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    [4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase
    2.
    发明申请
    [4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase 审中-公开
    [4-（5-氨基甲基-2-氟 - 苯基） - 哌啶-1-基] - （4-溴-3-甲基-5-丙氧基 - 噻吩-2-基） - 甲酮盐酸盐作为肥大细胞的抑制剂 类胰蛋白酶

    公开(公告)号：US20070142435A1

    公开(公告)日：2007-06-21

    申请号：US11520998

    申请日：2006-09-14

    申请人： Zhongli Gao ,  Larry Davis ,  Julian Levell ,  Mark Czekaj ,  Adam Sledeski

    发明人： Zhongli Gao ,  Larry Davis ,  Julian Levell ,  Mark Czekaj ,  Adam Sledeski

    IPC分类号： A61K31/453 ,  C07D409/02

    CPC分类号： C07D409/06

    摘要： The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed to the use of a compound of formula I as an inhibitor of tryptase, comprising introducing the compound into a composition comprising tryptase. In addition, the present invention is directed to the use of a compound of formula I for treating a patient suffering from, or subject to, a physiological condition in need of amelioration of an inhibitor of tryptase comprising administering to the patient a therapeutically effective amount of the compound of claim 1 The present invention is directed also to the preparation of a compound of formula I.

    摘要翻译： 本发明延伸到式I化合物：或所述化合物的前药，药学上可接受的盐或溶剂合物。 此外，本发明涉及包含药学有效量的式I化合物和药学上可接受的载体的药物组合物。 此外，本发明涉及式I化合物作为类胰蛋白酶抑制剂的用途，其包括将化合物引入包含类胰蛋白酶的组合物中。 此外，本发明涉及式I化合物用于治疗患有或受制于需要改善类胰蛋白酶抑制剂的生理条件的患者，包括向患者施用治疗有效量的 权利要求1的化合物本发明还涉及式I化合物的制备。