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1.
公开(公告)号:US07008623B1
公开(公告)日:2006-03-07
申请号:US09674716
申请日:1999-05-07
申请人: Jean-Yves Marcel Paul Bonnefoy , James Scott Crowe , Jonathan Henry Ellis , Nicholas Timothy Rapson , Jean Shearin
发明人: Jean-Yves Marcel Paul Bonnefoy , James Scott Crowe , Jonathan Henry Ellis , Nicholas Timothy Rapson , Jean Shearin
IPC分类号: C12P21/08 , C07K16/28 , A61K39/395
CPC分类号: C07K16/2851 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要: The invention relates to antibodies which bind to the CD23 (FCεRII) type II molecule particularly altered antibodies including antibodies which bind to the CD23 (FCεRII) type II molecule characterized by an affinity constant equal to or greater than 1×109 Ka Mol−1, the preparation of such antibodies, pharmaceutical compositions which contain such antibodies and their use in therapy particularly in the treatment of autoimmune and inflammatory disorders.
摘要翻译: 本发明涉及结合CD23(FCepsilonRII)II型分子的抗体,特别是改变的抗体,包括结合CD23(FCepsilonRII)II型分子的抗体,其特征在于亲和力常数等于或大于1×10 9 >这些抗体的制备,含有这些抗体的药物组合物及其在治疗中的用途,特别是用于治疗自身免疫性和炎症性疾病。
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2.
公开(公告)号:US06913930B2
公开(公告)日:2005-07-05
申请号:US10633517
申请日:2003-08-05
CPC分类号: G01N31/166 , B01J2219/00707 , G01N21/79
摘要: The present invention relates to an improved analytical method and apparatus therefor, in particular to a method and apparatus for continuous titration in which at least one parameter of at least one compound in a test mixture may be monitored as the composition of the mixture is continuously varied. The method comprises the steps of continuously mixing at least two component fluid streams to form a test mixture stream and passing the test mixture stream through a spectrophotometric detection zone, with the volume to volume ratio of at least two of the component streams forming the test mixture stream continuously and linearly varied with time by alteration of the relative proportions of the component streams forming the test mixture, while the total volume of the test mixture stream remains constant.
摘要翻译: 本发明涉及一种改进的分析方法及其装置,特别涉及用于连续滴定的方法和装置,其中当混合物的组合物连续变化时,可以监测测试混合物中至少一种化合物的至少一个参数 。 该方法包括以下步骤:将至少两种组分流体流连续混合以形成测试混合物流并使测试混合物流通过分光光度检测区,其中至少两个组分流体积与体积比形成测试混合物 通过改变形成试验混合物的组分流的相对比例,随着时间的流动连续和线性地变化,而试验混合物流的总体积保持恒定。
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公开(公告)号:US20040176342A1
公开(公告)日:2004-09-09
申请号:US10800840
申请日:2004-03-15
申请人: Glaxo Wellcome Inc.
发明人: Gordon J. Dow , Keith Arthur Johnson , Frances Furr Kelly , Robert William Lathrop , Rukmini Rajagopalan
IPC分类号: A61K031/573
摘要: A fluticasone lotion having improved vasoconstrictor and anti-inflammatory activity and higher than expected potency. The fluticasone lotion contains 0.05 weight percent fluticasone propionate and an oil-in-water vehicle that includes excipients. The fluticasone lotion is unexpectedly efficacious while exhibiting an improved safety profile.
摘要翻译: 具有改善的血管收缩剂和抗炎活性和高于预期效力的氟替卡松洗剂。 氟替卡松洗剂含有0.05重量%的丙酸氟替卡松和包含赋形剂的水包油载体。 氟替卡松乳液意外有效,同时表现出改善的安全性。
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4.
公开(公告)号:US20030166299A1
公开(公告)日:2003-09-04
申请号:US10243391
申请日:2002-09-12
发明人: Svetlana Velkovska , Kerwin Ng , Haim Kedar
IPC分类号: G01N001/10
CPC分类号: B01L3/021 , B01J19/0046 , B01J2219/00315 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00707 , C40B60/14 , G01N2035/00574 , Y10T436/119163 , Y10T436/255 , Y10T436/2575
摘要: A system for processing a plurality of solid supports comprises a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end. A stop is positioned within the lumen at a location spaced about the distal end and is sized to permit fluids to pass through the lumen while preventing the passage of solid supports. A fluid transfer device is configured to transfer fluids through the lumen such that when a fluid containing one or more solid supports is aspirated into the lumen, a solid support may be drawn into the lumen to lodge against the stop.
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公开(公告)号:US20020182208A1
公开(公告)日:2002-12-05
申请号:US10145712
申请日:2002-05-16
申请人: Glaxo Wellcome, Inc.
发明人: Martin J. Page , James S. Crowe
IPC分类号: A61K039/395 , C12N005/06
CPC分类号: C07K16/00 , A61K38/00 , A61K2039/505 , C07K16/2812 , C07K16/2893 , C07K2317/24 , C07K2317/41
摘要: The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector capable of expressing the heavy chain of the antibody wherein the vectors contain independently selectable markers; also included is a CHO cell-line capable of producing a human antibody or an altered antibody, the cell-line having been transfected with a vector capable of expressing the light chain of the antibody and the heavy chain of the antibody; process for the production of antibody using a CHO cell-line and antibody having CHO glycosylation.
摘要翻译: 本发明涉及能够产生抗体的CHO细胞系,已经用能够表达抗体轻链的载体共转染的细胞系和能够表达抗体重链的载体,其中载体 含有独立选择标记; 还包括能够产生人抗体或改变的抗体的CHO细胞系,已经用能够表达抗体轻链和抗体重链的载体转染细胞系; 使用CHO细胞系和具有CHO糖基化的抗体来生产抗体的方法。
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公开(公告)号:US6151973A
公开(公告)日:2000-11-28
申请号:US240758
申请日:1999-01-29
IPC分类号: G01N37/00 , B01J4/00 , B01J19/00 , C07B61/00 , C40B30/00 , C40B50/00 , C40B60/12 , C40B60/14 , G01N1/00
CPC分类号: B01J19/0046 , B01J2219/00315 , B01J2219/00468 , B01J2219/005 , C40B60/14
摘要: The invention provides exemplary systems and methods for processing solid supports. According to one system, a probe is provided having a distal end and a lumen terminating at the distal end. The transport mechanism is adapted to place the distal end of the probe into a well having a plurality of solid supports that are held within a fluid. A detection mechanism is provided to detect the presence or absence of one of the solid supports at the distal end while the distal end is within the fluid. A measuring system is provided to measure the general size of the attached solid support.
摘要翻译: 本发明提供了用于处理固体支持物的示例性系统和方法。 根据一个系统,提供具有远端和末端终止的管腔的探针。 传送机构适于将探头的远端放置在具有保持在流体内的多个固体支撑体的孔中。 提供了一种检测机构,用于在远端位于流体内时检测远端处固体支持物之一的存在或不存在。 提供测量系统来测量附着的固体支持物的一般尺寸。
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公开(公告)号:USD433502S
公开(公告)日:2000-11-07
申请号:US108584
申请日:1999-07-28
申请人: Paul K. Rand
设计人: Paul K. Rand
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公开(公告)号:US06143891A
公开(公告)日:2000-11-07
申请号:US68185
申请日:1998-05-14
申请人: Francis Gerard Fang , Shiping Xie
发明人: Francis Gerard Fang , Shiping Xie
IPC分类号: C07D491/04 , C07D491/22
CPC分类号: C07D491/04
摘要: The present invention relates to a process for preparing camptothecin and camptothecin analogs of Formula (I) from compounds of Formula (II) and to novel intermediates useful in their preparation, ##STR1## wherein R.sub.1 to R.sub.6 represent various substituents.
摘要翻译: PCT No.PCT / US96 / 17574 Sec。 371日期:1998年5月14日 102(e)日期1998年5月14日PCT提交1996年11月1日PCT公布。 出版物WO97 / 16454 日期:1997年5月9日本发明涉及由式(II)化合物制备式(I)的喜树碱和喜树碱类似物的方法及其制备中可用的新中间体,其中R 1至R 6表示各种取代基。
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公开(公告)号:US6143748A
公开(公告)日:2000-11-07
申请号:US930224
申请日:1997-09-30
IPC分类号: C07D239/34 , A61K31/505 , C07D239/00 , C07D239/52 , C07D411/04 , C07H19/06
CPC分类号: C07D411/04 , C07D239/00
摘要: The present invention is concerned with a process for the preparation of antiviral 1,3-oxathiolane nucleosides comprising an intramolecular glycosylation reaction to produce exclusively the .beta.-diastereomer, and intermediates useful in the process.
摘要翻译: PCT No.PCT / EP96 / 01353 371日期:1997年9月30日 102(e)日期1997年9月30日PCT 1996年3月26日PCT公布。 公开号WO96 / 30369 日期1996年10月3日本发明涉及制备抗病毒1,3-氧硫杂环戊烷核苷的方法,其包括仅产生β-非对映异构体的分子内糖基化反应,以及在该方法中有用的中间体。
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10.
公开(公告)号:US6140100A
公开(公告)日:2000-10-31
申请号:US640906
申请日:1996-05-09
IPC分类号: C12N15/09 , A61K38/00 , A61K47/48 , C12N1/19 , C12N9/48 , C12N9/64 , C12N9/96 , C12N15/57 , C12R1/865 , C12N15/62 , C12N15/79
CPC分类号: B82Y5/00 , A61K47/48361 , A61K47/48761 , C12N9/48 , C12N9/96 , A61K38/00
摘要: Conjugates of a cell targetting molecule and a mutant human carboxypeptidase A enzyme are provided. Suitable targetting molecules include antibodies, hormones, ligands, cytokines, antigens, oligonucleotides and peptidomimetics. Enzymes comprising a mutant human carboxypeptidase A enzyme are also provided.
摘要翻译: PCT No.PCT / GB94 / 02483第 371日期:1996年5月9日 102(e)日期1996年5月9日PCT 1994年11月11日PCT PCT。 公开号WO95 / 13095 日期1995年5月18日提供细胞靶向分子和突变型人羧肽酶A的结合体。 合适的靶向分子包括抗体,激素,配体,细胞因子,抗原,寡核苷酸和肽模拟物。 还提供了包含突变型人羧肽酶A酶的酶。
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