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公开(公告)号：US07030139B2
公开(公告)日：2006-04-18
申请号：US10474549
申请日：2002-04-18
IPC分类号： A61K31/445
CPC分类号： C07D231/12 , C07D233/56 , C07D235/12 , C07D235/30 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/06 , C07D471/04
摘要： Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain
摘要翻译： 通式（I）的化合物在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛
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公开(公告)号：US20060135554A1
公开(公告)日：2006-06-22
申请号：US11325124
申请日：2006-01-04
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D231/12 , C07D233/56 , C07D235/12 , C07D235/30 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/06 , C07D471/04
摘要： Compounds of general formula I are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译： 通式I的化合物在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在疼痛的治疗中的用途。
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公开(公告)号：US20050245503A1
公开(公告)日：2005-11-03
申请号：US10498864
申请日：2002-12-17
IPC分类号： C07D295/12 , A61K31/17 , A61K31/381 , A61K31/40 , A61K31/425 , A61K31/444 , A61K31/445 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/554 , A61P25/04 , C07C275/26 , C07C281/06 , C07D207/08 , C07D207/09 , C07D207/26 , C07D207/273 , C07D211/14 , C07D213/77 , C07D213/82 , C07D275/02 , C07D275/03 , C07D295/13 , C07D333/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/38 , A61K31/4184 , A61K31/473 , A61K31/4743 , A61K31/502
CPC分类号： C07D207/273 , C07D207/09 , C07D213/77 , C07D213/82 , C07D275/03 , C07D295/13 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： Compounds of formula (I) or (II) wherein R1, R2, R3, R4, W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）或（II）的化合物，其中R 1，R 2，R 3，R 4， ，W，Q，G，X和Y如说明书中所定义，以及其盐，对映异构体和包含该化合物的药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20090018116A1
公开(公告)日：2009-01-15
申请号：US11569295
申请日：2005-05-20
申请人： Shujuan Jin , Ziping Liu , Claire Milburn , Miroslaw Tomaszewski , Christopher Walpole , Zhong-Yong Wei , Hua Yang
发明人： Shujuan Jin , Ziping Liu , Claire Milburn , Miroslaw Tomaszewski , Christopher Walpole , Zhong-Yong Wei , Hua Yang
IPC分类号： A61K31/55 , A61K31/40 , C07D207/09 , C07C237/34 , A61P1/00 , A61P35/00 , A61K31/166 , C07D223/04
CPC分类号： C07C237/42 , C07C237/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/09 , C07D211/26 , C07D215/48 , C07D217/16 , C07D237/28 , C07D265/30 , C07D295/13 , C07D295/192 , C07D295/32 , C07D307/79 , C07D309/14 , C07D317/46 , C07D319/08 , C07D319/12 , C07D321/10 , C07D413/06 , C07D471/08
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3，R4和n如本说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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5.发明申请Muscarinic Receptor Agonists that are Effective in the Treatment of Pain, Alzheimer's Disease and Schizophrenia 审中-公开有效治疗疼痛，阿尔茨海默病和精神分裂症的毒蕈碱受体激动剂公开(公告)号：US20100173941A1
公开(公告)日：2010-07-08
申请号：US12303637
申请日：2007-06-08
IPC分类号： A61K31/454 , C07D405/14 , C07D403/04 , A61P25/28 , A61P29/00 , A61P25/18
CPC分类号： C07D405/14 , C07D401/04 , C07D403/04
摘要： Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, R6, R7, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3，R4，R5，R6，R7，m和n如本说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20070287695A1
公开(公告)日：2007-12-13
申请号：US11760011
申请日：2007-06-08
IPC分类号： A61K31/4545 , A61K31/454 , C07D403/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein A1, A2, G1, G2 G3, R1, R2, X, Y, Z, m, n and p are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I的化合物或其药学上可接受的盐：其中A 1，A 2，G 1，G 2， R 3，R 1，R 2，X 2，X，Y，Z，m，n和p如本说明书中所定义 因为制备包括这些化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US07956069B2
公开(公告)日：2011-06-07
申请号：US11760011
申请日：2007-06-08
IPC分类号： A61K31/454 , C07D403/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein A1, A2, G1, G2 G3, R1, R2, X, Y, Z, m, n and p are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中A1，A2，G1，G2 G3，R1，R2，X，Y，Z，m，n和p如说明书中所定义，以及盐和药物组合物，包括 制备化合物。 它们可用于治疗，特别是治疗疼痛。
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![Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands](/abs-image/US/2010/05/06/US20100113502A1/abs.jpg.150x150.jpg)
8.发明申请Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands 审中-公开新型四氢-1H-吡啶并[4,3-b]吲哚衍生物作为CB1受体配体公开(公告)号：US20100113502A1
公开(公告)日：2010-05-06
申请号：US11909089
申请日：2006-03-17
IPC分类号： A61K31/437 , C07D471/04 , A61P25/22
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2和R3如说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20070259888A1
公开(公告)日：2007-11-08
申请号：US11741888
申请日：2007-04-30
IPC分类号： A61K31/519 , A61K31/497 , A61K31/4545 , A61K31/454 , C07D401/02 , C07D403/02
CPC分类号： C07D405/12 , C07C235/50 , C07C235/54 , C07C2601/14 , C07D207/327 , C07D209/08 , C07D209/42 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/38 , C07D211/44 , C07D213/56 , C07D213/82 , C07D231/12 , C07D231/56 , C07D233/90 , C07D235/26 , C07D241/26 , C07D249/18 , C07D261/18 , C07D263/32 , C07D263/34 , C07D265/36 , C07D277/62 , C07D295/135 , C07D307/68 , C07D307/80 , C07D307/85 , C07D309/06 , C07D317/68 , C07D319/16 , C07D321/10 , C07D333/24 , C07D333/38 , C07D333/68 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10
摘要： Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中X，R 1，R 2和R 3如在本说明书中所定义，如 以及制备包括这些化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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10.发明申请Muscarinic Receptor Agonists that are Effective in the Treatment of Pain, Alzheimer's Disease and Schizophrenia 审中-公开有效治疗疼痛，阿尔茨海默病和精神分裂症的毒蕈碱受体激动剂公开(公告)号：US20100173935A1
公开(公告)日：2010-07-08
申请号：US12303641
申请日：2007-06-08
IPC分类号： A61K31/454 , C07D401/14 , C07D405/14 , C07D451/04 , A61K31/46 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00
CPC分类号： C07D401/14 , C07D405/14 , C07D451/04
摘要： Compounds of Formula IA, or pharmaceutically acceptable salts thereof: IA wherein G1, G2, G3, G4, R1, R2, X, Y, Z and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式IA化合物或其药学上可接受的盐：其中G1，G2，G3，G4，R1，R2，X，Y，Z和n如说明书中所定义，以及包括化合物的盐和药物组合物的制备 。 它们可用于治疗，特别是治疗疼痛。
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