摘要:
A micro-fluidic device containing a micro-fluidic inlet channel to convey a process flow, a plurality of micro-fluidic focusing channels to each convey one of a plurality of focusing flows, a focusing manifold coupled with the inlet channel at an inlet port thereof and with the plurality of focusing channels at a plurality of focusing channel ports thereof to focus the process flow by contacting and hydrodynamically impacting at least three sides of the process flow with the focusing flows, and a micro-fluidic outlet channel coupled with the focusing manifold at an outlet channel port to convey the combined focused process flow and focusing flow from the focusing manifold.
摘要:
A component of a chemical mixture is isolated via a high-throughput purification process. An analytical retention time and corresponding analytical chromatographic parameters are determined for the component. Based on the analytical retention time and the corresponding analytical chromatographic parameters, preparative chromatographic parameters are determined to isolate the component at an accelerated retention time using a preparative column. The chemical mixture is eluted through the preparative column using the preparative chromatographic parameters, and the component is isolated at the accelerated retention time.
摘要:
An automated discrete fluid sample analyzer includes a sample preparation module. The sample preparation module includes a well configured to receive a sample deposited by a pipettor and a sample preparation device in fluid communication with the well. The fluid sample is transferred from the well to the sample preparation device, and the sample preparation device prepares the fluid sample. The pipettor then aspirates the prepared fluid sample. The prepared fluid sample may be transferred from the sample preparation device back to the well, and the pipettor aspirates the prepared fluid sample from the well. In one embodiment, the sample preparation device includes a receptacle having a catalyst disposed therein. The catalyst may include a noble metal catalyst, such as cadmium. In another embodiment, the sample preparation device includes an ultraviolet lamp configured to apply ultraviolet light to the fluid sample. In yet another embodiment, the sample preparation device includes a heater configured to heat the fluid sample. In another aspect, a fluid sample is agitated to place more of the fluid sample in contact with the catalyst.
摘要:
The present invention provides a microarray comprising: a substrate comprising a diazotized substrate; and at least one polypeptide covalently bound to the diazotized substrate. The present invention also provides methods for making such a microarray.
摘要:
The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.
摘要:
An analytical system is provided which uses the kinetic energy of motion of the entire system to drive a fluid under analysis through the system. This is accomplished by use of a tethering system which is attached to the system. Various sensor detection systems may be used to analyze the sample collected within the confines of a sample isolation and concentration module contained within the system. Trace quantities of suspect materials may be detected or monitored by use of the instant system.
摘要:
A microfluidic component having a microfluidic channel is joined to an array component having a flexible array substrate. In an embodiment, the array component includes a prefabricated flexible array that couples with the microfluidic component in modular fashion. The modular architecture provides for different combinations of microfluidic components and array components that can be used to create customized processing and analysis tools.
摘要:
A device for applying a plurality of microdroplets onto a substrate comprises a dosing head substrate (10) having a plurality of nozzle openings (16) formed therein. For each nozzle opening (16), there is provided a media portion (18) to be filled with a liquid to be dosed. There is provided a deformable component (28) that is arranged adjacent the media portions (18). Finally, the device comprises an actuating means (34) for actuating the deformable component (30) such that the deformable component (30) deforms into the media portions (18) so as to simultaneously expel microdroplets from the plurality of nozzle openings (16).
摘要:
A flow cell for performing optical analysis of a fluid is provided. The flow cell comprises a monolithic cell housing that defines a detection chamber, fluid inlet and outlet ports and illumination and detection ports. Optical fibers are inserted in the illumination and detection ports, thereby forming substantially fluid-tight seals. A flow cell may be press-fit against a microfluidic device, with fluid sealing aided by O-rings.
摘要:
Liquid dispensing module and methods for dispensing a heated liquid onto a substrate. The dispensing module includes a dispenser body receiving liquid from a heated liquid distribution manifold and an actuator having a housing with an air piston movable in an air cavity and a solenoid valve for pressurizing the air cavity. Movement of the air piston controls a flow-regulating mechanism for selectively dispensing liquid from the dispenser body. A thermally insulating shield may be provided for reducing heat transfer from the manifold and/or dispenser body to the actuator so that the solenoid valve can be mounted directly to the housing and the effective volume of the air cavity can be reduced. The cycle time of the liquid dispensing module may be specified by selecting an initial volume of the air cavity and an effective valve flow coefficient for the actuator that characterizes the air flow to the air cavity.