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    Active CMOS Sensor Array For Electrochemical Biomolecular Detection
    1.
    发明申请
    Active CMOS Sensor Array For Electrochemical Biomolecular Detection 审中-公开
    有源CMOS传感器阵列用于电化学生物分子检测

    公开(公告)号：US20100300899A1

    公开(公告)日：2010-12-02

    申请号：US12819720

    申请日：2010-06-21

    申请人： Peter M. Levine ,  Kenneth L. Shepard ,  Ping Gong ,  Levicky Rastislav

    发明人： Peter M. Levine ,  Kenneth L. Shepard ,  Ping Gong ,  Levicky Rastislav

    IPC分类号： G01N27/26 ,  G01N27/28 ,  H01L21/30

    CPC分类号： G01N27/3277 ,  C12Q1/6825 ,  G01N27/48 ,  H01L23/5226 ,  H01L23/5283 ,  H01L23/53261

    摘要： Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-μm CMOS process. Integrated potentiostats, including control amplifiers and dual-slope ADCs, stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site resulting from biomolecular reactions occurring on the chip surface. Post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand operation in harsh electrochemical environments are described. Demonstrations showing example operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, and quantitative and specific DNA hybridization detection in real time.

    摘要翻译： 生物分子的电化学感测消除了对传统基于荧光的感测测定中所需的庞大的光学仪器的需要。 传感器接口电极和主动电化学检测电路在CMOS基板上的集成使传感平台小型化，增强了点对点应用的便携性，同时实现了高吞吐量，高度平行的分析。 一个实施例包括用于在标准0.25μmCMOS工艺中多路复用电化学生物分子检测的四乘四活性传感器阵列。 集成的恒电位仪，包括控制放大器和双斜率ADC，可激发电化学电池，并检测流经芯片表面上生物分子反应的每个传感器位置的片上金电极的电流。 描述了用于在CMOS中制造可承受恶劣电化学环境中的操作的生物相容的表面电极阵列的后处理技术。 显示用于生物分子检测的有源CMOS阵列的示例操作的演示包括可逆氧化还原物质的循环伏安法，DNA探针密度表征和实时定量和特异性DNA杂交检测。

    5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof
    3.
    发明申请
    5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof 失效
    5-羟基吲哚-3-羧酸酯衍生物及其用途

    公开(公告)号：US20080249155A1

    公开(公告)日：2008-10-09

    申请号：US10592619

    申请日：2005-03-11

    申请人： Ping Gong ,  Yanfang Zhao

    发明人： Ping Gong ,  Yanfang Zhao

    IPC分类号： A61K31/404 ,  A61P31/16 ,  C07D209/04

    CPC分类号： C07D209/42

    摘要： The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).

    摘要翻译： 本发明涉及式I的5-羟基 - 吲哚-3-羧酸酯衍生物，或外消旋混合物或光学异构体或其药学上可接受的盐和/或水合物，其中：取代基R 1， SUB 2，Z，X和Y如说明书中所定义。 式I化合物可用于制备用于治疗和/或预防病毒感染的药物，特别是用于制备用于抗HBV（乙型肝炎病毒）和抗HIV（人类免疫缺陷病毒）的药物。

    Client connection device for UPS system
    4.
    发明授权
    Client connection device for UPS system 有权
    UPS系统的客户端连接装置

    公开(公告)号：US09049796B2

    公开(公告)日：2015-06-02

    申请号：US13415301

    申请日：2012-03-08

    申请人： Hongjie Qiu ,  Ping Gong

    发明人： Hongjie Qiu ,  Ping Gong

    IPC分类号： H02B1/26 ,  H05K7/14

    CPC分类号： H05K7/1457

    摘要： A client connection device for a UPS system includes a frame on which a main input distribution unit, a bypass input distribution unit, a battery distribution unit, and an output distribution unit are provided, in which the main input distribution unit and the bypass input distribution unit are arranged on the frame with being opposite to each other up and down, the output distribution unit and the battery distribution unit are arranged on the frame on different sides of the main input distribution unit and the bypass input distribution unit, and the battery distribution unit is side placed near the main input distribution unit and the bypass input distribution unit. A client connection device for a UPS system is provided which can be of a compact structure, be space saving, and be convenient for space operation.

    摘要翻译： 用于UPS系统的客户端连接装置包括一个框架，主框架设有主输入分配单元，旁路输入分配单元，电池分配单元和输出分配单元，其中主输入分配单元和旁路输入分布 单元布置在框架上彼此上下相对，输出分配单元和电池分配单元布置在主输入分配单元和旁路输入分配单元的不同侧上的框架上，并且电池分布 单元侧面放置在主输入分配单元和旁路输入分配单元附近。 提供一种用于UPS系统的客户端连接装置，其结构紧凑，节省空间，方便空间操作。

    CLIENT CONNECTION DEVICE FOR UPS SYSTEM
    5.
    发明申请
    CLIENT CONNECTION DEVICE FOR UPS SYSTEM 有权
    用于UPS系统的客户端连接装置

    公开(公告)号：US20120250236A1

    公开(公告)日：2012-10-04

    申请号：US13415301

    申请日：2012-03-08

    申请人： Hongjie Qiu ,  Ping Gong

    发明人： Hongjie Qiu ,  Ping Gong

    IPC分类号： H05K7/00

    CPC分类号： H05K7/1457

    摘要： A client connection device for a UPS system includes a frame on which a main input distribution unit, a bypass input distribution unit, a battery distribution unit, and an output distribution unit are provided, in which the main input distribution unit and the bypass input distribution unit are arranged on the frame with being opposite to each other up and down, the output distribution unit and the battery distribution unit are arranged on the frame on different sides of the main input distribution unit and the bypass input distribution unit, and the battery distribution unit is side placed near the main input distribution unit and the bypass input distribution unit. A client connection device for a UPS system is provided which can be of a compact structure, be space saving, and be convenient for space operation.

    摘要翻译： 用于UPS系统的客户端连接装置包括一个框架，主框架设有主输入分配单元，旁路输入分配单元，电池分配单元和输出分配单元，其中主输入分配单元和旁路输入分布 单元布置在框架上彼此上下相对，输出分配单元和电池分配单元布置在主输入分配单元和旁路输入分配单元的不同侧上的框架上，并且电池分布 单元侧面放置在主输入分配单元和旁路输入分配单元附近。 提供一种用于UPS系统的客户端连接装置，其结构紧凑，节省空间，方便空间操作。

    5-hydroxyindole-3-carboxylate derivatives and uses thereof
    7.
    发明授权
    5-hydroxyindole-3-carboxylate derivatives and uses thereof 失效
    5-羟基吲哚-3-羧酸酯衍生物及其用途

    公开(公告)号：US07960427B2

    公开(公告)日：2011-06-14

    申请号：US10592619

    申请日：2005-03-11

    申请人： Ping Gong ,  Yanfang Zhao

    发明人： Ping Gong ,  Yanfang Zhao

    IPC分类号： A61K31/40 ,  C07D209/42

    CPC分类号： C07D209/42

    摘要： The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R1, R2, Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).

    摘要翻译： 本发明涉及式I的5-羟基 - 吲哚-3-羧酸酯衍生物或其外消旋混合物或光学异构体或其药学上可接受的盐和/或水合物，其中：取代基R 1，R 2，Z，X和Y如上所定义 在说明中。 式I化合物可用于制备用于治疗和/或预防病毒感染的药物，特别是用于制备用于抗HBV（乙型肝炎病毒）和抗HIV（人类免疫缺陷病毒）的药物。