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47 条记录 (耗时 0.038 秒)

    Synthesis of cyclopropylacetylene
    4.
    发明授权
    Synthesis of cyclopropylacetylene 失效
    环丙基乙炔的合成

    公开(公告)号：US6028237A

    公开(公告)日：2000-02-22

    申请号：US990471

    申请日：1997-12-15

    申请人： Rodney Lawrence Parsons, Jr.

    发明人： Rodney Lawrence Parsons, Jr.

    IPC分类号： C07C1/32 ,  C07C13/04 ,  C07C1/26 ,  C07C1/28

    CPC分类号： C07C13/04 ,  C07C1/328 ,  C07C2101/02

    摘要： The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

    摘要翻译： 本发明一般涉及用于合成环己基乙炔的新方法，该环乙炔是不对称合成（S）-6-氯-4-环丙基乙炔基-4-三氟甲基-1,4-二氢-2H- 苯并恶嗪-2-酮，其是有用的人类免疫缺陷病毒（HIV）逆转录酶抑制剂。

    Apparatus for holding small volumes of liquids
    5.
    发明授权
    Apparatus for holding small volumes of liquids 失效
    用于容纳少量液体的装置

    公开(公告)号：US6027695A

    公开(公告)日：2000-02-22

    申请号：US53287

    申请日：1998-04-01

    申请人： Kevin R. Oldenburg ,  Gregory F. Hollis ,  Thomas D. Y. Chung

    发明人： Kevin R. Oldenburg ,  Gregory F. Hollis ,  Thomas D. Y. Chung

    IPC分类号： B01L3/00 ,  C40B60/14 ,  G01N21/64

    CPC分类号： B01L3/5085 ,  B01J2219/00317 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/0893 ,  C40B60/14

    摘要： An apparatus for holding liquid, such as a microtiter plate, in which a plurality of wells are formed. Each of the wells have side walls that intersect in an edge that defines the boundary between adjacent wells. The edge boundary prevents liquid from collecting between the wells, thereby causing all of the liquid applied to the plate to enter one of the wells. The microtiter plate can be formed from a material having a reflectance and/or fluorescence that is optimized for the particular application in which the microtiter plate will be used. Microtiter plates for use in fluorescence measurement applications are made from material having low fluorescence, such as a liquid crystal polymer, while microtiter plates for use in luminescence measurements are made from material having a high reflectance. Microtiter plates for spectrophotometric applications are made with wells having clear bottoms and opaque walls. Such clear bottomed wells can be made by incorporating a photobleachable dye into the plate material so as to render it essentially opaque and then irradiating the bottoms of the wells so as to render them transparent. Such wells can also be made by forming the plate from an essentially transparent material and then irradiating the sidewalls with a beam of light so as to render them essentially opaque.

    摘要翻译： 一种用于保持液体的装置，例如微量滴定板，其中形成有多个孔。 每个井具有在限定相邻井之间的边界的边缘相交的侧壁。 边缘边界防止液体在井之间收集，从而使施加到板上的所有液体进入其中一个井。 微量滴定板可由具有针对其中将使用微量滴定板的具体应用而优化的反射率和/或荧光的材料形成。 用于荧光测量应用的微量滴定板由具有低荧光的材料制成，例如液晶聚合物，而用于发光测量的微量滴定板由具有高反射率的材料制成。 用于分光光度计的微量滴定板由具有透明底部和不透明壁的孔制成。 这种透明的有底孔可以通过将光可漂白的染料掺入板材中来制成，以使其基本不透明，然后照射孔的底部以使其变透明。 这样的孔也可以通过从基本上透明的材料形成板，然后用光束照射侧壁，以使它们基本上是不透明的。

    Preparation of asymmetric cyclic ureas using an alkali metal in liquid ammonia process
    6.
    发明授权
    Preparation of asymmetric cyclic ureas using an alkali metal in liquid ammonia process 失效
    在液氨工艺中使用碱金属制备不对称环脲

    公开(公告)号：US05998614A

    公开(公告)日：1999-12-07

    申请号：US110550

    申请日：1998-07-06

    申请人： Thomas E Smyser ,  Pasquale N. Confalone

    发明人： Thomas E Smyser ,  Pasquale N. Confalone

    IPC分类号： C07D243/04 ,  C07D491/04

    CPC分类号： C07D491/04 ,  C07D243/04

    摘要： The present invention describes a method for the preparation of asymmetric N,N'-disubstituted cyclic ureas through the selective monodebenzylation of symmetric N,N'-disubstituted cyclic ureas using a dissolving metal reduction. The intermediates can be alkylated to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection.

    摘要翻译： 本发明描述了通过使用溶解金属还原的对称N，N'-二取代环脲的选择性单脱氧烷基化制备不对称N，N'-二取代环脲的方法。 可以将中间体烷基化以得到可用作HIV蛋白酶抑制剂用于治疗HIV感染的化合物。