公开(公告)号：US20070105143A1

公开(公告)日：2007-05-10

申请号：US11592338

申请日：2006-11-03

申请人： Katsumi Fujimoto ,  Mei Shin ,  Yukio Kato

发明人： Katsumi Fujimoto ,  Mei Shin ,  Yukio Kato

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C07K14/4702 ,  C07K2319/00

摘要： Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily. The transcription factors of the present invention are also homologous to mouse Stra13 and rat SHARP that are related to neurocyte differentiation. The transcription factors of the present invention may be used as tools for developing pharmaceutical agents for diseases related to the differentiation and proliferation of cells.

摘要翻译： 分离人和小鼠衍生的bHLH型转录因子。 这些转录因子与转录因子DEC1共享同源性，当用cAMP分化时，其转录因子在人软骨细胞中被诱导。 因此，这些分离的转录因子被认为是属于DEC1亚家族的新型转录因子。 本发明的转录因子也与与神经细胞分化相关的小鼠Stra13和大鼠SHARP同源。 本发明的转录因子可用作开发用于与细胞分化和增殖有关的疾病的药物的工具。

公开(公告)号：US20060148677A1

公开(公告)日：2006-07-06

申请号：US11304595

申请日：2005-12-16

申请人： Yukio Kato ,  Katsumi Fujimoto

发明人： Yukio Kato ,  Katsumi Fujimoto

IPC分类号： A61K38/40

CPC分类号： C07K14/79 ,  A61K38/00 ,  A61K48/00 ,  G01N2333/79 ,  G01N2500/00

摘要： There are provided a chondrogenesis stimulator containing MTf, a chondrogenic differentiation suppressing agent containing an MTf antagonist, a screening method for obtaining an MTf activating agent, an MTf activating agent obtained by the screening method, a chondrogenesis stimulator containing an MTf activating agent as obtained by the screening method, and MTf which lacks the GPI anchor region.

摘要翻译： 提供含有MTf的软骨形成刺激剂，含有MTf拮抗剂的软骨形成分化抑制剂，获得MTf活化剂的筛选方法，通过筛选方法获得的MTf活化剂，含有MTf活化剂的软骨形成刺激剂，其由 筛选方法，缺乏GPI锚定区域的MTf。

公开(公告)号：US08553512B2

公开(公告)日：2013-10-08

申请号：US13078580

申请日：2011-04-01

申请人： Masaru Furukawa ,  Yukio Kato ,  Junguo Xu

发明人： Masaru Furukawa ,  Yukio Kato ,  Junguo Xu

IPC分类号： G11B27/36

CPC分类号： G11B5/6076 ,  G11B5/455

摘要： A magnetic head slider inspection device including a motor unit for revolving a disk medium, a slider unit provided with a reproducing head, which is levitated from a surface of the disk medium under force generated by the revolving disk medium, a magnetic field generator positioned at an opposite side of the disk medium with respect to the slider unit for generating a magnetic field substantially perpendicular to the disk medium surface, and a circuit unit for generating the magnetic field from the magnetic field generator, and measuring a resistance value of the reproducing head levitated from the disk medium surface.

摘要翻译： 一种磁头滑动器检查装置，包括用于旋转盘介质的马达单元，设置有再现头的滑块单元，其由旋转盘介质产生的力从盘介质的表面浮动;磁场发生器，位于 磁盘介质的相对于用于产生基本上垂直于盘介质表面的磁场的滑块单元的相对侧;以及电路单元，用于从磁场发生器产生磁场，并测量再现头的电阻值 从磁盘介质表面浮起。

公开(公告)号：US08526274B2

公开(公告)日：2013-09-03

申请号：US13153073

申请日：2011-06-03

申请人： Irizo Naniwa ,  Takuya Matsumoto ,  Yukio Kato

发明人： Irizo Naniwa ,  Takuya Matsumoto ,  Yukio Kato

IPC分类号： G11B11/00

CPC分类号： G11B5/3106 ,  G11B5/3136 ,  G11B5/40 ,  G11B5/607 ,  G11B5/6088 ,  G11B2005/0021

摘要： There is provided a thermally assisted magnetic recording device capable of preventing collision between a thermally assisted magnetic recording head and a disk due to thermal deformation of a near-field transducer. The thermally assisted magnetic recording device includes a temperature sensor for measuring the temperature in the vicinity of the near-field transducer, a table that stores the relationship between temperature and deformation in the vicinity of the near-field transducer, and a control unit. The control unit calculates the deformation in the vicinity of the near-field transducer, from the temperature measured by the temperature sensor and the relationship between temperature and deformation stored in the table. Then, the control unit drives the flying height control actuator according to the calculated deformation to control the distance between the thermally assisted magnetic recording and the disk in order to avoid contact between them.

摘要翻译： 提供了一种热辅助磁记录装置，其能够防止由于近场换能器的热变形引起的热辅助磁记录头与盘的碰撞。 热辅助磁记录装置包括用于测量近场换能器附近的温度的温度传感器，存储近场换能器附近的温度与变形之间的关系的表以及控制单元。 控制单元根据由温度传感器测量的温度和存储在表中的温度与变形之间的关系来计算近场换能器附近的变形。 然后，控制单元根据计算出的变形驱动飞行高度控制致动器，以控制热辅助磁记录与盘之间的距离，以避免它们之间的接触。

公开(公告)号：US20070207127A1

公开(公告)日：2007-09-06

申请号：US11630903

申请日：2005-06-27

申请人： Yukio Kato ,  Tetsuaki Hara ,  Jin Shao ,  Masakazu Shimizu

发明人： Yukio Kato ,  Tetsuaki Hara ,  Jin Shao ,  Masakazu Shimizu

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： C12N5/0605 ,  A61K35/12 ,  C12N2502/02

摘要： By a method of inducing differentiation of cells having: a step of co-culturing amniotic epithelial cells and amniotic interstitial cells so as to induce their differentiation into predetermined tissue cells, it is possible to efficiently induce differentiation of the amniotic epithelial cells and the amniotic interstitial cells. It is preferable that the amniotic epithelial cells or the amniotic interstitial cells are prepared by being cultured by a predetermined culture method.

摘要翻译： 通过诱导具有以下成分的细胞分化的方法：共培养羊膜上皮细胞和羊膜间质细胞以诱导其分化成预定的组织细胞的步骤，可以有效诱导羊膜上皮细胞和羊膜间质细胞的分化 细胞。 优选通过以预定培养方法培养来制备羊膜上皮细胞或羊膜间质细胞。

公开(公告)号：US06992178B2

公开(公告)日：2006-01-31

申请号：US10416178

申请日：2001-10-17

申请人： Yukio Kato ,  Shinichi Tsutsumi ,  Ryo Oda ,  Hideaki Shintani ,  Masahiro Nishimura

发明人： Yukio Kato ,  Shinichi Tsutsumi ,  Ryo Oda ,  Hideaki Shintani ,  Masahiro Nishimura

IPC分类号： C07K14/00 ,  A61K38/16

CPC分类号： C12N5/0654 ,  A61K35/12 ,  C07K14/42 ,  C12N5/0655 ,  C12N5/0663 ,  C12N5/0664 ,  C12N2501/59

摘要： The invention provides an agent for conferring resistance comprising a lectin as an effective component, which are able to confer resistance against external stimuli to animal cells, particularly mammalian cells, and to their cultured cells and various tissues in the living bodies. The agent for conferring resistance to external stimulus according to the invention can confer to such animal cells and/or tissues resistance against mechanical stimuli and/or proteolytic reactions, and thereby enhance graft fixation of the cells and/or tissues, as well as transplant tissues obtained by culturing them.

摘要翻译： 本发明提供了赋予抗性的试剂，其包含作为有效成分的凝集素，其能够赋予动物细胞，特别是哺乳动物细胞及其培养的细胞和生物体中的各种组织对外部刺激的抵抗力。 根据本发明赋予对外部刺激的抗性的试剂可以赋予这种动物细胞和/或组织对机械刺激和/或蛋白水解反应的抗性，从而增强细胞和/或组织以及移植组织的移植物固定 通过培养获得。

公开(公告)号：US06915688B2

公开(公告)日：2005-07-12

申请号：US10607017

申请日：2003-06-27

申请人： Yukio Kato ,  Hiromu Kikawa ,  Shinya Igarashi ,  Akira Takasago

发明人： Yukio Kato ,  Hiromu Kikawa ,  Shinya Igarashi ,  Akira Takasago

IPC分类号： G01F1/00 ,  F02D35/00 ,  G01F1/684 ,  G01F5/00 ,  G01F15/12

CPC分类号： G01F5/00 ,  G01F1/6842 ,  G01F15/12

摘要： In a gas-flow measuring instrument for measuring a gas flow in an intake gas passage for sucking gas, an abnormal output, deterioration per hour, stain, and breakage of a flow measuring element caused by fluid and foreign materials contained in intake gas are reduced. A gas-flow measuring instrument disposed in an intake gas passage for sucking gas for measuring a gas flow includes a bypass passage for bringing gas flowing along the intake gas passage, a bypass passage inlet opened to the upstream side of a main stream direction of gas in the intake gas passage, and a flow measuring element disposed in the bypass passage.

摘要翻译： 在用于测量吸入气体的进气通道中的气体流量的气体流量测量仪器中，由进气中的流体和异物引起的异常输出，每小时的劣化，污染和流量测量元件的破裂减少 。 设置在用于吸入气体的进气通道中的用于测量气体流量的气体流量测量仪器包括：旁通通道，用于使气体沿着进气通道流动，旁通通道入口通向气流主流方向的上游侧 在进气通道中，以及设置在旁通通道中的流量测量元件。

公开(公告)号：US06414821B1

公开(公告)日：2002-07-02

申请号：US09516234

申请日：2000-03-01

申请人： Mikio Tokuyama ,  Yukio Kato ,  Hiromitsu Tokisue ,  Junichi Matsuno

发明人： Mikio Tokuyama ,  Yukio Kato ,  Hiromitsu Tokisue ,  Junichi Matsuno

IPC分类号： G11B554

CPC分类号： G11B5/6005 ,  G11B5/4826 ,  G11B5/54 ,  G11B21/21 ,  G11B21/22

摘要： When a negative pressure slider is used in the magnetic head support mechanism with a loading/unloading function, the gimbals is likely to be deformed or damaged. Apart from the first tab provided to the front end of the suspension, the second tab is provided to the front end of the gimbals. In addition to the Suspension supporting ramp, the ramp portion has the second ramp for supporting the gimbals. This arrangement allows the slider mounting gimbals, in addition to the suspension, to be loaded/unloaded. Unlike the conventional drive in which only the suspension is loaded/unloaded, this arrangement enables the gimbals to be loaded/unloaded while maintaining a predetermined space between the gimbals and the suspension, thus reducing the risk of gimbals deformation and damage.

摘要翻译： 当在具有加载/卸载功能的磁头支撑机构中使用负压滑块时，万向节可能变形或损坏。 除了设置在悬架的前端的第一凸片之外，第二凸片设置在万向架的前端。 除了悬架支撑斜坡之外，斜坡部分具有用于支撑万向节的第二坡道。 这种布置允许除了悬架之外的滑块安装万向面被加载/卸载。 与只有悬架装载/卸载的常规驱动器不同，这种布置使得万向节能够在维持万向节和悬架之间的预定空间的同时被装载/卸载，从而降低了万向面变形和损坏的风险。

公开(公告)号：US5889285A

公开(公告)日：1999-03-30

申请号：US609614

申请日：1996-03-01

申请人： Mitsushi Murata ,  Tsunenori Takahashi ,  Yukio Kato

发明人： Mitsushi Murata ,  Tsunenori Takahashi ,  Yukio Kato

IPC分类号： C08F2/20 ,  B01F17/00 ,  C08F2/18

CPC分类号： B01F17/005 ,  B01F17/0007 ,  B01F17/0028 ,  B01F17/0042 ,  B01F17/0057 ,  B01F17/0064 ,  B01F17/0085 ,  C08F2/18

摘要： A suspending agent-containing slurry is disclosed which comprises a dispersant and a particulate suspending agent having a particle size distribution in which the particle diameter at weight-cumulative 95%, from the minimum particle size, is 1 .mu.m or smaller. A method for efficiently producing the suspending agent-containing slurry is also disclosed. A process for suspension polymerization by use of the suspending agent-containing slurry is further disclosed. The slurry not only has such an excellent suspending ability in suspension polymerization that it enables the production of vinyl polymer beads having a narrow bead size distribution, but also is capable of retaining this ability over long and of exhibiting the same ability even when it has a high concentration. The suspension polymerization process enables vinyl polymer beads having a narrow bead size distribution to be produced efficiently due to the use of the slurry.

摘要翻译： 公开了一种含悬浮剂的浆料，其包含分散剂和粒度分布的颗粒状悬浮剂，其中粒径从最小颗粒尺寸的重量累积95％为1μm或更小。 还公开了一种有效生产含悬浮剂的浆料的方法。 进一步公开了通过使用含悬浮剂的浆料进行悬浮聚合的方法。 该浆料不仅在悬浮聚合中具有优异的悬浮能力，能够制造具有窄珠粒度分布的乙烯基聚合物珠粒，而且能够长时间保持该能力，并且即使具有相同的能力也能表现出相同的能力 高浓度 悬浮聚合方法使得能够由于使用浆料而有效地制备具有窄珠粒度分布的乙烯基聚合物珠粒。

公开(公告)号：US5607920A

公开(公告)日：1997-03-04

申请号：US278617

申请日：1994-07-21

申请人： Yukio Kato ,  Haiou Pan ,  Kazuyuki Doi

发明人： Yukio Kato ,  Haiou Pan ,  Kazuyuki Doi

IPC分类号： A61K38/00 ,  C07K14/51 ,  C07K1/00 ,  C12N9/00

CPC分类号： C07K14/51 ,  A61K38/00 ,  Y10S530/84

摘要： The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed to a purified and isolated chondrocyte membrane protein, (CMP), which is a concanavalin A-binding protein, with a molecular weight of about 76 kD in SDS-PAGE. After treatment with endoglycosidase, CMP has an apparent molecular weight of about 67 kD. The N-terminal amino acid sequence and several internal amino acid sequences are given for CMP. These proteins can be used in assays, methods, or treatments involving differentiation of chondrocytes and the control of cartilaginous osteogenesis.

摘要翻译： 本发明涉及来自软骨细胞的不存在于来自软骨细胞的去分化细胞中的纯化和分离的伴刀豆球蛋白A-结合蛋白。 本发明还涉及在SDS-PAGE中分子量约76kD的纯化和分离的软骨细胞膜蛋白（CMP），其是刀豆素A结合蛋白，分子量约为76kD。 用糖苷内切酶处理后，CMP的表观分子量约为67kD。 给出了N末端氨基酸序列和几个内部氨基酸序列。 这些蛋白质可用于测定，方法或涉及软骨细胞分化和控制软骨成骨的治疗。