-
公开(公告)号：US10196584B2
公开(公告)日：2019-02-05
申请号：US15577294
申请日：2016-05-30
发明人： Hiroshi Tabata , Tetsuro Taira , Jun Fujii , Yoshihisa Misawa , Yoshio Shimizu
IPC分类号： C11B3/02 , C07C67/60 , C07C67/58 , C07C67/62 , C07C69/587 , C07C51/487
摘要： A production method of highly unsaturated fatty acids with a high purity/high yield that compensates for shortcomings of conventional techniques is provided.A purification method of highly unsaturated fatty acids and/or derivatives thereof comprising (a) contacting and stirring first raw materials comprising the substances with a first silver salt aqueous solution to collect a first oil layer and a first aqueous layer; (b) separating the first aqueous layer into a second silver salt aqueous solution and the substances; and (c) contacting and stirring the first oil layer with the second silver salt aqueous solution for separation into an oil layer and an aqueous layer to obtain a second aqueous layer comprising the substances.
-
公开(公告)号：US20160208296A1
公开(公告)日：2016-07-21
申请号：US14914804
申请日：2014-08-18
发明人： Yoshio SHIMIZU , Keisuke URYU , Tetsuro TAIRA , Jun FUJII
CPC分类号： C12P7/6427 , C07C67/03 , C07C67/08 , C07C67/54 , C07C67/56 , C07C67/60 , C11B1/025 , C11B3/10 , C11B3/12 , C11B5/0021 , C11C1/08 , C11C1/10 , C11C3/003 , C11C3/04 , C07C69/587
摘要： The present invention relates to the field of methods for purifying fatty acid ethyl esters. According to the present invention, a method for obtaining a ω3 fatty acid ethyl ester, such as EPA and DHA, each as a high purity product at a high yield is provided. In the method according to the present invention, a raw material fat including EPA and DHA is treated with a lipolytic enzyme and ethyl-esterification is performed as needed; the treated substance is fractionated into a glyceride fraction and a free fatty acid fraction; a fraction comprising more EPA ester and a fraction comprising DHA ester are obtained from the respective fractions; the fraction comprising more EPA ester is purified to prepare a high-purity EPA ester; and the fraction comprising more DHA ester is purified to prepare a high-purity DHA ester.
摘要翻译： 本发明涉及纯化脂肪酸乙酯的方法领域。 根据本发明，提供了以高产率获得ω3脂肪酸乙酯如EPA和DHA作为高纯度产品的方法。 在本发明的方法中，用脂肪分解酶处理包含EPA和DHA的原料脂肪，根据需要进行乙基酯化; 将处理过的物质分馏成甘油酯级分和游离脂肪酸级分; 从相应的级分获得包含更多EPA酯和包含DHA酯的级分的级分; 将包含更多EPA酯的级分纯化以制备高纯度EPA酯; 并且将包含更多DHA酯的级分进行纯化以制备高纯度DHA酯。
-
公开(公告)号：US20140005144A1
公开(公告)日：2014-01-02
申请号：US14012023
申请日：2013-08-28
发明人： Teruyuki Kanada , Toru Kuyama , Takahiko Hada , Takafumi Ishihara
IPC分类号： A61K31/685 , A61K31/683 , A61K35/56
CPC分类号： A61K31/685 , A23L2/52 , A23L17/40 , A23L17/50 , A23L33/10 , A61K31/66 , A61K31/683 , A61K35/612 , A61K35/618
摘要： It is an object of the present invention to provide a leukotriene receptor antagonist that can be conveniently prepared from a natural source.The object has been achieved by finding that a marine product such as a squid phospholipid extract or an Akiami paste shrimp phospholipid extract contains the antagonists of BLT and CysLT1, which are leukotriene receptors. Therefore, the present invention provides a dietary composition and a pharmaceutical composition for inhibiting the activity of leukotriene receptors, containing a squid phospholipid extract or an Akiami paste shrimp phospholipid extract.
摘要翻译： 本发明的目的是提供可以从天然来源方便地制备的白三烯受体拮抗剂。 该目的已经通过发现诸如鱿鱼磷脂提取物或Akiami糊虾磷脂提取物的海产品含有作为白三烯受体的BLT和CysLT1的拮抗剂来实现。 因此，本发明提供了含有鱿鱼磷脂提取物或Akiami糊虾磷脂提取物的白三烯受体的抑制活性的饮食组合物和药物组合物。
-
4.发明申请ORALLY ADMINISTERED COMPOSITION AND DIETARY COMPOSITION HAVING SERUM LIPID IMPROVING EFFECT 审中-公开口服组合物和具有血清脂质改善效果的膳食组合物公开(公告)号：US20130165514A1
公开(公告)日：2013-06-27
申请号：US13816627
申请日：2011-02-18
IPC分类号： A61K31/232
CPC分类号： A61K31/232 , A23L33/12 , A23V2002/00 , A23V2200/326 , A23V2250/1868
摘要： The present invention provides an orally administered composition and a dietary composition, which have a serum lipid improving effect. The orally administered composition and dietary composition, having a serum lipid improving effect, according to the present invention camp rise 2.0% by weight or less of a DHA ethyl ester composition comprising 75% by weight or more of DHA ethyl ester. It is preferable to comprise 1.2% by weight or less of the DHA ethyl ester composition. It is preferable not to substantially comprise a DHA ethyl ester composition comprising 30% by weight or less of DHA ethyl ester.
摘要翻译： 本发明提供具有血脂改善效果的口服给药组合物和饮食组合物。 根据本发明的具有血清脂质改善作用的口服组合物和膳食组合物营养液增加了包含75重量％以上的DHA乙酯的DHA乙酯组合物的2.0重量％以下。 优选含有1.2重量％以下的DHA乙酯组合物。 优选不包含含有30重量％或更少的DHA乙酯的DHA乙酯组合物。
-
公开(公告)号：US20210115411A1
公开(公告)日：2021-04-22
申请号：US16976431
申请日：2019-02-27
发明人： Hidetoshi Yamada , Sayaka Yuki , Akira Yano , Naomichi Bamba , Tadahiro Tsushima , Yoshihisa Misawa
摘要： The present invention provides a lipoxygenase that enables the highly efficient formation of an oxide of a highly unsaturated fatty acid or an oxide of a highly unsaturated fatty acid derivative from a highly unsaturated fatty acid or a highly unsaturated fatty acid derivative. The present invention provides a lipoxygenase that enables the highly efficient formation of 8-hydroxyeicosatetraenoic acid from arachidonic acid, the highly efficient formation of 8-hydroxyeicosapentaenoic acid from eicosapentaenoic acid, and the highly efficient formation of 10-hydroxy docosahexaenoic acid from docosahexaenoic acid. Specifically, the present invention provides a polynucleotide that comprises the nucleic acid sequence represented by SEQ ID NO: 1 and 3, or a homolog thereof, and a polypeptide that comprises the amino acid sequence represented by SEQ ID NO: 2 and 4, or a homolog thereof. Also provided is a composition that comprises a membrane protein of an organism belonging to the class Malacostraca and is for carrying out a lipoxygenase reaction.
-
公开(公告)号：US10189770B2
公开(公告)日：2019-01-29
申请号：US15577726
申请日：2016-05-30
IPC分类号： C07C67/62 , B01D15/00 , B01J20/10 , B01J20/12 , B01J20/20 , C07C67/58 , C07C67/60 , C07C69/533 , C07C69/58 , B01D15/08 , C11B3/00
摘要： The present invention provides a method of producing/purifying highly unsaturated fatty acids and/or derivatives thereof while suppressing deterioration of a silver salt aqueous solution, in production/purification of highly unsaturated fatty acids and/or derivatives thereof using the aqueous solution of silver salt. The present invention also contacts or mixes a mixture having a peroxide value (POV) of 10 or smaller with an aqueous solution of silver salt, in a method of purifying highly unsaturated fatty acids and/or derivatives thereof from a mixture comprising highly unsaturated fatty acids and/or derivatives thereof.
-
7.发明授权公开(公告)号：US10005712B2
公开(公告)日：2018-06-26
申请号：US15116176
申请日：2015-01-14
IPC分类号： C07C51/00 , C07C67/24 , C07C51/353
CPC分类号： C07C67/24 , C07C17/093 , C07C17/361 , C07C29/147 , C07C51/353 , C07C67/32 , C07C67/343 , C07C303/28 , C07C69/587 , C07C33/02 , C07C69/602 , C07C309/73 , C07C21/215
摘要： The present invention relates to a method for the chemical conversion of an unsaturated fatty acid, particularly a carbon chain extension reaction. According to the present invention, a method for extending the length of a carbon chain in an unsaturated fatty acid by two carbon atoms is provided, said method comprising a step of heating a malonic acid ester derivative of an unsaturated fatty acid to reflux in a lower fatty acid solution in the presence of an antioxidative agent. It is preferred that the unsaturated fatty acid is an unsaturated fatty acid having 16 to 24 carbon atoms. It is preferred that the unsaturated fatty acid is selected from the group consisting of linoleic acid, linolenic acid, arachidonic acid, stearidonic acid, icosatetraenoic acid, icosapentaenoic acid, tetracosahexaenoic acid and docosahexaenoic acid. According to the method of the present invention, a carbon chain extension reaction can be completed within a shorter time.
-
公开(公告)号：US20110224452A1
公开(公告)日：2011-09-15
申请号：US13062969
申请日：2009-09-02
IPC分类号： C07C51/487
CPC分类号： C11C1/005 , C07C67/58 , C11C1/08 , C07C69/587
摘要： A method of obtaining a polyunsaturated fatty acid derivative comprises contacting a mixture of fatty acid derivatives with a silver salt aqueous solution, and adjusting the free fatty acid content in the silver salt aqueous solution to 0.2 meq or less per gram of silver when repeatedly using the silver salt aqueous solution. A polyunsaturated fatty acid derivative having high purity and excellent quality can thus be economically obtained.
摘要翻译： 获得多不饱和脂肪酸衍生物的方法包括使脂肪酸衍生物与银盐水溶液的混合物接触，并将银盐水溶液中的游离脂肪酸含量调节至每克银0.2meq以下，反复使用 银盐水溶液。 因此可以经济地获得纯度高，品质优良的多不饱和脂肪酸衍生物。
-
9.发明申请METHOD OF PHYSICOCHEMICALLY PRODUCING GLYCOGEN AND GLYCOGEN OBTAINED BY THE SAME 审中-公开物理化学生产由其获得的GLYCOGEN和GLYCOGG的方法公开(公告)号：US20080262217A1
公开(公告)日：2008-10-23
申请号：US12145256
申请日：2008-06-24
IPC分类号： C08B31/00
CPC分类号： C08B37/0009
摘要： A method of producing glycogen is provided. The method comprises the step of heat- and pressure-treating a sugar-containing material under acidic conditions. The sugar-containing material is a polysaccharide or an oligosaccharide. Alternatively, the sugar-containing material is a plant material selected from the group consisting of Panax notoginseng, Yun Nan San-chi powder (trademark), Panax ginseng, wheat flour, soybean, soy flour, shiitake, and coffee extract residue. Representatively, the glycogen includes a molecule having a molecular weight of 10,000 or less. The glycogen has a specific rotation of [α]D+197° and anomeric proton peaks at 5.37 ppm and 4.95 to 5.33 ppm in 1H NMR spectra.
摘要翻译： 提供了制备糖原的方法。 该方法包括在酸性条件下对含糖材料进行加热和加压处理的步骤。 含糖材料是多糖或寡糖。 或者，含糖材料是选自三七，云南三奇粉（商标），人参，小麦粉，大豆，大豆粉，香菇和咖啡提取物残渣的植物材料。 代表性地，糖原包括分子量为10,000以下的分子。 在1 H NMR光谱中，糖原具有α-D + 197°的比旋光度和5.37ppm和4.95- 5.33ppm的异质质子峰。
-
10.发明授权Process for physicochemically producing glycogen and glycogen obtained thereby 有权由此获得的物理化学产生糖原和糖原的方法公开(公告)号：US07396543B2
公开(公告)日：2008-07-08
申请号：US10497694
申请日：2002-12-06
IPC分类号： A61K36/00 , A61K36/258
CPC分类号： C08B37/0009
摘要： A method of producing glycogen is provided. The method comprises the step of heat- and pressure-treating a sugar-containing material under acidic conditions. The sugar-containing material is a polysaccharide or an oligosaccharide. Alternatively, the sugar-containing material is a plant material selected from the group consisting of Panax notoginseng, Yun Nan San-chi powder (trademark), Panax ginseng, wheat flour, soybean, soy flour, shiitake, and coffee extract residue. Representatively, the glycogen includes a molecule having a molecular weight of 10,000 or less. The glycogen has a specific rotation of [α]D+197° and anomeric proton peaks at 5.37 ppm and 4.95 to 5.33 ppm in 1H NMR spectra.
摘要翻译： 提供了制备糖原的方法。 该方法包括在酸性条件下对含糖材料进行加热和加压处理的步骤。 含糖材料是多糖或寡糖。 或者，含糖材料是选自三七，云南三奇粉（商标），人参，小麦粉，大豆，大豆粉，香菇和咖啡提取物残渣的植物材料。 代表性地，糖原包括分子量为10,000以下的分子。 在1 H NMR光谱中，糖原具有α-D + 197°的比旋光度和5.37ppm和4.95- 5.33ppm的异质质子峰。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.017 秒)
