuergen Boehmke ,  Kenneth L. Shepard

    发明人： Yuergen Boehmke ,  Kenneth L. Shepard

    IPC分类号： H04M3/22 ,  H04M3/24

    CPC分类号： H04M3/2218 ,  H04M3/241

    摘要： A system, method and apparatus is disclosed for capturing call processing failures in a telecommunication system occurring at a telecommunication switch control processor as the failures occur. The system includes a computing system adapted for communicating with the telecommunication system. The computing system includes one or more computers having one or more processors for executing logic instructions; a memory associated with the computing system for storing the instructions; a storage device adapted for communicating with the computing system for storing data; and a communication device associated with the computing system for establishing a communication link between the computing system and the telecommunication system. The logic instructions are executed by the computing system and cause the one or more processors to establish a communication link between the computing system and the telecommunication system; continually capture call processing failure data occurring at the telecommunication switch control processor; and store the captured call processing failure data to the storage device. The method includes establishing a communication link between a computing system and the telecommunication system; the computing system continually capturing call processing failure data occurring at the telecommunication switch control processor; and storing the captured call processing failure data to the storage device. The apparatus includes a computer adapted for communicating with the telecommunication system, the computer having one or more processors to execute logic instructions associated with one or more computer software programs and a memory for storing the logic instructions; a first adapter coupled to the computer for interfacing the computer to a server; a second adapter coupled to the computer for continually capturing call processing failure data at the telecommunication switch control processor; and a communication device coupled to the computer for establishing a communication link between the computer and the telecommunication system.

    System, method and apparatus for capturing and processing call processing failures occurring at a digital wireless switch
    2.
    发明授权
    System, method and apparatus for capturing and processing call processing failures occurring at a digital wireless switch 有权
    用于捕获和处理在数字无线交换机处发生的呼叫处理故障的系统，方法和装置

    公开(公告)号：US06788933B2

    公开(公告)日：2004-09-07

    申请号：US09746504

    申请日：2000-12-22

    申请人： Yuergen Boehmke ,  Kenneth L. Shepard

    发明人： Yuergen Boehmke ,  Kenneth L. Shepard

    IPC分类号： H04Q720

    CPC分类号： H04W24/00 ,  H04L12/1895 ,  H04L51/00

    摘要： A system, method and apparatus is disclosed for capturing call processing failures in a telecommunication system occurring at a telecommunication digital cellular switch as the failures occur. The system includes a computing system adapted for communicating with the telecommunication system, the computing system including one or more computers having one or more processors for executing logic instructions; a memory associated with the computing system for storing the instructions; a storage device adapted for communicating with the computing system for storing data; and a communication device associated with the computing system for establishing a communication link between the computing system and the telecommunication system. The method includes establishing a communication link between a computing system and the telecommunication system; the computing system continually capturing call processing failure data occurring at the telecommunication digital cellular switch; and storing the captured call processing failure data to the storage device. The apparatus includes a computer adapted for communicating with the telecommunication system, the computer having one or more processors to execute logic instructions associated with one or more computer software programs and a memory for storing the logic instructions; a first adapter coupled to the computer for interfacing the computer to a server; a second adapter coupled to the computer for continually capturing call processing failure data at the telecommunication digital cellular switch; and a communication device coupled to the computer for establishing a communication link between the computer and the telecommunication system.

    摘要翻译： 公开了一种系统，方法和装置，用于在发生故障时在电信数字蜂窝交换机处发生的电信系统中捕获呼叫处理故障。 该系统包括适于与电信系统进行通信的计算系统，所述计算系统包括具有用于执行逻辑指令的一个或多个处理器的一个或多个计算机; 与用于存储指令的计算系统相关联的存储器; 适于与所述计算系统进行通信以存储数据的存储装置; 以及与所述计算系统相关联的用于在所述计算系统和所述电信系统之间建立通信链路的通信设备。 该方法包括在计算系统和电信系统之间建立通信链路; 计算系统连续地捕获在电信数字蜂窝交换机处发生的呼叫处理失败数据; 并将所捕获的呼叫处理失败数据存储到存储装置。 该装置包括适于与电信系统通信的计算机，该计算机具有一个或多个处理器以执行与一个或多个计算机软件程序相关联的逻辑指令和用于存储逻辑指令的存储器; 耦合到计算机的第一适配器，用于将计算机连接到服务器; 耦合到所述计算机的第二适配器，用于在所述电信数字蜂窝交换机处不断地捕获呼叫处理失败数据; 以及耦合到所述计算机的通信设备，用于在所述计算机和所述电信系统之间建立通信链路。

    Systems and methods for a DNA-based thermometer
    3.
    发明授权
    Systems and methods for a DNA-based thermometer 有权
    基于DNA的温度计的系统和方法

    公开(公告)号：US09194801B2

    公开(公告)日：2015-11-24

    申请号：US13595106

    申请日：2012-08-27

    申请人： Kenneth L. Shepard ,  Ioannis Kymissis ,  Haig Norian

    发明人： Kenneth L. Shepard ,  Ioannis Kymissis ,  Haig Norian

    IPC分类号： G01N25/00 ,  G01N21/64 ,  B01J19/00 ,  G01K11/20

    CPC分类号： G01N21/6486 ,  B01J19/0046 ,  G01K11/20 ,  G01K2213/00 ,  G01N21/6428

    摘要： DNA-based temperature sensor for measuring temperature through a transition of one or more strands of DNA from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the DNA is in the coupled configuration, includes a receptacle adapted to receive the DNA and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a DNA-based temperature sensing solution are also provided.

    摘要翻译： 基于DNA的温度传感器，用于通过一个或多个DNA链从温度阈值的耦合配置转变为解耦配置来测量温度，以及当DNA处于耦合配置时适于发射荧光的荧光染料包括： 适于在溶液中接收DNA和荧光染料的容器，适于获取从溶液发射的荧光图像的成像装置，具有多个区域的图像，以及适于确定对应于多个区域的多个荧光水平的处理器 每个图像的多个区域，并且基于所确定的荧光水平生成温度图。 还提供了一种测量温度的方法和基于DNA的温度感测解决方案。

    Active CMOS Sensor Array For Electrochemical Biomolecular Detection
    4.
    发明申请
    Active CMOS Sensor Array For Electrochemical Biomolecular Detection 审中-公开
    有源CMOS传感器阵列用于电化学生物分子检测

    公开(公告)号：US20100300899A1

    公开(公告)日：2010-12-02

    申请号：US12819720

    申请日：2010-06-21

    申请人： Peter M. Levine ,  Kenneth L. Shepard ,  Ping Gong ,  Levicky Rastislav

    发明人： Peter M. Levine ,  Kenneth L. Shepard ,  Ping Gong ,  Levicky Rastislav

    IPC分类号： G01N27/26 ,  G01N27/28 ,  H01L21/30

    CPC分类号： G01N27/3277 ,  C12Q1/6825 ,  G01N27/48 ,  H01L23/5226 ,  H01L23/5283 ,  H01L23/53261

    摘要： Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time.

    摘要翻译： 生物分子的电化学感测消除了对传统基于荧光的感测测定中所需的庞大的光学仪器的需要。 传感器接口电极和主动电化学检测电路在CMOS基板上的集成使传感平台小型化，增强了点对点应用的便携性，同时实现了高吞吐量，高度平行的分析。 一个实施例包括用于在标准0.25μmCMOS工艺中多路复用电化学生物分子检测的四乘四活性传感器阵列。 集成的恒电位仪，包括控制放大器和双斜率ADC，可激发电化学电池，并检测流经芯片表面上生物分子反应的每个传感器位置的片上金电极的电流。 描述了用于在CMOS中制造可承受恶劣电化学环境中的操作的生物相容的表面电极阵列的后处理技术。 显示用于生物分子检测的有源CMOS阵列的示例操作的演示包括可逆氧化还原物质的循环伏安法，DNA探针密度表征和实时定量和特异性DNA杂交检测。

    Active CMOS biosensor chip for fluorescent-based detection
    5.
    发明授权
    Active CMOS biosensor chip for fluorescent-based detection 有权
    有源CMOS生物传感器芯片，用于荧光检测

    公开(公告)号：US07738086B2

    公开(公告)日：2010-06-15

    申请号：US11800468

    申请日：2007-05-04

    申请人： Kenneth L. Shepard ,  Rastislav Levicky ,  George Patounakis

    发明人： Kenneth L. Shepard ,  Rastislav Levicky ,  George Patounakis

    IPC分类号： G01N21/00

    CPC分类号： H04N5/37452 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6454 ,  H01L27/14621 ,  H01L27/14643

    摘要： An active CMOS biosensor chip for fluorescent-based detection is provided that enables time-gated, time-resolved fluorescence spectroscopy. In one embodiment, analytes are loaded with fluorophores that are bound to probe molecules immobilized on the surface of the chip. Photodiodes and other circuitry in the chip are used to measure the fluorescent intensity of the fluorophore at different times. These measurements are then averaged to generate a representation of the transient fluorescent decay response unique to the fluorophores. In addition to its low-cost, compact form, the biosensor chip provides capabilities beyond those of macroscopic instrumentation by enabling time-gated operation for background rejection, easing requirements on optical filters, and by characterizing fluorescence lifetime, allowing for a more detailed characterization of fluorophore labels and their environment. The biosensor chip can be used for a variety of applications including biological, medical, in-the-field applications, and fluorescent lifetime imaging applications.

    摘要翻译： 提供了用于基于荧光的检测的有源CMOS生物传感器芯片，其能够进行时间选择的时间分辨荧光光谱。 在一个实施方案中，分析物载有与固定在芯片表面上的探针分子结合的荧光团。 芯片中的光电二极管和其他电路用于在不同时间测量荧光团的荧光强度。 然后对这些测量进行平均以产生荧光团特有的瞬态荧光衰变响应的表示。 除了其低成本，紧凑的形式之外，生物传感器芯片通过实现背景抑制的时间门控操作，对光学滤波器的放宽要求以及通过表征荧光寿命来提供超出宏观仪器的功能，允许更详细的表征 荧光标签及其环境。 生物传感器芯片可用于各种应用，包括生物，医学，现场应用和荧光寿命成像应用。

    Imino-bridged benzocycloheptapyridines
    10.
    发明授权
    Imino-bridged benzocycloheptapyridines 失效
    亚氨基桥接的苯并环庚啶

    公开(公告)号：US4229455A

    公开(公告)日：1980-10-21

    申请号：US952354

    申请日：1978-10-18

    申请人： Kenneth L. Shepard ,  Wasyl Halczenko

    发明人： Kenneth L. Shepard ,  Wasyl Halczenko

    IPC分类号： C07D471/04 ,  C07D471/08 ,  A61K31/44

    CPC分类号： C07D471/04 ,  Y10S514/906

    摘要： Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.

    摘要翻译： 在环庚烷环中具有亚胺桥的苯并环庚三烯类，其衍生物和药学上可接受的盐可用作抗焦虑剂，作为肌肉松弛剂和用于治疗锥体外系疾病如帕金森氏病。