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20 条记录 (耗时 0.026 秒)

    Redox molecules and methods of making the same
    4.
    发明授权
    Redox molecules and methods of making the same 有权
    氧化还原分子和制备方法

    公开(公告)号：US08283347B2

    公开(公告)日：2012-10-09

    申请号：US12790165

    申请日：2010-05-28

    申请人： Jiangfeng Fei ,  William Chiang ,  Frank Kerrigan ,  Stuart Green

    发明人： Jiangfeng Fei ,  William Chiang ,  Frank Kerrigan ,  Stuart Green

    IPC分类号： C07D279/18 ,  A61K31/5415

    CPC分类号： C07D279/18

    摘要： A non-leaching mediator may include a compound having the general formula (I): and salts thereof, where n is about 9, and X is a halogen; a compound having the general formula (II): and salts thereof, where n is about 9, and X is a halogen; and/or a compound, having the general formula (III): and salts thereof, where n is about 8, and X is a halogen.

    摘要翻译： 非浸出介体可以包括具有通式（I）的化合物及其盐，其中n为约9，X为卤素; 具有通式（II）的化合物及其盐，其中n为约9，X为卤素; 和/或具有通式（III）的化合物及其盐，其中n为约8，X为卤素。

    Redox Molecules And Methods Of Making The Same
    5.
    发明申请
    Redox Molecules And Methods Of Making The Same 有权
    氧化还原分子及其制作方法

    公开(公告)号：US20100300896A1

    公开(公告)日：2010-12-02

    申请号：US12790165

    申请日：2010-05-28

    申请人： Jiangfeng Fei ,  William Chiang ,  Frank Kerrigan ,  Stuart Green

    发明人： Jiangfeng Fei ,  William Chiang ,  Frank Kerrigan ,  Stuart Green

    IPC分类号： C07D279/18 ,  G01N27/26

    CPC分类号： C07D279/18

    摘要： A non-leaching mediator may include a compound having the general formula (I): and salts thereof, where n is about 9, and X is a halogen; a compound having the general formula (II): and salts thereof, where n is about 9, and X is a halogen; and/or a compound, having the general formula (III): and salts thereof, where n is about 8, and X is a halogen.

    摘要翻译： 非浸出介体可以包括具有通式（I）的化合物及其盐，其中n为约9，X为卤素; 具有通式（II）的化合物及其盐，其中n为约9，X为卤素; 和/或具有通式（III）的化合物及其盐，其中n为约8，X为卤素。

    Methods and systems for analyzing and determining ligand-residue interaction
    6.
    发明申请
    Methods and systems for analyzing and determining ligand-residue interaction 失效
    用于分析和测定配体 - 残基相互作用的方法和系统

    公开(公告)号：US20050123995A1

    公开(公告)日：2005-06-09

    申请号：US10920234

    申请日：2004-08-18

    申请人： Stephan Brunner ,  David Mosenkis ,  Frank Hollinger ,  William Chiang

    发明人： Stephan Brunner ,  David Mosenkis ,  Frank Hollinger ,  William Chiang

    IPC分类号： C12Q20060101 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  G06F17/00 ,  G06F17/30 ,  G06F19/00 ,  G06F19/16

    CPC分类号： G01N33/5695 ,  G06F19/16 ,  G06F19/701 ,  G06F19/706

    摘要： A method implemented in the form of a computer simulation code for evaluating the free energy of binding between polypeptide amino acid residues and one or more molecular fragment types is presented. The basis of the method is a novel weighted Metropolis Monte Carlo approach for sampling the grand canonical ensemble. By making use of the properties of the grand canonical ensemble, the affinity of fragments for binding in the vicinity of each protein residue can be efficiently computed. The binding volume associated to each fragment-residue pair is estimated on the basis of a simple proximity criteria, and a useful affinity mapping of the protein surface can be obtained in this way. The analysis of such data for various fragment types provides valuable information to help identify protein binding sites, as well as to identify key fragments used for building potential drug leads.

    摘要翻译： 提出了一种用于评估多肽氨基酸残基与一种或多种分子片段类型之间的结合自由能的计算机模拟代码形式的方法。 该方法的基础是一种新颖的加权大都会蒙特卡罗方法，用于抽样大规模集合。 通过利用大规模集合的性质，可以有效地计算片段在每个蛋白质残基附近的结合亲和力。 基于简单的接近标准估计与每个片段 - 残基对相关联的结合体积，并且可以以这种方式获得蛋白质表面的有用亲和力图谱。 对于各种片段类型的这种数据的分析提供了有价值的信息，以帮助鉴定蛋白质结合位点，以及鉴定用于构建潜在药物引线的关键片段。

    Methods of determining ligand residue binding affinity
    9.
    发明申请
    Methods of determining ligand residue binding affinity 审中-公开
    确定配体残基结合亲和力的方法

    公开(公告)号：US20050123993A1

    公开(公告)日：2005-06-09

    申请号：US10730267

    申请日：2003-12-09

    申请人： Stephan Brunner ,  David Mosenkis ,  Frank Hollinger ,  William Chiang

    发明人： Stephan Brunner ,  David Mosenkis ,  Frank Hollinger ,  William Chiang

    IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  G06F19/00

    CPC分类号： G01N33/5695 ,  G16B15/00

    摘要： Methods and systems for determining the affinity between polypeptide amino acid residues and one or more molecular fragments, and for using the affinity values to aid in drug design including a computer simulation which calculates the interaction energy between a polypeptide and at least one molecular fragment. An affinity value is then assigned to at least one fragment and residue pair if the fragment is in the vicinity of the residue. Affinity values are used to rank fragments, build ligands and determine binding sites.

    摘要翻译： 用于确定多肽氨基酸残基与一个或多个分子片段之间的亲和力的方法和系统，以及用于使用亲和力值来辅助药物设计，包括计算多肽与至少一个分子片段之间的相互作用能的计算机模拟。 如果片段在残基附近，则将亲和力值分配给至少一个片段和残基对。 亲和力值用于对片段进行排序，构建配体并确定结合位点。

    Method of making a light-emitting fiber
    10.
    发明授权
    Method of making a light-emitting fiber 失效
    制造发光纤维的方法

    公开(公告)号：US06228228B1

    公开(公告)日：2001-05-08

    申请号：US09418774

    申请日：1999-10-15

    申请人： Bawa Singh ,  William Ronald Roach ,  William Chiang

    发明人： Bawa Singh ,  William Ronald Roach ,  William Chiang

    IPC分类号： H05B3300

    CPC分类号： G09F9/305 ,  H01L27/32 ,  H01L51/5203 ,  H01L51/5287 ,  Y10S362/80

    摘要： A display as for images and/or information comprises a plurality of light-emitting fibers disposed in side-by-side arrangement to define a viewing surface. Each light-emitting fiber includes a plurality of light-emitting elements disposed along its length, each having two electrodes between which are applied electrical signals to cause the light-emitting element to emit light to display a pixel or sub-pixel of the image and/or information. The light-emitting fiber includes an electrical conductor disposed along its length to serve as a first electrode, a layer of light-emissive material disposed thereon, and a plurality of electrical contacts disposed on the light-emissive material to serve as the second electrodes of the light-emitting elements, and are formed in a continuous process wherein a transparent fiber passes through a plurality of processing chambers for receiving the electrical conductor, the light-emissive layer and the plurality of electrical contacts thereon. The method of making a light-emitting fiber comprises providing a length of a fiber, forming a first electrode along the fiber, depositing a light-emitting material along the fiber in electrical contact with the first electrode, and forming a plurality of second electrodes along the fiber in electrical contact with the light-emitting material.

    摘要翻译： 关于图像和/或信息的显示包括并排布置的多个发光纤维，以限定观察表面。 每个发光光纤包括沿着其长度设置的多个发光元件，每个发光元件具有两个电极，它们之间被施加电信号，以使发光元件发光以显示图像的像素或子像素;以及 /或信息。 发光光纤包括沿其长度布置以用作第一电极的电导体，设置在其上的发光材料层，以及设置在发光材料上以用作第二电极的第二电极的多个电触点 发光元件，并且以连续工艺形成，其中透明光纤通过用于接收电导体，发光层和多个电触点的多个处理室。 制造发光纤维的方法包括提供长度的纤维，沿着纤维形成第一电极，沿着光纤与第一电极电接触沉积发光材料，并沿着第一电极形成多个第二电极 光纤与发光材料电接触。