Analytical method and apparatus therefor involving continuous titration
    2.
    发明授权
    Analytical method and apparatus therefor involving continuous titration 失效
    用于连续滴定的分析方法和装置

    公开(公告)号:US06913930B2

    公开(公告)日:2005-07-05

    申请号:US10633517

    申请日:2003-08-05

    IPC分类号: G01N1/10 G01N21/79 G01N31/16

    摘要: The present invention relates to an improved analytical method and apparatus therefor, in particular to a method and apparatus for continuous titration in which at least one parameter of at least one compound in a test mixture may be monitored as the composition of the mixture is continuously varied. The method comprises the steps of continuously mixing at least two component fluid streams to form a test mixture stream and passing the test mixture stream through a spectrophotometric detection zone, with the volume to volume ratio of at least two of the component streams forming the test mixture stream continuously and linearly varied with time by alteration of the relative proportions of the component streams forming the test mixture, while the total volume of the test mixture stream remains constant.

    摘要翻译: 本发明涉及一种改进的分析方法及其装置,特别涉及用于连续滴定的方法和装置,其中当混合物的组合物连续变化时,可以监测测试混合物中至少一种化合物的至少一个参数 。 该方法包括以下步骤:将至少两种组分流体流连续混合以形成测试混合物流并使测试混合物流通过分光光度检测区,其中至少两个组分流体积与体积比形成测试混合物 通过改变形成试验混合物的组分流的相对比例,随着时间的流动连续和线性地变化,而试验混合物流的总体积保持恒定。

    GLYCOSYLATED ANTIBODY
    5.
    发明申请
    GLYCOSYLATED ANTIBODY 审中-公开
    谷氨酸抗体

    公开(公告)号:US20020182208A1

    公开(公告)日:2002-12-05

    申请号:US10145712

    申请日:2002-05-16

    IPC分类号: A61K039/395 C12N005/06

    摘要: The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector capable of expressing the heavy chain of the antibody wherein the vectors contain independently selectable markers; also included is a CHO cell-line capable of producing a human antibody or an altered antibody, the cell-line having been transfected with a vector capable of expressing the light chain of the antibody and the heavy chain of the antibody; process for the production of antibody using a CHO cell-line and antibody having CHO glycosylation.

    摘要翻译: 本发明涉及能够产生抗体的CHO细胞系,已经用能够表达抗体轻链的载体共转染的细胞系和能够表达抗体重链的载体,其中载体 含有独立选择标记; 还包括能够产生人抗体或改变的抗体的CHO细胞系,已经用能够表达抗体轻链和抗体重链的载体转染细胞系; 使用CHO细胞系和具有CHO糖基化的抗体来生产抗体的方法。

    Bead picking apparatus and method
    6.
    发明授权
    Bead picking apparatus and method 失效
    珠挑选设备和方法

    公开(公告)号:US6151973A

    公开(公告)日:2000-11-28

    申请号:US240758

    申请日:1999-01-29

    摘要: The invention provides exemplary systems and methods for processing solid supports. According to one system, a probe is provided having a distal end and a lumen terminating at the distal end. The transport mechanism is adapted to place the distal end of the probe into a well having a plurality of solid supports that are held within a fluid. A detection mechanism is provided to detect the presence or absence of one of the solid supports at the distal end while the distal end is within the fluid. A measuring system is provided to measure the general size of the attached solid support.

    摘要翻译: 本发明提供了用于处理固体支持物的示例性系统和方法。 根据一个系统,提供具有远端和末端终止的管腔的探针。 传送机构适于将探头的远端放置在具有保持在流体内的多个固体支撑体的孔中。 提供了一种检测机构,用于在远端位于流体内时检测远端处固体支持物之一的存在或不存在。 提供测量系统来测量附着的固体支持物的一般尺寸。

    Method for preparing camptothecin derivatives
    8.
    发明授权
    Method for preparing camptothecin derivatives 失效
    喜树碱衍生物的制备方法

    公开(公告)号:US06143891A

    公开(公告)日:2000-11-07

    申请号:US68185

    申请日:1998-05-14

    IPC分类号: C07D491/04 C07D491/22

    CPC分类号: C07D491/04

    摘要: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, ##STR1## wherein R.sub.1 to R.sub.6 represent various substituents.

    摘要翻译: PCT No.PCT / US96 / 17574 Sec。 371日期:1998年5月14日 102(e)日期1998年5月14日PCT提交1996年11月1日PCT公布。 出版物WO97 / 16454 日期:1997年5月9日本发明涉及由式(II)化合物制备式(I)的喜树碱和喜树碱类似物的方法及其制备中可用的新中间体,其中R 1至R 6表示各种取代基。