公开(公告)号：US20050020775A1

公开(公告)日：2005-01-27

申请号：US10892006

申请日：2004-07-15

申请人： Yun-Tai Wu ,  Mark Stewart ,  David Mitchell ,  Edward McBride

发明人： Yun-Tai Wu ,  Mark Stewart ,  David Mitchell ,  Edward McBride

IPC分类号： C08F220/12 ,  C08L33/08 ,  C08L23/00 ,  C08F118/02 ,  C08L23/04 ,  C08L27/04 ,  C08L33/04 ,  C08L35/02

CPC分类号： C08L33/08 ,  C08F220/12

摘要： Disclosed are random copolymers derived from ethylene and at least two different alkyl acrylate comonomers, with or without an acid cure site-containing comonomer. In particular, disclosed are copolymers derived from copolymerization of (a) from 10 to 50 weight % of ethylene; (b) from 5 to 55 weight % of a first alkyl acrylate; (b) from 15 to 80 weight % of a second alkyl acrylate; and (d) from 0 to 7 weight % of a monoalkyl ester of 1,4-butene-dioic acid. Such copolymers exhibit lower glass transition temperatures (Tg) relative to previous ethylene copolymers comprising a single alkyl acrylate comonomer and maintain the good heat and fluid resistance when employed to produce cured elastomeric compositions as well as the improved low temperature properties. This invention also provides compounded compositions comprising these copolymers, and cured compositions (i.e., vulcanizates) as well as rubber articles formed from these compounded compositions, such as hoses, dampers, seals, gaskets, constant velocity joint (CVJ) boots and shaft boots.

摘要翻译： 公开了衍生自乙烯和至少两种不同的丙烯酸烷基酯共聚单体的无规共聚物，具有或不具有含酸固化位点的共聚单体。 特别地，公开了衍生自（a）10至50重量％的乙烯的共聚合的共聚物; （b）5至55重量％的第一丙烯酸烷基酯; （b）15至80重量％的第二丙烯酸烷基酯; 和（d）0至7重量％的1,4-丁二烯酸的单烷基酯。 这种共聚物相对于包含单一烷基丙烯酸酯共聚单体的先前乙烯共聚物显示较低的玻璃化转变温度（Tg），并且当用于产生固化的弹性体组合物以及改进的低温性能时，保持良好的耐热和耐流体性。 本发明还提供了包含这些共聚物和固化组合物（即硫化橡胶）的复合组合物以及由这些复合组合物形成的橡胶制品，例如软管，阻尼器，密封件，垫圈，等速万向节（CVJ）靴和轴靴。

公开(公告)号：US07153918B2

公开(公告)日：2006-12-26

申请号：US10892006

申请日：2004-07-15

申请人： Yun-Tai Wu ,  Mark Aaron Stewart ,  David John Mitchell ,  Edward McBride

发明人： Yun-Tai Wu ,  Mark Aaron Stewart ,  David John Mitchell ,  Edward McBride

IPC分类号： C08F234/04

CPC分类号： C08L33/08 ,  C08F220/12

摘要： Disclosed are random copolymers derived from ethylene and at least two different alkyl acrylate comonomers, with or without an acid cure site-containing comonomer. In particular, disclosed are copolymers derived from copolymerization of (a) from 10 to 50 weight % of ethylene; (b) from 5 to 55 weight % of a first alkyl acrylate; (b) from 15 to 80 weight % of a second alkyl acrylate; and (d) from 0 to 7 weight % of a monoalkyl ester of 1,4-butene-dioic acid. Such copolymers exhibit lower glass transition temperatures (Tg) relative to previous ethylene copolymers comprising a single alkyl acrylate comonomer and maintain the good heat and fluid resistance when employed to produce cured elastomeric compositions as well as the improved low temperature properties. This invention also provides compounded compositions comprising these copolymers, and cured compositions (i.e., vulcanizates) as well as rubber articles formed from these compounded compositions, such as hoses, dampers, seals, gaskets, constant velocity joint (CVJ) boots and shaft boots.

摘要翻译： 公开了衍生自乙烯和至少两种不同的丙烯酸烷基酯共聚单体的无规共聚物，具有或不具有含酸固化位点的共聚单体。 特别地，公开了衍生自（a）10至50重量％的乙烯的共聚合的共聚物; （b）5至55重量％的第一丙烯酸烷基酯; （b）15至80重量％的第二丙烯酸烷基酯; 和（d）0至7重量％的1,4-丁二烯酸的单烷基酯。 这种共聚物相对于包含单一烷基丙烯酸酯共聚单体的先前乙烯共聚物显示较低的玻璃化转变温度（Tg），并且当用于产生固化的弹性体组合物以及改进的低温性能时，保持良好的耐热和耐流体性。 本发明还提供了包含这些共聚物和固化组合物（即硫化橡胶）的复合组合物以及由这些复合组合物形成的橡胶制品，例如软管，阻尼器，密封件，垫圈，等速万向节（CVJ）靴和轴靴。

公开(公告)号：US20060154736A1

公开(公告)日：2006-07-13

申请号：US11364065

申请日：2006-02-28

申请人： Scott McBride ,  Edward McBride

发明人： Scott McBride ,  Edward McBride

IPC分类号： A63B69/36

CPC分类号： A63B71/0669 ,  A63B69/3691 ,  A63B2102/32

摘要： A golf course including a plurality of holes, where at least one of said holes includes a plurality of initial teeing areas displaced at similar, or different specific par distances from a target cup, and at different directions from a target cup such that plurality of teeing areas are disposed at different acute angles from the target cup, and encompass different terrain and different trajectories to target cup. A gold hole of the present invention comprises a target green encompassing a target cup, and a middle area between a plurality of initial teeing areas and the target green. A method of playing the golf course and golf hole is also described. The method of sequentially playing a golf game on the present course results in a relatively inexhaustible number of different games of golf thereon.

摘要翻译： 一种高尔夫球场，其包括多个孔，其中至少一个所述孔包括多个初始发球区域，所述多个初始发球区域以与靶杯相似或不同的特定距离移位，并且在与靶杯不同的方向上移位，使得多个发球区域 区域与目标杯配置成不同的锐角，并且涵盖与目标杯不同的地形和不同的轨迹。 本发明的金孔包括包围目标杯的目标绿色和多个初始发球区域与目标绿色之间的中间区域。 还描述了打高尔夫球场和高尔夫球洞的方法。 在当前课程上顺序打高尔夫游戏的方法导致其上不同游戏的不同游戏的数量不同。

公开(公告)号：US20110301087A1

公开(公告)日：2011-12-08

申请号：US13127602

申请日：2009-11-04

申请人： Edward McBride ,  Athan Kuliopulos ,  Thomas J. McMurry

发明人： Edward McBride ,  Athan Kuliopulos ,  Thomas J. McMurry

IPC分类号： A61K38/17 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  A61P1/00 ,  A61K38/06 ,  A61P25/22 ,  A61P25/30 ,  A61P25/28 ,  A61P15/06 ,  A61K38/10 ,  A61K38/08 ,  C07K5/08 ,  A61P25/00

CPC分类号： C07K14/57509 ,  A61K38/00 ,  A61K47/542 ,  A61K47/543

摘要： The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) receptor 1, also known as the CRF1, CRHR1, CRFR1, CRHR, CRF-R. The CRF1 receptor compounds are derived from the intracellular loops and domains of CRF1 receptor. The invention also relates to the use of these CRF1 receptor compounds and pharmaceutical compositions comprising the CRF1 receptor compounds in the treatment of diseases and conditions associated with CRF1 receptor modulation, such as inflammatory bowel disease (peripherally acting), irritable bowel syndrome (IBS), stress response (colonic motor activity), anxiety, sleep disorder, addictive behavior, acute and chronic neurodegeneration, preterm labor and pain.

摘要翻译： 本发明一般涉及用于促肾上腺皮质激素释放激素（或因子）受体1（也称为CRF1）的G蛋白偶联受体的变构调节剂（例如，负变构和正变构调节剂，变构激动剂和前变体调节剂） ，CRHR1，CRFR1，CRHR，CRF-R。 CRF1受体化合物衍生自CRF1受体的细胞内环和结构域。 本发明还涉及这些CRF1受体化合物和包含CRF1受体化合物的药物组合物在治疗与CRF1受体调节有关的疾病和病症（例如炎性肠病（外周作用）），肠易激综合征（IBS）， 压力反应（结肠运动活动），焦虑症，睡眠障碍，成瘾行为，急性和慢性神经变性，早产和疼痛。

公开(公告)号：US07001957B2

公开(公告)日：2006-02-21

申请号：US10417806

申请日：2003-04-17

申请人： Edward McBride

发明人： Edward McBride

IPC分类号： C08F8/32 ,  C08L3/36 ,  C01B33/12

CPC分类号： C08K5/17 ,  C08F8/32 ,  C08F2800/20 ,  Y10T428/264 ,  Y10T428/2913 ,  C08L33/064 ,  C08F220/14

摘要： An improved method of making an ethylene acrylate (AEM) elastomer or a polyacrylate (ACM) elastomer wherein an aqueous solution of hexamethylene diamine (HMDA) is employed as the curative agent rather than hexamethylene diamine carbamate (HMDAC). The HMDA reacts with the curative-site monomer derived from the monoalkyl ester of a 1,4-butene-dioic acid in the presence of water, producing (i.e., after press-curing and any secondary heat-curing) a crosslinked elastomer with properties essentially indistinguishable from that produced using HMDAC as the curative agent. Advantageously, the aqueous solution of HMDA can be blended directly into the compound or it can be deposited on an additive such as silica or carbon black prior to blending. Elastomers produced by the improved method according to the present invention are particularly useful in automotive applications requiring oil resistant compositions.

公开(公告)号：US20050148758A1

公开(公告)日：2005-07-07

申请号：US11050052

申请日：2005-02-03

申请人： Donald Putzig ,  Edward McBride

发明人： Donald Putzig ,  Edward McBride

IPC分类号： B01J31/04 ,  B01J31/18 ,  B01J31/22 ,  B01J31/38 ,  C08G63/183 ,  C08G63/82 ,  C08G63/83 ,  C08G63/85 ,  C08G63/87 ,  C08G63/78

CPC分类号： C08G63/82 ,  B01J31/04 ,  B01J31/1805 ,  B01J31/2234 ,  B01J2231/14 ,  B01J2231/40 ,  B01J2531/46 ,  B01J2531/96 ,  C08G63/183 ,  C08G63/826 ,  C08G63/83 ,  C08G63/85 ,  C08G63/87

摘要： A composition that can be used as catalyst in esterification, transesterification or polycondensation is disclosed, which comprises a stable solution comprising (a) titanium in the form of a titanium α-hydroxycarboxylic acid or its salt, (b) a C1-C6 carboxylic acid, and (c) zinc in the form of a water-soluble zinc salt, and (d) water; and substantially free of an alkanolamine, an aminocarboxylic acid, or combinations two or more thereof. Also disclosed is an esterification, transesterification or polycondensation process, which comprises contacting, in the presence of the solution composition, an organic acid or its ester or its salt with an alcohol, optionally in the presence of a phosphorus compound, an organic or inorganic toning agent such as cobalt acetate, or combinations thereof.

摘要翻译： 公开了可用作酯化，酯交换或缩聚中的催化剂的组合物，其包含稳定溶液，其包含（a）钛α-羟基羧酸或其盐形式的钛，（b）C 1 -C（C）-C 6羧酸，和（c）水溶性锌盐形式的锌，和（d）水; 并且基本上不含链烷醇胺，氨基羧酸或其两种或更多种的组合。 还公开了酯化，酯交换或缩聚方法，其包括在溶液组合物存在下，有机酸或其酯或其盐与醇，任选在磷化合物，有机或无机调色剂 例如乙酸钴或其组合。

公开(公告)号：US5859093A

公开(公告)日：1999-01-12

申请号：US987630

申请日：1997-12-09

申请人： Edward McBride

发明人： Edward McBride

IPC分类号： C08L91/06 ,  C09J123/08 ,  C09J133/10 ,  C08K5/01

CPC分类号： C09J123/0869 ,  C08L2205/02 ,  C08L2205/03 ,  C08L91/06

摘要： A hot-melt adhesive for use as a shoe last adhesive, particularly one in a form for use in a direct through feed adhesive dispensing system, made from a melt-blend of a copolymer of ethylene and carboxylic acid, a synthetic wax such as a Fischer-Tropsch wax, and an ethylene/unsaturated carboxylic acid wax having a melt index of at least about 5000 dg/min.

摘要翻译： 一种用作鞋末粘合剂的热熔粘合剂，特别是用于直接通过进料粘合剂分配系统的形式的热熔粘合剂，其由乙烯和羧酸的共聚物的熔融共混物制成，合成蜡如 费 - 托蜡和熔体指数为至少约5000dg / min的乙烯/不饱和羧酸蜡。

公开(公告)号：US5234986A

公开(公告)日：1993-08-10

申请号：US844327

申请日：1992-03-02

申请人： Edward McBride

发明人： Edward McBride

IPC分类号： C08L25/00 ,  C08L25/16 ,  C08L67/00 ,  C08L93/04 ,  C09J123/02 ,  C09J123/08 ,  C09J125/00 ,  C09J125/18 ,  C09J129/04 ,  C09J131/04 ,  C09J133/04 ,  C09J133/08 ,  C09J159/00 ,  C09J167/00 ,  C09J167/02 ,  C09J173/00

CPC分类号： C09J173/00 ,  C09J123/0853 ,  C09J123/0869 ,  C09J167/025 ,  C08L2205/03 ,  C08L25/16 ,  C08L67/00 ,  C08L93/04

摘要： Copolymers of ethylene with such monomers as an alkyl acrylate and carbon monoxide or with vinyl acetate alone are blended with a thermoplastic block-polyester elastomer and a tackifier to produce thermally stable, hot-melt adhesive compositions which adhere well to polyvinyl chloride and which retain adhesivity at elevated temperatures. Fillers, plasticizers and compatible waxes may also be present in the composition.

摘要翻译： 乙烯与单体如丙烯酸烷基酯和一氧化碳或与乙酸乙烯酯单独的共聚物与热塑性嵌段 - 聚酯弹性体和增粘剂共混，以产生热稳定的热熔粘合剂组合物，该粘合剂组合物很好地粘附在聚氯乙烯上并保持粘合性 在高温下。 填料，增塑剂和相容的蜡也可以存在于组合物中。