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公开(公告)号：US09898578B2
公开(公告)日：2018-02-20
申请号：US10817244
申请日：2004-04-03
摘要： Systems and methods for displaying gene- and/or protein-related data with respect to chromosome maps at locations identifying relevant positioning of the genes with which the gene- and/or protein related data are associated. Multiple experiments may be plotted onto the display adjacent one or more chromosome maps. Automatic extraction of genomic location, based on accession numbers or other unique identifiers and cross connection with expression data is provided. Statistical assessments of correlations between expression and genome localization may be performed. Zooming capabilities, thumbnail/fullview toggling, browsability and linked data may be included as features of the visualization systems described.
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公开(公告)号：US06364890B1
公开(公告)日：2002-04-02
申请号：US09614318
申请日：2000-07-12
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B1732
CPC分类号： A61B5/15144 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.
摘要翻译： 一种用于通过穿刺从患者皮肤取样血液的装置。 该装置包括用于切割皮肤的一个或多个刺血针和用于从穿刺伤口输送血液的导流板单元。 板单元具有用于将流体传导到一个或多个目标位置的一个或多个通道。 优选地，存在用于传导第一部分流体的第一通道，所述第一部分流体包含更多的来自穿刺伤口的最初发射的流体（初始流体）和用于传导含有较少初始流体的第二部分流体的第二通道 从穿刺伤口。 通过毛细血管力将血液吸入通道。 该装置可用于以相对简单的程序来刺激皮肤并获得代表性的血液样品。
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公开(公告)号：US06660018B2
公开(公告)日：2003-12-09
申请号：US09846139
申请日：2001-04-30
IPC分类号： A61B1714
CPC分类号： A61B5/150977 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150396 , A61B5/150427 , A61B5/15142 , A61B5/157 , A61B17/205
摘要： A device for puncturing the skin of a patient. The device includes first and second protrusions, each protrusion puncturing the skin when pressed against the skin. The first and second protrusions are arranged such that the first protrusion punctures the skin at a location less than a predetermined distance from the second protrusion. The distance is chosen to be less than the discriminatable distance between distinct pain perception points in the patient, such that the patient perceives a single puncture when the first and second protrusions puncture the skin. In one embodiment of the invention, the device includes a base lip that applies a lateral force to the skin when the base lip is pressed against the skin. In this embodiment, the protrusions are pressed into the skin as the base lip is pressed against the skin.
摘要翻译： 一种用于刺穿患者皮肤的装置。 该装置包括第一和第二突起，每个突出部在压靠皮肤时刺入皮肤。 第一突起和第二突起被布置成使得第一突起在距离第二突起小于预定距离的位置刺穿皮肤。 该距离选择为小于患者中不同疼痛感知点之间的可区分距离，使得当第一和第二突起刺穿皮肤时，患者感知到单次穿刺。 在本发明的一个实施例中，所述装置包括基底唇部，当基底唇被压靠在皮肤上时，所述基部唇缘向皮肤施加横向力。 在该实施例中，当基底唇被压在皮肤上时，突起被压入皮肤。
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4.发明授权Method and apparatus for fabricating replicate arrays of nucleic acid molecules 失效用于制造核酸分子重复阵列的方法和装置公开(公告)号：US06309828B1
公开(公告)日：2001-10-30
申请号：US09195421
申请日：1998-11-18
申请人： Arthur Schleifer , Michael P. Caren , Leslie A. Leonard , Charles Z. Hotz , Michel G. M. Perbost
发明人： Arthur Schleifer , Michael P. Caren , Leslie A. Leonard , Charles Z. Hotz , Michel G. M. Perbost
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00315 , B01J2219/00351 , B01J2219/00369 , B01J2219/00423 , B01J2219/00452 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00722 , B01L3/0258 , B01L3/0262 , B01L3/0275 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2400/0439 , C40B40/06 , C40B60/14
摘要： A method and apparatus for fabricating replicate arrays of nucleic acid molecules include the preparation of the molecules and the application the molecules onto a substrate in an ordered array. The apparatus comprises a synthesis unit and a plurality of outlets. The synthesis unit comprises a plurality of synthesis chambers that are spatially arranged relative to each other to provide an array suitable for conducting parallel nucleic acid syntheses. The chambers are suitable for containing discrete compositions of nucleic acid molecules. Each outlet of the plurality of outlets communicates with a single synthesis chamber. The plurality of outlets are configured such that nucleic acid molecules can be removed from the chambers through the outlet and deposited onto the substrate in an ordered array that corresponds to the spatial arrangement of the synthesis chambers.
摘要翻译： 用于制造核酸分子的重复阵列的方法和装置包括分子的制备和以有序阵列将分子施加到基底上。 该装置包括合成单元和多个出口。 合成单元包括相对于彼此空间布置的多个合成室，以提供适于进行平行核酸合成的阵列。 这些室适合含有离散的核酸分子组合物。 多个出口的每个出口与单个合成室连通。 多个出口被配置成使得核酸分子可以通过出口从室中除去并以对应于合成室的空间布置的有序阵列沉积到基板上。
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公开(公告)号：US6132449A
公开(公告)日：2000-10-17
申请号：US264597
申请日：1999-03-08
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113 , A61B5/14532
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.
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