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公开(公告)号：US20110104232A1
公开(公告)日：2011-05-05
申请号：US13006586
申请日：2011-01-14
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
IPC分类号： A61K31/665 , A61K9/70 , A61K35/12 , A61P17/02 , A61P19/00
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译： 公开了制备控释组合物的新方法。 具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。 还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。
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公开(公告)号：US08197838B2
公开(公告)日：2012-06-12
申请号：US13006586
申请日：2011-01-14
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
IPC分类号： A61K31/665 , A61K9/70 , A61K35/12 , A61P17/02 , A61P19/00
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译： 公开了制备控释组合物的新方法。 具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。 还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。
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公开(公告)号：US08034363B2
公开(公告)日：2011-10-11
申请号：US12332414
申请日：2008-12-11
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译： 公开了制备控释组合物的新方法。 具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。 还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。
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公开(公告)号：US20100150981A1
公开(公告)日：2010-06-17
申请号：US12332414
申请日：2008-12-11
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译： 公开了制备控释组合物的新方法。 具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。 还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。
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公开(公告)号：US20100268335A1
公开(公告)日：2010-10-21
申请号：US12761601
申请日：2010-04-16
申请人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong , Jeannette Chantalat , Michael Southall
发明人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong , Jeannette Chantalat , Michael Southall
CPC分类号： A61L15/18 , A61B17/06066 , A61B17/06166 , A61B17/064 , A61B2017/00884 , A61B2017/00889 , A61L15/42 , A61L26/0004 , A61L26/0066 , A61L27/306 , A61L27/50 , A61L29/106 , A61L29/14 , A61L31/088 , A61L31/14 , A61L2300/404 , A61N1/205 , A61N1/303 , Y10T428/256 , Y10T428/2982
摘要： Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting.
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公开(公告)号：US07927676B2
公开(公告)日：2011-04-19
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译： 提供具有围绕它们设置聚合物泡沫的血管闭塞装置。 用等离子体处理聚合物以促进血栓形成。 还提供了制造和使用这种装置的方法。 优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。
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公开(公告)号：US20100249927A1
公开(公告)日：2010-09-30
申请号：US12731848
申请日：2010-03-25
申请人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong
发明人： Chunlin Yang , Ying Sun , Frank R. Cichocki, JR. , Saumen N. Bar , James E. Hauschild , Uri Herzberg , Yufu Li , Xintian Ming , Wei Kong
CPC分类号： A61L27/306 , A61L27/52 , A61L27/54 , A61L29/106 , A61L29/14 , A61L29/16 , A61L31/088 , A61L31/145 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/606 , A61L2300/622 , A61L2420/04 , Y10T428/256
摘要： Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting.
摘要翻译： 公开了具有电偶颗粒的可植入医疗装置。 颗粒可以涂覆在医疗装置的表面的至少一部分上。 此外，电化学颗粒可以包含在用于制造抗微生物医疗装置的材料中，或者可以嵌入医疗装置的表面中。 本发明还提供了新的涂布方法和加工方法。 该装置可具有促进抗微生物，消炎和组织再生的有利特征和作用。
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公开(公告)号：US20070239205A1
公开(公告)日：2007-10-11
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Davis , Darren Sherman
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译： 提供具有围绕它们设置聚合物泡沫的血管闭塞装置。 用等离子体处理聚合物以促进血栓形成。 还提供了制造和使用这种装置的方法。 优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。
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公开(公告)号：US10213195B2
公开(公告)日：2019-02-26
申请号：US12777922
申请日：2010-05-11
申请人： Joseph H. Contiliano , Yufu Li , Zhigang Li
发明人： Joseph H. Contiliano , Yufu Li , Zhigang Li
摘要： The present invention provides a fixation device that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the fixation device within tissue and securing the fixation device in the tissue once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, and includes at least one anti-rotational member integral therewith, Fixation device kits utilizing the fixation device, and methods of fixation in tissue are also provided.
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公开(公告)号：US09849220B2
公开(公告)日：2017-12-26
申请号：US13124532
申请日：2009-10-16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/406 , A61L2300/608 , A61L2420/08 , C08L67/04
摘要： An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug which is highly soluble in water, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.
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